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The potential of memory enhancement through modulation of perineuronal nets

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Perineuronal nets as regulators of parvalbumin interneuron function: Factors implicated in their formation and degradation

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Extracellular matrix remodeling with stress and depression: Studies in human, rodent and zebrafish models

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From molecules to behavior: Implications for perineuronal net remodeling in learning and memory

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The Effects of Normal Aging on Regional Accumulation of Hyaluronan and Chondroitin Sulfate Proteoglycans in the Mouse Brain

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Regulation of the E/I-balance by the neural matrisome

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Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin

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Distinct roles for hyaluronan in neural stem cell niches and perineuronal nets

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Chondroitin sulfate proteoglycans: key modulators of neuronal plasticity, long-term memory, neurodegenerative, and psychiatric disorders

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MiR‐29 coordinates age‐dependent plasticity brakes in the adult visual cortex

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The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling

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Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain

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Glycosaminoglycans' for brain health: Harnessing glycosaminoglycan based biomaterials for treating central nervous system diseases and in-vitro modeling

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Perineuronal nets affect memory and learning after synapse withdrawal

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The Density of Perineuronal Nets Increases With Age in the Inferior Colliculus in the Fischer Brown Norway Rat

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Postnatal Fluoxetine Treatment Alters Perineuronal Net Formation and Maintenance in the Hippocampus

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Perineuronal Nets in the CNS: Architects of Memory and Potential Therapeutic Target in Neuropsychiatric Disorders

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Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in skt Mice

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A view of the genetic and proteomic profile of extracellular matrix molecules in aging and stroke

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Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors

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Mass spectrometry methods for analysis of extracellular matrix components in neurological diseases

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Achieving Molecular Recognition of Structural Analogues in Surface‐Enhanced Raman Spectroscopy: Inducing Charge and Geometry Complementarity to Mimic Molecular Docking

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Proteoglycans as Therapeutic Targets in Brain Cancer

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Hyaluronan hydrates and compartmentalises the CNS / PNS extracellular matrix and provides niche environments conducive to the optimisation of neuronal activity

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The effect of electrospun scaffolds on the glycosaminoglycan profile of differentiating neural stem cells

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Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice

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Aging-Associated Changes in Cognition, Expression and Epigenetic Regulation of Chondroitin 6-Sulfotransferase Chst3

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Retrosplenial cortex microglia and perineuronal net densities are associated with memory impairment in aged rhesus macaques

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Recovery of Forearm and Fine Digit Function After Chronic Spinal Cord Injury by Simultaneous Blockade of Inhibitory Matrix Chondroitin Sulfate Proteoglycan Production and the Receptor PTPσ

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The Effect of Hapln4 Link Protein Deficiency on Extracellular Space Diffusion Parameters and Perineuronal Nets in the Auditory System During Aging

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Chemistry and Function of Glycosaminoglycans in the Nervous System

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Inferior collicular cells that project to the auditory thalamus are increasingly surrounded by perineuronal nets with age

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Targeted Analysis of the Size Distribution of Heavy Chain-Modified Hyaluronan with Solid-State Nanopores

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Resilience to Alzheimer's disease associates with alterations in perineuronal nets

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Designing neuroreparative strategies using aged regenerating animal models

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Changes in Brain Matrix Glycan Sulfation Associate With Reactive Gliosis and Motor Coordination in Mice With Head Trauma

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Sleep and Memory Consolidation Dysfunction in Psychiatric Disorders: Evidence for the Involvement of Extracellular Matrix Molecules

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Matrix disequilibrium in Alzheimer’s disease and conditions that increase Alzheimer’s disease risk

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Perineuronal nets: Role in normal brain physiology and aging, and pathology of various diseases

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Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia

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Impact of hyaluronan size on localization and solubility of the extracellular matrix in the mouse brain

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CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice

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Astrocytes and Alcohol Throughout the Lifespan

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Cerebral Modifications and Visual Pathway Reorganization in Maculopathy: A Systematic Review

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Increased levels of extracellular matrix proteins associated with extracellular vesicles from brains of aged mice

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Perineuronal nets in the developing brain: implications for neurodevelopmental disorders

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Sensory deafferentation modulates and redistributes neurocan in the rat auditory brainstem

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Upregulation of proteoglycans in the perilesion perimeter in ventral horns after spinal cord injury

