Cited by 290Nerve injury and regenerationPlanarian Biology and ElectrostimulationNeurogenesis and neuroplasticity mechanisms

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Nerve dependence in tissue, organ, and appendage regeneration

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Kumar, Anoop, Brockes, Jeremy P.·2012·Trends in Neurosciences

DOI 10.1016/j.tins.2012.08.003

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Abstract

Many regeneration contexts require the presence of regenerating nerves as a transient component of the progenitor cell niche. Here we review nerve involvement in regeneration of various structures in vertebrates and invertebrates. Nerves are also implicated as persistent determinants in the niche of certain stem cells in mammals, as well as in Drosophila. We consider our present understanding of the cellular and molecular mechanisms underlying nerve dependence, including evidence of critical interactions with glia and non-neural cell types. The example of the salamander aneurogenic limb illustrates that developmental interactions between the limb bud and its innervation can be determinative for adult regeneration. These phenomena provide a different perspective on nerve cells to that based on chemical and electrical excitability.

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Authors: Kumar, A., & Brockes, J. P.
Affiliations: Institute of Structural and Molecular Biology (GB)
Corresponding author: Brockes, Jeremy P.
ORCID: Brockes, Jeremy P.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2012-11
Volume: 35
Issue: 11
Pages: 691-699
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2012.08.003
OpenAlex: W2048672935
Cited by: 290
References: 72
Citations by year: 2026: 11 · 2025: 26 · 2024: 19 · 2023: 21 · 2022: 14 · 2021: 23 · 2020: 22 · 2019: 21 · 2018: 18 · 2017: 25 · 2016: 33 · 2015: 26 · 2014: 24 · 2013: 7
FWCI: 1.93
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/3.0/ (vor, 257 d)
Locations: Trends in Neurosciences (publishedVersion, cc-by)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Medical Research Council
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: tissue regeneration, organ regeneration, appendage regeneration, stem cell niche, glial interactions, salamander regeneration, vertebrate regeneration
MeSH terms: Animals, Axons, Denervation, Drosophila melanogaster, Ear, External, Extremities, Fishes, Hydra, Invertebrates, Mice, Inbred Strains, Organ Specificity, Peripheral Nerves, Planarians, Regeneration, Schwann Cells, Species Specificity, Tail, Caudata, Urodela, Vertebrates, Xenopus laevis, Axotomy, Mice

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Nerve dependence in tissue, organ, and appendage regeneration

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