Cited by 379Alzheimer's disease research and treatmentsTrace Elements in HealthDementia and Cognitive Impairment Research

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Alzheimer's disease, metal ions and metal homeostatic therapy

Zatta, Paolo, Drago, Denise, Bolognin, Silvia, Sensi, Stefano L.·2009·Trends in Pharmacological Sciences

DOI 10.1016/j.tips.2009.05.002

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Abstract

Mounting evidences support the idea that endogenous 'biometals', such as copper, iron, zinc and exogenous ones such as aluminum, can be involved as factors or cofactors in the etiopathogenesis of a variety of neurodegenerative diseases. Alzheimer's disease (AD) is a multifactorial neurodegenerative condition associated with pathological accumulation of amyloid plaques and with the appearance of deposit of neurofibrillary tangles. In AD, the process of beta-amyloid (Abeta) misfolding and plaque aggregation is greatly influenced by alterations in the homeostasis of the aforementioned metal ions. Here, we discuss the most recent evidences that associate metal ion dyshomeostasis with the development of AD. As for aluminum, a role for this ion in AD pathogenesis is still controversial. Thus, here, we also critically review new findings that argue for and against the 'aluminum hypothesis'. Finally, it is discussed how therapeutic strategies aimed at restoring metal homeostasis can delay and modify the progression of AD-related neurodegeneration.

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RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., & Ashe, K. H. (2006) · Nature · doi:10.1038/nature04533 · Cited by 2,769
Retracted
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Alzheimer's disease: the amyloid cascade hypothesis
Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879
Copper, iron and zinc in Alzheimer's disease senile plaques
Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., & Markesbery, W. R. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00092-6 · Cited by 2,120
Intracellular amyloid-β in Alzheimer's disease
LaFerla, F. M., Green, K. N., & Oddo, S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2168 · Cited by 1,942
The neurobiology of zinc in health and disease
Frederickson, C. J., Koh, J., & Bush, A. I. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1671 · Cited by 1,841
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function
Cleary, J. P., Walsh, D. M., Hofmeister, J. J., Shankar, G. M., Kuskowski, M. A., Selkoe, D. J., & Ashe, K. H. (2004) · Nature Neuroscience · doi:10.1038/nn1372 · Cited by 1,722
The Dialysis Encephalopathy Syndrome
Alfrey, A. C., LeGendre, G. R., & Kaehny, W. D. (1976) · New England Journal of Medicine · doi:10.1056/nejm197601222940402 · Cited by 1,628

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Research works printed but not linked: 1

Lovestone, 1997, The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes, Neuroscience, 78, 309

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Self-citation

Authors: Zatta, P., Drago, D., Bolognin, S., & Sensi, S. L.
Affiliations: University of Padua (IT)
University of California, Irvine (US)
Corresponding author: Zatta, Paolo
Sensi, Stefano L.
ORCID: Drago, Denise
Bolognin, Silvia
Sensi, Stefano L.
Venue: Trends in Pharmacological Sciences
Publisher: Elsevier BV
Published: 2009-07
Volume: 30
Issue: 7
Pages: 346-355
ISSN: 0165-6147 (ISSN-L)
DOI: 10.1016/j.tips.2009.05.002
OpenAlex: W2025615265
Cited by: 369
References: 118
Citations by year: 2026: 11 · 2025: 11 · 2024: 23 · 2023: 22 · 2022: 18 · 2021: 15 · 2020: 24 · 2019: 19 · 2018: 21 · 2017: 17 · 2016: 25 · 2015: 13 · 2014: 28 · 2013: 19 · 2012: 29
FWCI: 3.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Pharmacological Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, metal ions, metal homeostasis, copper, iron, zinc, aluminum, amyloid plaques, neurofibrillary tangles, neurodegeneration
MeSH terms: Alzheimer Disease, Animals, Homeostasis, Humans, Clioquinol, Metals, Plaque, Amyloid

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Alzheimer's disease, metal ions and metal homeostatic therapy

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