The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
The sigma-1 receptor chaperone as an inter-organelle signaling modulator
Open accessAbstract
Inter-organelle signaling plays important roles in many physiological functions. Endoplasmic reticulum (ER)-mitochondrion signaling affects intra-mitochondrial calcium (Ca2+) homeostasis and cellular bioenergetics. ER-nucleus signaling attenuates ER stress. ER-plasma membrane signaling regulates cytosolic Ca2+ homeostasis, and ER-mitochondrion-plasma membrane signaling regulates hippocampal dendritic spine formation. Here we propose that the sigma-1 receptor (Sig-1R), an ER chaperone protein, acts as an inter-organelle signaling modulator. Sig-1Rs normally reside at the ER-mitochondrion contact called the MAM (mitochondrion-associated ER membrane), where Sig-1Rs regulate ER-mitochondrion signaling and the ER-nucleus cross-talk. When cells are stimulated by ligands or undergo prolonged stress, Sig-1Rs translocate from the MAM to the ER reticular network and plasmalemma/plasma membrane to regulate a variety of functional proteins, including ion channels, receptors, and kinases. Thus, the Sig-1R serves as an inter-organelle signaling modulator locally at the MAM and remotely at the plasmalemma/plasma membrane. Many pharmacological/physiological effects of Sig-1Rs may relate to this unique action of Sig-1Rs.
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Cites
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Self-citationThe therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization
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Metadata
- Authors
- Su, T.-P., Hayashi, T., Maurice, T., Buch, S., & Ruoho, A. E.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 31
- Issue
- 12
- Pages
- 557-566
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2131087015
- Cited by
- 466
- References
- 108
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- green
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