Substance use disorders and the orbitofrontal cortex: Systematic review of behavioural decision-making and neuroimaging studies
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Background: Orbitofrontal cortex dysfunctions have been frequently documented in people with substance use disorders. The exact role of this cortical region, however, remains unspecified. Aims: To assess the functionality of the orbitofrontal cortex in people with substance use disorders. Method: Reports of studies using behavioural decision-making tasks and/or neuroimaging techniques to investigate orbitofrontal cortex functioning in cases of substance misuse were reviewed. Studies focusing exclusively on tobacco-smoking and gambling were excluded. Results: Fifty-two research articles were evaluated. Most studies showed significant deficits in decision-making in people with substance use disorders. A consistent finding in the neuroimaging studies was hypoactivity of the orbitofrontal cortex after detoxification. The association between hyperactivity of this region and craving or cue reactivity was not consistent across studies. Conclusions: The orbitofrontal cortex has an important role in addictive behaviours. Further studies are needed to elucidate the underlying neuronal substrates of cue reactivity, craving and decision-making, and the implications for treatment and relapse prevention.
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Insula activity is correlated with craving-associated stimuli and craving intensity.
“That the insula is the neural basis for reward and cravings (Paulus, 2007) is further supported by the results of several imaging studies, which demonstrate that insula activity is correlated with craving-associated stimuli (Brody et al., 2002; Dom et al., 2005; Kilts et al., 2001, 2004; Naqvi and Bechara, 2009), and craving intensity (G.-J. Wang et al., 1999).”
From Atypical interoception as a common risk factor for psychopathology: A review (2021) · cites this paper as Dom et al., 2005
Neuroimaging studies have found abnormal orbitofrontal cortex function associated with substance abuse.
“numerous neuroimaging studies have found abnormal OFC function associated with substance abuse (Boettiger et al., 2007; Dom et al., 2005; Ersche et al., 2005; London et al., 2000; Volkow and Fowler, 2000).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Dom et al., 2005
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Hare, T. A., O'Doherty, J., Camerer, C. F., Schultz, W., & Rangel, A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1309-08.2008 · Cited by 792 · see citing works
“A large number of psychiatric diseases involve deficits in decision-making mechanisms (Dom et al., 2005; Paulus, 2007).”
BackgroundImpulsivity, frontal lobes and risk for addiction
Crews, F. T., & Boettiger, C. A. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.04.018 · Cited by 679 · see citing works
“Consistent with the data described above is the fact that numerous neuroimaging studies have found abnormal OFC function associated with substance abuse (Boettiger et al., 2007; Dom et al., 2005; Ersche et al., 2005; London et al., 2000; Volkow and Fowler, 2000).”
Brand, M., Young, K. S., & Laier, C. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00375 · Cited by 565 · see citing works
“…experience cue-reactivity and craving, as it is well-known from substance dependency (e.g., Grant et al., 1996; Anton, 1999; Childress et al., 1999; Tiffany and Conklin, 2000; Bonson et al., 2002; Brody et al., 2002, 2007; Franken, 2003; Dom et al., 2005; Heinz et al., 2008; Field et al., 2009)?”
BackgroundMinority Stress and Substance Use in Sexual Minority Adolescents: A Meta-analysis
Goldbach, J. T., Tanner‐Smith, E. E., Bagwell, M., & Dunlap, S. L. (2013) · Prevention Science · doi:10.1007/s11121-013-0393-7 · Cited by 513 · see citing works
“2001), impairs decision making (Dom et al. 2005), and is associated with poor school performance (Kandel et al.”
BackgroundOrbitofrontal cortex, decision-making and drug addiction
Schoenbaum, G., Roesch, M. R., & Stalnaker, T. A. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2005.12.006 · Cited by 499 · see citing works
Food and drug cues activate similar brain regions: A meta-analysis of functional MRI studies
Tang, D., Fellows, L. K., Small, D. M., & Dagher, A. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.03.009 · Cited by 457 · see citing works
“There are also many reported inconsistencies on the role of the OFC in drug cue reactivity and craving [66,71].”
BackgroundDrug Addiction and the Memory Systems of the Brain
Robbins, T. W., Ersche, K. D., & Everitt, B. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.020 · Cited by 446 · see citing works
Reflection Impulsivity in Current and Former Substance Users
Clark, L., Robbins, T. W., Ersche, K. D., & Sahakian, B. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.007 · Cited by 355 · see citing works
Fettes, P., Schulze, L., & Downar, J. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00025 · Cited by 299 · see citing works
“In addition to structural and functional abnormalities within the OFC, those with SUDs perform poorly on the Gambling Task (Grant et al., 2000; Bolla et al., 2003; Dom et al., 2005), a test of real-world decision-making known to rely heavily on the OFC (Bechara et al., 1999; Li et al., 2010).”
