The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Targeting DNA methylation for epigenetic therapy
Open accessAbstract
DNA methylation patterns are established during embryonic development and faithfully copied through somatic cell divisions. Based on our understanding of DNA methylation and other interrelated epigenetic modifications, a comprehensive view of the epigenetic landscape and cancer epigenome is evolving. The cancer methylome is highly disrupted, making DNA methylation an excellent target for anti-cancer therapies. During the last few decades, an increasing number of drugs targeting DNA methylation have been developed in an effort to increase efficacy, stability and to decrease toxicity. The earliest and the most successful epigenetic drug to date, 5-Azacytidine, is currently recommended as the first-line treatment for high risk myelodysplastic syndromes (MDS) patients. Encouraging results from clinical trials have prompted further efforts to elucidate epigenetic alterations in cancer and subsequently develop new epigenetic therapies. This review delineates the latest cancer epigenetic models, recent discovery of hypomethylation agents and their application in the clinic.
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Cancer epigenetics reaches mainstream oncology
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Folate and DNA Methylation: A Review of Molecular Mechanisms and the Evidence for Folate's Role
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Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy
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DNA methylation profiles in cancer diagnosis and therapeutics
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The role of tumor-associated macrophages in tumor immune evasion
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Metadata
- Authors
- Yang, X., Lay, F., Han, H., & Jones, P. A.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 31
- Issue
- 11
- Pages
- 536-546
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2013250198
- Cited by
- 326
- References
- 18
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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