Impact of low dose oral exposure to bisphenol A (BPA) on the neonatal rat hypothalamic and hippocampal transcriptome: a clarity-BPA consortium study

Arambula, Sheryl E.; Belcher, Scott M.; Planchart, Antonio; Turner, Stephen D.; Patisaul, Heather B.

doi:10.1210/en.2016-1339

Cited by 87Effects and risks of endocrine disrupting chemicalsEstrogen and related hormone effectsSexual Differentiation and Disorders

Impact of low dose oral exposure to bisphenol A (BPA) on the neonatal rat hypothalamic and hippocampal transcriptome: a clarity-BPA consortium study

Open access

Arambula, Sheryl E., Belcher, Scott M., Planchart, Antonio, Turner, Stephen D., Patisaul, Heather B.·2016·Endocrinology

DOI 10.1210/en.2016-1339PMC PMC5045502

Open this paper in CoChat — free account Open PDF

Abstract

Bisphenol A (BPA) is an endocrine disrupting, high volume production chemical found in a variety of products.Evidence of prenatal exposure has raised concerns that developmental BPA may disrupt sex-specific brain organization and, consequently, induce lasting changes on neurophysiology and behavior.We and others have shown that exposure to BPA at doses below the noobserved-adverse-effect level can disrupt the sex-specific expression of estrogen-responsive genes in the neonatal rat brain including estrogen receptors (ERs).The present studies, conducted as part of the Consortium Linking Academic and Regulatory Insights of BPA Toxicity program, expanded this work by examining the hippocampal and hypothalamic transcriptome on postnatal day 1 with the hypothesis that genes sensitive to estrogen and/or sexually dimorphic in expression would be altered by prenatal BPA exposure.NCTR Sprague-Dawley dams were gavaged from gestational day 6 until parturition with BPA (0-, 2.5-, 25-, 250-, 2500-, or 25 000-g/kg body weight [bw]/d).Ethinyl estradiol was used as a reference estrogen (0.05-or 0.5-g/kg bw/d).Postnatal day 1 brains were microdissected and gene expression was assessed with RNA-sequencing (0-, 2.5-, and 2500-g/kg bw BPA groups only) and/or quantitative real-time PCR (all exposure groups).BPA-related transcriptional changes were mainly confined to the hypothalamus.Consistent with prior observations, BPA induced sex-specific effects on hypothalamic ER␣ and ER␤ (Esr1 and Esr2) expression and hippocampal and hypothalamic oxytocin (Oxt) expression.These data demonstrate prenatal BPA exposure, even at doses below the current no-observed-adverse-effect level, can alter gene expression in the developing brain.(Endocrinology 157: 3856 -3872, 2016) B isphenol A (BPA) is a well-known endocrine-disrupt- ing compound (EDC) used in a wide range of products, including food and beverage containers, medical equipment, plastic water pipes, and thermal receipts, from which it can leach, thereby resulting in human exposure (1-3).BPA has been found in human fetal plasma and in placental tissue (1, 2), indicating that maternal BPA is able to cross the placenta.Evidence of prenatal exposure has raised concern that subtle effects of developmental BPA exposure on brain organization and sexual differentiation may have long-term impacts on neurophysiology and behavior (3-5).Over the past decade, the National Toxicology Program (NTP), World Health Organization, Food and Agricultural Organization, and others have expressed concern for effects on the brain and behavior (6 -10).The Food and Drug Administration (FDA), however, subsequently departed from this view and in 2014 stated that