BackgroundVerdejo‐García, A., & Pérez-Garcı́a, M. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0632-8 · Cited by 305 · see citing works
“…alterations on decision-making processes assessed by the IGT adds to the growing body of evidence about the existence of impairments in the ability to make adaptive decisions involving uncertainty and risk, in users of different types of drugs (Dom et al. 2005; Verdejo-García et al. 2006a).”
MethodBoettiger, C. A., Mitchell, J. M., Tavares, V. C., Robertson, M., Joslyn, G., D'Esposito, M., & Fields, H. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2551-07.2007 · Cited by 300 · see citing works
“Our finding of reduced OFC activity during decision making among AA subjects is consistent with the common finding of OFC dysfunction in substance abusers (London et al., 2000; Volkow and Fowler, 2000; Dom et al., 2005).”
ResultDecision-Making Dysfunctions in Psychiatry—Altered Homeostatic Processing?
Paulus, M. P. (2007) · Science · doi:10.1126/science.1142997 · Cited by 296 · see citing works
Feil, J., Sheppard, D., Fitzgerald, P. B., Yücel, M., Lubman, D. I., & Bradshaw, J. L. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.03.001 · Cited by 342 · see citing works
“Thus, the role of the OFC in decision-making has been strongly implicated in continued substance use, despite knowledge of harmful or risky consequences (Dom et al., 2005).”
BackgroundAnabolic–androgenic steroid dependence: an emerging disorder
Kanayama, G., Brower, K. J., Wood, R. I., Hudson, J. I., & Pope, H. G. (2009) · Addiction · doi:10.1111/j.1360-0443.2009.02734.x · Cited by 296 · see citing works
Effects of non-invasive neurostimulation on craving: A meta-analysis
Jansen, J. M., Daams, J. G., Koeter, M. W. J., Veltman, D. J., van den Brink, W., & Goudriaan, A. E. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.009 · Cited by 284 · see citing works
The neurobiology of impulsivity and substance use disorders: implications for treatment
Kozak, K., Lucatch, A. M., Lowe, D. J. E., Balodis, I., Mackillop, J., & George, T. P. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13977 · Cited by 266 · see citing works
The role of interoception in addiction: A critical review
Verdejo‐García, A., Clark, L., & Dunn, B. D. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.05.007 · Cited by 270 · see citing works
Hayashi, T., Ko, J. H., Strafella, A. P., & Dagher, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212185110 · Cited by 251 · see citing works
“Neuroimaging studies in addiction have revealed cue-related responses in numerous brain areas, including frontal, visual, and parietal cortices and subcortical areas (18, 19), but none has investigated the neural substrates of the incorporation of contextual information into craving.”
BackgroundDurazzo, T. C., Tosun, D., Buckley, S. T., Gazdzinski, S. P., Mon, A., Fryer, S. L., & Meyerhoff, D. J. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01452.x · Cited by 237 · see citing works
“Specifically, the OFC is involved in emotion-related learning and regulation of internal affective and drive states (Dom et al., 2005 14230; Rolls, 2004).”
BackgroundLeeman, R. F., & Potenza, M. N. (2013) · The Canadian Journal of Psychiatry · doi:10.1177/070674371305800503 · Cited by 235 · see citing works
Ersche, K. D., Williams, G. B., Robbins, T. W., & Bullmore, E. T. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.02.017 · Cited by 205 · see citing works
Atypical interoception as a common risk factor for psychopathology: A review
Brewer, R., Murphy, J., & Bird, G. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.036 · Cited by 180 · see citing works
Brain stimulation in the study and treatment of addiction
Feil, J., & Zangen, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.006 · Cited by 181 · see citing works
Cheetham, A., Allen, N. B., Whittle, S., Simmons, J. G., Yücel, M., & Lubman, D. I. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.029 · Cited by 169 · see citing works
Diekhof, E. K., Falkai, P., & Gruber, O. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.07.004 · Cited by 165 · see citing works
“…and exhibited increased activation to drug-related stimuli compared to neutral stimuli in abstinent individuals, especially during the state of craving or acute withdrawal (e.g., Wrase et al., 2002; see also: Goldstein and Volkow, 2002; Dom et al., 2005; see also Table 1 and Supplementary Table 1).”
BackgroundKekic, M., McClelland, J., Campbell, I. C., Nestler, S., Rubia, K., David, A. S., & Schmidt, U. H. (2014) · Appetite · doi:10.1016/j.appet.2014.03.010 · Cited by 162 · see citing works
Cocaine exposure causes long-term increases in impulsive choice.
Simon, N. W., Mendez, I. A., & Setlow, B. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.3.543 · Cited by 162 · see citing works
“…with a large body of literature detailing links between drug addiction and OFC in humans (Bechara et al., 2001; Bolla, Eldreth, Matochik, & Cadet, 2005; Dom et al., 2005; Fillmore & Rush, 2006; Grant, Contoreggi, & London, 2000; Hornak et al., 2004; Rogers et al., 1999; Volkow & Fowler, 2000).”
