PRELIMINARY ANALYSIS OF FUNCTIONS OF THE TEMPORAL LOBES IN MONKEYS

KLÜVER, HEINRICH

doi:10.1001/archneurpsyc.1939.02270240017001

Cited by 1,696Memory and Neural MechanismsVisual perception and processing mechanismsNeurology and Historical Studies

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PRELIMINARY ANALYSIS OF FUNCTIONS OF THE TEMPORAL LOBES IN MONKEYS

KLÜVER, HEINRICH·1939·Archives of Neurology And Psychiatry

DOI 10.1001/archneurpsyc.1939.02270240017001

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Abstract

In previous communications1we pointed out that the chief symptoms following bilateral temporal lobectomy in the rhesus monkey consist in "psychic blindness" (Seelenblindheit) or visual agnosia, strong "oral" tendencies and profound emotional changes. Our results were primarily based on an analysis of the behavioral symptoms of a female rhesus monkey which had been studied for a period of four months following the operations. The type of disturbance analyzed in that case seemed to be similar to the "associative mind blindness" of Lissauer.2It is true that the diagnosis "agnosia" can be only of practical importance and merely serves to raise a number of questions. A review of the clinical literature indicates that the more carefully a case is studied the more difficult it may be to decide whether there is really an "agnostic" or merely a "visual" defect, that is, whether the variety of "agnostic" symptoms can be

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Hypersexuality occurs in individuals with frontal lobe damage or Kluver-Bucy syndrome.
“This goes back to the original findings of hypersexuality in individuals with frontal lobe damage or Kluver-Bucy syndrome.94”
From Assessment and treatment of compulsive sexual behavior disorder: a sexual medicine perspective (2024) · cites this paper as [94]

A PROPOSED MECHANISM OF EMOTION
PAPEZ, J. W. (1937) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1937.02260220069003 · Cited by 3,563

