Cited by 954Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

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Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors

Neumann, Inga D., Landgraf, Rainer·2012·Trends in Neurosciences

DOI 10.1016/j.tins.2012.08.004

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Abstract

Oxytocin and vasopressin are regulators of anxiety, stress-coping, and sociality. They are released within hypothalamic and limbic areas from dendrites, axons, and perikarya independently of, or coordinated with, secretion from neurohypophysial terminals. Central oxytocin exerts anxiolytic and antidepressive effects, whereas vasopressin tends to show anxiogenic and depressive actions. Evidence from pharmacological and genetic association studies confirms their involvement in individual variation of emotional traits extending to psychopathology. Based on their opposing effects on emotional behaviors, we propose that a balanced activity of both brain neuropeptide systems is important for appropriate emotional behaviors. Shifting the balance between the neuropeptide systems towards oxytocin, by positive social stimuli and/or psychopharmacotherapy, may help to improve emotional behaviors and reinstate mental health.

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de la Mora, M. P., Pérez-Carrera, D., Crespo-Ramírez, M., Tarakanov, A., Fuxe, K., & Borroto-Escuela, D. O. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.07.004 · Cited by 63
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“In general, central OT is anxiolytic, antidepressive, and prosocial, whereas AVP is anxiogenic and can heighten depressive-type behaviors (8).”
Background
Endogenous oxytocin, cortisol, and testosterone in response to group singing
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Recognizing others: rodent’s social memories.
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Validation of an enzyme-linked immunoassay (ELISA) for plasma oxytocin in a novel mammal species reveals potential errors induced by sampling procedure
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Intranasal oxytocin mechanisms can be better understood, but its effects on social cognition and behavior are not to be sniffed at
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Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice
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Sex differences in the control of social investigation and anxiety by vasopressin cells of the paraventricular nucleus of the hypothalamus
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Vasopressin and oxytocin in CSF and plasma of patients with aneurysmal subarachnoid haemorrhage
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Self-citation
Effects of Human–Dog Interactions on Salivary Oxytocin Concentrations and Heart Rate Variability: A Four-Condition Cross-Over Trial
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Peripheral Administration of a Long-Acting Peptide Oxytocin Receptor Agonist Inhibits Fear-Induced Freezing
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Authors: Neumann, I. D., & Landgraf, R.
Affiliations: University of Regensburg (DE)
Max Planck Institute of Psychiatry (DE)
Corresponding author: Neumann, Inga D.
ORCID: Neumann, Inga D.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2012-11
Volume: 35
Issue: 11
Pages: 649-659
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2012.08.004
OpenAlex: W2069300470
Cited by: 954
References: 135
Citations by year: 2026: 40 · 2025: 59 · 2024: 61 · 2023: 54 · 2022: 76 · 2021: 89 · 2020: 75 · 2019: 74 · 2018: 74 · 2017: 74 · 2016: 73 · 2015: 86 · 2014: 76 · 2013: 41 · 2012: 2
FWCI: 9.15
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: oxytocin, vasopressin, anxiety, depression, social behavior, stress coping, hypothalamus, limbic system, emotional behavior, psychopharmacological treatment, social stimuli
MeSH terms: Adaptation, Psychological, Administration, Intranasal, Animals, Anxiety, Brain Chemistry, Depression, Emotions, Female, Homeostasis, Humans, Hypothalamus, Lactation, Limbic System, Male, Models, Biological, Oxytocin, Phobic Disorders, Pregnancy, Reproduction, Rodentia, Social Behavior, Vasopressins, Receptors, Vasopressin, Receptors, Oxytocin, Polymorphism, Single Nucleotide

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Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors

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