BackgroundA meta-analysis of the relationship between trait mindfulness and substance use behaviors
Karyadi, K. A., VanderVeen, J. D., & Cyders, M. A. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.07.014 · Cited by 158 · see citing works
“In particular, because trait mindfulness involves the use of higher order cognitive processes (Ives-Delliperi et al., 2011), it is possible that higher levels of substance use behaviors reduce trait mindfulness by impairing higher order cognitive processes (Dom et al., 2005).”
BackgroundInfluentialCastellanos-Ryan, N., Rubia, K., & Conrod, P. J. (2011) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01331.x · Cited by 152 · see citing works
López‐Caneda, E., Holguı́n, S. R., Cadaveira, F., Corral, M., & Doallo, S. (2013) · Alcohol and Alcoholism · doi:10.1093/alcalc/agt168 · Cited by 154 · see citing works
“Figure 2 On the other hand, neuroimaging studies have found abnormal IFC functioning linked to substance use (for reviews see Volkow and Fowler, 2000; Dom et al ., 2005; Feil et al ., 2010), including alcohol (Pfefferbaum et al ., 2001; Noël et al ., 2001; Li et al ., 2009).”
BackgroundMethamphetamine use causes cognitive impairment and altered decision-making
Mizoguchi, H., & Yamada, K. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2018.12.019 · Cited by 152 · see citing works
Calu, D. J., Stalnaker, T. A., Franz, T. M., Singh, T., Shaham, Y., & Schoenbaum, G. M. (2007) · Learning & Memory · doi:10.1101/lm.534807 · Cited by 146 · see citing works
“Notably, these same areas are also implicated in drug craving in humans and rats and in incubation of craving in rats (Volkow and Fowler 2000; Goldstein et al. 2001; Fuchs et al. 2004; Dom et al. 2005; Kalivas and Volkow 2005; Lu et al. 2005b).”
BackgroundBrain Neuroimaging in Cannabis Use: A Review
Quickfall, J., & Crockford, D. N. (2006) · Journal of Neuropsychiatry · doi:10.1176/jnp.2006.18.3.318 · Cited by 143 · see citing works
Ceftriaxone, a Beta-Lactam Antibiotic, Reduces Ethanol Consumption in Alcohol-Preferring Rats
Sari, Y., Sakai, M., Weedman, J. M., Rebec, G. V., & Bell, R. L. (2011) · Alcohol and Alcoholism · doi:10.1093/alcalc/agr023 · Cited by 137 · see citing works
“The importance of glutamate projections from the PFC, particularly to the NAc and the VTA, has been confirmed by clinical neuroimaging studies during craving for commonly abused drugs such as ethanol, cocaine, methamphetamine, heroin and nicotine (Childress et al., 1999; Dom et al., 2005; Garavan et al., 2000; Goldste…”
BackgroundReduced orbitofrontal cortical thickness in male adolescents with internet addiction
Hong, S.-B., Kim, J.-W., Choi, E.-J., Kim, H.-H., Suh, J.-E., Kim, C.-D., Klauser, P., Whittle, S., Yűcel, M., Pantelis, C., et al. (2013) · Behavioral and Brain Functions · doi:10.1186/1744-9081-9-11 · Cited by 136 · see citing works
“The result of this study is not only in line with numerous other findings in the literature implicating the role of the OFC in addiction [4-6], but also with those indicating that this brain region in the right hemisphere might be particularly important [21].”
BackgroundResultTreatment of anabolic–androgenic steroid dependence: Emerging evidence and its implications
Kanayama, G., Brower, K. J., Wood, R. I., Hudson, J. I., & Pope, H. G. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.01.011 · Cited by 129 · see citing works
“…being purely a consequence of it (Kanayama et al., 2009c), and they may be associated with cognitive deficits in impulsivity, risk-taking, and decision-making (Bickel and Marsch, 2001; de Wit, 2008; Dom et al., 2005; Reynolds, 2006; Verdejo-Garcia and Bechara, 2009; Verdejo-Garcia et al., 2008).”
BackgroundHomers regulate drug-induced neuroplasticity: Implications for addiction
Szumlinski, K. K., Ary, A. W., & Lominac, K. D. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.031 · Cited by 128 · see citing works
Schizophrenia in the Internalizing-Externalizing Framework: A Third Dimension?
Kotov, R., Chang, S.-W., Fochtmann, L. J., Mojtabai, R., Carlson, G. A., Sedler, M. J., & Bromet, E. J. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq024 · Cited by 121 · see citing works
Bickel, W. K., & Yi, R. (2008) · Advances in health economics and health services research · doi:10.1016/s0731-2199(08)20012-9 · Cited by 122 · see citing works
The role of the orbitofrontal cortex in alcohol use, abuse, and dependence
Moorman, D. E. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.010 · Cited by 109 · see citing works
“In recent years the orbitofrontal cortex (OFC) has been identified as a region that is disrupted in addiction to drugs of abuse (Dom et al., 2005; Everitt et al., 2007; Fettes et al., 2017; London et al., 2000; Porrino and Lyons, 2000; Schoenbaum and Shaham, 2008; Volkow and Fowler, 2000).”
Reduced connexin 43 immunolabeling in the orbitofrontal cortex in alcohol dependence and depression
Miguel-Hidalgo, J. J., Wilson, B. A., Hussain, S., Meshram, A., Rajkowska, G., & Stockmeier, C. A. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.04.007 · Cited by 110 · see citing works
“The OFC is a PFC subdivision heavily involved in the regulation of emotion and decision-making, which are dysfunctional in both alcoholism and major depression (Austin et al., 2001; Dom et al., 2005; Drevets, 2007; Volkow and Fowler, 2000).”
Dymond, S., Lawrence, N., Dunkley, B. T., Yuen, K. S. L., Hinton, E. C., Dixon, M. R., Cox, W. M., Hoon, A. E., Munnelly, A., Muthukumaraswamy, S. D., et al. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.01.019 · Cited by 108 · see citing works
“…decisions and actions, and is associated with increased levels of approach motivation to anticipated rewards (Berridge and Kringelbach, 2008; Dom et al., 2005; Levy and Glimcher, 2012; Nusslock et al., 2012; Paulus et al., 2003), exaggerated OFC responses to near-misses in PG may reflect a…”
RESEARCH FOCUS ON COMPULSIVE BEHAVIOUR IN ANIMALS: Compulsive alcohol drinking in rodents
Vengeliene, V., Célèrier, E., Chaskiel, L., Penzo, F., & Spanagel, R. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2009.00177.x · Cited by 103 · see citing works
“Impairment in orbitofrontal cortex dependent behaviours, such as decision-making, was also demonstrated in human drug addicts (Dom et al. 2005), suggesting that abnormal functioning of this region is likely to contribute to the vicious cycle of uncontrolled alcohol © 2009 The Authors.”
BackgroundDom, G., Wilde, B. D., Hulstijn, W., van den Brink, W., & Sabbe, B. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00202.x · Cited by 102 · see citing works
Self-citationInhibitory Control Deficits in Childhood and Risk for Substance Use Disorders: A Review
Ivanov, I., Schulz, K. P., London, E. D., & Newcorn, J. H. (2008) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990802013334 · Cited by 102 · see citing works
“(47) reported that functional neuroimaging techniques (e.”
Brain Morphology at Entry into Treatment for Alcohol Dependence Is Related to Relapse Propensity
Cardenas, V. A., Durazzo, T. C., Gazdzinski, S. P., Mon, A., Studholme, C., & Meyerhoff, D. J. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.04.003 · Cited by 100 · see citing works
Hill, S., Wang, S., Kostelnik, B., Carter, H., Holmes, B., McDermott, M. D., Zezza, N., Stiffler, S., & Keshavan, M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.001 · Cited by 105 · see citing works
“This conclusion is supported by three considerations: 1) analyses demonstrating risk-group differences were performed with presence of SUDs as covariates, 2) supplemental analyses in which all 22 SUD cases were removed confirmed the significant risk-group differences, and 3) comorbid internalizing disorders do not exp…”
InfluentialKufahl, P. R., Zavala, A. R., Singh, A., Thiel, K. J., Dickey, E. D., Joyce, J. N., & Neisewander, J. L. (2009) · Synapse · doi:10.1002/syn.20666 · Cited by 96 · see citing works
“Structural and functional abnormalities within the OFC have been reported in several studies of human cocaine abusers (Dom et al., 2005;Volkow and Fowler, 2000), and the OFC of these individuals demonstrates activation by systemic cocaine (Kufahl et al.”
BackgroundBEHAVIOURAL ASPECTS OF IMPULSIVITY IN ALCOHOLICS WITH AND WITHOUT A CLUSTER-B PERSONALITY DISORDER
Dom, G., Wilde, B. D., Hulstijn, W., van den Brink, W., & Sabbe, B. (2006) · Alcohol and Alcoholism · doi:10.1093/alcalc/agl030 · Cited by 93 · see citing works
“…that abnormalities in these brain regions have recently been proposed to underlie both addictive processes and cluster-B disorders, i.e. borderline and antisocial personality disorders (PDs) (Lubman et al., 2004; Seguin, 2004; Berlin et al., 2005; Dom et al., 2005; Kalivas and Volkow, 2005).”
BackgroundSelf-citationSetlow, B., Mendez, I. A., Mitchell, M. R., & Simon, N. W. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283305eb4 · Cited by 92 · see citing works
“…cocaineinduced overexcitation), and suggested that such increased inhibition could account for the decreased functional activity of OFC observed in cocaine users (Dom et al., 2005) (although notably, there were no effects of this cocaine administration regimen on impulsive choice in this study).”
BackgroundDecision-making and the frontal lobes
Volz, K. G., Schubotz, R. I., & von Cramon, D. Y. (2006) · Current Opinion in Neurology · doi:10.1097/01.wco.0000236621.83872.71 · Cited by 90 · see citing works
Neural responses to monetary incentives among self-injuring adolescent girls
Sauder, C. L., Derbidge, C. M., & Beauchaine, T. P. (2016) · Development and Psychopathology · doi:10.1017/s0954579415000449 · Cited by 89 · see citing works
What is the Role of Dependence‐Related Behavior in Medication‐Overuse Headache?
Radat, F., & Lantéri‐Minet, M. (2010) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2010.01755.x · Cited by 89 · see citing works
Zhao, D., Zhang, M., Tian, W., Cao, X., Yin, L., Liu, Y., Xu, T., Luo, W., & Yuan, T. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01252-5 · Cited by 84 · see citing works
“The circuit (MPFCOrbital areas) has been documented in people with SUD, with both regions implicated in cue reactivity [57].”
BackgroundGarland, E. L., Boettiger, C. A., & Howard, M. O. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.02.014 · Cited by 85 · see citing works
“In fact, craving has been associated with increased activity in orbitofrontal cortex [57,87] whereas efforts to inhibit”
BackgroundTransition to substance use disorders: impulsivity for reward and learning from reward
Poulton, A., & Hester, R. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz077 · Cited by 79 · see citing works
“Substance-dependent individuals have consistently been shown to perform poorly on the IGT, generally favoring choices that result in small, immediate gains but large losses over time (Grant et al., 2000; Dom et al., 2005; Fridberg et al., 2010).”
BackgroundMethodAmes, S. L., Grenard, J. L., Stacy, A. W., Xiao, L., He, Q., Wong, S. W. H., Xue, G., Wiers, R. W. H. J., & Bechara, A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.09.013 · Cited by 81 · see citing works
Qrunfleh, A. M., Alazizi, A., & Sari, Y. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113482529 · Cited by 80 · see citing works
In Medication‐Overuse Headache, fMRI Shows Long‐Lasting Dysfunction in Midbrain Areas
Ferraro, S., Grazzi, L., Muffatti, R., Nava, S., Ghielmetti, F., Bertolino, N., Mandelli, M. L., Visintin, E., Bruzzone, M. G., Nigri, A., et al. (2012) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2012.02276.x · Cited by 81 · see citing works
Functional imaging of an alcohol‐ I mplicit A ssociation T est ( IAT )
Ames, S. L., Grenard, J. L., He, Q., Stacy, A. W., Wong, S. W. H., Xiao, L., Xue, G., & Bechara, A. (2013) · Addiction Biology · doi:10.1111/adb.12071 · Cited by 79 · see citing works
“…is generally consistent with other imaging studies observing diminished control ability and abnormal/reduced frontal activity in humans with substance use problems as a result of learned responses to drug cues (see Volkow & Fowler 2000; Dom et al. 2005; Everitt et al. 2008; Koob & Volkow 2010).”
ResultInvolvement of the endocannabinoid system in reward processing in the human brain
van Hell, H. H., Jager, G., Bossong, M. G., Brouwer, A., Jansma, J. M., Zuurman, L., van Gerven, J., Kahn, R. S., & Ramsey, N. F. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2428-8 · Cited by 77 · see citing works
“These have all been associated with reward processing (Hayden et al. 2008; McCoy and Platt 2005; Tabuchi et al. 2005; Dom et al. 2005; Egerton et al. 2005; Wallis and Kennerley 2010) or effects of THC administration (Fusar-Poli et al. 2009; Stokes et al. 2010).”
BackgroundSleep disturbance and the long-term impact of early adversity
Fuligni, A. J., Chiang, J. J., & Tottenham, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.021 · Cited by 78 · see citing works
Boettiger, C. A., Kelley, E. A., Mitchell, J., D’Esposito, M., & Fields, H. L. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.02.008 · Cited by 77 · see citing works
“It should come as no surprise then, that neuroimaging studies have repeatedly foundabnormalOFC functioning in substance abusers (Boettiger et al., 2007; Dom et al., 2005; Ersche et al., 2005; London et al., 2000; Volkow and Fowler, 2000).”
Neural Circuitry Associated with Risk for Alcohol Use Disorders
Tessner, K. D., & Hill, S. Y. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9111-4 · Cited by 71 · see citing works
“The OFC, particularly in the right hemisphere, appears to be a neural substrate for mechanisms of inhibition and has been implicated in substance use disorders (reviewed by Dom et al. 2005).”
Tanning as an addictive behavior: a literature review
Nolan, B. V., Taylor, S. L., Liguori, A., & Feldman, S. R. (2009) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2009.00392.x · Cited by 69 · see citing works
Bühringer, G., Wïttchen, H., Gottlebe, K., Kufeld, C., & Goschke, T. (2008) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.246 · Cited by 66 · see citing works
Reduced cortical gray matter volume in male adolescents with substance and conduct problems
Dalwani, M. S., Sakai, J. T., Mikulich‐Gilbertson, S. K., Tanabe, J., Raymond, K. M., McWilliams, S. K., Thompson, L. L., Banich, M. T., & Crowley, T. J. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.04.006 · Cited by 67 · see citing works
“Despite these differences, many authors suggest that inhibitory dysfunction in PFC is a key neural mechanism underlying addiction (Dom et al., 2005; Jentsch and Taylor, 1999; Goldstein and Volkow, 2002).”
BackgroundNegotiating the Relationship Between Addiction, Ethics, and Brain Science
Buchman, D. Z., Skinner, W., & Illes, J. (2010) · AJOB Neuroscience · doi:10.1080/21507740903508609 · Cited by 61 · see citing works
“Brain areas such as the prefrontal cortex have been identified as being directly involved in assessing the reward potential of decision making and vulnerability to relapse (Bechara and Damasio 2002; Dom et al. 2005).”
BackgroundHill, S. Y., Wang, S., Carter, H., Tessner, K. D., Holmes, B., McDermott, M., Zezza, N., & Stiffler, S. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.05.006 · Cited by 59 · see citing works
“Other regions such as the orbitofrontal cortex have been studied far more extensively as candidate regions for addiction susceptibility because of their involvement in disinhibitory processes (Dom et al., 2005).”
Cognitive factors associated with gaming disorder
Billieux, J., Potenza, M. N., Maurage, P., Brevers, D., Brand, M., & King, D. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815298-0.00016-2 · Cited by 59 · see citing works
Long-term effects of prior cocaine exposure on Morris water maze performance
Mendez, I. A., Montgomery, K. S., LaSarge, C. L., Simon, N. W., Bizon, J. L., & Setlow, B. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.005 · Cited by 57 · see citing works
Compulsive drug use and its neural substrates
Lesscher, H. M. B., & Vanderschuren, L. J. M. J. (2012) · Reviews in the Neurosciences · doi:10.1515/revneuro-2012-0066 · Cited by 54 · see citing works
“…thought to underlie the neurocognitive deficits associated with drug addiction (Rogers and Robbins, 2001; Goldstein and Volkow, 2002; Bechara, 2005; Dom et al., 2005; Garavan and Stout, 2005; Robbins et al., 2008), as well as the risk for relapse to drug seeking (Kalivas and McFarland, 2003;…”
The developmental psychopathology of motivation in adolescence
Fairchild, G. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.07.009 · Cited by 53 · see citing works
Nanda, P., Tandon, N., Mathew, I. T., Padmanabhan, J. L., Clementz, B. A., Pearlson, G. D., Sweeney, J. A., Tamminga, C. A., & Keshavan, M. S. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.11.030 · Cited by 51 · see citing works
“…rates of suicidality and substance abuse in PBP and SZA, as orbitofrontal abnormalities and impulsivity have both been observed to be associated with past history of suicide attempts (Mahon et al., 2012;Matsuo et al., 2009) and substance use disorders (Dom et al., 2005; Jentsch and Taylor, 1999).”
Association between P3 event‐related brain potential amplitude and adolescent problem behavior
Iacono, W. G., & McGue, M. K. (2006) · Psychophysiology · doi:10.1111/j.1469-8986.2006.00422.x · Cited by 52 · see citing works
Insular neural system controls decision-making in healthy and methamphetamine-treated rats
Mizoguchi, H., Katahira, K., Inutsuka, A., Fukumoto, K., Nakamura, A., Wang, T., Nagai, T., Sato, J., Sawada, M., Ohira, H., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418014112 · Cited by 49 · see citing works
“05] and not significant effect on time [F(4,48) = 0.”
BackgroundInfluentialThe role of impulsivity in the aetiology of drug dependence: reward sensitivity versus automaticity
Hogarth, L. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2172-0 · Cited by 50 · see citing works
“2007; Nelson and Killcross 2006), fronto-executive impairment (Dom et al. 2005; Garavan and Hester 2007; Goldstein et al. 2009; London et al. 2000) and perseveration of selfadministration under punishment (Belin et al.”
BackgroundLee, D., Lee, J., Lee, J. E., & Jung, Y. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.02.005 · Cited by 52 · see citing works
“The orbitofrontal cortex monitors reward values and decision-making related to substance addiction (Dom et al., 2005; Volkow and Fowler, 2000).”
BackgroundNaish, K. R., Vedelago, L., MacKillop, J. M., & Amlung, M. T. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.08.018 · Cited by 49 · see citing works
“For example, SUAD are associated with behavioral characteristics such as heightened impulsivity (Perry & Carroll, 2008), impaired decision-making (Dom et al., 2005), and poor inhibitory control (Fillmore, 2003).”
BackgroundEvaluation of Interoceptive Awareness in Alcohol-Addicted Patients
Çöl, I. A., Sönmez, M. B., & Vardar, E. (2015) · Nöro Psikiyatri Arşivi · doi:10.5152/npa.2015.9898 · Cited by 48 · see citing works
“In studies conducted with substance addicts, stimuli acting as reminders of the substance have shown increased insular activation, and this situation has been reported to be associated with the craving intensity (11,13,14).”
BackgroundZois, E., Kiefer, F., Leménager, T., Vollstädt‐Klein, S., Mann, K. F., & Fauth‐Bühler, M. (2016) · Addiction Biology · doi:10.1111/adb.12368 · Cited by 46 · see citing works
“…unveiled gray matter (GM) volume alterations in different SUD populations compared with healthy controls (HCs) (De Bellis et al. 2005; Yucel et al. 2008; Tanabe et al. 2009; Demirakca et al. 2011), as well as brain functional abnormalities (Dom et al. 2005; Schacht, Anton & Myrick 2013).”
BackgroundSharma, E., Vaidya, N., Iyengar, U., Zhang, Y., Holla, B., Purushottam, M., Chakrabarti, A., Fernandes, G., Heron, J., Hickman, M., et al. (2020) · BMC Psychiatry · doi:10.1186/s12888-019-2373-3 · Cited by 41 · see citing works
Brain responses to emotional salience and reward in alcohol use disorder
Alba‐Ferrara, L., Müller‐Oehring, E. M., Sullivan, E. V., Pfefferbaum, A., & Schulte, T. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9374-8 · Cited by 43 · see citing works
“…to a reward (Tachibana and Hikosaka 2012), the OFC seems to integrate multiple sources of information regarding the reward outcome , and to calculate how rewarding is a reward (Gallagher et al. 1999; Wallis 2007) for decision-making (e.g., Dom et al. 2005; Kim et al. 2006; Tanabe et al. 2009).”
BackgroundAltbäcker, A., Plózer, E., Darnai, G., Perlaki, G., Horváth, R., Orsi, G., Nagy, S. A., Bogner, P., Schwarcz, A., Kovács, N., et al. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9454-9 · Cited by 42 · see citing works
“To find out whether there are hemisphere and gender-related differences in the involvement of OFC in Internet addiction, future studies are needed (Dom et al. 2005).”
BackgroundVoisin, D. R., Hong, J. S., & King, K. M. (2012) · Children and Youth Services Review · doi:10.1016/j.childyouth.2012.07.003 · Cited by 41 · see citing works
Neurocognition as a Moderator and Mediator in Adolescent Substance Misuse Prevention
Riggs, N. R., & Greenberg, M. T. (2009) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990903005940 · Cited by 41 · see citing works
“A second, and more recent, domain of research that links neurocognitive function to substance misuse has focused on the role of the orbitofrontal (OFC) and ventromedial (VM) regions of the prefrontal cortex, which are critical in affective decision-making (15), or decision-making in emotionally arousing situations.”
BackgroundLeménager, T., Richter, A., Reinhard, I., Gelbke, J., Beckmann, B., Heinrich, M., Kniest, A., Mann, K. F., & Hermann, D. (2011) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e31820b3e3d · Cited by 38 · see citing works
“For example, among patients with alcoholism, individuals with cluster B PDs show particularly impaired decision making on the IGT (Dom et al., 2005).”
BackgroundInfluentialValue-Based Decision Making in Mental Illness
Mukherjee, D., & Kable, J. W. (2014) · Clinical Psychological Science · doi:10.1177/2167702614531580 · Cited by 41 · see citing works
“, 2007), and substance-use disorder (Dom et al., 2005), all align with the present findings.”
BackgroundResultHermann, D., Leménager, T., Gelbke, J., Welzel, H., Skopp, G., & Mann, K. F. (2009) · European Addiction Research · doi:10.1159/000189788 · Cited by 40 · see citing works
Cognitive-behavioural therapy for bipolar disorder
Scott, J. L., Paykel, E. S., Morriss, R. K., Bentall, R. P., Kinderman, P., Johnson, T. L., Abbott, R., & Hayhurst, H. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.188.5.488 · Cited by 40 · see citing works
“…A. Bateman Halliwick Unit, St Ann’s Hospital, London,UK Neurobehavioural characteristics and relapse in addiction The systematic review by Dom et al (2005) of studies using behavioural decisionmaking tasks and/or neuroimaging techniques to investigate orbitofrontal cortex functioning in…”
BackgroundInsula and Orbitofrontal Cortical Morphology in Substance Dependence Is Modulated by Sex
Tanabe, J., York, P., Krmpotich, T., Miller, D., Dalwani, M., Sakai, J., Mikulich-Gilbertson, S., Thompson, L., Claus, E., Banich, M., et al. (2012) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3347 · Cited by 38 · see citing works
“Many studies showing reduced prefrontal cortex volumes in SDI are based on VBM.3,13,16,37 Some investigators using VBM have failed to replicate the finding of reduced gray matter volume in stimulant or polydrug users.18,19 Another possibility is that alterations in prefrontal morphometry may have resolved due to the l…”
BackgroundBalodis, I. M., Lacadie, C., & Potenza, M. N. (2011) · Journal of Gambling Studies · doi:10.1007/s10899-011-9259-8 · Cited by 38 · see citing works
“For example, only one-third of studies report OFC signal changes with drug craving (Dom et al. 2005; Wilson et al. 2004).”
Hill, S., Tessner, K., Wang, S., Carter, H., & McDermott, M. D. (2010) · Psychiatry Research · doi:10.1016/j.pscychresns.2009.11.006 · Cited by 40 · see citing works
“Because the OFC appears to be a neural substrate for mechanisms of inhibition and has been implicated in a variety of impulsive behaviors (Dom et al., 2005), variation in OFC morphology could be the basis for a common vulnerability factor for a number of adult psychopathological conditions…”
BackgroundZhukovsky, P., Puaud, M., Jupp, B., Sala‐Bayo, J., Alsiö, J., Xia, J., Searle, L., Morris, Z. S., Sabir, A., Giuliano, C., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0381-0 · Cited by 36 · see citing works
Orbitofrontal Dysfunction and Medication Overuse in Patients With M igraine
Biagianti, B., Grazzi, L., Gambini, O., Usai, S., Muffatti, R., Scarone, S., & Bussone, G. (2012) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2012.02277.x · Cited by 36 · see citing works
“exhibited an overall impairment in comparison to healthy controls.(7) Some functional neuroimaging studies have given evidence that the decision-making deficit shown by various samples of addicts was”
BackgroundmTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking
Morisot, N., Berger, A. L., Phamluong, K., Laguesse, S., Moffat, J. J., & Dorit Ron, A. (2019) · eLife · doi:10.7554/elife.51333 · Cited by 35 · see citing works
Meil, W. M., LaPorte, D. J., Mills, J. L., Sesti, A., Collins, S. M., & Stiver, A. G. (2016) · Addictive Behaviors · doi:10.1016/j.addbeh.2016.06.014 · Cited by 34 · see citing works
Brown, T. G., Ouimet, M. C., Eldeb, M., Tremblay, J., Vingilis, E. R., Nadeau, L., Pruessner, J. C., & Bechara, A. (2017) · Personality and Individual Differences · doi:10.1016/j.paid.2017.03.007 · Cited by 34 · see citing works
Ieong, H. F.-H., & Yuan, Z. (2017) · Scientific Reports · doi:10.1038/srep46522 · Cited by 33 · see citing works
“…measures from both the intuitive and traditional normalization methods are shown in Supplementary Figure S6. metabolic studies 10,11,42–45 have reported the hypofunctionality of OFC in psychoactive-dependent individuals during late withdrawal ( > 7 days) and prolonged abstinence 46 .”
Adolescent Brain Surface Area Pre- and Post-Cannabis and Alcohol Initiation
Infante, M. A., Courtney, K. E., Castro, N., Squeglia, L. M., & Jacobus, J. (2018) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2018.79.835 · Cited by 33 · see citing works
“The medial orbitofrontal cortex is part of the stress and reward system (Montague & Berns, 2002) and is relevant to substance use disorders (Dom et al., 2005).”
Background
- Authors
- Dom, G., Sabbe, B., Hulstijn, W., & van Den Brink, W.
- Affiliations
- University of Antwerp (BE)
- Corresponding author
- Dom, G.
- ORCID
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2005-09
- Volume
- 187
- Issue
- 3
- Pages
- 209-220
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2221703765
- Cited by
- 231
- References
- 88
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 10 · 2020: 8 · 2019: 25 · 2018: 11 · 2017: 10 · 2016: 7 · 2015: 10 · 2014: 9 · 2013: 13 · 2012: 16
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- substance use disorders, orbitofrontal cortex, decision-making, addiction, cue reactivity, craving, neuroimaging, detoxification, relapse prevention
- MeSH terms
- Brain Mapping, Cues, Decision Making, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Substance-Related Disorders, Positron-Emission Tomography
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