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/en.2016-1339

Cites

108 of 108 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Developmental exposure to doses as low as 2.5 μg/kg bw sex specifically alters the mRNA expression of ERα and ERβ in sexually dimorphic hypothalamic and limbic subnuclei in the neonatal and older rat brain.
“For example, we have repeatedly shown that developmental exposure to doses as low as 2.5 µg/kg bw sex specifically alters the mRNA expression of ERα and ERβ in sexually dimorphic hypothalamic and limbic subnuclei in the neonatal and older rat brain (86–90).”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [88]
The section ‘Effect of prenatal BPA or EE exposure on hypothalamic gene expression’ reports that 2.5 µg/kg BPA increased both Esr1 (ERα) and Esr2 (ERβ) expression in neonatal females, but not males. The Abstract describes a prior study finding sex-dependent changes in hypothalamic and amygdala subregions on postnatal day 1. This paper’s own measurements used the whole hypothalamus rather than individual subnuclei, and it does not establish the claimed effects in older rats. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Developmental BPA exposure can perturb ERα and ERβ gene expression throughout the rat hypothalamus and components of the mesolimbic dopamine system, including the PVN and BnST, across the lifespan.
“We have repeatedly shown that developmental BPA exposure can perturb ERα and ERβ gene expression throughout the rat hypothalamus and components of the mesolimbic dopamine system, including the PVN and BnST (86–90), across the lifespan.”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [88]
The Discussion (page not available in our copy) reports BPA-related changes in Esr1 and Esr2 expression in neonatal rat hypothalamus, with effects varying by subregion. It does not establish ERα and ERβ changes across the lifespan or in the BnST. Its mention of the adult PVN concerns oxytocin neurons, not ER gene expression. (LLM, conf=0.87)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Perinatal Exposure to Bisphenol-A Impairs Spatial Memory through Upregulation of Neurexin1 and Neuroligin3 Expression in Male Mouse Brain
Kumar, D., & Thakur, M. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110482 · Cited by 37 · see citing works
Retracted
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219 · see citing works
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581 · see citing works
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J.-Å. (1998) · Endocrinology · doi:10.1210/endo.139.10.6216 · Cited by 4,203 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Sensitive periods in the development of the brain and behavior
Knudsen, E. I. (2004) · Journal of Cognitive Neuroscience · doi:10.1162/0898929042304796 · Cited by 1,842 · see citing works
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543 · see citing works
Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure
Ikezuki, Y., Tsutsumi, O., Takai, Y., Kamei, Y., & Taketani, Y. (2002) · Human Reproduction · doi:10.1093/humrep/17.11.2839 · Cited by 886 · see citing works
Estradiol and the Developing Brain
McCARTHY, M. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00010.2007 · Cited by 885 · see citing works
How to do successful gene expression analysis using real-time PCR
Derveaux, S., Vandesompele, J., & Hellemans, J. (2009) · Methods · doi:10.1016/j.ymeth.2009.11.001 · Cited by 791 · see citing works
Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists
Barkhem, T., Carlsson, B., Nilsson, Y., Enmark, E., Gustafsson, J.-Α., & Nilsson, S. V. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.1.105 · Cited by 770 · see citing works
Wired for Reproduction: Organization and Development of Sexually Dimorphic Circuits in the Mammalian Forebrain
Simerly, R. B. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142745 · Cited by 723 · see citing works
Parent bisphenol A accumulation in the human maternal-fetal-placental unit.
Schönfelder, G., Wittfoht, W., Hopp, H., Talsness, C. E., Paul, M., & Chahoud, I. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.021100703 · Cited by 668 · see citing works
The Environmental Estrogen Bisphenol A Stimulates Prolactin Release in Vitro and in Vivo
Steinmetz, R. W., Brown, N. G., Allen, D. L., Bigsby, R. M., & Ben‐Jonathan, N. (1997) · Endocrinology · doi:10.1210/endo.138.5.5132 · Cited by 520 · see citing works
Inhibition of Testicular Steroidogenesis by the Xenoestrogen Bisphenol A Is Associated with Reduced Pituitary Luteinizing Hormone Secretion and Decreased Steroidogenic Enzyme Gene Expression in Rat Leydig Cells
Akingbemi, B. T., Sottas, C. M., Koulova, A., Klinefelter, G. R., & Hardy, M. P. (2003) · Endocrinology · doi:10.1210/en.2003-1174 · Cited by 516 · see citing works
NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A
Chapin, R. E., Adams, J., Boekelheide, K., Gray, L. E., Hayward, S. W., Lees, P. S. J., Mcintyre, B., Portier, K. M., Schnorr, T. M., Selevan, S. G., et al. (2008) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20147 · Cited by 504 · see citing works
Sexual Differentiation of the Vertebrate Brain: Principles and Mechanisms
Cooke, B., Hegstrom, C. D., Villeneuve, L. S., & Breedlove, S. M. (1998) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1998.0171 · Cited by 504 · see citing works
Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure
Kundakovic, M., Gudsnuk, K., Franks, B., Madrid, J., Miller, R. L., Perera, F. P., & Champagne, F. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214056110 · Cited by 490 · see citing works
Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair
Jung, H., Yoon, B. C., & Holt, C. E. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3210 · Cited by 487 · see citing works
Minireview: sex differences in adult and developing brains: compensation, compensation, compensation
De Vries, G. J. (2004) · Endocrinology · doi:10.1210/en.2003-1504 · Cited by 486 · see citing works
The Epigenetics of Sex Differences in the Brain: Figure 1.
McCarthy, M. M., Auger, A. P., Bale, T. L., Vries, G. J. D., Dunn, G. A., Forger, N. G., Murray, E. K., Nugent, B. M., Schwarz, J. M., & Wilson, M. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3331-09.2009 · Cited by 478 · see citing works
DNA methylation of BDNF as a biomarker of early-life adversity
Kundakovic, M., Gudsnuk, K., Herbstman, J. B., Tang, D., Perera, F. P., & Champagne, F. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408355111 · Cited by 426 · see citing works
Statistical Design and Analysis of RNA Sequencing Data
Auer, P. L., & Doerge, R. W. (2010) · Genetics · doi:10.1534/genetics.110.114983 · Cited by 393 · see citing works
Brain feminization requires active repression of masculinization via DNA methylation
Nugent, B. M., Wright, C. L., Shetty, A. C., Hodes, G. E., Lenz, K. M., Mahurkar, A., Russo, S. J., Devine, S. E., & McCarthy, M. M. (2015) · Nature Neuroscience · doi:10.1038/nn.3988 · Cited by 390 · see citing works
A shared vesicular carrier allows synaptic corelease of GABA and glycine
Wojcik, S. M., Katsurabayashi, S., Guillemin, I., Friauf, E., Rosenmund, C., Brose, N., & Rhee, J.-S. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.016 · Cited by 374 · see citing works
Atlas Of The Developing Rat Brain
Paxinos, G., & Fritchle, A. L. R. (1991) · Medical Entomology and Zoology · Cited by 345 · see citing works
Hippocampal development in the rat: Cytogenesis and morphogenesis examined with autoradiography and low‐level X‐irradiation
Bayer, S. A., & Altman, J. (1974) · Journal of Comparative Neurology · doi:10.1002/cne.901580105 · Cited by 344 · see citing works
Gestational Exposure to Bisphenol A Produces Transgenerational Changes in Behaviors and Gene Expression
Wolstenholme, J. T., Edwards, M., Shetty, S. R. J., Gatewood, J. D., Taylor, J. A., Rissman, E. F., & Connelly, J. J. (2012) · Endocrinology · doi:10.1210/en.2012-1195 · Cited by 319 · see citing works
Projections from vasopressin, oxytocin, and neurophysin neurons to neural targets in the rat and human
Sofroniew, M. V. (1980) · Journal of Histochemistry & Cytochemistry · doi:10.1177/28.5.7381192 · Cited by 317 · see citing works
The role of bisphenol A in shaping the brain, epigenome and behavior
Wolstenholme, J. T., Rissman, E. F., & Connelly, J. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.10.001 · Cited by 309 · see citing works
The Establishment of GABAergic and Glutamatergic Synapses on CA1 Pyramidal Neurons is Sequential and Correlates with the Development of the Apical Dendrite
Tyzio, R., Represa, A., Jorquera, I., Ben-Ari, Y., Gozlan, H., & Aniksztejn, L. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-23-10372.1999 · Cited by 297 · see citing works
NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A.
Shelby, M. D. (2008) · PubMed · Cited by 262 · see citing works
Immuno-electron microscopical demonstration of vasopressin and oxytocin synapses in the limbic system of the rat
Buijs, R. M., & Swaab, D. F. (1979) · Cell and Tissue Research · doi:10.1007/bf00233648 · Cited by 262 · see citing works
Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids
Leuner, B., Caponiti, J., & Gould, E. (2011) · Hippocampus · doi:10.1002/hipo.20947 · Cited by 237 · see citing works
Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates
Leranth, C., Hajszán, T., Szigeti‐Buck, K., Bober, J., & MacLusky, N. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806139105 · Cited by 232 · see citing works