Mukhamedshina, Y. O., Povysheva, T. V., Nikolenko, V. N., Kuznecov, M. S., Rizvanov, A. A., & Chelyshev, Y. A. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.04.006 · Cited by 9 · see citing works

Cerebral Modifications in Glaucoma and Macular Degeneration: Analysis of Current Evidence in Literature and Their Implications on Therapeutic Perspectives

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Orchestrating the Matrix: The Role of Glial Cells and Systemic Signals in Perineuronal Net Dynamics

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Circadian Rhythms of Perineuronal Net CompositionPreprint

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Morphological and Molecular Characteristics of Perineuronal Nets in the Human Prefrontal Cortex—A Possible Link to Microcircuitry Specialization

Banovac, I., Prkačin, M. V., Kirchbaum, I., Trnski, S., Bobić‐Rasonja, M., Sedmak, G., Petanjek, Z., & Milošević, N. J. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04306-1 · Cited by 7 · see citing works

Operation spinal cord regeneration: Patterning information residing in extracellular matrix glycosaminoglycans

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Reconstruction of the Carbohydrate 6-O Sulfotransferase Gene Family Evolution in Vertebrates Reveals Novel Member, CHST16, Lost in Amniotes

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Assessing translational applicability of perineuronal net dysfunction in Alzheimer’s disease across species

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Disaccharide Analysis of Glycosaminoglycans From Twenty‐Four Organs of Young and Aged Mice

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Targeting CA2 Perineuronal Nets Restores Recognition Memory and Theta Oscillations in Aged Mice

Mehak, S. F., Shivakumar, A. B., Jijimon, F., Gupta, A., Pillai, V. G., & Gangadharan, G. (2025) · Aging Cell · doi:10.1111/acel.70139 · Cited by 6 · see citing works

Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease

Sakata, J. T., Alonge, K. M., Diethorn, E. J., Krishnan, K., Milman, N., Ramsaran, A. I., Wan, X., & Sorg, B. A. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1367-25.2025 · Cited by 6 · see citing works

Perineuronal Nets: From Structure to Neurological Disorders

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A Therapeutic Link between Astrogliosis and Remyelination in a Mouse Model of Multiple Sclerosis

Pearson, C. S. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2844-17.2017 · Cited by 6 · see citing works

Achieving Molecular Recognition of Structural Analogues in Surface‐Enhanced Raman Spectroscopy: Inducing Charge and Geometry Complementarity to Mimic Molecular Docking

Leong, S. X., Kao, Y., Han, X., Poh, Z. W., Chen, J. R. T., Tan, E. X., Leong, Y. X., Lee, Y. H., Teo, W. X., Yip, G. W., et al. (2023) · Angewandte Chemie · doi:10.1002/ange.202309610 · Cited by 5 · see citing works

Regulation of CNS Plasticity Through the Extracellular Matrix

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Extracellular matrix and microglial regulation of cognitive agingPreprint

Gray, D. T., Gutierrez, A., Jami‐Alahmadi, Y., Pandey, V., Pan, L., Zhang, Y., Wohlschlegel, J. A., McDevitt, R. A., & Biase, L. M. D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.04.574215 · Cited by 5 · see citing works

Turning back time: Aging plasticity and its rejuvenation

Radulescu, C. I., Pilch, K. S., Wang, X., Gibbs, F., & Barnes, S. J. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103097 · Cited by 4 · see citing works

Midbrain extracellular matrix and microglia are associated with cognition in aging mice

Gray, D. T., Gutierrez, A., Jami‐Alahmadi, Y., Pandey, V., Pan, L., Zhang, Y., Wohlschlegel, J. A., McDevitt, R. A., & Biase, L. M. D. (2025) · Nature Communications · doi:10.1038/s41467-025-66434-z · Cited by 4 · see citing works

Restoring the pattern of proteoglycan sulphation in perineuronal nets corrects age-related memory lossPreprint

Yang, S., Gigout, S., Molinaro, A., Naito-Matsui, Y., Hilton, S., Foscarin, S., Nieuwenhuis, B., Verhaagen, J., Pizzorusso, T., Saksida, L. M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.03.894188 · Cited by 4 · see citing works

Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing

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Chondroitin 4-sulphate depletion enhances synaptic plasticity and memory in agingPreprint

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THE ROLE OF BRAIN CHONDROITIN 4 SULFATES (C4S) IN AGING MICE

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Joint Meeting in Karachi

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