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Wnt signaling in axon guidance
Abstract
Recent studies have identified Wnt proteins as conserved axon guidance molecules in vertebrates and invertebrates. Wnt proteins are a large family of diffusible factors that play several important roles, both in embryonic development and in adult function. The signaling mechanisms of Wnt proteins are complex and, because Wnts are newly discovered as axon guidance cues, little is known about how Wnt signaling controls the direction of growth cone navigation - a process that is crucial in development of the nervous system. This review summarizes recent work on the role of Wnts in axon guidance and discusses the possible signaling mechanisms involved in growth cone guidance. Understanding how Wnts regulate axon wiring will not only help us to understand how the nervous system is connected but also provide possible tools for axon regeneration.
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“During axonal guidance, another Wnt pathway via the Ryk receptor and proto-oncoprotein Src regulates repulsion of neurons.104,105”
From Wnt signal transduction pathways (2008) · cites this paper as [105]
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Wnt signal transduction pathways
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Hinck, L. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.11.002 · Cited by 187
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Okerlund, N. D., & Cheyette, B. N. R. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-011-9083-6 · Cited by 149
“Interestingly, the relevant Wnt–Fzd pathway seems to involve β-catenin, but not the entire canonical Wnt pathway in which β-catenin drives gene transcription (Zou 2004).”
BackgroundSchmitz, C., Kinge, P., & Hutter, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510527104 · Cited by 131
Directional guidance of nerve growth cones
Wen, Z., & Zheng, J. Q. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.12.005 · Cited by 123
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“More recent studies have revealed that Wnt signaling is critically involved in key processes of the formation and plasticity of the nervous system, including neurogenesis [3], axon guidance [4], dendritic development [5], synaptic differentiation [6] and plasticity [7,8].”
Background‘Suicide’ of crickets harbouring hairworms: a proteomics investigation
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“In the animal kingdom, the Wnt proteins play several important parts in embryonic development and in adult function of the CNS: synaptogenesis, regulation of apoptosis, axon guidance, formation of neural crest, CNS patterning and cell migration (Patapoutian & Reichardt, 2000; Packard et al ., 2003; Zou, 2004).”
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Zou, Y., & Lyuksyutova, A. I. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.01.006 · Cited by 102
“A recent development in axon guidance studies has been the finding that morphogens, which are known to specify cell fate by concentration gradients, are axon guidance cues, adding to the repertoire of wiring instructions for navigating growth cones [3–9].”
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Blakely, B. D., Bye, C. R., Fernando, C. V., Horne, M. K., Macheda, M. L., Stacker, S. A., Arenas, E., & Parish, C. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018373 · Cited by 100
“. Wnts also participate in axon guidance elsewhere in the central nervous system”
BackgroundLopez‐Verrilli, M. A., & Court, F. A. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00205 · Cited by 100
“, 2011), independently from axonal mRNA synthesized in the neuronal nuclei, which needs to be transported a long way before translation, or even provide guiding clues to regenerating axons, such as the axonal guidance protein Wnt, which has been detected in exosomes from motor neurons (Zou, 2004; Korkut et al., 2009).”
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“In addition to their involvement in a number of diverse developmental processes (Logan and Nusse, 2004), Wnts play roles in various aspects of nervous system development, such as cell fate determination, synapse formation, axon guidance and neurite outgrowth (Ciani and Salinas, 2005; Fradkin et al., 2005; Zou, 2004).”
BackgroundNon‐conventional Frizzled ligands and Wnt receptors
Hendrickx, M., & Leyns, L. (2008) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2008.01016.x · Cited by 97
Wolf, A. M., Lyuksyutova, A. I., Fenstermaker, A. G., Shafer, B., Lo, C. G., & Zou, Y. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0029-08.2008 · Cited by 95
“Identification of this PI3K – PKC pathway does not exclude other pathways, such as the PCP pathway, for orchestrating different aspects of this cellular process (Logan and Nusse, 2004; Zou, 2004).”