The glutamate and neutral amino acid transporter family: physiological and pharmacological implications
Kanai, Y., & Hediger, M. A. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.073 · Cited by 218 · see citing works
Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: estrogenicity profiles and uterotropic activity
Diel, P. R., Schulz, T., Smolnikar, K., Strunck, E., Vollmer, G., & Michna, H. (2000) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(00)00051-0 · Cited by 215 · see citing works
Effects of perinatal exposure to bisphenol A on sociosexual behavior of female and male rats.
Farabollini, F., Porrini, S., Seta, D. D., Bianchi-Jassir, F., & Dessì‐Fulgheri, F. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s3409 · Cited by 204 · see citing works
Elucidating the links between endocrine disruptors and neurodevelopment
Schug, T. T., Blawas, A. M., Gray, K., Heindel, J. J., & Lawler, C. P. (2015) · Endocrinology · doi:10.1210/en.2014-1734 · Cited by 204 · see citing works
Bisphenol A: Human exposure and neurobehavior
Mustieles, V., Pérez‐Lobato, R., Olea, N., & Fernández, M. F. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.06.002 · Cited by 203 · see citing works
Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV
Patisaul, H. B., Fortino, A. E., & Polston, E. K. (2006) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2005.11.004 · Cited by 195 · see citing works
Self-citation
Toxicity Evaluation of Bisphenol A Administered by Gavage to Sprague Dawley Rats From Gestation Day 6 Through Postnatal Day 90
Delclos, K. B., Camacho, L., Lewis, S. M., Vanlandingham, M. M., Latendresse, J. R., Olson, G. R., Davis, K. J., Patton, R. E., da Costa, G. G., Woodling, K. A., et al. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu022 · Cited by 172 · see citing works
Oxytocin, But Not Oxytocin Receptor, is Regulated by Oestrogen Receptor β in the Female Mouse Hypothalamus
Patisaul, H. B., Scordalakes, E. M., Young, L. J., & Rissman, E. F. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01061.x · Cited by 160 · see citing works
Self-citation
Prostaglandin D2 mediates neuronal protection via the DP1 receptor
Liang, X., Wu, L., Hand, T. A., & Andreasson, K. I. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02870.x · Cited by 159 · see citing works
Transgenerational effects of prenatal bisphenol A on social recognition
Wolstenholme, J. T., Goldsby, J. A., & Rissman, E. F. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.09.007 · Cited by 157 · see citing works
Risk to all or none?
Beronius, A., Rudén, C., Håkansson, H., & Hanberg, A. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2009.11.007 · Cited by 153 · see citing works
mRNA coding for oxytocin is present in axons of the hypothalamo-neurohypophysial tract.
Jirikowski, G. F., Sanna, P. P., & Bloom, F. E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.19.7400 · Cited by 149 · see citing works
A comparison of RNA-Seq and high-density exon array for detecting differential gene expression between closely related species
Liu, S., Lin, L., Jiang, P., Wang, D., & Xing, Y. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq817 · Cited by 146 · see citing works
Atlas of the developing mouse brain at E 17.5, P0, and P6
Paxinos, G., Halliday, G. M., WATSON, C. R. R., Koutcherov, Y., & Wang, H. (2007) · Elsevier eBooks · Cited by 143 · see citing works
Estradiol and Bisphenol A Stimulate Androgen Receptor and Estrogen Receptor Gene Expression in Fetal Mouse Prostate Mesenchyme Cells
Richter, C. A., Taylor, J. A., Ruhlen, R. L., Welshons, W. V., & vom Saal, F. S. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9804 · Cited by 142 · see citing works
Comparative assessment of methods for the computational inference of transcript isoform abundance from RNA-seq data
Kanitz, A., Gypas, F., Gruber, A. J., Gruber, A. J., Martin, G., & Zavolan, M. (2015) · Genome biology · doi:10.1186/s13059-015-0702-5 · Cited by 141 · see citing works
Prenatal bisphenol A exposure alters sex-specific estrogen receptor expression in the neonatal rat hypothalamus and amygdala
Cao, J., Rebuli, M. E., Rogers, J., Todd, K. L., Leyrer, S. M., Ferguson, S. A., & Patisaul, H. B. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft035 · Cited by 141 · see citing works
Self-citation
Sexually dimorphic expression of hypothalamic estrogen receptors α and β and kiss1 in neonatal male and female rats
Cao, J., & Patisaul, H. B. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22648 · Cited by 127 · see citing works
Self-citation
The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids
Gasnier, B. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1091-2 · Cited by 121 · see citing works
Bisphenol A induces leptin receptor expression, creating more binding sites for leptin, and activates the JAK/Stat, MAPK/ERK and PI3K/Akt signalling pathways in human ovarian cancer cell
Ptak, A., & Gregoraszczuk, E. Ł. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.02.003 · Cited by 118 · see citing works
Estrogen-Induced Memory Enhancements Are Blocked by Acute Bisphenol A in Adult Female Rats: Role of Dendritic Spines
Inagaki, T., Frankfurt, M., & Luine, V. N. (2012) · Endocrinology · doi:10.1210/en.2012-1121 · Cited by 117 · see citing works
Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague–Dawley rats
Doerge, D. R., Twaddle, N. C., Vanlandingham, M. M., Brown, R. P., & Fisher, J. W. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.07.009 · Cited by 113 · see citing works
The Pre- and Postnatal Influence of Hormones and Neurotransmitters on Sexual Differentiation of the Mammalian Hypothalamus
Döhler, K. D. (1991) · International review of cytology · doi:10.1016/s0074-7696(08)62016-1 · Cited by 112 · see citing works
Ontogenetic expression and sex differences of aromatase and estrogen receptor-α/β mRNA in the mouse hippocampus
Ivanova, T., & Beyer, C. (2000) · Cell and Tissue Research · doi:10.1007/s004410000199 · Cited by 111 · see citing works
Anxiogenic effects of developmental bisphenol A exposure are associated with gene expression changes in the juvenile rat amygdala and mitigated by soy
Patisaul, H. B., Sullivan, A. W., Radford, M. E., Walker, D. M., Adewale, H. B., Winnik, B., Coughlin, J. L., Buckley, B., & Gore, A. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043890 · Cited by 106 · see citing works
Self-citation
Assessment of sex specific endocrine disrupting effects in the prenatal and pre-pubertal rodent brain
Rebuli, M. E., & Patisaul, H. B. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.08.021 · Cited by 104 · see citing works
Self-citation
Hippocampal development – Old and new findings
Khalaf‐Nazzal, R., & Francis, F. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.05.061 · Cited by 103 · see citing works
Neonatal bisphenol A exposure alters sexually dimorphic gene expression in the postnatal rat hypothalamus
Cao, J., Mickens, J. A., McCaffrey, K. A., Leyrer, S. M., & Patisaul, H. B. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2011.11.002 · Cited by 102 · see citing works
Self-citation
NIEHS/FDA CLARITY-BPA research program update
Heindel, J. J., Newbold, R. R., Bucher, J. R., Camacho, L., Delclos, K. B., Lewis, S. M., Vanlandingham, M. M., Churchwell, M. I., Twaddle, N. C., McLellen, M., et al. (2015) · Reproductive Toxicology · doi:10.1016/j.reprotox.2015.07.075 · Cited by 99 · see citing works
Consortium-Based Science: The NIEHS’s Multipronged, Collaborative Approach to Assessing the Health Effects of Bisphenol A
Birnbaum, L. S., Bucher, J. R., Collman, G. W., Zeldin, D. C., Johnson, A. F., Schug, T. T., & Heindel, J. J. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1205330 · Cited by 97 · see citing works
Differential disruption of nuclear volume and neuronal phenotype in the preoptic area by neonatal exposure to genistein and bisphenol-A
Patisaul, H. B., Fortino, A. E., & Polston, E. K. (2006) · NeuroToxicology · doi:10.1016/j.neuro.2006.10.001 · Cited by 94 · see citing works
Self-citation
Late postnatal maturation of excitatory synaptic transmission permits adult‐like expression of hippocampal‐dependent behaviors
Dumas, T. C. (2005) · Hippocampus · doi:10.1002/hipo.20077 · Cited by 94 · see citing works
Hippocampal microinfusion of oxytocin attenuates the behavioural response to stress by means of dynamic interplay with the glucocorticoid-catecholamine responses
Cohen, H., Kaplan, Z., Kozlovsky, N., Gidron, Y., Matar, M. A., & Zohar, J. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02003.x · Cited by 94 · see citing works
Neonatal exposure to bisphenol A modifies the abundance of estrogen receptor α transcripts with alternative 5′-untranslated regions in the female rat preoptic area
Monje, L. D., Varayoud, J., Luque, E. H., & Ramos, J. G. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0014 · Cited by 93 · see citing works
A new approach to synergize academic and guideline-compliant research: The CLARITY-BPA research program
Schug, T. T., Heindel, J. J., Camacho, L., Delclos, K. B., Howard, P. C., Johnson, A. F., Aungst, J. L., Keefe, D., Newbold, R. R., Walker, N. J., et al. (2013) · Reproductive Toxicology · doi:10.1016/j.reprotox.2013.05.010 · Cited by 90 · see citing works
Effects of developmental exposure to bisphenol A on spatial navigational learning and memory in rats: A CLARITY-BPA study
Johnson, S. A., Javurek, A. B., Painter, M. S., Ellersieck, M. R., Welsh, T. H., Camacho, L., Lewis, S. M., Vanlandingham, M. M., Ferguson, S. A., & Rosenfeld, C. S. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.09.005 · Cited by 88 · see citing works
