The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors
Abstract
Oxytocin and vasopressin are regulators of anxiety, stress-coping, and sociality. They are released within hypothalamic and limbic areas from dendrites, axons, and perikarya independently of, or coordinated with, secretion from neurohypophysial terminals. Central oxytocin exerts anxiolytic and antidepressive effects, whereas vasopressin tends to show anxiogenic and depressive actions. Evidence from pharmacological and genetic association studies confirms their involvement in individual variation of emotional traits extending to psychopathology. Based on their opposing effects on emotional behaviors, we propose that a balanced activity of both brain neuropeptide systems is important for appropriate emotional behaviors. Shifting the balance between the neuropeptide systems towards oxytocin, by positive social stimuli and/or psychopharmacotherapy, may help to improve emotional behaviors and reinstate mental health.
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In the citing paper
“In general, central OT is anxiolytic, antidepressive, and prosocial, whereas AVP is anxiogenic and can heighten depressive-type behaviors (8).”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [8]
In the citing paper
“Although the chemical structures of OT and AVP as well as their receptors are quite similar, OT and AVP can have distinct or even opposing actions.”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [3]
In the citing paper
“Although oxytocin facilitates parturition and lactation in females, decreased oxytocin levels have been linked with depression (not only postpartum depression) and maternal neglect [362,363].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [363]
Citations
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Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
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Research works printed but not linked: 1
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Cited by
Sorted by citations
Brain correlates of music-evoked emotions
Koelsch, S. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3666 · Cited by 1,544
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Self-citationOxytocin pathways and the evolution of human behavior
Carter, C. S. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115110 · Cited by 714
Anxiety, depression, and the microbiome: A role for gut peptides
Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520
“This suggests that social behaviors may be regulated by a synchrony of activity of OT and VP acting at distinct brain regions, and that a balance of OT and VP activity is necessary for the modulation of a wide range of social behaviors (Neumann & Landgraf, 2012).”
Background
Metadata
- Authors
- Neumann, I. D., & Landgraf, R.
- Affiliations
- University of Regensburg (DE)
- Max Planck Institute of Psychiatry (DE)
- Corresponding author
- Neumann, Inga D.
- ORCID
- Neumann, Inga D.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 35
- Issue
- 11
- Pages
- 649-659
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2069300470
- Cited by
- 954
- References
- 135
- Citations by year
- 2026: 40 · 2025: 59 · 2024: 61 · 2023: 54 · 2022: 76 · 2021: 89 · 2020: 75 · 2019: 74 · 2018: 74 · 2017: 74 · 2016: 73 · 2015: 86 · 2014: 76 · 2013: 41 · 2012: 2
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, vasopressin, anxiety, depression, social behavior, stress coping, hypothalamus, limbic system, emotional behavior, psychopharmacological treatment, social stimuli
- MeSH terms
- Adaptation, Psychological, Administration, Intranasal, Animals, Anxiety, Brain Chemistry, Depression, Emotions, Female, Homeostasis, Humans, Hypothalamus, Lactation, Limbic System, Male, Models, Biological, Oxytocin, Phobic Disorders, Pregnancy, Reproduction, Rodentia, Social Behavior, Vasopressins, Receptors, Vasopressin, Receptors, Oxytocin, Polymorphism, Single Nucleotide
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