Cited by 120Smoking Behavior and CessationGenetic Associations and EpidemiologyNicotinic Acetylcholine Receptors Study

Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25

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Bierut, Laura Jean·2010·Trends in Pharmacological Sciences

Abstract

Due to the adverse health consequences related to smoking, it is important to understand factors that contribute to nicotine dependence. The most replicated genetic finding for nicotine dependence points to variants on chromosome 15, which includes the alpha5-alpha3-beta4 nicotinic receptor gene cluster. A compelling functional variant is a polymorphism, rs16969968, which alters an amino acid in the alpha5 nicotinic receptor subunit. Several prominent studies report that the replicated nicotine dependence locus also influences the risk for lung cancer and chronic obstructive pulmonary disease. This represents an exciting convergence of genetic findings, and highlights the potential for research on smoking to inform public health.

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  1. [6]Substance Abuse and Mental Health Services Administration 2004 Overview of findings from the 2003 National Survey on Drug Use and Health NSDUH Series H-24 (Studies, O.o.A., ed) 27656739

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Authors
Bierut, L. J.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Bierut, Laura Jean
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2010-01
Volume
31
Issue
1
Pages
46-51
ISSN
0165-6147 (ISSN-L)
OpenAlex
W1981386943
Cited by
120
References
44
Citations by year
2025: 2 · 2024: 2 · 2023: 6 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 2 · 2017: 13 · 2016: 10 · 2015: 8 · 2014: 10 · 2013: 12 · 2012: 15
FWCI
1.24
Type
journal article
Language
en
Open access
Locations
  • Trends in Pharmacological Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Drug Abuse (K02DA021237)
  • National Cancer Institute (P01CA089392)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
nicotine dependence, nicotinic acetylcholine receptors, CHRNA5, CHRNA3, CHRNB4, rs16969968, lung cancer risk, chronic obstructive pulmonary disease, smoking-related diseases, genetic susceptibility
MeSH terms
Animals, Chromosomes, Human, Pair 15, Humans, Lung Neoplasms, Nerve Tissue Proteins, Receptors, Nicotinic, Tobacco Use Disorder, Amino Acid Substitution, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Pulmonary Disease, Chronic Obstructive

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