The impact of neonatal bisphenol-A exposure on sexually dimorphic hypothalamic nuclei in the female rat
Adewale, H. B., Todd, K. L., Mickens, J. A., & Patisaul, H. B. (2011) · NeuroToxicology · doi:10.1016/j.neuro.2010.07.008 · Cited by 86 · see citing works
Self-citation
Cellular Mechanisms of Estradiol-Mediated Sexual Differentiation of the Brain
Wright, C. L., Schwarz, J., Dean, S., & McCarthy, M. (2010) · Trends in endocrinology and metabolism · doi:10.1016/j.tem.2010.05.004 · Cited by 85 · see citing works
Investigation of the effects of subchronic low dose oral exposure to bisphenol A (BPA) and ethinyl estradiol (EE) on estrogen receptor expression in the juvenile and adult female rat hypothalamus
Rebuli, M. E., Cao, J., Sluzas, E., Delclos, K. B., Camacho, L., Lewis, S. M., Vanlandingham, M. M., & Patisaul, H. B. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu074 · Cited by 83 · see citing works
Self-citation
Neonatal Low- and High-Dose Exposure to Estradiol Benzoate in the Male Rat: I. Effects on the Prostate Gland1
Putz, O., Schwartz, C. B., Kim, S. S., LeBlanc, G. A., Cooper, R. L., & Prins, G. S. (2001) · Biology of Reproduction · doi:10.1095/biolreprod65.5.1496 · Cited by 82 · see citing works
Comparison of Life-Stage-Dependent Internal Dosimetry for Bisphenol A, Ethinyl Estradiol, a Reference Estrogen, and Endogenous Estradiol to Test an Estrogenic Mode of Action in Sprague Dawley Rats
Churchwell, M. I., Camacho, L., Vanlandingham, M. M., Twaddle, N. C., Sepehr, E., Delclos, K. B., Fisher, J. W., & Doerge, D. R. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu021 · Cited by 79 · see citing works
A novel model for neuroendocrine toxicology: neurobehavioral effects of BPA exposure in a prosocial species, the prairie vole (Microtus ochrogaster)
Sullivan, A. W., Beach, E. C., Stetzik, L. A., Perry, A., D'Addezio, A. S., Cushing, B. S., & Patisaul, H. B. (2014) · Endocrinology · doi:10.1210/en.2014-1379 · Cited by 79 · see citing works
Self-citation
Bisphenol-A Impairs Myelination Potential During Development in the Hippocampus of the Rat Brain
Tiwari, S. K., Agarwal, S., Chauhan, L. K. S., Mishra, V. N., & Chaturvedi, R. K. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8817-3 · Cited by 78 · see citing works
Overlapping but distinct effects of genistein and ethinyl estradiol (EE2) in female Sprague–Dawley rats in multigenerational reproductive and chronic toxicity studies
Delclos, K. B., Weis, C. C., Bucci, T. J., Olson, G., Mellick, P., Sadovova, N., Latendresse, J. R., Thorn, B., & Newbold, R. R. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2008.12.005 · Cited by 77 · see citing works
Exposure of neonatal female rats to bisphenol A disrupts hypothalamic LHRH pre-mRNA processing and estrogen receptor alpha expression in nuclei controlling estrous cyclicity
Monje, L. D., Varayoud, J., Muñoz‐de‐Toro, M., Luque, E. H., & Ramos, J. G. (2010) · Reproductive Toxicology · doi:10.1016/j.reprotox.2010.08.004 · Cited by 75 · see citing works
Prenatal exposure to bisphenol A impacts neuronal morphology in the hippocampal CA1 region in developing and aged mice
Kimura, E., Matsuyoshi, C., Miyazaki, W., Benner, S., Hosokawa, M., Yokoyama, K., Kakeyama, M., & Tohyama, C. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1485-x · Cited by 72 · see citing works
Identification of sexually dimorphic genes in the neonatal mouse cortex and hippocampus
Armoskus, C., Moreira, D., Bollinger, K., Jimenez, O., Taniguchi, S., & Tsai, H. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.017 · Cited by 70 · see citing works
Changes in memory and synaptic plasticity induced in male rats after maternal exposure to bisphenol A
Wang, C., Niu, R., Zhu, Y., Han, H., Luo, G., Zhou, B., & Wang, J. (2014) · Toxicology · doi:10.1016/j.tox.2014.05.001 · Cited by 70 · see citing works
Exposure to Low-Dose Bisphenol A Impairs Meiosis in the Rat Seminiferous Tubule Culture Model: A Physiotoxicogenomic Approach
Ali, S., Steinmetz, G., Montillet, G., Perrard, M., Loundou, A., Durand, P., Guichaoua, M.-R., & Prat, O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106245 · Cited by 69 · see citing works
Neonatal Low- and High-Dose Exposure to Estradiol Benzoate in the Male Rat: II. Effects on Male Puberty and the Reproductive Tract
Putz, O., Schwartz, C. B., LeBlanc, G. A., Cooper, R. L., & Prins, G. S. (2001) · Biology of Reproduction · doi:10.1095/biolreprod65.5.1506 · Cited by 67 · see citing works
Statistical Issues in the Analysis of Low-Dose Endocrine Disruptor Data
Haseman, J. K. (2001) · Toxicological Sciences · doi:10.1093/toxsci/61.2.201 · Cited by 65 · see citing works
Bisphenol-A exposure during adolescence leads to enduring alterations in cognition and dendritic spine density in adult male and female rats
Bowman, R. E., Luine, V. N., Weinstein, S. D., Khandaker, H., DeWolf, S., & Frankfurt, M. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.12.007 · Cited by 64 · see citing works
Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study
Rebuli, M. E., Camacho, L., Adonay, M. E., Reif, D. M., Aylor, D. L., & Patisaul, H. B. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv163 · Cited by 64 · see citing works
Self-citation
Sexually Dimorphic Effects of Ancestral Exposure to Vinclozolin on Stress Reactivity in Rats
Gillette, R., Miller-Crews, I., Nilsson, E. E., Skinner, M. K., Gore, A. C., & Crews, D. (2014) · Endocrinology · doi:10.1210/en.2014-1253 · Cited by 62 · see citing works
Sex-specific <i>Esr2</i> mRNA expression in the rat hypothalamus and amygdala is altered by neonatal bisphenol A exposure
Cao, J., Joyner, L., Mickens, J. A., Leyrer, S. M., & Patisaul, H. B. (2014) · Reproduction · doi:10.1530/rep-13-0501 · Cited by 61 · see citing works
Self-citation
Sex differences in the location of immunochemically defined cell populations in the mouse preoptic area/anterior hypothalamus
Wolfe, C. A., Doren, M. V., Walker, H. J., Seney, M. L., McClellan, K., & Tobet, S. A. (2005) · Developmental Brain Research · doi:10.1016/j.devbrainres.2005.03.001 · Cited by 54 · see citing works
Influence of season on estrous and luteinizing hormone responses to estradiol benzoate in ovariectomized sows
Cox, N. M., Ramirez, J. L., Matamoros, I. A., Bennett, W. A., & Britt, J. H. (1987) · Theriogenology · doi:10.1016/0093-691x(87)90228-7 · Cited by 52 · see citing works
Risk Evaluation of Endocrine-Disrupting Chemicals: Effects of Developmental Exposure to Low Doses of Bisphenol A on Behavior and Physiology in Mice ( <i>Mus musculus</i> )
Gioiosa, L., Palanza, P., Parmigiani, S., & vom Saal, F. S. (2015) · Dose-Response · doi:10.1177/1559325815610760 · Cited by 41 · see citing works
Effects of perinatal bisphenol A exposure during early development on radial arm maze behavior in adult male and female rats
Sadowski, R. N., Park, P., Neese, S. L., Ferguson, D. C., Schantz, S. L., & Juraska, J. M. (2014) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2014.01.002 · Cited by 36 · see citing works
Early Neuroendocrine Disruption in Hypothalamus and Hippocampus: Developmental Effects Including Female Sexual Maturation and Implications for Endocrine Disrupting Chemical Screening
Bourguignon, J.-P., Franssen, D., Gérard, A., Janssen, S., Pinson, A., Naveau, E., & Parent, A. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12107 · Cited by 36 · see citing works
The organizational effects of oxytocin on the central expression of estrogen receptor α and oxytocin in adulthood
Kramer, K. M., Yoshida, S., Papademetriou, E., & Cushing, B. S. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-71 · Cited by 36 · see citing works
Alterations of neurotransmitter norepinephrine and gamma-aminobutyric acid correlate with murine behavioral perturbations related to bisphenol A exposure
Ogi, H., Itoh, K., Ikegaya, H., & Fushiki, S. (2015) · Brain and Development · doi:10.1016/j.braindev.2014.12.008 · Cited by 35 · see citing works
Probable gamma-aminobutyric acid involvement in bisphenol A effect at the hypothalamic level in adult male rats
Cardoso, N., Pandolfi, M., Lavalle, J., Carbone, S., Ponzo, O., Scacchi, P. A., & Reynoso, R. (2011) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-011-0102-6 · Cited by 22 · see citing works
Postnatal development of the rat striatum – a study using in situ DNA end labeling technique
Maciejewska, B., Lipowska, M., Kowiański, P., Domaradzka-Pytel, B., & Moryś, J. (1998) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-1998-1255 · Cited by 20 · see citing works
Microarray Analysis of Perinatal-Estrogen-Induced Changes in Gene Expression Related to Brain Sexual Differentiation in Mice
SAKAKIBARA, M., Uenoyama, Y., Minabe, S., Watanabe, Y., Deura, C., Nakamura, S., Suzuki, G., Maeda, K., & Tsukamura, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079437 · Cited by 19 · see citing works
Quantitative mechanistically based dose-response modeling with endocrine-active compounds.
Andersen, M. E., Conolly, R. B., Faustman, E. M., Kavlock, R. J., Portier, C. J., Sheehan, D. M., Wier, P. J., & Ziese, L. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107s4631 · Cited by 19 · see citing works
Quantitative Mechanistically Based Dose-Response Modeling with Endocrine-Active Compounds
Andersen, M. E., Conolly, R. B., Faustman, E. M., Kavlock, R. J., Portier, C. J., Sheehan, D. M., Wier, P. J., & Ziese, L. (1999) · Environmental Health Perspectives · doi:10.2307/3434556 · Cited by 4 · see citing works