BackgroundSelf-citationAxon guidance and injury — lessons from Wnts and Wnt signaling
Onishi, K., Hollis, E. R., II, & Zou, Y. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.05.005 · Cited by 92
“In the same year, Drosophila Wnt5 was found to repel axons via another Wnt receptor, Derailed [2 ,3].”
Self-citationSato, Y., Fu, Y., Liu, H., Lee, M. Y., & Shaw, M. H. (2021) · BMC Cancer · doi:10.1186/s12885-021-08974-3 · Cited by 100
Miyashita, T., Koda, M., Kitajo, K., Yamazaki, M., Takahashi, K., Kikuchi, A., & Yamashita, T. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0776 · Cited by 90
“Members of the Wnt family of proteins are key regulators of pivotal developmental processes that include patterning, the specification of cell fate, and the determination of tissue polarity (Ciani et al., 2005; Zou, 2004).”
Wang, J., Ruan, N.-J., Qian, L., Lei, W., Chen, F., & Luo, Z. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709939200 · Cited by 85
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“Wnt/Ryk signaling pathway to activate intracellular signaling cascades.(7,25,38) Ryk is a single span transmembrane receptor”
BackgroundWnt signaling promotes axonal regeneration following optic nerve injury in the mouse
Patel, A. K., Park, K. K., & Hackam, A. S. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.12.020 · Cited by 83
“Previous studies have shown that Wnt signaling ligands can act as attractive or repulsive axonal guidance cues for ascending and descending axons in the corticospinal tract during development (Zou, 2004).”
BackgroundWnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryosPreprint
Nakamura, K., Kim, S. Y., Ishidate, T., Bei, Y., Pang, K. M., Shirayama, M., Trzepacz, C., Brownell, D. R., & Mello, C. C. (2005) · Genes & Development · doi:10.1101/gad.1323705 · Cited by 81
“Wnt proteins are secreted signaling molecules important in numerous developmental events in animals (Cadigan and Nusse 1997; Zou 2004).”
BackgroundKemp, C. R., Willems, E., Wawrzak, D., Hendrickx, M., Agbor, T. A., & Leyns, L. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21198 · Cited by 83
“By 9.0 dpc, expression of Fzd10 is found in the dorsal neural tube (O). guiding the dVE to its anterior position through Fzd5 and Fzd8 (Zou, 2004; Kimura-Yoshida et al., 2005).”
BackgroundInfluentialMutations of the Sonic Hedgehog Pathway Underlie Hypothalamic Hamartoma with Gelastic Epilepsy
Hildebrand, M. S., Griffin, N. G., Damiano, J. A., Cops, E. J., Burgess, R., Öztürk, E., Jones, N. C., Leventer, R. J., Freeman, J. L., Harvey, A. S., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.05.031 · Cited by 74
A Wnt-Frz/Ror-Dsh Pathway Regulates Neurite Outgrowth in Caenorhabditis elegans
Song, S., Zhang, B., Sun, H. J., Li, X., Xiang, Y., Liu, Z., Huang, X., & Ding, M. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001056 · Cited by 73
“Wnt signaling, first identified in regulating embryonic pattern formation, has recently been linked to neurite A/P guidance [5].”
BackgroundJNK Signaling Pathway Involvement in Spinal Cord Neuron Development and Death
Schellino, R., Boido, M., & Vercelli, A. (2019) · Cells · doi:10.3390/cells8121576 · Cited by 72
“Wnt-Frizzled signaling plays a fundamental role in spinal cord development and function by activating several pathways [50].”
BackgroundThe Plane Facts of PCP in the CNS
Goodrich, L. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.003 · Cited by 73
“In vertebrates, Fz-mediated axon guidance is thought to occur in response to a Wnt cue (Lyuksyutova et al., 2003; Zou, 2004).”
