The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems
Open accessAbstract
The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum (ER) protein resides specifically at the interface between ER and mitochondria, called the MAM, where the Sig-1R is recently reported to be involved in certain CNS diseases. In addition to being able to translocate to the plasma membrane to interact with ion channels and other receptors, the Sig-1R is found to exist at the nuclear envelope where it recruits chromatin-remodeling factors to affect the transcription of genes. As well, thorough experimental and bioinformatic means, Sig-1Rs are reported to interact with other membranous or soluble proteins at other loci, including the cytosol. We propose that the Sig-1R is a pluripotent modulator with resultant multiple functional manifestations in the living system.
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Metadata
- Authors
- Su, T.-P., Su, T.-C., Nakamura, Y., & Tsai, S.-Y.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 37
- Issue
- 4
- Pages
- 262-278
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2271406622
- Cited by
- 320
- References
- 135
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- green
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