Amitriptyline induces coenzyme Q deficiency and oxidative damage in mouse lung and liver

Triggering and modulation of apoptosis by oxidative stress

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Mitochondria and reactive oxygen species

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Metabolism and function of coenzyme Q

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The antioxidant role of coenzyme Q

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Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

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The in-depth evaluation of suspected mitochondrial disease

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Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells

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Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver

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Redox and oxidant-mediated regulation of apoptosis signaling pathways: immuno-pharmaco-redox conception of oxidative siege versus cell death commitment

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Clinical, psychiatric and manometric profile of cyclic vomiting syndrome in adults and response to tricyclic therapy¹

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Antidepressant drugs as adjuvant analgesics

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THE MANAGEMENT OF TREATMENT-RESISTANT DEPRESSION IN DISORDERS ON THE INTERFACE OF PSYCHIATRY AND MEDICINE

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Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study

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Therapeutic Efficacy and Safety of Amitriptyline in Patients with Cystic Fibrosis

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Differential induction of NF‐κB activity and neural cell death by antidepressants in vitro

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Neuronal cell death induced by antidepressants: lack of correlation with Egr-1, NF-κB and extracellular signal-regulated protein kinase activation

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Coenzyme Q-pool function in glycerol-3-phosphate oxidation in hamster brown adipose tissue mitochondria

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In vitro studies of the phototoxic potential of the antidepressant drugs amitriptyline and imipramine

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Acute oxidant damage promoted on cancer cells by amitriptyline in comparison with some common chemotherapeutic drugs

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Antioxidant defense against antidepressants in C6 and 1321N1 cells

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The Neurotoxic Effects of Amitriptyline Are Mediated by Apoptosis and are Effectively Blocked by Inhibition of Caspase Activity

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Coenzyme Q10 and alpha-tocopherol protect against amitriptyline toxicity

Cordero, M. D., Moreno‐Fernández, A. M., Gómez-Skármeta, J. L., de Miguel, M., Garrido‐Maraver, J., Oropesa-Ávila, M., Hernández, M., Navas, P., & Sánchez-Alcázar, J. A. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.12.026 · Cited by 39 · see citing works

Antidepressants upregulate messenger RNA levels of the neuroprotective enzyme superoxide dismutase (SOD1).

Li, X.-M., Chlan‐Fourney, J., Juorio, A. V., Bennett, V. L., Shrikhande, S., & Bowen, R. (2000) · PubMed Central · Cited by 38 · see citing works

A proposed mechanism for amitriptyline neurotoxicity based on its detergent nature

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Cytotoxic effects of amitriptyline in human fibroblasts

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Induction of apoptosis in proliferating lymphocytes by tricyclic antidepressants

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Efficacy of Nebivolol and Amitriptyline in the Prophylaxis of Cyclic Vomiting Syndrome

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Amitriptyline affects histamine-N-methyltransferase and diamine oxidase activity in rats and guinea pigs

Rajtar, S., & Irman-Florjanc, T. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.07.025 · Cited by 4 · see citing works

Antidepressants- and antipsychotics-induced hepatotoxicity

Todorović, N., Đorđević, J., Pejić, S., Đorđević, N. O., & Pajović, S. B. (2021) · Archives of Toxicology · doi:10.1007/s00204-020-02963-4 · Cited by 119 · see citing works

Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches

Balmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103 · see citing works

Growth inhibition and coordinated physiological regulation of zebrafish (Danio rerio) embryos upon sublethal exposure to antidepressant amitriptyline

Yang, M., Qiu, W., Chen, J., Zhan, J., Pan, C., Lei, X., & Wu, M. (2014) · Aquatic Toxicology · doi:10.1016/j.aquatox.2013.12.029 · Cited by 100 · see citing works

Increased oxidative stress in patients with depression and its relationship to treatment

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In vitro inhibition of mitochondrial respiratory rate by antidepressants

Hroudová, J., & Fišar, Z. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.07.017 · Cited by 85 · see citing works

Drug induced mitochondrial dysfunction: Mechanisms and adverse clinical consequences

Vuda, M., & Kamath, A. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.10.005 · Cited by 83 · see citing works