BackgroundCheusova, T., Khan, M. A., Schubert, S. W., Gavin, A., Buchou, T., Jacob, G., Sticht, H., Allende, J. E., Boldyreff, B., Brenner, H. R., et al. (2006) · Genes & Development · doi:10.1101/gad.375206 · Cited by 64
“The planar-cell polarity part of the Wnt/ -catenin pathway is also implicated in post-synaptic cytoskeletal reorganization since members of this pathway, namely -catenin, Dishevelled, and the tumor suppressor protein adenomatous polyposis coli, directly associate with players of the post-synaptic membrane (Luo et al.…”
BackgroundAn Overview of Neural Differentiation Potential of Human Adipose Derived Stem Cells
Salehi, H., Amirpour, N., Niapour, A., & Razavi, S. (2015) · Stem Cell Reviews and Reports · doi:10.1007/s12015-015-9631-7 · Cited by 65
Wnt and lithium: a common destiny in the therapy of nervous system pathologies?
Meffre, D., Grenier, J., Bernard, S., Courtin, F., Dudev, T., Shackleford, G., Jafarian-Tehrani, M., & Massaad, C. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1378-1 · Cited by 66
“The stabilization of β-catenin may play a role by indirectly affecting cadherinmediated adhesion [58].”
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“Wnt proteins are also involved in axon guidance within the spinal cord in an anterior-posterior direction [36].”
BackgroundAxon Guidance Molecules Guiding Neuroinflammation
Lee, W. S., Lee, W., Bae, Y. C., & Suk, K. (2019) · Experimental Neurobiology · doi:10.5607/en.2019.28.3.311 · Cited by 61
Wong, C. T., Ahmad, E., Li, H., & Crawford, D. A. (2014) · Cell Communication and Signaling · doi:10.1186/1478-811x-12-19 · Cited by 65
“Wnt signalling also modulates neurite outgrowth [66], axon growth and guidance [67-70], dendritic development and arborization [71,72], radial migration [73], and synapse formation and plasticity [74,75].”
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“It is widely assumed that noncanonical ligands act independently of the -catenin pathway and signal either via JnK phosphorylation or via Ca 2 release and activation of calmodulin kinase II (Zou, 2004; Lyu et al., 2008; Farías et al., 2009).”
Mohamed, A. M., & Chin-Sang, I. D. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2005.11.019 · Cited by 50
“Examples of these cues include Netrins, Slits, Ephrins, Semaphorins and Wnts, for reviews, see Dickson (2002) and Zou (2004).”
BackgroundA β-Catenin-Dependent Wnt Pathway Mediates Anteroposterior Axon Guidance in C. elegans Motor Neurons
Maro, G. S., Klassen, M. P., & Shen, K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004690 · Cited by 48
“Whereas substantial research has implicated a variety of Wnts and their receptors in the regulation of axon guidance, our understanding of the downstream signaling pathways remains limited [7,8].”
BackgroundDkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis
Kohn, M. J., Kaneko, K. J., & Depamphilis, M. (2005) · Molecular Reproduction and Development · doi:10.1002/mrd.20314 · Cited by 41
“DKK3 is also an effector of Wnt signaling (Caricasole et al., 2003), and Wnt signaling has clear roles in axon guidance (reviewed in Zou, 2004).”
BackgroundDerailed regulates development of the Drosophila neuromuscular junction
Liebl, F. L. W., Wu, Y., Featherstone, D. E., Noordermeer, J. N., Fradkin, L. G., & Hing, H. K. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20562 · Cited by 40
“Wg and Gbb are evolutionary conserved proteins involved in a number of developmental processes including cell fate specification, axis patterning, and recently, neural development (for reviews see Logan and Nusse, 2004; Zou, 2004; Ille and Sommer, 2005; Marques, 2005).”
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“Therefore, Wnt signaling might logically contribute to elongation and guidance of newly sprouted ORN neuritis during development of the olfactory system, expanding the guidance functions of Wnt molecules to the peripheral neurites (Zou, 2004; Bovolenta, 2005; Ille and Sommer 2005).”
