Dishevelled promotes axon differentiation by regulating atypical protein kinase C
Abstract
The atypical protein kinase C (aPKC) in complex with PAR3 and PAR6 is required for axon-dendrite differentiation, but the upstream factors responsible for regulating its activity are largely unknown. Here, we report that in cultured hippocampal neurons aPKC is directly regulated by Dishevelled (Dvl), an immediate downstream effector of Wnt. We found that downregulation of Dvl abrogated axon differentiation, whereas Dvl overexpression resulted in multiple axon formation. Interestingly, Dvl was associated with aPKC and this interaction resulted in aPKC stabilization and activation. Furthermore, the multiple axon formation resulting from Dvl overexpression was attenuated by expressing a dominant-negative aPKC in these neurons and overexpression of aPKC prevented the loss of axon caused by Dvl downregulation. Finally, Wnt5a, a noncanonical Wnt, activated aPKC and promoted axon differentiation. The Wnt5a effect on axon differentiation was attenuated by downregulating Dvl or inhibiting aPKC. Thus, Dvl-aPKC interaction can promote axon differentiation mediated by the PAR3-PAR6-aPKC complex.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PI3K/AKT, RAS/ERK, WNT and β-catenin pathways control soma size, dendritic arborization, axon generation, spine development and synapse function.
“These pathways control soma size, dendritic arborization, axon generation, spine development and synapse function [184–188].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [187]
Cites
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325 · see citing works
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,017 · see citing works
The establishment of polarity by hippocampal neurons in culture.
Dotti, C., Sullivan, C., & Banker, G. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01454.1988 · Cited by 1,862 · see citing works
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
Joberty, G., Petersen, C., Gao, L., & Macara, I. G. (2000) · Nature Cell Biology · doi:10.1038/35019573 · Cited by 928 · see citing works
Drewes, G., Ebneth, A., Preuss, U., Mandelkow, E.-M., & Mandelkow, E. (1997) · Cell · doi:10.1016/s0092-8674(00)80208-1 · Cited by 878 · see citing works
GSK-3β Regulates Phosphorylation of CRMP-2 and Neuronal Polarity
Yoshimura, T., Kawano, Y., Arimura, N., Kawabata, S., Kikuchi, A., & Kaibuchi, K. (2005) · Cell · doi:10.1016/j.cell.2004.11.012 · Cited by 877 · see citing works
Kühl, M., Sheldahl, L. C., Park, M., Miller, J. R., & Moon, R. T. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)02028-x · Cited by 862 · see citing works
Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity
Etienne-Manneville, S., & Hall, A. (2003) · Nature · doi:10.1038/nature01423 · Cited by 835 · see citing works
Efficient Gene Transfer into the Embryonic Mouse Brain Using in Vivo Electroporation
Saito, T., & Nakatsuji, N. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0439 · Cited by 770 · see citing works
A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
Lin, D., Edwards, A. S., Fawcett, J. P., Mbamalu, G., Scott, J. D., & Pawson, T. (2000) · Nature Cell Biology · doi:10.1038/35019582 · Cited by 743 · see citing works
Craig, A. M., & Banker, G. A. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.001411 · Cited by 678 · see citing works
WNTS in the vertebrate nervous system: from patterning to neuronal connectivity
Ciani, L., & Salinas, P. C. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1665 · Cited by 631 · see citing works