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Scoville, W. B., & Milner, B. (1957) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.20.1.11 · Cited by 7,322
Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502
Fears, phobias, and preparedness: toward an evolved module of fear and fear learning
Öhman, A., & Mineka, S. (2001) · Psychological Review · doi:10.1037/0033-295x.108.3.483 · Cited by 3,147
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Kalivas, P. W., & Volkow, N. D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1403 · Cited by 2,757
A neuropsychological theory of positive affect and its influence on cognition.
Ashby, F. G., Isen, A. M., & Turken, A. U. (1999) · Psychological Review · doi:10.1037/0033-295x.106.3.529 · Cited by 2,270
Neurobiology of emotion perception I: the neural basis of normal emotion perception
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00168-9 · Cited by 2,173
“Bilateral lesions of the temporal lobes (Kluver and Bucy 1939), and, particularly, the amygdala (Zola-Morgan et al 1991) result in significant changes in social behavior in monkeys, including hyperorality, social disinhibition, and an absence of emotional motor and vocal reactions usually associated with emotional sta…”
Background
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00007-6 · Cited by 2,129
A differential neural response in the human amygdala to fearful and happy facial expressions
Morris, J. S., Frith, C. D., Perrett, D. I., Rowland, D., Young, A. W., Calder, A. J., & Dolan, R. J. (1996) · Nature · doi:10.1038/383812a0 · Cited by 2,013
Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making
Bechara, A., Damasio, H., Damasio, A. R., & Lee, G. P. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05473.1999 · Cited by 2,001
“This interpretation is consistent with the studies showing that monkeys with lesions of the amygdala have an increased tendency to approach objects such as snakes (Kluver and Bucy, 1939; Zola-Morgan et al., 1991; Figure 5.”
Result
On the primacy of affect.
Zajonc, R. B. (1984) · American Psychologist · doi:10.1037/0003-066x.39.2.117 · Cited by 1,937
The neural and computational bases of semantic cognition
Ralph, M. A. L., Jefferies, E., Patterson, K., & Rogers, T. T. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.150 · Cited by 1,864
The Social Brain: Neural Basis of Social Knowledge
Adolphs, R. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163514 · Cited by 1,827
The Amygdaloid Complex: Anatomy and Physiology
SAH, P., FABER, E. S. L., LOPEZ DE ARMENTIA, M., & POWER, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00002.2003 · Cited by 1,745
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
Tsou, K., Brown, S., Sañudo-Peña, M. C., Mackie, K., & Walker, J. M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00436-3 · Cited by 1,586
The Enigmatic temporal pole: a review of findings on social and emotional processing
Olson, I. R., Plotzker, A., & Ezzyat, Y. (2007) · Brain · doi:10.1093/brain/awm052 · Cited by 1,370
“The Klüver–Bucy syndrome in monkeys consists of tameness and diminished fear, hyperorality, hypersexuality, blunted affect, visual agnosia and social withdrawal (Kluver and Bucy, 1939; Kling et al., 1993).”
Background
Neuroscience and Biobehavioral Reviews
McFarland, W., Jacobs, M. S., & Morgane, P. J. (1979) · Brain Research Bulletin · doi:10.1016/s0361-9230(79)80030-1 · Cited by 1,366
A neuromodulatory role for the human amygdala in processing emotional facial expressions
Morris, J. (1998) · Brain · doi:10.1093/brain/121.1.47 · Cited by 1,291
Cortical pathways to the mammalian amygdala
McDonald, A. J. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00003-3 · Cited by 1,303
Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys
Carmichael, S. T., & Price, J. L. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903630408 · Cited by 1,197
Amygdalo‐cortical projections in the monkey ( Macaca fascicularis )
Amaral, D. G., & Price, J. L. (1984) · Journal of Comparative Neurology · doi:10.1002/cne.902300402 · Cited by 1,162
Valence, gender, and lateralization of functional brain anatomy in emotion: a meta-analysis of findings from neuroimaging
Wager, T. D., Phan, K. L., Liberzon, I., & Taylor, S. F. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00078-8 · Cited by 1,150
“Since the original descriptions of nonhuman primates with temporal lobe and amygdala ablations (Kluver and Bucy, 1939), evidence has implicated the amygdala in the processing of fear-related stimuli (Weiskrantz, 1956).”