BackgroundDoes Planar Cell Polarity Signaling Steer Growth Cones?
Zou, Y. (2012) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-394592-1.00009-0 · Cited by 38
“This has also led to the investigation on how Wnt family morphogens signal in growth cones to guide axons (Zou, 2004).”
BackgroundSelf-citationBurton, E. A., Simon, K. A., Hou, S., Ren, D., & Luk, Y. (2009) · Langmuir · doi:10.1021/la803261b · Cited by 38
Celsr3 and Fzd3 in axon guidance
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“Wnt signaling plays important roles in nervous system development and function, including axon guidance, synapse formation, and plasticity (Zou, 2004; Salinas and Zou, 2008) and has also been associated with neurodegenerative diseases, including Alzheimer disease, Parkinson disease,…”
Self-citationElliott, K. L., Fritzsch, B., & Duncan, J. S. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00252 · Cited by 37
“Given the role of several other PCP proteins in axon guidance in other neuronal systems (Zou, 2004; Hua et al., 2014; Qu et al., 2014; Chai et al., 2015; Wang et al., 2017), it is likely that additional PCP proteins play also a role in inner ear afferent navigation.”
BackgroundGhimire, S. R., & Deans, M. R. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1740-19.2019 · Cited by 32
“Intercellular signals relayed by planar cell polarity (PCP) proteins contribute to an array of developmental events, including axon outgrowth and guidance, and the establishment of planar polarity (Zou, 2004; Wang and Nathans, 2007; Goodrich and Strutt, 2011; Tissir and Goffinet, 2013).”
BackgroundInfluentialExpression and Manipulation of the APC-β-Catenin Pathway During Peripheral Neuron Regeneration
Duraikannu, A., Martinez, J. A., Chandrasekhar, A., & Zochodne, D. W. (2018) · Scientific Reports · doi:10.1038/s41598-018-31167-1 · Cited by 34
Modulating Wnt signaling to improve cell replacement therapy for Parkinson's disease
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Zheng, C., Díaz-Cuadros, M., & Chalfie, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518686112 · Cited by 33
“Wnt signals evoke downstream activity mainly through three different intracellular pathways: the β-catenin-dependent canonical pathway, the planar cell polarity (PCP) pathway, and the Wnt/calcium pathway (13, 14).”
BackgroundWnt signalling pathway and tau phosphorylation: A comprehensive study on known connections
Hadi, F., Akrami, H., Shahpasand, K., & Fattahi, M. R. (2020) · Cell Biochemistry and Function · doi:10.1002/cbf.3530 · Cited by 29
Wnt Signaling in Neural Circuit Development
Fradkin, L. G., Garriga, G., Salinas, P. C., Thomas, J. B., Yu, X., & Zou, Y. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3429-05.2005 · Cited by 32
“…important roles in several aspects of neural circuit development, such as neuronal migration, axon pathfinding, dendritic morphogenesis, and synaptic differentiation (Schnorrer and Dickson, 2004; Yoshikawa and Thomas, 2004; Zou, 2004; Ciani and Salinas, 2005; Charron and Tessier-Lavigne, 2005).”
BackgroundResultSelf-citationCarpenter, G. H., Khosravani, N., Ekström, J., Osailan, S. M., Paterson, K. P., & Proctor, G. (2008) · Experimental Physiology · doi:10.1113/expphysiol.2008.045112 · Cited by 29
“By comparison with other models, Ectodysplasin (Hinck, 2004) and Wingless/Int (Wnt) pathways (Zou, 2004) may be involved, and all these molecules are expressed in developing embryonic salivary glands (Hoffman et al. 2002).”