Flagged first, then by citations

1 of the 109 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

EFSA. Panel on food contact materials, enzymes, flavourings and processing acids (CEF). EFSA J. 2015;13:3978.
McCarthy MM, Auger AP, Bale TL, et al. The epigenetics of sex differences in the brain. J Neurosci. 2009;29:12815-12823.

Sorted by citations

Re‐evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs
EFSA Panel on Food Contact Materials, E. A. P. A. (., Lambré, C., Baviera, J. M. B., Bolognesi, C., Chesson, A., Cocconcelli, P. S., Crebelli, R., Gott, D. M., Grob, K., Lampi, E., et al. (2023) · EFSA Journal · doi:10.2903/j.efsa.2023.6857 · Cited by 431 · see citing works
Neuro-toxic and Reproductive Effects of BPA
Santoro, A., Chianese, R., Troisi, J., Richards, S. M., Nori, S. L., Fasano, S., Guida, M., Plunk, E. C., Viggiano, A., Pierantoni, R., et al. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190726112101 · Cited by 281 · see citing works
Endocrine disruptors and the future of toxicology testing — lessons from CLARITY–BPA
Vandenberg, L. N., Hunt, P. A., & Gore, A. C. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0173-y · Cited by 171 · see citing works
Endocrine-disrupting chemicals: Effects on neuroendocrine systems and the neurobiology of social behavior
Gore, A. C., Krishnan, K., & Reilly, M. P. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.11.006 · Cited by 152 · see citing works
CLARITY‐BPA academic laboratory studies identify consistent low‐dose Bisphenol A effects on multiple organ systems
Prins, G. S., Patisaul, H. B., Belcher, S. M., & Vandenberg, L. N. (2018) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13125 · Cited by 107 · see citing works
Self-citation
Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases
Preciados, M., Yoo, C., & Roy, D. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122086 · Cited by 105 · see citing works
Early life bisphenol A exposure and neurobehavior at 8 years of age: Identifying windows of heightened vulnerability
Stacy, S. L., Papandonatos, G. D., Calafat, A. M., Chen, A., Yolton, K. A., Lanphear, B. P., & Braun, J. M. (2017) · Environment International · doi:10.1016/j.envint.2017.07.021 · Cited by 100 · see citing works
Transgenerational Effects of Bisphenol A on Gene Expression and DNA Methylation of Imprinted Genes in Brain
Drobná, Z., Henriksen, A. D. P., Wolstenholme, J. T., Montiel, C., Lambeth, P. S., Shang, S., Harris, E. P., Zhou, C., Flaws, J. A., Adli, M., et al. (2017) · Endocrinology · doi:10.1210/en.2017-00730 · Cited by 97 · see citing works
Bisphenol A Exposure, Ovarian Follicle Numbers, and Female Sex Steroid Hormone Levels: Results From a CLARITY-BPA Study
Patel, S. A., Brehm, E., Gao, L., Rattan, S., Ziv‐Gal, A., & Flaws, J. A. (2017) · Endocrinology · doi:10.1210/en.2016-1887 · Cited by 94 · see citing works
Multi- and Transgenerational Outcomes of an Exposure to a Mixture of Endocrine-Disrupting Chemicals (EDCs) on Puberty and Maternal Behavior in the Female Rat
Rodríguez, D. L., Aylwin, C. F., Delli, V., Sevrin, E., Campanile, M., Martin, M. J., Franssen, D., Gérard, A., Blacher, S., Tirelli, E., et al. (2021) · Environmental Health Perspectives · doi:10.1289/ehp8795 · Cited by 90 · see citing works
Bisphenol A and Phthalates: How Environmental Chemicals Are Reshaping Toxicology
Warner, G. R., & Flaws, J. A. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy232 · Cited by 88 · see citing works
Genotoxic, cytotoxic, and cytopathological effects in rats exposed for 18 months to a mixture of 13 chemicals in doses below NOAEL levels
Tsatsakis, A. M., Docea, A. O., Constantin, C., Călina, D. C., Zlatian, O. M., Νikolouzakis, Τ. Κ., Stivaktakis, P. D., Kalogeraki, A. M., Liesivuori, J., Tzanakakis, G. N., et al. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.09.004 · Cited by 84 · see citing works
Evaluation of Bisphenol A (BPA) Exposures on Prostate Stem Cell Homeostasis and Prostate Cancer Risk in the NCTR-Sprague-Dawley Rat: An NIEHS/FDA CLARITY-BPA Consortium Study
Prins, G. S., Hu, W., Xie, L., Shi, G., Hu, D.-P., Birch, L. A., & Bosland, M. C. (2018) · Environmental Health Perspectives · doi:10.1289/ehp3953 · Cited by 78 · see citing works
Sex Differences in the Effects of Prenatal Bisphenol A Exposure on Genes Associated with Autism Spectrum Disorder in the Hippocampus
Thongkorn, S., Kanlayaprasit, S., Jindatip, D., Tencomnao, T., Hu, V. W., & Sarachana, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-39386-w · Cited by 66 · see citing works
Prenatal bisphenol A (BPA) exposure alters the transcriptome of the neonate rat amygdala in a sex-specific manner: a CLARITY-BPA consortium study
Arambula, S. E., Jima, D. D., & Patisaul, H. B. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.10.005 · Cited by 69 · see citing works
Self-citation
Achieving <scp>CLARITY</scp> on bisphenol A, brain and behaviour
Patisaul, H. B. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12730 · Cited by 76 · see citing works
Self-citation
Gestational low-dose BPA exposure impacts suprachiasmatic nucleus neurogenesis and circadian activity with transgenerational effects
Nesan, D., Feighan, K. M., Antle, M. C., & Kurrasch, D. M. (2021) · Science Advances · doi:10.1126/sciadv.abd1159 · Cited by 66 · see citing works
Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions
Thongkorn, S., Kanlayaprasit, S., Panjabud, P., Saeliw, T., Jantheang, T., Kasitipradit, K., Sarobol, S., Jindatip, D., Hu, V. W., Tencomnao, T., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-80390-2 · Cited by 64 · see citing works
A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
Camacho, L., Lewis, S. M., Vanlandingham, M. M., Olson, G. R., Davis, K. J., Patton, R. E., Twaddle, N. C., Doerge, D. R., Churchwell, M. I., Bryant, M., et al. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110728 · Cited by 64 · see citing works
The parental brain and behavior: A target for endocrine disruption
Keller, M., Vandenberg, L. N., & Charlier, T. D. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100765 · Cited by 62 · see citing works
Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction
Xin, F., Fischer, E., Krapp, C. J., Krizman, E. N., Lan, Y., Mesaros, C., Snyder, N. W., Bansal, A., Robinson, M. B., Simmons, R. A., et al. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.05.010 · Cited by 61 · see citing works
Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies
Heindel, J. J., Belcher, S. M., Flaws, J. A., Prins, G. S., Ho, S., Mao, J., Patisaul, H. B., Ricke, W. A., Rosenfeld, C. S., Soto, A. M., et al. (2020) · Reproductive Toxicology · doi:10.1016/j.reprotox.2020.05.014 · Cited by 61 · see citing works
Self-citation
Gene expression and DNA methylation changes in the hypothalamus and hippocampus of adult rats developmentally exposed to bisphenol A or ethinyl estradiol: a CLARITY-BPA consortium study
Cheong, A. W. Y., Johnson, S. A., Howald, E. C., Ellersieck, M. R., Camacho, L., Lewis, S. M., Vanlandingham, M. M., Ying, J., Ho, S., & Rosenfeld, C. S. (2018) · Epigenetics · doi:10.1080/15592294.2018.1497388 · Cited by 60 · see citing works
In utero exposure to endocrine disruptors and developmental neurotoxicity: Implications for behavioural and neurological disorders in adult life
Arul, G. L. R., Subhashree, K. D., & Kantayya, K. E. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111829 · Cited by 57 · see citing works
EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain
Rock, K. D., Horman, B. M., Phillips, A. L., McRitchie, S., Watson, S. L., Deese-Spruill, J., Jima, D. D., Sumner, S., Stapleton, H. M., & Patisaul, H. B. (2018) · Endocrine Connections · doi:10.1530/ec-17-0373 · Cited by 56 · see citing works
Self-citation
Environmentally Relevant Perinatal Exposures to Bisphenol A Disrupt Postnatal Kiss1/NKB Neuronal Maturation and Puberty Onset in Female Mice
Ruíz-Pino, F., Miceli, D., Franssen, D., Vazquez, M. J., Farinetti, A., Castellano, J. M., Panzica, G., & Tena‐Sempere, M. (2019) · Environmental Health Perspectives · doi:10.1289/ehp5570 · Cited by 56 · see citing works
Endocrine Disruption of Vasopressin Systems and Related Behaviors
Patisaul, H. B. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00134 · Cited by 54 · see citing works
Self-citation
Sexual Behavior: From Hormonal Regulation to Endocrine Disruption
Mhaouty‐Kodja, S., Naulé, L., & Capela, D. (2018) · Neuroendocrinology · doi:10.1159/000494558 · Cited by 49 · see citing works
Early developmental exposure to bisphenol A and bisphenol S disrupts socio-cognitive function, isotocin equilibrium, and excitation-inhibition balance in developing zebrafish
Naderi, M., Puar, P., JavadiEsfahani, R., & Kwong, R. W. M. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.11.009 · Cited by 47 · see citing works
Prenatal Bisphenol A Exposure in Mice Induces Multitissue Multiomics Disruptions Linking to Cardiometabolic Disorders
Shu, L., Meng, Q., Tsai, B., Diamante, G., Chen, Y.-W., Mikhail, A., Luk, H., Ritz, B. R., Allard, P., & Yang, X. (2018) · Endocrinology · doi:10.1210/en.2018-00817 · Cited by 45 · see citing works
Effects of perinatal bisphenol A exposure on the volume of sexually-dimorphic nuclei of juvenile rats: A CLARITY-BPA consortium study
Arambula, S. E., Fuchs, J., Cao, J., & Patisaul, H. B. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.09.002 · Cited by 41 · see citing works
Self-citation
Genome-Wide SNP Discovery in Indigenous Cattle Breeds of South Africa
Zwane, A. A., Schnabel, R. D., Hoff, J. L., Choudhury, A., Makgahlela, M. L., Maiwashe, A., van Marle-Köster, E., & Taylor, J. F. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00273 · Cited by 41 · see citing works
Perinatal bisphenol A (BPA) exposure alters brain oxytocin receptor (OTR) expression in a sex- and region- specific manner: A CLARITY-BPA consortium follow-up study
Witchey, S. K., Fuchs, J., & Patisaul, H. B. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.06.007 · Cited by 40 · see citing works
Self-citation
Autism-Related Transcription Factors Underlying the Sex-Specific Effects of Prenatal Bisphenol A Exposure on Transcriptome-Interactome Profiles in the Offspring Prefrontal Cortex
Kanlayaprasit, S., Thongkorn, S., Panjabud, P., Jindatip, D., Hu, V. W., Kikkawa, T., Osumi, N., & Sarachana, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413201 · Cited by 41 · see citing works
Long term transcriptional and behavioral effects in mice developmentally exposed to a mixture of endocrine disruptors associated with delayed human neurodevelopment
Repouskou, A., Papadopoulou, A.-K., Panagiotidou, E., Trichas, P., Lindh, C. H., Bergman, Å., Gennings, C., Bornehag, C., Rüegg, J., Kitraki, E., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-66379-x · Cited by 41 · see citing works
Exposure to bisphenol A differentially impacts neurodevelopment and behavior in Drosophila melanogaster from distinct genetic backgrounds
Nguyen, U. T.-H., Tinsley, B., Sen, Y., Stein, J., Palacios, Y., Ceballos, A., Welch, C. J., Nzenkue, K., Penn, A., Murphy, L., et al. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2020.12.007 · Cited by 40 · see citing works
Persistent vs transient alteration of folliculogenesis and estrous cycle after neonatal vs adult exposure to Bisphenol A
Rodríguez, D. L., Franssen, D., Sevrin, E., Gérard, A., Balsat, C., Blacher, S., Noël, A., & Parent, A. (2019) · Endocrinology · doi:10.1210/en.2019-00505 · Cited by 39 · see citing works
Low-dose developmental exposure to bisphenol A induces sex-specific effects in bone of Fischer 344 rat offspring
Lind, T., Lejonklou, M. H., Dunder, L., Rasmusson, A. J., Larsson, S., Melhus, H., & Lind, P. (2017) · Environmental Research · doi:10.1016/j.envres.2017.07.020 · Cited by 37 · see citing works
Bisphenol A Exposure in utero Disrupts Hypothalamic Gene Expression Particularly Genes Suspected in Autism Spectrum Disorders and Neuron and Hormone Signaling
Henriksen, A. D. P., Andrade, A., Harris, E. P., Rissman, E. F., & Wolstenholme, J. T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093129 · Cited by 37 · see citing works
Bisphenol A and cognitive function in school-age boys: Is BPA predominantly related to behavior?
Rodríguez‐Carrillo, A., Mustieles, V., Pérez‐Lobato, R., Molina-Molina, J.-M., Reina-Pérez, I., Vela-Soria, F., Rubio, S., Olea, N., & Fernández, M. F. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.06.006 · Cited by 35 · see citing works
Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus
Thongkorn, S., Kanlayaprasit, S., Kasitipradit, K., Lertpeerapan, P., Panjabud, P., Hu, V. W., Jindatip, D., & Sarachana, T. (2023) · Biology of Sex Differences · doi:10.1186/s13293-023-00496-w · Cited by 33 · see citing works
Maternal environmental exposure to bisphenols and epigenome-wide DNA methylation in infant cord blood
McCabe, C. F., Padmanabhan, V., Dolinoy, D. C., Domino, S. E., Jones, T. R., Bakulski, K. M., & Goodrich, J. M. (2020) · Current Zoology · doi:10.1093/eep/dvaa021 · Cited by 34 · see citing works
Flaws in design, execution and interpretation limit CLARITY‐BPA’s value for risk assessments of bisphenol A
Saal, F. S. V. (2018) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13195 · Cited by 33 · see citing works
The expression of select genes necessary for membrane-associated estrogen receptor signaling differ by sex in adult rat hippocampus
Meitzen, J., Britson, K. A., Tuomela, K. E., & Mermelstein, P. G. (2017) · Steroids · doi:10.1016/j.steroids.2017.09.012 · Cited by 30 · see citing works
Hypothalamic transcriptomic alterations in male and female California mice (Peromyscus californicus) developmentally exposed to bisphenol A or ethinyl estradiol
Johnson, S. A., Spollen, W. G., Manshack, L. K., Bivens, N. J., Givan, S. A., & Rosenfeld, C. S. (2017) · Physiological Reports · doi:10.14814/phy2.13133 · Cited by 29 · see citing works
The Use and Misuse of Historical Controls in Regulatory Toxicology: Lessons from the CLARITY-BPA Study
Vandenberg, L. N., Prins, G. S., Patisaul, H. B., & Zoeller, R. T. (2019) · Endocrinology · doi:10.1210/endocr/bqz014 · Cited by 28 · see citing works
Self-citation
Early-life bisphenol AP exposure impacted neurobehaviors in adulthood through microglial activation in mice
Wu, X., Li, S., Zhang, M., Bai, S., Ni, Y., Xu, Q., Fan, Y., Lu, C., Xu, Z., Ji, C., et al. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.137935 · Cited by 25 · see citing works
Impacts of Gestational FireMaster 550 Exposure on the Neonatal Cortex Are Sex Specific and Largely Attributable to the Organophosphate Esters
Witchey, S. K., Doyle, M. G., Fredenburg, J. D., Armour, G. S., Horman, B. M., Odenkirk, M. T., Aylor, D. L., Baker, E. S., & Patisaul, H. B. (2022) · Neuroendocrinology · doi:10.1159/000526959 · Cited by 24 · see citing works
Self-citation
Low Dose Effects and Nonmonotonic Dose Responses for Endocrine Disruptors
Vandenberg, L. N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821985-0.00006-2 · Cited by 21 · see citing works
Biotechnology-based microbial degradation of plastic additives
Lumio, R. T., Tan, M. A., & Magpantay, H. D. (2021) · 3 Biotech · doi:10.1007/s13205-021-02884-8 · Cited by 21 · see citing works
Estrogenic and anti-estrogenic assessment of the flame retardant, 2-ethylhexyl diphenyl phosphate (EHDPP), and its metabolites: Evidence from in vitro, in silico, and transcriptome studies
Tachachartvanich, P., Sangsuwan, R., Duangta, S., Navasumrit, P., Ruchirawat, S., & Ruchirawat, M. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.137303 · Cited by 14 · see citing works
Combining Micropunch Histology and Multidimensional Lipidomic Measurements for In-Depth Tissue Mapping
Odenkirk, M. T., Horman, B. M., Dodds, J. N., Patisaul, H. B., & Baker, E. S. (2021) · ACS Measurement Science Au · doi:10.1021/acsmeasuresciau.1c00035 · Cited by 12 · see citing works
Self-citation
Evaluating endocrine disrupting chemicals: A perspective on the novel assessments in CLARITY‐BPA
Howdeshell, K. L., Beverly, B., Blain, R. B., Goldstone, A. E., Hartman, P. A., Lemeris, C., Newbold, R. R., Rooney, A. A., & Bucher, J. R. (2023) · Birth Defects Research · doi:10.1002/bdr2.2238 · Cited by 12 · see citing works
Endocrine Disrupting Chemicals and Behavior
Arambula, S. E., & Patisaul, H. B. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65191-7 · Cited by 12 · see citing works
Self-citation
Hypothalamic gene expression changes in F1 California mice (Peromyscus californicus) parents developmentally exposed to bisphenol A or ethinyl estradiol
Johnson, S. A., Ellersieck, M. R., & Rosenfeld, C. S. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e00672 · Cited by 11 · see citing works
Prepubertal exposure to high dose of cadmium induces hypothalamic injury through transcriptome profiling alteration and neuronal degeneration in female rats
Saedi, S., Shirazi, M. R. J., Niazi‎, A., Tahmasebi, A., & Ebrahimie, E. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109379 · Cited by 11 · see citing works
Machine learning reveals common transcriptomic signatures across rat brain and placenta following developmental organophosphate ester exposure
Newell, A. J., Jima, D. D., Reading, B. J., & Patisaul, H. B. (2023) · Toxicological Sciences · doi:10.1093/toxsci/kfad062 · Cited by 10 · see citing works
Self-citation
Impact of a bisphenol A, F, and S mixture and maternal care on the brain transcriptome of rat dams and pups
Lapp, H. E., Margolis, A. E., & Champagne, F. A. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.08.014 · Cited by 10 · see citing works
Thymoquinone inhibits Neuroinflammatory mediators and vasoconstriction injury via NF-κB dependent NeuN/GFAP/Ki-67 in hypertensive Dams and F1 male pups on exposure to a mixture of Bisphenol-A analogues
Okoh, O. S., Akintunde, J. K., Akamo, A. J., & Akpan, U. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.117162 · Cited by 8 · see citing works
Effects of environmental toxicant exposures on oxytocin and vasopressin systems in the developing brain: factors imparting risk and resilience
Martin, E. M., Xue, J., & Smith, C. J. W. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115723 · Cited by 7 · see citing works
EDCs: Focus on reproductive alterations in mammalian and nonmammalian models
Maradonna, F., & Meccariello, R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824464-7.00003-9 · Cited by 7 · see citing works
Maternal exposure to low-dose bisphenol A and its potential neurotoxic impact on male pups: A histological, immunohistochemical, and ultrastructural study
Morsy, M. M., Ahmad, M. M., & Hassan, N. H. (2024) · Tissue and Cell · doi:10.1016/j.tice.2024.102503 · Cited by 6 · see citing works
Is Bisphenol A (BPA) a Threat to Children's Behavior?
de Granada, M. (2018) · JOURNAL OF MENTAL HEALTH AND CLINICAL PSYCHOLOGY · doi:10.29245/2578-2959/2018/1.1115 · Cited by 6 · see citing works
Chemical Contributions to Neurodevelopmental Disorders
Patisaul, H. (2017) · Policy Insights from the Behavioral and Brain Sciences · doi:10.1177/2372732217719909 · Cited by 4 · see citing works
Self-citation
Distinct epigenetic modulation of differentially expressed genes in the adult mouse brain following prenatal exposure to low-dose bisphenol A
Weng, J., Zhu, Y.-Y., Liao, L., Yang, X.-T., Dong, Y., Meng, W., Sun, D., Liu, Y., Peng, W.-Z., & Jiang, Y. P. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09875-4 · Cited by 5 · see citing works
Evaluation of p21 expression and related autism‐like behavior in Bisphenol‐A exposed offspring of Wistar albino rats
Singha, S. P., Memon, S., Bano, U., Isaac, A. D., & Shahani, M. Y. (2022) · Birth Defects Research · doi:10.1002/bdr2.2022 · Cited by 9 · see citing works
Behavioral Outcome as a Primary Organizing Principle for Mechanistic Data in Developmental Neurotoxicity
Sobin, C. A., & Golub, M. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809405-1.00029-8 · Cited by 3 · see citing works
A potential role for dendritic spines in bisphenol-A induced memory impairments during adolescence and adulthood
Frankfurt, M., Luine, V. N., & Bowman, R. E. (2020) · Vitamins and hormones · doi:10.1016/bs.vh.2020.04.004 · Cited by 3 · see citing works
Sex-specific Actions of Endocrine Disruptors
Larebeke, N. V., & Fučić, A. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160738-00121 · Cited by 2 · see citing works
RETRACTED: Sexual orientation, neuropsychiatric disorders and the neurotransmitters involved
Li, H., Fernández‐Guasti, A., Xu, Y., & Swaab, D. F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.048 · Cited by 2 · see citing works
Retracted
Prenatal bisphenol A exposure perturbs sex-dependent transcriptomic regionalization of autism-associated genes in the developing brain
Sukjamnong, S., Saeliw, T., Panjabud, P., Thongkorn, S., Kanlayaprasit, S., Lertpeerapan, P., Hu, V. W., & Sarachana, T. (2026) · Biology Direct · doi:10.1186/s13062-026-00803-6 · Cited by 1 · see citing works
Environmental and Physiological Cues on the Hypothalamus During Aging
Nehlin, J. O. (2017) · Healthy ageing and longevity · doi:10.1007/978-3-319-63001-4_9 · Cited by 1 · see citing works
Multi- and transgenerational outcomes of an exposure to a mixture of endocrine-disrupting chemicals (EDCs) on puberty and maternal behavior in the female rat
Lopez-Rodriguez, D., Aylwin, C. F., Delli, V., Sevrin, E., Campanile, M., Martin, M., Franssen, D., Gerard, A., Blacher, S., Tirelli, E., et al. (2022) · Yearbook of pediatric endocrinology · doi:10.1530/ey.19.7.13 · Cited by 1 · see citing works
The Effects of Bisphenol A on Various Human Systems
Huang, Y. (2023) · Highlights in Science Engineering and Technology · doi:10.54097/hset.v65i.11261 · Cited by 1 · see citing works
Historical Perspective of Bisphenol A and Phthalates in the Environment and Their Health Effects
Bhat, R. A., Kumar, D., Bhat, S. M., & Sofi, I. R. (2019) · Advances in environmental engineering and green technologies book series · doi:10.4018/978-1-5225-9452-9.ch013 · Cited by 1 · see citing works
New EU criteria for endocrine disrupters
(2018) · TemaNord · doi:10.6027/tn2018-537 · Cited by 1 · see citing works
Estrogens and female developing brain: two sides of the coin
Резніков, А. Г. (2021) · Reproductive Endocrinology · doi:10.18370/2309-4117.2021.59.8-12
Analysis of the Toxic Effects of Bisphenol A on the Groups of Vertebrate Animals: a Comprehensive Review of Research 2015-2021
Ahn, Y. M., Kim, D.-H., & Cho, S. N. (2021) · JOURNAL OF ENVIRONMENTAL ANALYSIS, HEALTH AND TOXICOLOGY · doi:10.36278/jeaht.24.3.107
Transcriptional Profiling of Neurological Development of Drosophila Following Bisphenol A Exposure
Johnson, E. (2021) · doi:10.31979/etd.g2xp-ucc9
The Effects of Bisphenol A Exposure and Calbindin Knockout on Behavior, Gene Expression, and Sexual Differentiation of the Brain
Harris, E. (2017) · doi:10.18130/v3h79s
Metabolism disrupting chemicals in the development of human diseases
Spyropoulos, D. D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824464-7.00006-4
การศกษาผลของการทแมไดรบบสฟนอลเอตอทรานสครปโตมและอนเทอรแอกโตมของยนทเกยวของกบโรคออทซมสเปกตรมในเซลลระบบประสาทของลกหน
ทองกร, ส. (2017) · doi:10.58837/chula.the.2017.826
Distinct Epigenetic Modulation of Differentially Expressed Genes in the Adult Brain Following Prenatal Exposure to Low-Dose Bisphenol APreprint
Weng, J., Zhu, Y.-Y., Liao, L., Yang, X.-T., Dong, Y., Meng, W., Sun, D., Liu, Y., Peng, W.-Z., & Jiang, Y. P. (2023) · Research Square · doi:10.21203/rs.3.rs-3692941/v1
Prenatal exposure to Bisphenol A sex-specifically disrupts prepulse inhibition and decreases parvalbumin-positive neurons in the prefrontal cortex of adult rats
Ghanbarzehi, A., Mehrabi, S., Piryaei, A., Azedi, F., Mohammadi, A., & Shahbazi, A. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.114933
Effects of bisphenol-a on vasopressin regulating synaptic plasticity of hippocampus
Xu, X., Wang, J., & Yang, Y. (2025) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2025.107531
Perinatal Exposure to Organophosphate Flame Retardants Induces Sex- and Hormone-Dependent Alterations in Anxiety, Memory, Neurotransmitter Content, and Hippocampal Gene ExpressionPreprint
Wiersielis, K., Moran, K. M., Mukadam, R., Early, J., Appel, V., Rojas, C. M., Yasrebi, A., DeGroat, T., Knox, N., & Roepke, T. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.21.700648
Firemaster 550 differentially alters gene expression underlying synaptic function in amygdala of prairie voles after gestational or lactational exposure
Newell, A. J., Massri, A. J., Gillera, S. E. A., Berger, J. M., Panduri, V., Liu, L., Gerrish, K., & Patisaul, H. B. (2026) · NeuroToxicology · doi:10.1016/j.neuro.2026.103546
Self-citation