Hippocampal Neuronal Polarity Specified by Spatially Localized mPar3/mPar6 and PI 3-Kinase Activity
Shi, S.-H., Jan, L. Y., & Jan, Y.-N. (2003) · Cell · doi:10.1016/s0092-8674(02)01249-7 · Cited by 600 · see citing works
Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling
Lyuksyutova, A. I., Lu, C.-C., Milanesio, N., King, L. A., Guo, N., Wang, Y., Nathans, J., Tessier‐Lavigne, M., & Zou, Y. (2003) · Science · doi:10.1126/science.1089610 · Cited by 557 · see citing works
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
Wallingford, J. B., & Habas, R. (2005) · Development · doi:10.1242/dev.02068 · Cited by 509 · see citing works
Both the Establishment and the Maintenance of Neuronal Polarity Require Active Mechanisms
Jiang, H., Guo, W., Liang, X., & Rao, Y. (2005) · Cell · doi:10.1016/j.cell.2004.12.033 · Cited by 494 · see citing works
Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development
Rosso, S. B., Sussman, D., Wynshaw-Boris, A., & Salinas, P. C. (2005) · Nature Neuroscience · doi:10.1038/nn1374 · Cited by 485 · see citing works
Mammalian Ryk Is a Wnt Coreceptor Required for Stimulation of Neurite Outgrowth
Lu, W., Yamamoto, V. N., Ortega, B., & Baltimore, D. (2004) · Cell · doi:10.1016/j.cell.2004.09.019 · Cited by 466 · see citing works
Wnt-mediated axon guidance via the Drosophila Derailed receptor
Yoshikawa, S., McKinnon, R. D., Kokel, M., & Thomas, J. B. (2003) · Nature · doi:10.1038/nature01522 · Cited by 416 · see citing works
Benton, R., & Johnston, D. S. (2003) · Cell · doi:10.1016/s0092-8674(03)00938-3 · Cited by 410 · see citing works
The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity.
Schwamborn, J. C., & Püschel, A. W. (2004) · Nature Neuroscience · doi:10.1038/nn1295 · Cited by 385 · see citing works
PAR-6–PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1
Nishimura, T., Yamaguchi, T., Kato, K., Yoshizawa, M., Nabeshima, Y.-I., Ohno, S., Hoshino, M., & Kaibuchi, K. (2005) · Nature Cell Biology · doi:10.1038/ncb1227 · Cited by 365 · see citing works
Mammalian SAD Kinases Are Required for Neuronal Polarization
Kishi, M., Pan, Y. A., Crump, J. G., & Sanes, J. R. (2005) · Science · doi:10.1126/science.1107403 · Cited by 343 · see citing works
Macara, I. G. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1332 · Cited by 341 · see citing works
Centrosome localization determines neuronal polarity
de Anda, F. C., Pollarolo, G., Silva, J. S. D., Camoletto, P. G., Feiguin, F. M., & Dotti, C. G. (2005) · Nature · doi:10.1038/nature03811 · Cited by 337 · see citing works
Suzuki, A., Hirata, M., Kamimura, K., Maniwa, R., Yamanaka, T., Mizuno, K., Kishikawa, M., Hirose, H., Amano, Y., Izumi, N., et al. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.021 · Cited by 319 · see citing works
Lucas, F. R., Goold, R., Gordon‐Weeks, P. R., & Salinas, P. C. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.10.1351 · Cited by 301 · see citing works
Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity.
Nishimura, T., Kato, K., Yamaguchi, T., Fukata, Y., Ohno, S., & Kaibuchi, K. (2004) · Nature Cell Biology · doi:10.1038/ncb1118 · Cited by 289 · see citing works
Atypical PKC Phosphorylates PAR-1 Kinases to Regulate Localization and Activity
Hurov, J., Watkins, J. L., & Piwnica-Worms, H. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.04.007 · Cited by 282 · see citing works
Experimentally induced alteration in the polarity of developing neurons
Dotti, C. G., & Banker, G. A. (1987) · Nature · doi:10.1038/330254a0 · Cited by 278 · see citing works