ResultChu, T., Zhou, H., Wang, T., Lu, L., Li, F., Liu, B., Kong, X., & Feng, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.11.029 · Cited by 28
Construction and reconstruction of brain circuits: normal and pathological axon guidance
Roig‐Puiggros, S., Vigouroux, R. J., Beckman, D., Bocai, N. I., Chiou, B., Davimes, J. G., Gómez, G., Grassi, S., Hoque, A., Karikari, T. K., et al. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14900 · Cited by 29
“The disruption of the Wnt gradient, results in a randomization of the growth of post-crossing commissural axons, which randomly turn toward the anterior or posterior part (Yoshikawa et al. 2003; Zou 2004).”
BackgroundNeuronal Target Identification Requires AHA-1-Mediated Fine-Tuning of Wnt Signaling in C. elegans
Zhang, J., Li, X., Jevince, A. R., Guan, L., Wang, J., Hall, D. H., Huang, X., & Ding, M. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003618 · Cited by 27
“Wnt signaling has recently been linked to axon guidance and synapse patterning [14,15].”
BackgroundAgrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle
Walker, L. J., Roque, R. A., Navarro, M. F., & Granato, M. (2021) · Development · doi:10.1242/dev.199790 · Cited by 24
“Although a functional role for Wnt:MuSK signaling to establish prepatterning in mouse is more controversial (Messéant et al., 2015; Remédio et al., 2016), Wnt proteins in mammals regulate both AChR clustering (Henriquez et al., 2008; Wang et al., 2008) and axon guidance (reviewed by Zou, 2004).”
BackgroundTargeting axon guidance cues for neural circuit repair after spinal cord injury
Zou, Y. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20961852 · Cited by 22
Self-citationControl of dendritic diversity
Landgraf, M., & Evers, J. F. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.005 · Cited by 23
CNS regeneration: A morphogen's tale
Vergara, M. N., Arsenijévic, Y., & Rio‐Tsonis, K. D. (2005) · Journal of Neurobiology · doi:10.1002/neu.20158 · Cited by 22
“In nervous tissues, these molecules act as conserved axon guidance cues, and are also able to remodel axons and act as retrograde signals during synapse formation in the Cerebellum (reviewed by Zou, 2004).”
BackgroundYamagami, T., Pleasure, D., Lam, K. S., & Zhou, C. J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.02.004 · Cited by 21
Wang, Y., Molotkov, A., Song, L., Li, Y., Pleasure, D., & Zhou, C. J. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21712 · Cited by 20
“Recently, canonical Wnt/ -catenin signaling has been demonstrated to act as directional guidance cues for axons in the anterior-posterior axis of the vertebrate spinal cord (Zou, 2004) and to control the migration of growth cones and neuronal cell bodies as well as neuronal polarity in the anterior-posterior axis of w…”
BackgroundDarkazalli, A., Vied, C., Badger, C.-D., & Levenson, C. W. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2015.4322 · Cited by 19
“45–48 Perhaps the best example of the multi-mechanistic effect exerted by hMSCs on cell-cell and environment-cell signaling in the brain is given by the neuroactive ligand-receptor interaction KEGG pathway, which is comprised of a comprehensive list of genes encoding neuroactive receptors.”
González‐Casacuberta, I., Morén, C., Juárez‐Flores, D. L., Esteve‐Codina, A., Sierra, C., Catalán‐García, M., Guitart‐Mampel, M., Tobías, E., Milisenda, J. C., Pont‐Sunyer, C., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.01.021 · Cited by 17
Booker‐Dwyer, T., Hirsh, S., & Zhao, H. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20606 · Cited by 15
“There is increasing evidence that Wnt signaling contributes to the formation of neuronal connections at later developmental stages (Zou, 2004; Ciani and Salinas, 2005).”