Prenatal bisphenol A exposure alters sex-specific estrogen receptor expression in the neonatal rat hypothalamus and amygdala
Cao, J., Rebuli, M. E., Rogers, J., Todd, K. L., Leyrer, S. M., Ferguson, S. A., & Patisaul, H. B. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft035 · Cited by 141 · see citing works
Self-citation
Prenatal Bisphenol A (BPA) Exposure Alters Sex Specific Estrogen Receptor Expression in the Neonatal Rat Hypothalamus and Amygdala
Words, K., Toxicology, D., Sciences, T., & Patisaul, H. B. (2013)
Self-citation
Prenatal bisphenol A (BPA) exposure alters the transcriptome of the neonate rat amygdala in a sex-specific manner: a CLARITY-BPA consortium study
Arambula, S. E., Jima, D. D., & Patisaul, H. B. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.10.005 · Cited by 69 · see citing works
Self-citation
Neonatal bisphenol A exposure alters sexually dimorphic gene expression in the postnatal rat hypothalamus
Cao, J., Mickens, J. A., McCaffrey, K. A., Leyrer, S. M., & Patisaul, H. B. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2011.11.002 · Cited by 102 · see citing works
Self-citation
Investigation of the effects of subchronic low dose oral exposure to bisphenol A (BPA) and ethinyl estradiol (EE) on estrogen receptor expression in the juvenile and adult female rat hypothalamus
Rebuli, M. E., Cao, J., Sluzas, E., Delclos, K. B., Camacho, L., Lewis, S. M., Vanlandingham, M. M., & Patisaul, H. B. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu074 · Cited by 83 · see citing works
Self-citation