Background
The amygdala theory of autism
Baron-Cohen, S., Ring, H. A., Bullmore, E. T., Wheelwright, S., Ashwin, C., & Williams, S. C. R. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00011-7 · Cited by 1,130
“…any object, and fellatio with both same sex and opposite sex monkeys), hyperorality (a tendency to investigate objects with their mouths, not their hands, even if the object was inedible), and in some (but not all) cases, an inability to recognize objects (visual agnosia) (Kluver & Bucy, 1939).”
Background
The neuroanatomical and neurochemical basis of conditioned fear
Fendt, M., & Fanselow, M. S. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00016-0 · Cited by 1,092
The hippocampus and behavior.
Douglas, R. (1967) · Psychological bulletin · doi:10.1037/h0024599 · Cited by 1,092
Unit activity in prefrontal cortex during delayed-response performance: neuronal correlates of transient memory.
Fuster, J. M. (1973) · Journal of Neurophysiology · doi:10.1152/jn.1973.36.1.61 · Cited by 995
Toward a general psychobiological theory of emotions
Panksepp, J. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00012759 · Cited by 999
Neuropsychology of fear and loathing
Calder, A., Lawrence, A., & Young, A. (2001) · Nature Reviews Neuroscience · doi:10.1028/35072584 · Cited by 974
Histoanatomic observations of the brain in early infantile autism
Bauman, M., & Kemper, T. L. (1985) · Neurology · doi:10.1212/wnl.35.6.866 · Cited by 964
Neuropsychology of fear and loathing
Calder, A. J., Lawrence, A. D., & Young, A. W. (2001) · Nature reviews. Neuroscience · doi:10.1038/35072584 · Cited by 927
Social cognition and the human brain
Adolphs, R. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(99)01399-6 · Cited by 895
Limbic lesions and the problem of stimulus--reinforcement associations.
Jones, B., & Mishkin, M. (1972) · Experimental Neurology · doi:10.1016/0014-4886(72)90030-1 · Cited by 864
What does the amygdala contribute to social cognition
Adolphs, R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05445.x · Cited by 836
Two routes to emotional memory: Distinct neural processes for valence and arousal
Kensinger, E. A., & Corkin, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306408101 · Cited by 848
Quantitative analysis of interictal behavior in temporal lobe epilepsy.
Bear, D. M., & Fedio, P. (1977) · Archives of Neurology · doi:10.1001/archneur.1977.00500200014003 · Cited by 829
Emotion and motivation
Ward, J. (2013) · doi:10.4135/9781483346274.n93 · Cited by 803
Activation of neurons projecting to the paraventricular hypothalamic nucleus by intravenous lipopolysaccharide
Elmquist, J. K., & Saper, C. B. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961021)374:3 · Cited by 153
Conceptual representations in mind and brain: Theoretical developments, current evidence and future directions
Kiefer, M., & Friedemann Pulvermüller, A. (2011) · Cortex · doi:10.1016/j.cortex.2011.04.006 · Cited by 918
Brain activity during transient sadness and happiness in healthy women
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.3.341 · Cited by 737
A revised limbic system model for memory, emotion and behaviour
Catani, M., Dell’Acqua, F., & de Schotten, M. T. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.001 · Cited by 813
An anatomy of schizophrenia?
Stevens, J. (1973) · Archives of General Psychiatry · doi:10.1001/archpsyc.1973.04200020023003 · Cited by 719
Topography of projections from amygdala to bed nuclei of the stria terminalis
Dong, H.-W., Petrovich, G. D., & Swanson, L. W. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00079-0 · Cited by 714
Different types of fear-conditioned behaviour mediated by separate nuclei within amygdala
Killcross, S., Robbins, T. W., & Everitt, B. J. (1997) · Nature · doi:10.1038/41097 · Cited by 652
The amygdala, reward and emotion
Murray, E. A. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.08.013 · Cited by 679
Neural bases of eye and gaze processing: The core of social cognition
Itier, R. J., & Batty, M. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.02.004 · Cited by 671
“C IH R A uthor M anuscript C IH R A uthor M anuscript C IH R A uthor M anuscript as the Klüver-Bucy Syndrome (Klüver and Bucy, 1939).”
Cognitive neuroscience
Tennant, M. (2019) · Psychology and Adult Learning · doi:10.1037/e526232004-001 · Cited by 671
Sexual motivation: a neural and behavioural analysis of the mechanisms underlying appetitive and copulatory responses of male rats
Everitt, B. J. (1990) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80222-2 · Cited by 650
Combinatorial amygdalar inputs to hippocampal domains and hypothalamic behavior systems
Petrovich, G. D., Canteras, N. S., & Swanson, L. W. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00080-7 · Cited by 662
Amygdala circuitry in attentional and representational processes
Holland, P. C., & Gallagher, M. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(98)01271-6 · Cited by 614
Cortical and subcortical afferents to the amygdala of the rhesus monkey (Macaca mulatta)
Aggleton, J. P., Burton, M. J., & Passingham, R. E. (1980) · Brain Research · doi:10.1016/0006-8993(80)90279-6 · Cited by 610
Distinct behavioural profiles in frontotemporal dementia and semantic dementia
Snowden, J. S. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.3.323 · Cited by 591
Amygdala Response to Fearful Faces in Anxious and Depressed Children
Thomas, K. M. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.11.1057 · Cited by 582
Emotion, Cognition, and Mental State Representation in Amygdala and Prefrontal Cortex
Salzman, C. D., & Fusi, S. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135256 · Cited by 628
“…lesions of primate amygdala produced a wide range of behavioral and emotional effects (Aggleton & Passingham 1981, Jones & Mishkin 1972, Kluver & Bucy 1939, Spiegler & Mishkin 1981, Weiskrantz 1956); but in recent years, scientists have increasingly recognized the importance of using…”
Background
Amygdala and Orbitofrontal Reactivity to Social Threat in Individuals with Impulsive Aggression
Coccaro, E. F., McCloskey, M. S., Fitzgerald, D. A., & Phan, K. L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.024 · Cited by 591
Androgen modulates N-methyl-D-aspartate-mediated depolarization in CA1 hippocampal pyramidal cells
Pouliot, W. A., Handa, R. J., & Beck, S. G. (1996) · Synapse · doi:10.1002/(sici)1098-2396(199605)23:1 · Cited by 128
A cognitive neuroscience perspective on psychopathy: Evidence for paralimbic system dysfunction
Kiehl, K. A. (2006) · Psychiatry Research · doi:10.1016/j.psychres.2005.09.013 · Cited by 593
“Damage to the medial temporal lobe in general (Kluever and Bucy, 1938, 1939), and neural tracts that pass through the amygdala in particular (Aggleton, 1992), have long been associated with emotional and behavioral changes in monkeys.”
Background
Characterization of inducible cyclooxygenase in rat brain
Breder, C., Dewitt, D., & Kraig, R. (1995) · The Journal of comparative neurology · doi:10.1002/cne.903550208 · Cited by 550
“Lesion studies by Kluver and Bucy (1939) suggested that these nuclei play a critical role in discriminating characteristics of sensory input used for the planning of behavior.”
Background
Brain processing of visual sexual stimuli in human males
Redout�, J., Stol�ru, S., Gr�goire, M.-C., Costes, N., Cinotti, L., Lavenne, F., Bars, D. L., Forest, M. G., & Pujol, J. F. (2000) · Human Brain Mapping · doi:10.1002/1097-0193(200011)11:3 · Cited by 522
A review of systems and networks of the limbic forebrain/limbic midbrain
Morgane, P. J., Galler, J. R., & Mokler, D. J. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.01.001 · Cited by 519
“The Klüver– Bucy syndrome has been at the forefront of limbic biology since 1937 (Klüver and Bucy, 1937, 1938, 1939).”
Background
Separate neural pathways for the visual analysis of object shape in perception and prehension.
Goodale, M., Meenan, J. P., Bülthoff, H., Nicolle, D., Murphy, K., & Racicot, C. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00132-9 · Cited by 501
Orbitofrontal cortex, decision-making and drug addiction
Schoenbaum, G., Roesch, M. R., & Stalnaker, T. A. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2005.12.006 · Cited by 499
Psychiatric comorbidity in epilepsy.
Swinkels, W. A. M., Kuyk, J., van Dyck, R., & Spinhoven, P. (2005) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2005.04.012 · Cited by 499
The Human Amygdala and the Induction and Experience of Fear
Feinstein, J. S., Adolphs, R., Damasio, A., & Tranel, D. (2011) · Current Biology · doi:10.1016/j.cub.2010.11.042 · Cited by 497
Précis of O'Keefe & Nadel'sThe hippocampus as a cognitive map
O'Keefe, J. M., & Nadel, L. (1979) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00063949 · Cited by 562
Encoding predicted outcome and acquired value in orbitofrontal cortex during cue sampling depends upon input from basolateral amygdala.
Schoenbaum, G., Setlow, B., Saddoris, M. P., & Gallagher, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00474-4 · Cited by 484
Role of the Amygdala in Decision‐Making
Bechara, A., Damásio, H., & Damásio, A. R. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07094.x · Cited by 491
Amygdalo-cortical sprouting continues into early adulthood: implications for the development of normal and abnormal function during adolescence
Cunningham, M. G., Bhattacharyya, S., & Benes, F. M. (2002) · Journal of Comparative Neurology · doi:10.1002/cne.10376 · Cited by 474
“…cats with abnormally increased neuronal activity within the BLA show a reduced ability to interact socially and tend to hide when introduced to novel stimuli (Adamec, 1978, 1991), whereas animals with amygdala ablations appear to lose the fear response (Kluver and Bucy, 1939; Aggleton, 1992).”
Background
Interactions between the amygdala and ventral striatum in stimulus-reward associations: studies using a second-order schedule of sexual reinforcement
Everitt, B. J., Cador, M., & Robbins, T. W. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90353-9 · Cited by 444
Hunger selectively modulates corticolimbic activation to food stimuli in humans
LaBar, K. S., Gitelman, D. R., Parrish, T. B., Kim, Y.-H., Nobre, A. C., & Mesulam, M. M. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.2.493 · Cited by 444
Thalamoamygdaloid projections in the rat: A test of the amygdala's role in sensory processing
Turner, B. H., & Herkenham, M. A. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903130208 · Cited by 440
Functional neuroimaging studies of human emotions
Phan, K. L., Wager, T. D., Taylor, S. F., & Liberzon, I. (2004) · CNS Spectrums · doi:10.1017/s1092852900009196 · Cited by 433
OCCIPITOTEMPORAL CORTICOCORTICAL CONNECTIONS IN THE RHESUS MONKEY.
Kuypers, H., Szwarcbart, M. K., Mishkin, M., & Rosvold, H. (1965) · Experimental Neurology · doi:10.1016/0014-4886(65)90016-6 · Cited by 424
Oxytocin and sexual behavior
Carter, C. S. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80176-9 · Cited by 417
A Theory of Emotion, and its Application to Understanding the Neural Basis of Emotion
Rolls, E. (1990) · Cognition & Emotion · doi:10.1080/02699939008410795 · Cited by 411
“These behavioural changes comprise much of the Kluver-Bucy syndrome which is produced in monkeys by bilateral anterior temporal lobectomy (Kluver & Bucy, 1939).”
Background
The amygdala and emotion
Gallagher, M., & Chiba, A. A. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80076-6 · Cited by 410
The Role of the Central Nucleus of the Amygdala in Mediating Fear and Anxiety in the Primate
Kalin, N. H., Shelton, S. E., & Davidson, R. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0292-04.2004 · Cited by 406
“Until recently, amygdala lesion studies in nonhuman primates that have assessed effects on emotion have used large nonselective lesions (Kluver and Bucy, 1939) or methods that have destroyed neurons as well as fibers of passage (Weiskrantz, 1956; Aggleton and Passingham, 1981; Zola- Morgan et al.,…”
Background
Distribution of cerebral degeneration in Alzheimer's disease: A clinico-pathological study
Brun, A., & Gustafson, L. (1976) · Archiv f�r Psychiatrie und Nervenkrankheiten · doi:10.1007/bf00367450 · Cited by 397
Neurons in the amygdala of the monkey with responses selective for faces.
Leonard, C. M., Rolls, E. T., Wilson, F. A., & Baylis, G. C. (1985) · Behavioural Brain Research · doi:10.1016/0166-4328(85)90062-2 · Cited by 396
Brain mechanisms for offense, defense, and submission
Adams, D. B. (1979) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00061926 · Cited by 395
Cholinergic systems in the rat brain: I. projections to the limbic telencephalon.
Woolf, N., Eckenstein, F., & Butcher, L. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90236-3 · Cited by 389
Amygdala and Ventral Hippocampus Contribute Differentially to Mechanisms of Fear and Anxiety.
McHugh, S. B., Deacon, R. M. J., Rawlins, J. N. P., & Bannerman, D. M. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.1.63 · Cited by 384
Topographical organization of amygdaloid projections to the caudatoputamen, nucleus accumbens, and related striatal-like areas of the rat brain
Mcdonald, A. J. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90248-m · Cited by 372
Neural Responses to Facial Expression and Face Identity in the Monkey Amygdala
Gothard, K. M., Battaglia, F. P., Erickson, C. A., Spitler, K. M., & Amaral, D. G. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00714.2006 · Cited by 343
A developmental neurobiological model of motivated behavior: Anatomy, connectivity and ontogeny of the triadic nodes
Ernst, M., & Fudge, J. L. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.009 · Cited by 358
EMOTIONAL LEARNING: A COMPUTATIONAL MODEL OF THE AMYGDALA
Balkenius, C., & Morén, J. (2001) · Cybernetics and systems · doi:10.1080/01969720118947 · Cited by 354
“Human lesions of the amygdala appear to contribute to a large portion of the so-called KlÏver^Bucy Syndrome, which may result from damage to the temporal cortex (KlÏver & Bucy, 1939).”
Background
The biological affects: a typology.
Buck, R. (1999) · Psychological Review · doi:10.1037/0033-295x.106.2.301 · Cited by 346
The objects of action and perception
Goodale, M. A., & Humphrey, G. K. (1998) · Cognition · doi:10.1016/s0010-0277(98)00017-1 · Cited by 442
“Thus, monkeys which show profound deficits in object recognition following inferotemporal lesions are nevertheless as capable as normal animals at picking up small food objects (Klüver and Bucy, 1939), at catching flying insects (Pribram, 1967), and at orienting their fingers in a precision grip to grasp morsels of fo…”
Background
Re-valuing the amygdala
Morrison, S. E., & Salzman, C. D. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.02.007 · Cited by 354
“Non-human primate studies Lesions of the amygdala, which produce an extraordinarily wide range of behavioral and emotional effects, have historically provided a rich source of data about possible functions of the amygdala [45,46] (reviewed in [47]).”
Research Review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder
Pelphrey, K. A., Shultz, S., Hudac, C. M., & Wyk, B. C. V. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02349.x · Cited by 405
“…structures, has been implicated in helping to recognize the emotional states of others through analysis of facial expressions (e.g., Morris et al., 1996), as well as in multiple aspects of the experience and regulation of emotion (e.g., Davis & Whalen, 2001; Klü ver & Bucy, 1997; LeDoux, 2000).”
Single neuron responses in amygdala of alert monkey during complex sensory stimulation with affective significance
Nishijo, H., Ono, T., & Nishino, H. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-10-03570.1988 · Cited by 333
Medial temporal lobe structures and autism: A review of clinical and experimental findings
Bachevalier, J. (1994) · Neuropsychologia · doi:10.1016/0028-3932(94)90025-6 · Cited by 322
Emotion, decision making, and the amygdala.
Seymour, B., & Dolan, R. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.020 · Cited by 324
Selectivity between faces in the responses of a population of neurons in the cortex in the superior temporal sulcus of the monkey.
Baylis, G. C., Rolls, E. T., & Leonard, C. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)91356-3 · Cited by 324
Neuroanatomical correlates of a lactate-induced anxiety attack.
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Frodl, T., Meisenzahl, E., Zetzsche, T., Bottlender, R., Born, C., Groll, C., Jäger, M., Leinsinger, G., Hahn, K., & Möller, H.-J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01359-2 · Cited by 316
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Authors: KLÜVER, H.
Corresponding author: KLÜVER, HEINRICH
Venue: Archives of Neurology And Psychiatry
Publisher: American Medical Association (AMA)
Published: 1939-12-01
Volume: 42
Issue: 6
Pages: 979
ISSN: 0096-6754 (ISSN-L)
DOI: 10.1001/archneurpsyc.1939.02270240017001
OpenAlex: W2169771257
Cited by: 1,696
References: 0
Citations by year: 2026: 6 · 2025: 7 · 2024: 22 · 2023: 9 · 2022: 11 · 2021: 27 · 2020: 21 · 2019: 16 · 2018: 25 · 2017: 27 · 2016: 26 · 2015: 34 · 2014: 32 · 2013: 43 · 2012: 39
FWCI: 2.32
Type: journal article
Language: en
Open access: closed
Locations: Archives of Neurology And Psychiatry (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Life Sciences › Neuroscience › Neurology › Neurology and Historical Studies
Keywords: temporal lobe, rhesus monkeys, visual agnosia, emotional change, behavioral symptoms

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PRELIMINARY ANALYSIS OF FUNCTIONS OF THE TEMPORAL LOBES IN MONKEYS

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