Hendi, A., Niu, L., Snow, A. W., Ikegami, R., Wang, Z., & Mizumoto, K. (2022) · eLife · doi:10.7554/elife.80555 · Cited by 19
Wnts send axons up and down the spinal cord
Dickson, B. J. (2005) · Nature Neuroscience · doi:10.1038/nn0905-1130 · Cited by 14
Development of the Central Nervous System
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Kandemir, B., Dag, U., Bakır-Güngör, B., Durası, İ. M., Erdoğan, B., Şahin, E., Sezerman, O. U., & Kurnaz, I. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170585 · Cited by 12
The RNA-binding protein Nab2 regulates the proteome of the developing Drosophila brain
Corgiat, E. B., List, S. M., Rounds, J. C., Corbett, A. H., & Moberg, K. H. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100877 · Cited by 12
Liebl, F. L. W., McKeown, C. L., Yao, Y., & Hing, H. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012778 · Cited by 13
“Wnt proteins signal through at least three types of receptors including the Frizzled (Fz) family of receptors [18,19], the Ryk/ Drl family of receptor tyrosine kinases [30–34], and the receptor tyrosine kinase-like orphan receptor (Ror) [35,36].”
Slit neuronal secretion coordinates optic lobe morphogenesis in Drosophila
Caipo, L., González-Ramírez, M. C., Guzmán-Palma, P., Contreras, E. G., Palominos, T., Fuenzalida‐Uribe, N., Hassan, B. A., Campusano, J. M., Sierralta, J. A., & Oliva, C. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.10.004 · Cited by 13
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Duan, X., Gao, Y., & Liu, Y. (2017) · Cell Discovery · doi:10.1038/celldisc.2017.15 · Cited by 11
The Roles of Wnt Signaling in Early Mouse Development and Embryonic Stem Cells
KempMarijke, C. R., & Leyns, L. (2007) · Cited by 11
Zhang, N., Lin, J., Chin, J. S., Wiraja, C., Xu, C., McGrouther, D. A., & Chew, S. Y. (2022) · Journal of Tissue Engineering · doi:10.1177/20417314221087417 · Cited by 11
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“This finding is thought to underline the physiology of the 24 h embryos, i.e., yolk protein hydrolysis, mitosis, and blastoderm forming (Zou, 2004; Vasiev et al., 2010; Mottier-Pavie et al., 2016; Yamazaki et al., 2016).”
BackgroundInfluentialReceptor binding and tortuosity explain morphogen local-to-global diffusion coefficient transition
Zhu, S., Loo, Y. T., Veerapathiran, S., Loo, T. Y. J., Trần, B. N., Teh, C., Zhong, J., Matsudaira, P. T., Saunders, T. E., & Wohland, T. (2024) · Biophysical Journal · doi:10.1016/j.bpj.2024.07.024 · Cited by 9
Albano, G. A., & Hackam, A. S. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1417928 · Cited by 8
“…dynamics and gene transcription, including PI3K signaling, JAK/STAT, MAPK/ ERK, semaphorin-plexin, Ephrins and Wnt signaling (Gao et al., 1999; Zou, 2004; Limoni and Niquille, 2021; Yuasa-Kawada et al., 2023); ii) axon projection towards the target area; iii) synapse establishment between…”
BackgroundAblation of Protein Kinase CK2β in Skeletal Muscle Fibers Interferes with Their Oxidative Capacity
Eiber, N., Simeone, L., & Hashemolhosseini, S. (2017) · Pharmaceuticals · doi:10.3390/ph10010013 · Cited by 8
Corgiat, E. B., List, S. M., Rounds, J. C., Yu, D., Chen, P., Corbett, A. H., & Moberg, K. H. (2022) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkac100 · Cited by 9
“One pathway with an emerging role in both axonal and dendritic development is the planar cell polarity (PCP)-noncanonical Wnt pathway (Zou 2004; Andre et al. 2012; Zou 2012; Gombos et al. 2015; Misra et al. 2016).”