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling
Sun, T., Lu, B., Feng, J., Reinhard, C., Jan, Y. N., Fantl, W. J., & Williams, L. T. (2001) · Nature Cell Biology · doi:10.1038/35083016 · Cited by 255 · see citing works
Regulation of AChR Clustering by Dishevelled Interacting with MuSK and PAK1
Luo, Z., Wang, Q., Zhou, J., Wang, J., Luo, Z., Liu, M., He, X., Wynshaw-Boris, A. J., Xiong, W., Lu, B., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00783-3 · Cited by 238 · see citing works
Self-citationWnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans
Prasad, B. C., & Clark, S. G. (2006) · Development · doi:10.1242/dev.02357 · Cited by 219 · see citing works
The atypical protein kinase Cs
Moscat, J., & Díaz-Meco, M. T. (2000) · EMBO Reports · doi:10.1093/embo-reports/kvd098 · Cited by 217 · see citing works
Wnt Signals and Frizzled Activity Orient Anterior-Posterior Axon Outgrowth in C. elegans
Hilliard, M. A., & Bargmann, C. I. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.01.013 · Cited by 199 · see citing works
Böhm, H., Brinkmann, V., Dráb, M., HENSKE, A., & Kurzchalia, T. V. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00260-0 · Cited by 165 · see citing works
Chen, Y. M., Wang, Q. J., Hu, H. S., Yu, P. C., Zhu, J., Drewes, G., Piwnica-Worms, H., & Luo, Z. G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509955103 · Cited by 161 · see citing works
Self-citationWnt signaling in axon guidance
Zou, Y. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.015 · Cited by 138 · see citing works
Regulation of Lethal giant larvae by Dishevelled
Dollar, G. L., Weber, U., Mlodzik, M., & Sokol, S. Y. (2005) · Nature · doi:10.1038/nature04116 · Cited by 131 · see citing works
Dishevelled-1 Regulates Microtubule Stability
Krylova, O. Y., Messenger, M. J., & Salinas, P. C. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.1.83 · Cited by 120 · see citing works
Requirement of dendritic Akt degradation by the ubiquitin–proteasome system for neuronal polarity
Yan, D., Guo, L., & Wang, Y. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200511028 · Cited by 98 · see citing works
Synaptogenesis: Wnt and TGF-β Take Centre Stage
Salinas, P. C. (2003) · Current Biology · doi:10.1016/s0960-9822(02)01429-x · Cited by 47 · see citing works
Wnts as Retrograde Signals for Axon and Growth Cone Differentiation
Burden, S. J. (2000) · Cell · doi:10.1016/s0092-8674(00)80685-6 · Cited by 37 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
Shackelford, D. B., & Shaw, R. J. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2676 · Cited by 1,943 · see citing works
Targeting the Wnt/β-catenin signaling pathway in cancer
Zhang, Y., & Wang, X. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00990-3 · Cited by 1,431 · see citing works
GSK3 signalling in neural development
Hur, E., & Zhou, F. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2870 · Cited by 828 · see citing works
Dishevelled: The hub of Wnt signaling
Gao, C., & Chen, Y. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.11.021 · Cited by 751 · see citing works
Self-citationThe PAR Proteins: Fundamental Players in Animal Cell Polarization
Goldstein, B., & Macara, I. G. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.10.007 · Cited by 746 · see citing works
Wnt/Ca2+ signaling pathway: a brief overview
De, A. (2011) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmr079 · Cited by 532 · see citing works
Establishment of axon-dendrite polarity in developing neurons.
