The DOI matches its Crossref record; 116 of the 118 references it cites were found in a registry or an index.
Alzheimer's disease, metal ions and metal homeostatic therapy
Abstract
Mounting evidences support the idea that endogenous 'biometals', such as copper, iron, zinc and exogenous ones such as aluminum, can be involved as factors or cofactors in the etiopathogenesis of a variety of neurodegenerative diseases. Alzheimer's disease (AD) is a multifactorial neurodegenerative condition associated with pathological accumulation of amyloid plaques and with the appearance of deposit of neurofibrillary tangles. In AD, the process of beta-amyloid (Abeta) misfolding and plaque aggregation is greatly influenced by alterations in the homeostasis of the aforementioned metal ions. Here, we discuss the most recent evidences that associate metal ion dyshomeostasis with the development of AD. As for aluminum, a role for this ion in AD pathogenesis is still controversial. Thus, here, we also critically review new findings that argue for and against the 'aluminum hypothesis'. Finally, it is discussed how therapeutic strategies aimed at restoring metal homeostasis can delay and modify the progression of AD-related neurodegeneration.
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In the citing paper
“Post-mortem examination of the brain suggested that bio-available metals (i.e., copper, zinc, and iron) are found in high concentration in the amyloid plaques.”
From The effect of Cu2+ and Zn2+ on the Aβ42 peptide aggregation and cellular toxicity (2013) · cites this paper as [15]
In the citing paper
“However, use of non-specific chelators (i.e., CQ) that do not interact selectively with the Aβ–metal species exhibit adverse side effects that will likely limit their long term clinical use.3,28,29,31,44,46–48”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [28]
In the citing paper
“as well as lead to formation of reactive oxygen species (ROS) and oxidative stress.3,26–31,33–36”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [28]
In the citing paper
“Copper, iron and zinc deposits are observed within the core and periphery of senile plaques, and co-localize with Aβ [539].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [539]
In the citing paper
“Subsequently, there is evidence suggesting that metals similar to iron, zinc, or copper may have a role in AD-related pathogenesis [166].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [166]
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Cites
1 retracted
RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
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Flagged first, then by citations
2 of the 118 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Lovestone, 1997, The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes, Neuroscience, 78, 309
Cited by
Sorted by citations
Zhang, J., Zhang, Y., Wang, J., Xia, Y., Zhang, J., & Chen, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01911-3 · Cited by 1,138
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994
History and progress of hypotheses and clinical trials for Alzheimer’s disease
Liu, P.-P., Xie, Y., Meng, X.-Y., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0063-8 · Cited by 723
Bioinorganic Chemistry of Alzheimer’s Disease
Kepp, K. P. (2012) · Chemical Reviews · doi:10.1021/cr300009x · Cited by 683
Metabolism and functions of copper in brain
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Metadata
- Authors
- Zatta, P., Drago, D., Bolognin, S., & Sensi, S. L.
- Affiliations
- University of Padua (IT)
- University of California, Irvine (US)
- Corresponding author
- Zatta, Paolo
- Sensi, Stefano L.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 30
- Issue
- 7
- Pages
- 346-355
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2025615265
- Cited by
- 369
- References
- 118
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 23 · 2023: 22 · 2022: 18 · 2021: 15 · 2020: 24 · 2019: 19 · 2018: 21 · 2017: 17 · 2016: 25 · 2015: 13 · 2014: 28 · 2013: 19 · 2012: 29
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, metal ions, metal homeostasis, copper, iron, zinc, aluminum, amyloid plaques, neurofibrillary tangles, neurodegeneration
- MeSH terms
- Alzheimer Disease, Animals, Homeostasis, Humans, Clioquinol, Metals, Plaque, Amyloid
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