Changes in memory and synaptic plasticity induced in male rats after maternal exposure to bisphenol A
Abstract
Bisphenol A (BPA), a component of polycarbonate and epoxy resins, has been reported to adversely impact the central nervous system, especially with respect to learning and memory. However, the precise effect and specific mechanisms have not been fully elucidated. In the present study, pregnant Sprague-Dawley rats were orally administered with BPA at 0.05, 0.5, 5 or 50mg/kg·body weight (BW) per day from embryonic day 9 (E 9) to E 20. We examined the effects of maternal BPA exposure on memory and synaptic structure in the hippocampus of male offspring at postnatal day (PND) 21. Maternal BPA exposure significantly affected locomotor activity, exploratory habits, and emotional behavior in open field test, and increased reference and especially working memory errors in the radial arm maze during the postnatal developing stage. Maternal BPA exposure had an adverse effect on synaptic structure, including a widened synaptic cleft, a thinned postsynaptic density (PSD), unclear synaptic surface and disappeared synaptic vesicles. Furthermore, maternal BPA exposure decreased the mRNA and protein expressions of synaptophysin, PSD-95, spinophilin, GluR1 and NMDAR1 in the hippocampus of male offspring on PND 21. These results showed that fetal growth and development was more sensitive to BPA exposure. The decreased learning and memory induced by maternal exposure to BPA in this study may be involved in synaptic plasticity alteration.
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Pre- and perinatal exposures to BPA at or below the TDI (≤50 μg/kg/day) have resulted in adverse effects on memory processes in rodents.
“In rodents, pre- and perinatal exposures to BPA at or below the TDI (tolerable daily intake; ⩽50 μg/kg/day) have resulted in adverse effects on memory processes [4–9].”
From The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation (2017) · cites this paper as [8]
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EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
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“Bisphenol-A (BPA), a widely used synthetic compound in plastics, disrupts endocrine function and interferes with physiological actions of endogenous gonadal hormones.”
BackgroundSelf-citation
- Authors
- Wang, C., Niu, R., Zhu, Y., Han, H., Luo, G., Zhou, B., & Wang, J.
- Affiliations
- Shanxi Agricultural University (CN)
- Corresponding author
- Wang, Jundong
- Venue
- Toxicology
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 322
- Pages
- 51-60
- ISSN
- 0300-483X (ISSN-L)
- OpenAlex
- W2074403754
- Cited by
- 70
- References
- 7
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 11 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 10 · 2014: 4
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- bisphenol A, maternal exposure, learning and memory, working memory, synaptic plasticity, hippocampus, synaptic structure, postsynaptic density, synaptic vesicles, synaptophysin, PSD-95, spinophilin, GluR1, NMDAR1, locomotor activity, exploratory behavior, emotional behavior, male offspring, fetal development
- MeSH terms
- Bisphenol A Compounds, Animals, Behavior, Animal, Benzhydryl Compounds, Estrogens, Non-Steroidal, Female, Male, Maternal-Fetal Exchange, Memory, Motor Activity, Nerve Tissue Proteins, Neuronal Plasticity, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, RNA, Gonadal Steroid Hormones, Synapses, Blotting, Western, Rats, Sprague-Dawley, Maze Learning, Maternal Exposure, Microscopy, Electron, Transmission, Rats, Real-Time Polymerase Chain Reaction
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