Cited by 174Cholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsMedicinal Plants and Neuroprotection

Neuroprotective effects of huperzine A: New therapeutic targets for neurodegenerative disease

Zhang, Hai Yan, Tang, Xi Can·2006·Trends in Pharmacological Sciences

Abstract

In recent years, the most common pharmacological treatment for Alzheimer's disease (AD) has been acetylcholinesterase (AChE) inhibition. However, this single-target approach has limited effectiveness and there is evidence that a multitarget approach might be more effective. Huperzine A (HupA), a novel alkaloid isolated from a Chinese herb, has neuroprotective effects that go beyond the inhibition of AChE. Recent data have demonstrated that HupA can ameliorate the learning and memory deficiency in animal models and AD patients. Its potentially beneficial actions include modification of beta-amyloid peptide processing, reduction of oxidative stress, neuronal protection against apoptosis, and regulation of the expression and secretion of nerve growth factor (NGF) and NGF signaling.

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Crossref · 10.1016/j.tips.2006.10.004

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Authors
Zhang, H. Y., & Tang, X. C.
Affiliations
Chinese Academy of Sciences (CN)
Corresponding author
Tang, Xi Can
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2006-12
Volume
27
Issue
12
Pages
619-625
ISSN
0165-6147 (ISSN-L)
OpenAlex
W1989251920
Cited by
174
References
73
Citations by year
2026: 1 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 3 · 2021: 7 · 2020: 12 · 2019: 7 · 2018: 11 · 2017: 8 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 11 · 2012: 12
FWCI
1.09
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Pharmacological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
huperzine A, neuroprotection, Alzheimer's disease, acetylcholinesterase inhibition, multi-target therapy, oxidative stress, neuronal apoptosis, nerve growth factor, NGF signaling, learning and memory impairment, neurodegenerative diseases
MeSH terms
Alkaloids, Alzheimer Disease, Animals, Cholinesterase Inhibitors, Humans, Sesquiterpenes, Amyloid beta-Protein Precursor, Apoptosis, Neuroprotective Agents

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