Barnes, A. P., & Polleux, F. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125536 · Cited by 523 · see citing works
Rho and Ras GTPases in axon growth, guidance, and branching
Hall, A., & Lalli, G. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001818 · Cited by 437 · see citing works
Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
Song, P., Gao, Z., Bao, Y., Chen, L., Huang, Y., Liu, Y., Dong, Q., & Wei, X. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01563-4 · Cited by 382 · see citing works
AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity
Hedstrom, K. L., Ogawa, Y., & Rasband, M. N. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200806112 · Cited by 371 · see citing works
Wnt signaling pathways meet Rho GTPasesPreprint
Schlessinger, K., Hall, A., & Tolwinski, N. S. (2009) · Genes & Development · doi:10.1101/gad.1760809 · Cited by 366 · see citing works
SnapShot: Noncanonical Wnt Signaling Pathways
Semënov, M. V., Habas, R., MacDonald, B. T., & He, X. (2007) · Cell · doi:10.1016/j.cell.2007.12.011 · Cited by 349 · see citing works
The ASD Living Biology: from cell proliferation to clinical phenotype
Courchesne, E., Pramparo, T., Gazestani, V. H., Lombardo, M. V., Pierce, K., & Lewis, N. E. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0056-y · Cited by 333 · see citing works
Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases
Narimatsu, M., Bose, R., Pye, M., Zhang, L. N., Miller, B., Ching, P. V., Sakuma, R., Luga, V., Roncari, L., Attisano, L., et al. (2009) · Cell · doi:10.1016/j.cell.2009.02.025 · Cited by 330 · see citing works
Sabbah, M., Emami, S., Redeuilh, G., Julien-Grille, S., Prevost, G. P., Zimber, A., Ouelaa-Benslama, R., Bracke, M., Wever, O. D., & Gespach, C. P. (2008) · Drug Resistance Updates · doi:10.1016/j.drup.2008.07.001 · Cited by 322 · see citing works
Wnt5a: its signalling, functions and implication in diseases
Kikuchi, A., Yamamoto, H., Sato, A., & Matsumoto, S. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02294.x · Cited by 317 · see citing works
Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module
Humbert, P. O., Grzeschik, N. A., Brumby, A. M., Galea, R. C., Elsum, I. A., & Richardson, H. E. (2008) · Oncogene · doi:10.1038/onc.2008.341 · Cited by 313 · see citing works
Polarity proteins in migration and invasion
Etienne‐Manneville, S. (2008) · Oncogene · doi:10.1038/onc.2008.347 · Cited by 289 · see citing works
Wnt signaling in neural circuit assembly
Salinas, P. C., & Zou, Y. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125649 · Cited by 274 · see citing works
WNT signaling in neuronal maturation and synaptogenesis
Rosso, S. B., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00103 · Cited by 272 · see citing works
Ho, H. H., Susman, M. W., Bikoff, J. B., Ryu, Y. K., Jonas, A. M., Hu, L. S., Kuruvilla, R., & Greenberg, M. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200421109 · Cited by 272 · see citing works
Wnt signalling and the control of cellular metabolism
Sethi, J. K., & Vidal‐Puig, A. (2010) · Biochemical Journal · doi:10.1042/bj20091866 · Cited by 246 · see citing works
Planar Cell Polarity Signaling: The Developing Cell's CompassPreprint
Vladar, E. K., Antic, D., & Axelrod, J. D. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002964 · Cited by 242 · see citing works
Dishevelled: A masterful conductor of complex Wnt signals
Sharma, M., Castro‐Piedras, I., Simmons, G. E., Jr., & Pruitt, K. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.03.004 · Cited by 216 · see citing works
WNT-5A: signaling and functions in health and disease
Kumawat, K., & Gosens, R. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2076-y · Cited by 191 · see citing works
Adell, T., Saló, E., Boutros, M., & Bartscherer, K. (2009) · Development · doi:10.1242/dev.033761 · Cited by 182 · see citing works
Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells
Nishita, M., Enomoto, M., Yamagata, K., & Minami, Y. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.03.001 · Cited by 178 · see citing works
Purro, S. A., Ciani, L., Flight, M. H., Stamatakou, E., Siomou, E., & Salinas, P. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2320-08.2008 · Cited by 171 · see citing works
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders
Wong, T., Li, G., Li, S., Gao, W., Chen, G., Gan, S., Zhang, M., Li, H., Wu, S., & Du, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01427-2 · Cited by 168 · see citing works
Li, L., Hutchins, B. I., & Kalil, K. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0183-09.2009 · Cited by 164 · see citing works
Canonical and noncanonical Wnt signaling in neural stem/progenitor cells
Bengoa‐Vergniory, N., & Kypta, R. M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2028-6 · Cited by 161 · see citing works
Identification of a novel Wnt5a–CK1ε–Dvl2–Plk1‐mediated primary cilia disassembly pathway
Lee, K. H., Johmura, Y., Yu, L., Park, J., Gao, Y., Bang, J. K., Zhou, M., Veenstra, T. D., Kim, B. Y., & Lee, K. S. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.144 · Cited by 159 · see citing works
Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis
Lai, S.-L., Chien, A. J., & Moon, R. T. (2009) · Cell Research · doi:10.1038/cr.2009.41 · Cited by 158 · see citing works
Christensen, S. T., Pedersen, S. F., Satir, P., Veland, I. R., & Schneider, L. H. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00810-7 · Cited by 156 · see citing works
Cilia, Wnt signaling, and the cytoskeleton
May‐Simera, H., & Kelley, M. W. (2012) · Cilia · doi:10.1186/2046-2530-1-7 · Cited by 151 · see citing works
Tight junction and polarity interaction in the transporting epithelial phenotype
Cereijido, M., Contreras, R. G., Shoshani, L., Flores-Benítez, D., & Larré, I. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.09.001 · Cited by 148 · see citing works
Centrosome Motility Is Essential for Initial Axon Formation in the Neocortex
de Anda, F. C., Meletis, K., Ge, X., Rei, D., & Tsai, L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0381-10.2010 · Cited by 137 · see citing works
Mori, D., Yamada, M., Mimori‐Kiyosue, Y., Shirai, Y., Suzuki, A., Ohno, S., Saya, H., Wynshaw-Boris, A. J., & Hirotsune, S. (2009) · Nature Cell Biology · doi:10.1038/ncb1919 · Cited by 130 · see citing works
Lgl1 Activation of Rab10 Promotes Axonal Membrane Trafficking Underlying Neuronal Polarization
Wang, T., Liu, Y., Xu, X., Deng, C.-Y., Wu, K.-Y., Zhu, J., Fu, X.-Q., He, M., & Luo, Z. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.007 · Cited by 126 · see citing works
Self-citationMutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways
Sancho, R. M., Law, B. M. H., & Harvey, K. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp337 · Cited by 125 · see citing works
Cellular responses to extracellular guidance cues
Berzat, A. C., & Hall, A. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.170 · Cited by 120 · see citing works
Wnt2 Expression and Signaling Is Increased by Different Classes of Antidepressant Treatments
Okamoto, H., Voleti, B., Banasr, M., Sarhan, M., Đurić, V., Girgenti, M. J., Dileone, R., Newton, S. S., & Duman, R. S. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.023 · Cited by 116 · see citing works
Tumor formation due to abnormalities in the β‐catenin‐independent pathway of Wnt signaling
Kikuchi, A., & Yamamoto, H. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2007.00675.x · Cited by 115 · see citing works
Cell division orientation and planar cell polarity pathways
Manil-Ségalen, M., & Bellaı̈che, Y. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.03.018 · Cited by 115 · see citing works
Liang, B., Duan, B.-Y., Zhou, X., Gong, J., & Luo, Z. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.117960 · Cited by 109 · see citing works
Self-citationWNTs in synapse formation and neuronal circuitry
Park, M., & Shen, K. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.145 · Cited by 106 · see citing works
Insight into the Role of Wnt5a-Induced Signaling in Normal and Cancer Cells
Endo, M., Nishita, M., Fujii, M., & Minami, Y. (2014) · International review of cytology · doi:10.1016/bs.ircmb.2014.10.003 · Cited by 102 · see citing works
Rieger, M. E., Zhou, B., Solomon, N., Sunohara, M., Li, C., Nguyen, C., Liu, Y., Pan, J., Minoo, P., Crandall, E. D., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.706416 · Cited by 101 · see citing works
Loss of Podocyte aPKCλ/ι Causes Polarity Defects and Nephrotic Syndrome
Huber, T. B., Hartleben, B. D., Winkelmann, K., Schneider, L., Becker, J. U., Leitges, M., Walz, G., Haller, H., & Schiffer, M. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008080871 · Cited by 100 · see citing works
Aberrant regulation of Wnt signaling in hepatocellular carcinoma
Liu, L., Xie, S., Chen, Y.-T., Xue, J.-L., Zhang, C., & Zhu, F. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i33.7486 · Cited by 100 · see citing works
Self-citationEarly Events in Axon/Dendrite Polarization
Cheng, P., & Poo, M. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113618 · Cited by 99 · see citing works
Endo, Y., Beauchamp, E. M., Woods, D. M., Taylor, W. G., Toretsky, J. A., Üren, A., & Rubin, J. S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01780-07 · Cited by 97 · see citing works
Widely Conserved Signaling Pathways in the Establishment of Cell PolarityPreprint
McCaffrey, L. M., & Macara, I. G. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001370 · Cited by 95 · see citing works
Wolf, A. M., Lyuksyutova, A. I., Fenstermaker, A. G., Shafer, B., Lo, C. G., & Zou, Y. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0029-08.2008 · Cited by 94 · see citing works
Pyramidal neuron polarity axis is defined at the bipolar stage
de Anda, F. C., Gärtner, A., Tsai, L., & Dotti, C. G. (2008) · Journal of Cell Science · doi:10.1242/jcs.023143 · Cited by 91 · see citing works
Peng, Y., Zeng, S.-Y., Song, H., Li, M.-Y., Yamada, M. K., & Yu, X. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3085-10.2010 · Cited by 90 · see citing works
Emerging mechanisms in morphogen‐mediated axon guidance
Sánchez‐Camacho, C., & Bovolenta, P. (2009) · BioEssays · doi:10.1002/bies.200900063 · Cited by 89 · see citing works
Chapter 7 Polarity Proteins and Cell–Cell Interactions in the Testis
Wong, E. W. P., & Cheng, C. Y. (2009) · International review of cytology · doi:10.1016/s1937-6448(09)78007-4 · Cited by 89 · see citing works
Barth, A. I. M., Caro-Gonzalez, H. Y., & Nelson, W. J. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.02.003 · Cited by 87 · see citing works
The Wnt signaling pathways and cell adhesion
Amin, N. (2011) · Frontiers in bioscience · doi:10.2741/3957 · Cited by 87 · see citing works
Signaling Pathways in Cell PolarityPreprint
McCaffrey, L. M., & Macara, I. G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009654 · Cited by 87 · see citing works
Lei, W., Xing, S., Deng, C.-Y., Ju, X.-C., Jiang, X., & Luo, Z. (2012) · Cell Research · doi:10.1038/cr.2012.40 · Cited by 86 · see citing works
Self-citationArredondo, S. B., Guerrero, F. G., Herrera-Soto, A., Jensen-Flores, J., Bustamante, D., Oñate‐Ponce, A., Henny, P., Varas‐Godoy, M., Inestrosa, N. C., & Varela‐Nallar, L. (2019) · Stem Cells · doi:10.1002/stem.3121 · Cited by 85 · see citing works
Wang, J., Ruan, N.-J., Qian, L., Lei, W., Chen, F., & Luo, Z. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709939200 · Cited by 85 · see citing works
Self-citationTakagishi, M., Enomoto, A., Asai, N., Ushida, K., Watanabe, T., Hashimoto, T., Kato, T., Weng, L., Matsumoto, S., Asai, M., et al. (2012) · Nature Communications · doi:10.1038/ncomms1861 · Cited by 84 · see citing works
Park, S., Kang, M.-J., & Han, J. (2018) · Molecular Brain · doi:10.1186/s13041-018-0383-6 · Cited by 83 · see citing works
Wnt signalling in the development of axon, dendrites and synapses
He, C.-W., Liao, C., & Pan, C. (2018) · Open Biology · doi:10.1098/rsob.180116 · Cited by 82 · see citing works
The Tangled Web of Non-Canonical Wnt Signalling in Neural Migration
Clark, C., Nourse, C. C., & Cooper, H. M. (2012) · Neurosignals · doi:10.1159/000332153 · Cited by 81 · see citing works
Chen, C., Orefice, L. L., Chiu, S., LeGates, T. A., Hattar, S. S., Huganir, R. L., Zhao, H., Xu, B., & Kuruvilla, R. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615792114 · Cited by 79 · see citing works
Par1b/MARK2 Phosphorylates Kinesin-Like Motor Protein GAKIN/KIF13B To Regulate Axon Formation
Yoshimura, Y., Terabayashi, T., & Miki, H. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01181-09 · Cited by 72 · see citing works
Dysregulated Wnt Signalling in the Alzheimer’s Brain
Aghaizu, N. D., Jin, H., & Whiting, P. J. (2020) · Brain Sciences · doi:10.3390/brainsci10120902 · Cited by 70 · see citing works
Dishevelled limits Notch signalling through inhibition of CSL
Collu, G. M., Hidalgo‐Sastre, A., Acar, A., Bayston, L. J., Gildea, C., Leverentz, M. K., Mills, C. G., Owens, T. W., Meurette, O., Dorey, K., et al. (2012) · Development · doi:10.1242/dev.081885 · Cited by 69 · see citing works
Regulation of Phosphatidylinositol Kinases and Metabolism by Wnt3a and Dvl
Qin, Y., Li, L., Pan, W., & Wu, D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.014399 · Cited by 68 · see citing works
The Plane Facts of PCP in the CNS
Goodrich, L. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.003 · Cited by 68 · see citing works
Neuronal Polarity: Positive and Negative Feedback Signals
Takano, T., Funahashi, Y., & Kaibuchi, K. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00069 · Cited by 65 · see citing works
JIP1 Mediates Anterograde Transport of Rab10 Cargos during Neuronal Polarization
Deng, C.-Y., Lei, W., Xu, X., Ju, X.-C., Liu, Y., & Luo, Z. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4496-13.2014 · Cited by 65 · see citing works
Self-citationLinking Cell Polarity to Cortical Development and Malformations
Hakanen, J., Ruiz-Reig, N., & Tissir, F. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00244 · Cited by 65 · see citing works
Rosenfeld, J. A., Crolla, J. A., Tomkins, S. E., Bader, P. I., Morrow, B. E., Gorski, J. L., Troxell, R., Forster‐Gibson, C., Cilliers, D. D., Hislop, R. G., et al. (2010) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33516 · Cited by 62 · see citing works
Wnt and lithium: a common destiny in the therapy of nervous system pathologies?
Meffre, D., Grenier, J., Bernard, S., Courtin, F., Dudev, T., Shackleford, G., Jafarian-Tehrani, M., & Massaad, C. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1378-1 · Cited by 61 · see citing works
Witze, E. S., Connacher, M. K., Houel, S., Schwartz, M. P., Morphew, M. K., Reid, L., Sacks, D. B., Anseth, K. S., & Ahn, N. G. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.08.019 · Cited by 59 · see citing works
Nakamuta, S., Funahashi, Y., Namba, T., Arimura, N., Picciotto, M. R., Tokumitsu, H., Soderling, T. R., Sakakibara, A., Miyata, T., Kamiguchi, H., et al. (2011) · Science Signaling · doi:10.1126/scisignal.2002011 · Cited by 59 · see citing works
Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a–dependent neurite outgrowth
Greer, Y. E., & Rubin, J. S. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201011111 · Cited by 58 · see citing works
Wynshaw-Boris, A. J. (2012) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-394592-1.00007-7 · Cited by 57 · see citing works
The many postures of noncanonical Wnt signaling in development and diseases
Xiao, Q., Chen, Z., Jin, X., Mao, R., & Chen, Z. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.06.061 · Cited by 57 · see citing works
Role of LKB1‐SAD/MARK pathway in neuronal polarization
Shelly, M., & Poo, M. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20884 · Cited by 56 · see citing works
Liu, X., Chen, W., Zhou, Y. L., Tang, K., & Zhang, J. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430117 · Cited by 55 · see citing works
Transcriptional profiling of intrinsic PNS factors in the postnatal mouse
Smith, R. P., Lerch, J. K., Pardinas, J. R., Buchser, W., Bixby, J. L., & Lemmon, V. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.07.015 · Cited by 55 · see citing works
Gu, X., Meng, S., Liu, S., Jia, C., Fang, Y., Li, S., Fu, C., Song, Q., Lin, L., & Xuemin, W. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0190-6 · Cited by 55 · see citing works
Wang, G., Krishnamurthy, K., Umapathy, N. S., Verin, A. D., & Bieberich, E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808909200 · Cited by 54 · see citing works
Motoneuron Wnts regulate neuromuscular junction development
Shen, C., Li, L., Zhao, K., Bai, L., Wang, A., Shu, X., Xiao, Y., Zhang, J., Zhang, K., Hui, T., et al. (2018) · eLife · doi:10.7554/elife.34625 · Cited by 53 · see citing works
Kimura‐Kuroda, J., Nishito, Y., Yanagisawa, H., Kuroda, Y., Komuta, Y., Kawano, H., & Hayashi, M. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13100987 · Cited by 51 · see citing works
Terabayashi, T., Itoh, T. J., Yamaguchi, H., Yoshimura, Y., Funato, Y., Ohno, S., & Miki, H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3986-07.2007 · Cited by 51 · see citing works
Thyroid hormone, gene expression, and Central Nervous System: Where we are
Giannocco, G., Kizys, M. M. L., Maciel, R. M. B., & de Souza, J. S. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.09.007 · Cited by 50 · see citing works
Chen, X., An, Y., Gao, Y., Guo, L., Lei, R. L., Xie, H., Sun, M., Hung, S. L., Sheng, X., Zou, J., et al. (2016) · Human Mutation · doi:10.1002/humu.23153 · Cited by 47 · see citing works
Jang, S., Park, J.-S., & Jeong, H. (2015) · Stem Cells International · doi:10.1155/2015/178618 · Cited by 47 · see citing works
Merks, A. M., Swinarski, M., Meyer, A. M., Müller, N. V., Özcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah‐Seyfried, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04566-1 · Cited by 45 · see citing works
Yebra, M., Diaferia, G. R., Montgomery, A. M. P., Kaido, T. J., Brunken, W. J., Koch, M., Hardiman, G., Crisá, L., & Cirulli, V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022750 · Cited by 44 · see citing works
Čajánek, L., Ganji, R. S., Henriques-Oliveira, C., Theofilopoulos, S., Koník, P., Bryja, V., & Arenas, E. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00745-12 · Cited by 44 · see citing works
PAR3–PAR6–atypical PKC polarity complex proteins in neuronal polarization
Hapak, S. M., Rothlin, C. V., & Ghosh, S. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2828-6 · Cited by 43 · see citing works
Caspase-3 Cleavage of Dishevelled Induces Elimination of Postsynaptic Structures
Wang, J., Chen, F., Fu, X.-Q., Ding, C.-S., Zhou, L., Zhang, X., & Luo, Z. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.02.009 · Cited by 42 · see citing works
Self-citation
- Authors
- Zhang, X., Zhu, J., Yang, G.-Y., Wang, Q.-J., Qian, L., Chen, Y.-M., Chen, F., Tao, Y., Hu, H.-S., Wang, T., & Luo, Z.-G.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Luo, Zhen-Ge
- Venue
- Nature Cell Biology
- Published
- 2007-06-10
- Volume
- 9
- Issue
- 7
- Pages
- 743-754
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2132289628
- Cited by
- 220
- References
- 43
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 14 · 2019: 7 · 2018: 10 · 2017: 6 · 2016: 6 · 2015: 12 · 2014: 11 · 2013: 19 · 2012: 16
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Dishevelled, atypical protein kinase C, Wnt5a, non-canonical Wnt signaling, hippocampal neurons, kinase activation, dominant negative kinase
- MeSH terms
- Wnt-5a Protein, Dishevelled Proteins, Protein Kinase C zeta, Animals, Axons, Carrier Proteins, Cells, Cultured, Dendrites, Embryo, Mammalian, Hippocampus, Nerve Tissue Proteins, Neurons, Phosphoproteins, Protein Kinase C, Signal Transduction, Cell Polarity, Adaptor Proteins, Signal Transducing, Wnt Proteins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review