BackgroundMarfull‐Oromí, P., Onishi, K., Han, X., Yates, J. R., & Zou, Y. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.09.018 · Cited by 8
Self-citationβ‐Catenin regulates membrane potential in muscle cells by regulating the α2 subunit of Na,K‐ ATP ase
Zhao, C., Zhang, J., Li, K., Yang, J., Yu, H., Duan, S., Jiang, K., & Li, X. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12564 · Cited by 8
“It has become evident that Wnt/b-catenin signalling plays an important role in the development and maturation of the nervous system, including neuronal development (Wodarz & Nusse, 1998; Ciani & Salinas, 2005), axon guidance and synapse formation (Burden, 2000; Lyuksyutova et al., 2003; Salinas, 2003; Yoshikawa et al.…”
BackgroundZhao, C., Yu, Y., Zhang, Y., Shen, J., Jiang, L., Sheng, G., Zhang, W., Lu, C., Jiang, K., Mao, S., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00831 · Cited by 8
“In the central nervous system (CNS), β-catenin participates in synaptic assembly: neural development, axonal growth, orientation, and synaptogenesis (Salinas, 2003; Yoshikawa et al., 2003; Zou, 2004).”
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“which were held responsible for the success and specificity of nerve fibre regeneration and plasticity during the process of synaptic re-establishment (Goshima et al. 2000; Himanen and Nikolov 2003; Kiryushko et al. 2004; Zou 2004; Zhang et al. 2005).”
BackgroundInfluentialWiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems
Nomdedeu‐Sancho, G., & Alsina, B. (2022) · Developmental Dynamics · doi:10.1002/dvdy.523 · Cited by 7
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“, 2011) and insulin signaling pathways are known to regulate insulin sensitivity, lipid metabolism, glucose and energy homeostasis; the axon guidance pathway is associated with Wnt proteins (Zou, 2004); and the tight junction pathway is related to the pathophysiology of diabetes (Harhaj and Antonetti, 2004).”
BackgroundLithium Therapy Effects on the Reproductive System
Filippa, V., & Mohamed, F. (2018) · Springer eBooks · doi:10.1007/978-3-319-95360-1_16 · Cited by 6
Sokol, S. Y., & Wharton, K. A. (2007) · Development · doi:10.1242/dev.008169 · Cited by 6
“In the nervous system, Wnts have been shown to regulate neuronal polarity and migration, axon pathfinding, and synaptogenesis (Hilliard and Bargmann, 2006; Lyuksyutova et al., 2003; Pan et al., 2006; Salinas, 2005; Speese and Budnik, 2007; Zhang et al., 2007; Zou, 2004).”
BackgroundBaeriswyl, T., & Stoeckli, E. T. (2006) · Europe PMC (PubMed Central) · Cited by 6
Development of the Peripheral Nervous System
Schoenwolf, G. C., Bleyl, S. B., Brauer, P. R., & Francis‐West, P. H. (2009) · Elsevier eBooks · doi:10.1016/b978-0-443-06811-9.10010-7 · Cited by 6
Molecular Control of Circuit Plasticity and the Permanence of Imprinted Odor MemoryPreprint
Wu, Y., Ma, L., Qiu, Q., Xu, W., Misra, A., Duyck, K., Blanck, J. F., Scott, A. R., Chen, S., Hassan, H., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.29.486284 · Cited by 6
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Chakraborty, A., Mondal, S., Mahajan, S., & Sharma, V. K. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18571 · Cited by 5
“Extracellular matrix proteins such as cadherin, and extracellular developmental proteins such as Wnt are also involved in axon guidance and synapse formation in the nervous system [105,106], and were highly expanded in both peafowl species.”
Background
Metadata
- Authors
- Zou, Y.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Zou, Yimin
- ORCID
- Zou, Yimin
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 27
- Issue
- 9
- Pages
- 528-532
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W1983145618
- Cited by
- 138
- References
- 45
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 9 · 2021: 14 · 2020: 3 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 3
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS047484)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt signaling, axon guidance, Wnt proteins, axon guidance cues, brain development, axon regeneration
- MeSH terms
- Animals, Axons, Models, Neurological, Proto-Oncogene Proteins, Signal Transduction, Wnt Proteins
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