The DOI matches its Crossref record; 93 of the 95 references it cites were found in a registry or an index.
Orbitofrontal cortex, decision-making and drug addiction
Open accessAbstract
The orbitofrontal cortex, as a part of prefrontal cortex, is implicated in executive function. However, within this broad region, the orbitofrontal cortex is distinguished by its unique pattern of connections with crucial subcortical associative learning nodes, such as basolateral amygdala and nucleus accumbens. By virtue of these connections, the orbitofrontal cortex is uniquely positioned to use associative information to project into the future, and to use the value of perceived or expected outcomes to guide decisions. This review will discuss recent evidence that supports this proposal and will examine evidence that loss of this signal, as the result of drug-induced changes in these brain circuits, might account for the maladaptive decision-making that characterizes drug addiction.
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“Thus, the pattern of behavior seen with OFC damage in humans, as well as in non-human primates and rodents (Bechara, 2005; Schoenbaum et al., 2006), is highly reminiscent of addictive behavior.”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Schoenbaum et al., 2006
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“an essential function of the OFC is the flexible assignment of value to environmental stimuli, which critically determines how such stimuli influence our actions (Schoenbaum et al., 2006).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Schoenbaum et al., 2006
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Pessoa, L. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2317 · Cited by 2,350
Frames, Biases, and Rational Decision-Making in the Human Brain
Martino, B. D., Kumaran, D., Seymour, B., & Dolan, R. J. (2006) · Science · doi:10.1126/science.1128356 · Cited by 1,687
Affective neuroscience of pleasure: reward in humans and animals
Berridge, K. C., & Kringelbach, M. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1099-6 · Cited by 1,254
Mental fatigue: Costs and benefits
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Neural ensembles in CA3 transiently encode paths forward of the animal at a decision point
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Metadata
- Authors
- Schoenbaum, G., Roesch, M. R., & Stalnaker, T. A.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Schoenbaum, Geoffrey
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 29
- Issue
- 2
- Pages
- 116-124
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC2430629
- OpenAlex
- W2099221443
- Cited by
- 499
- References
- 95
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 18 · 2023: 15 · 2022: 18 · 2021: 21 · 2020: 60 · 2019: 28 · 2018: 19 · 2017: 24 · 2016: 22 · 2015: 16 · 2014: 18 · 2013: 27 · 2012: 21
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01DA015718)
- National Institute on Deafness and Other Communication Disorders (T32 DC 00054, T32DC000054)
- National Institute of Neurological Disorders and Stroke (T32 NS07375, T32NS007375)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- orbitofrontal cortex, decision-making, drug addiction, prefrontal cortex, executive function, associative learning, basolateral amygdala, nucleus accumbens, outcome value, maladaptive decision-making
- MeSH terms
- Animals, Decision Making, Humans, Neural Pathways, Orbit, Prefrontal Cortex, Substance-Related Disorders
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