Authors: Arambula, S. E., Belcher, S. M., Planchart, A., Turner, S. D., & Patisaul, H. B.
Affiliations: North Carolina State University (US)
University of Virginia (US)
Corresponding author: Patisaul, Heather B.
ORCID: Arambula, Sheryl E.
Belcher, Scott M.
Planchart, Antonio
Turner, Stephen D.
Patisaul, Heather B.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2016-08-29
Volume: 157
Issue: 10
Pages: 3856-3872
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2016-1339
PMC: PMC5045502
OpenAlex: W2516280552
Cited by: 87
References: 109
Citations by year: 2026: 3 · 2025: 4 · 2024: 3 · 2023: 9 · 2022: 4 · 2021: 14 · 2020: 7 · 2019: 14 · 2018: 15 · 2017: 13 · 2016: 1
FWCI: 9.01
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Endocrinology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: North Carolina State University
Directorate for Biological Sciences
National Institute of Environmental Health Sciences (U01ES020929, U011ES020929, AES12013, P30ES025128)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords: bisphenol A, endocrine disruptors, prenatal exposure, neonatal brain development, hypothalamus, hippocampus, transcriptome, estrogen receptor, sex differences, oxytocin, ethinyl estradiol, low-dose exposure, gene expression, developmental neurotoxicity, Sprague-Dawley rats, microdissection, RNA sequencing
MeSH terms: Bisphenol A Compounds, Administration, Oral, Animals, Animals, Newborn, Benzhydryl Compounds, Estrogens, Non-Steroidal, Female, Hippocampus, Hypothalamus, Male, Phenols, Random Allocation, Sex Characteristics, Gene Expression, Rats, Sprague-Dawley, Rats, Transcriptome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Impact of low dose oral exposure to bisphenol A (BPA) on the neonatal rat hypothalamic and hippocampal transcriptome: a clarity-BPA consortium study

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks