Nerve dependence in tissue, organ, and appendage regeneration

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

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Comparative Aspects of Animal Regeneration

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Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate

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Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

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A New Murine Model for Mammalian Wound Repair and Regeneration

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A stepwise model system for limb regeneration

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Progressive determination during formation of the anteroposterior axis in Xenopus laevis

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Nerve dependency of regeneration: the role of Distal-less and FGF signaling in amphibian limb regeneration

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The cellular and molecular mechanisms of tissue repair and regeneration as revealed by studies in Xenopus

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Brief Local Application of Progesterone via a Wearable Bioreactor Induces Long-Term Regenerative Response in Adult Xenopus Hindlimb

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Injury and stress responses of adult neural crest-derived cells

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Mechanisms of Neonatal Heart Regeneration

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Endogenous Electric Field‐Coupled PD@BP Biomimetic Periosteum Promotes Bone Regeneration through Sensory Nerve via Fanconi Anemia Signaling Pathway

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A Stable Thoracic Hox Code and Epimorphosis Characterize Posterior Regeneration in Capitella teleta

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Cross-limb communication during Xenopus hind-limb regenerative response: non-local bioelectric injury signals

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Axonal regrowth is impaired during digit tip regeneration in mice

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Wnt/β-Catenin Signaling Pathway in Skin Carcinogenesis and Therapy

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Axo‐glial interaction in the injured PNS

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A Paradigm Shift in Tissue Engineering: From a Top–Down to a Bottom–Up Strategy

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Recent advancements in understanding endogenous heart regeneration—insights from adult zebrafish and neonatal mice

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Flexible Sono–Piezo Patch for Functional Sweat Gland Repair through Endogenous Microenvironmental Remodeling

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Cellular and molecular mechanisms that regulate mammalian digit tip regeneration

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Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and PathologiesPreprint

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Mass Spectrometry Imaging and Identification of Peptides Associated with Cephalic Ganglia Regeneration in Schmidtea mediterranea

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Somatic multicellularity as a satisficing solution to the prediction-error minimization problem

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Hyperinnervation improves Xenopus laevis limb regeneration

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Entangled cellular and molecular relationships at the sensory neuron-cancer interface

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The multifaceted role of nerves in animal regeneration

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Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies

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Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi

Edgar, A., Mitchell, D. G., & Martindale, M. Q. (2021) · Genes · doi:10.3390/genes12060867 · Cited by 27

A comparative perspective on lung and gill regeneration

Cádiz, L., & Jonz, M. G. (2020) · Journal of Experimental Biology · doi:10.1242/jeb.226076 · Cited by 27

Bioengineered Lacrimal Gland Organ Regeneration in Vivo

Hirayama, M., Tsubota, K., & Tsuji, T. (2015) · Journal of Functional Biomaterials · doi:10.3390/jfb6030634 · Cited by 25

Genetic, epigenetic, and post‐transcriptional basis of divergent tissue regenerative capacities among vertebrates

Khyeam, S., Lee, S., & Huang, G. N. (2021) · Advanced Genetics · doi:10.1002/ggn2.10042 · Cited by 25

Ion channel signaling influences cellular proliferation and phagocyte activity during axolotl tail regeneration

Franklin, B. M., Voss, S. R., & Osborn, J. L. (2017) · Mechanisms of Development · doi:10.1016/j.mod.2017.06.001 · Cited by 25

Transcriptomic responses to wounding: meta-analysis of gene expression microarray data

Sass, P., Dąbrowski, M., Charzyńska, A., & Sachadyn, P. (2017) · BMC Genomics · doi:10.1186/s12864-017-4202-8 · Cited by 25

Enduring questions in regenerative biology and the search for answers

Seifert, A. W., Duncan, E. M., & Zayas, R. M. (2023) · Communications Biology · doi:10.1038/s42003-023-05505-7 · Cited by 26

Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy

Chang, J. C., Durinck, S., Chen, M. Z., Martinez-Martín, N., Zhang, J. A., Lehoux, I. E., Li, H., Lin, M. H., Wu, J., Bainbridge, T. W., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45354-1 · Cited by 24

The salamander blastema within the broader context of metazoan regeneration

Tajer, B. J., Savage, A. M., & Whited, J. L. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1206157 · Cited by 25

Tumor-nerve interactions in cancer regulation and progression

Zhao, J., Cheng, L., Yang, J., Xu, F., Qi, W., Liao, K., Zhou, L., Cao, L., Chen, J., & Lin, Y. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217483 · Cited by 24

Regulation of dorso-ventral polarity by the nerve cord during annelid regeneration: A review of experimental evidence

Boilly, B., Boilly‐Marer, Y., & Bely, A. E. (2017) · Regeneration · doi:10.1002/reg2.78 · Cited by 23

Interrupting Neuron—Tumor Interactions to Overcome Treatment Resistance

Hunt, P. J., Kabotyanski, K. E., Călin, G. A., Xie, T., Myers, J. N., & Amit, M. (2020) · Cancers · doi:10.3390/cancers12123741 · Cited by 22

Parasympathetic and sympathetic axons are bundled in the cardiac ventricles and undergo physiological reinnervation during heart regeneration

Salamon, R. J., Halbe, P., Kasberg, W., Bae, J., Audhya, A., & Mahmoud, A. I. (2023) · iScience · doi:10.1016/j.isci.2023.107709 · Cited by 22

Nerves, H2O2 and Shh: Three players in the game of regeneration

Meda, F., Rampon, C., Dupont, E., Gauron, C., Mourton, A., Quéguiner, I., Thauvin, M., Volovitch, M., Joliot, A., & Vriz, S. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.015 · Cited by 22

Sensory nerve‐deficient microenvironment impairs tooth homeostasis by inducing apoptosis of dental pulp stem cells

Liu, A., Zhang, L., Fei, D., Guo, H., Wu, M., Liu, J., He, X., Zhang, Y., Xuan, K., & Li, B. (2020) · Cell Proliferation · doi:10.1111/cpr.12803 · Cited by 22

Heart Regeneration in Adult Mammals after Myocardial Damage.

Cui, B., Zheng, Y., Sun, L., Shi, T., Shi, Z., Wang, L., Huang, G., & Sun, N. (2018) · PubMed Central · doi:10.6515/acs.201803_34(2).20171206a · Cited by 21

Transcriptional analysis of scar-free wound healing during early stages of tail regeneration in the green anole lizard, Anolis carolinensis

Xu, C., Hutchins, E. D., Tokuyama, M. A., Wilson‐Rawls, J., & Kusumi, K. (2019) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2019.100025 · Cited by 22

Neural regulation in tooth regeneration of Ambystoma mexicanum

Makanae, A., Tajika, Y., Nishimura, K., Saito, N., Tanaka, J.-I., & Satoh, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-66142-2 · Cited by 21

Selective promotion of sensory innervation–mediated immunoregulation for tissue repair

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Tissue Regeneration: The Dark Side of Opioids

Dromard, C., Rabiller, L., Jourdan, G., Cousin, B., Pénicaud, L., Casteilla, L., & Lorsignol, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147336 · Cited by 19

Neuroregulation during Bone Formation and Regeneration: Mechanisms and Strategies

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Ivermectin Promotes Peripheral Nerve Regeneration during Wound Healing

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Tooth, hair and claw: Comparing epithelial stem cell niches of ectodermal appendages

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It Cuts Both Ways: An Annelid Model System for the Study of Regeneration in the Laboratory and in the Classroom

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The sea spider Pycnogonum litorale overturns the paradigm of the absence of axial regeneration in molting animals

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Sensory nerves, but not sympathetic nerves, promote reparative dentine formation after dentine injury via CGRP ‐mediated angiogenesis: An in vivo study

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Cholangiocarcinoma Malignant Traits Are Promoted by Schwann Cells through TGFβ Signaling in a Model of Perineural Invasion

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Injuries to appendage extremities and digit tips: A clinical and cellular update

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Engineering a synthetic cell panel to identify signalling components reprogrammed by the cell growth regulator anterior gradient-2

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Quo vadis: tracing the fate of neural crest cells

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Exoskeletal and eye repair in Dalmanitina socialis (Trilobita): An example of blastemal regeneration in the Ordovician?

Fatka, O., Budil, P., & Zicha, O. (2021) · International Journal of Paleopathology · doi:10.1016/j.ijpp.2021.05.011 · Cited by 17

The Contribution of Innervation to Tissue Repair and RegenerationPreprint

Johnston, A. P. W., & Miller, F. D. (2022) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041233 · Cited by 18

Nerves and Proliferation of Progenitor Cells in Limb Regeneration

Stocum, D. L. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22643 · Cited by 16

Pericytes in Cutaneous Wound Healing

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Endocrine regulation of regeneration: Linking global signals to local processes

Easterling, M. R., Engbrecht, K. M., & Crespi, E. J. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.113220 · Cited by 16

The Methylome and Transcriptome of Fetal Skin: Implications for Scarless Healing

Podolak-Popinigis, J., Ronowicz, A., Dmochowska, M., Jakubiak, A. A., & Sachadyn, P. (2016) · Epigenomics · doi:10.2217/epi-2016-0068 · Cited by 16

Neural dependency in wound healing and regeneration

Noble, A., Qubrosi, R., Cariba, S., Favaro, K. J., & Payne, S. L. (2023) · Developmental Dynamics · doi:10.1002/dvdy.650 · Cited by 18

Marvels of spiny mouse regeneration: cellular players and their interactions in restoring tissue architecture in mammals

Tomasso, A., Disela, V., Longaker, M. T., & Bartscherer, K. (2024) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2024.102228 · Cited by 19

Schwann cells in regeneration and cancer: an epithelial–mesenchymal transition perspective

Gracià, F., Sánchez‐Laorden, B. L., & Gomez-Sanchez, J. A. (2025) · Open Biology · doi:10.1098/rsob.240337 · Cited by 16

Nerve regeneration in the cephalopod molluscOctopus vulgaris:label-free multiphoton microscopy as a tool for investigation

Imperadore, P., Uckermann, O., Galli, R., Steiner, G. R., Kirsch, M., & Fiorito, G. (2018) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0889 · Cited by 15

Endocrine Regulation of Epimorphic Regeneration

Easterling, M. R., Engbrecht, K. M., & Crespi, E. J. (2019) · Endocrinology · doi:10.1210/en.2019-00321 · Cited by 15

First Insights into Human Fingertip Regeneration by Echo-Doppler Imaging and Wound Microenvironment Assessment

Jafari, P., Müller, C. T., Grognuz, A., Applegate, L. A., Raffoul, W., di Summa, P. G., & Durand, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18051054 · Cited by 15

Digit Tip Injuries: Current Treatment and Future Regenerative Paradigms

Miller, T. J., Deptula, P. L., Buncke, G. M., & Maan, Z. N. (2019) · Stem Cells International · doi:10.1155/2019/9619080 · Cited by 15

Stimulating ideas for heart regeneration: the future of nerve-directed heart therapy

Brandt, E. B., Bashar, S. J., & Mahmoud, A. I. (2019) · Bioelectronic Medicine · doi:10.1186/s42234-019-0024-0 · Cited by 16

Temporal and spatial analysis of enteric nervous system regeneration in the sea cucumber Holothuria glaberrima

Tossas, K., Qi‐Huang, S., Cuyar, E., & García‐Arrarás, J. E. (2014) · Regeneration · doi:10.1002/reg2.15 · Cited by 15

Adenosine enhances progenitor cell recruitment and nerve growth via its A2B receptor during adult fin regeneration

Rampon, C., Gauron, C., Meda, F., Volovitch, M., & Vriz, S. (2014) · Purinergic Signalling · doi:10.1007/s11302-014-9420-9 · Cited by 15

A system for bioelectronic delivery of treatment directed toward wound healing

Baniya, P., Tebyani, M., Asefifeyzabadi, N., Nguyen, T., Hernandez, C., Zhu, K., Li, H., Selberg, J. A., Hsieh, H., Pansodtee, P., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-41572-w · Cited by 14

Zebrafish can regenerate endoskeleton in larval pectoral fin but the regenerative ability declines

Yoshida, K., Kawakami, K., Abe, G., & Tamura, K. (2020) · Developmental Biology · doi:10.1016/j.ydbio.2020.04.010 · Cited by 14

Could we also be regenerative superheroes, like salamanders?

Dall’Agnese, A., & Puri, P. (2016) · BioEssays · doi:10.1002/bies.201600015 · Cited by 14

Loss of the ability to regenerate body appendages in vertebrates: from side effects of evolutionary innovations to gene loss

Zaraisky, A. G., Araslanova, K. R., Shitikov, A. D., & Tereshina, M. B. (2024) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.13102 · Cited by 14

Adult Stem Cells and Cardiac Regeneration

Turksen, K. (2013) · Stem Cell Reviews and Reports · doi:10.1007/s12015-013-9448-1 · Cited by 13

3D Printing for Neural Repair: Bridging the Gap in Regenerative Medicine

Clair‐Glover, M. S., Yue, Z., & Dottori, M. (2025) · Advanced Materials · doi:10.1002/adma.202507590 · Cited by 14

Skeletal callus formation is a nerve‐independent regenerative response to limb amputation in mice and Xenopus

Miura, S., Takahashi, Y., Satoh, A., & Endo, T. (2015) · Regeneration · doi:10.1002/reg2.39 · Cited by 12

Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices

Pagella, P., Miran, S., & Mitsiadis, T. (2015) · Journal of Visualized Experiments · doi:10.3791/53114 · Cited by 12

Temperature‐Programmable Deformable Microneedles for Scar‐Free Healing of Infective Wounds via Sensory Nerve Regeneration

Su, Y., Zhang, M., Yu, B., Feng, T., Zhu, D., Guo, X., Wang, Y., Ding, L., Li, Z., Kong, Y., et al. (2025) · Small · doi:10.1002/smll.202501491 · Cited by 11

Intersection between lung cancer and neuroscience: Opportunities and challenges

Xiao, X., Huang, L., Li, M., & Zhang, Q. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217701 · Cited by 12

Endogenous Mechanisms of Cardiac Regeneration

Xiang, M. S. W., & Kikuchi, K. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.04.002 · Cited by 11

Many Voices in a Choir: Tumor-Induced Neurogenesis and Neuronal Driven Alternative Splicing Sound Like Suspects in Tumor Growth and Dissemination

Dlamini, Z., Mathabe, K., Padayachy, L. C., Marima, R. M., Evangelou, G., Syrigos, K. N., Bianchi, A., Lolas, G., & Hull, R. (2021) · Cancers · doi:10.3390/cancers13092138 · Cited by 11

Does regeneration recapitulate phylogeny? Planaria as a model of body-axis specification in ancestral eumetazoa

Fields, C., & Levin, M. G. (2020) · Communicative & Integrative Biology · doi:10.1080/19420889.2020.1729601 · Cited by 11

A computational model of planarian regeneration

De, A., Chakravarthy, V. S., & Levin, M. G. (2016) · International Journal of Parallel Emergent and Distributed Systems · doi:10.1080/17445760.2016.1185521 · Cited by 11

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Unsworth, S. P., Brownell, I., & Wong, S. Y. (2016) · Journal of Visualized Experiments · doi:10.3791/54050 · Cited by 11

Mini-review: Trophic interactions between cancer cells and primary afferent neurons

Hunt, P. J., Andújar, F. N., Silverman, D. A., & Amit, M. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135658 · Cited by 10

The Secreted Protein Disulfide Isomerase Ag1 Lost by Ancestors of Poorly Regenerating Vertebrates Is Required for Xenopus laevis Tail Regeneration

Ivanova, A. S., Tereshina, M. B., Araslanova, K. R., Martynova, N. Y., & Zaraisky, A. G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.738940 · Cited by 10

Isolation, Culture, and Characterization of Primary Schwann Cells, Keratinocytes, and Fibroblasts from Human Foreskin

Jagadeeshaprasad, M. G., Govindappa, P. K., Nelson, A. M., & Elfar, J. C. (2022) · Journal of Visualized Experiments · doi:10.3791/63776 · Cited by 10

Mesenchymal stroma drives axonogenesis and nerve-induced aggressiveness in osteosarcoma

Pompo, G. D., Mitsiadis, T. A., Pagella, P., Pasquarelli, A., Bettini, G., Sabattini, S., Righi, A., Avnet, S., & Baldini, N. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03532-2 · Cited by 9

Ectopic head regeneration after nervous system ablation in a sea anemone

Gavgani, F. M., Kraus, J. E. M., Al‐Shaer, L., November, J., Seybold, A., Fournon-Berodia, I., Lerstad, B., Hausen, H., Layden, M. J., & Rentzsch, F. (2025) · Current Biology · doi:10.1016/j.cub.2025.10.061 · Cited by 9

Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice

Sosnowski, P., Sass, P., Słonimska, P., Płatek, R., Kamińska, J., Baczyński-Keller, J., Mucha, P., Peszyńska-Sularz, G., Czupryn, A., Pikuła, M., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15050610 · Cited by 9

Charging Ahead: Examining the Future Therapeutic Potential of Electroceuticals

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Unraveling the peripheral nervous System's role in tumor: A Double-edged Sword

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