The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Retrograde axonal transport: pathways to cell death?
Open accessAbstract
Active transport along the axon is critical to the neuron. Motor-driven transport supplies the distal synapse with newly synthesized proteins and lipids, and clears damaged or misfolded proteins. Microtubule motors also drive long-distance signaling along the axon via signaling endosomes. While positive signaling initiated by neurotrophic factors has been well-studied, recent research has focused on stress signaling along the axon. Here, the connections between axonal transport alterations and neurodegeneration are discussed, including evidence for defective transport of vesicles, mitochondria, degradative organelles, and signaling endosomes in models of Amyotrophic Lateral Sclerosis, Huntington's, Parkinson's and Alzheimer's disease. Defects in transport are sufficient to induce neurodegeneration, but recent progress suggests that changes in retrograde signaling pathways correlate with rapidly progressive neuronal cell death.
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Metadata
- Authors
- Perlson, E., Maday, S., Fu, M.-M., Moughamian, A. J., & Holzbaur, E. L. F.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 33
- Issue
- 7
- Pages
- 335-344
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2032211921
- Cited by
- 339
- References
- 15
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