Oral treatment with amitriptyline induces coenzyme Q deficiency and oxidative stress in psychiatric patients

Moreno-Fernández, A. M., Cordero, M. D., Garrido-Maraver, J., Alcocer-Gómez, E., Casas-Barquero, N., Carmona-López, M. I., Sánchez-Alcázar, J. A., & de Miguel, M. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.11.002 · Cited by 54 · see citing works

Acute treatment with ketamine and chronic treatment with minocycline exert antidepressant-like effects and antioxidant properties in rats subjected different stressful events

Maciel, A. L., Abelaira, H. M., de Moura, A. B., de Souza, T. G., Rosa, T., Matos, D., Tuon, T., Garbossa, L., Strassi, A. P., Fileti, M. E., et al. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.12.005 · Cited by 35 · see citing works

Tricyclic Antidepressants Amitriptyline and Desipramine Induced Neurotoxicity Associated with Parkinson’s Disease

Lee, M.-Y., Hong, S., Kim, N., Shin, K. S., & Kang, S. J. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.0131 · Cited by 25 · see citing works

Amitriptyline at an Environmentally Relevant Concentration Alters the Profile of Metabolites Beyond Monoamines in Gilt-Head Bream

Ziarrusta, H., Ribbenstedt, A., Mijangos, L., Picart‐Armada, S., Perera-Lluna, A., Prieto, A., Izagirre, U., Benskin, J. P., Olivares, M., Zuloaga, O., et al. (2019) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4381 · Cited by 21 · see citing works

Integrated biological response to environmentally-relevant concentration of amitriptyline in Sparus aurata

Blanco-Rayón, E., Ziarrusta, H., Mijangos, L., Olivares, M., Zuloaga, O., Etxebarría, N., & Izagirre, U. (2021) · Ecological Indicators · doi:10.1016/j.ecolind.2021.108028 · Cited by 13 · see citing works

Therapeutic Effects of Turnera diffusa Extract Against Amitriptyline-Induced Toxic Hepatic Inflammation

Hasan, A. F., Mutar, T. F., Tousson, E., & Felemban, S. G. (2021) · OnLine Journal of Biological Sciences · doi:10.3844/ojbsci.2021.395.408 · Cited by 10 · see citing works

Amitriptyline down-regulates coenzyme Q10 biosynthesis in lung cancer cells

Ortíz, T., Paz, M. V., Díaz-Parrado, E., Illanes, M., Fernández-Rodríguez, A., Sánchez-Alcázar, J. A., & de Miguel, M. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.01.017 · Cited by 10 · see citing works

Oxidative Therapy Against Cancer

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Drug- or toxin-induced mitochondrial toxicity

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The effect of Ashwagandha Versus Amitriptyline on the Histological Structure of Submandibular Glands in Albino Rats

Idrees, I., Taqa, G. A., & ALtaaye, S. (2022) · Egyptian Journal of Veterinary Science · doi:10.21608/ejvs.2022.156115.1381 · Cited by 2 · see citing works

The effect of serotonergic receptors (5HT3) on seizure threshold and mitochondrial damage induced by amitriptyline in the mouse brain

Jahani, R., Dadashi, M., Chahardori, M., & Mohammadi, H. (2025) · Letters in Drug Design & Discovery · doi:10.1016/j.lddd.2025.100130 · Cited by 1 · see citing works

Repeated administration of fluvoxamine worsens gentamicin-induced nephrotoxicity in rats

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Antioxidants Supplementation in Acute Amitriptyline Abuse for Pain

Ali, S. H. K., Raja, K. W. A., Navabshan, I., Habeeb, M., & Ismail, Y. (2021) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-021-03721-7 · Cited by 1 · see citing works

Impact of antidepressant drug clomipramine on hepatorenal functions, lipid peroxidation, micronucleus frequencies and DNA damage using an alkaline comet assay

Agha, F. E., Youness, E. R., & Hassanane, M. M. (2013) · Journal of Experimental and Applied Animal Sciences · doi:10.20454/jeaas.2013.713

The effect of topical neuromodulatory medications on orofacial tissue in vitro

Al‐Musawi, M. (2016)

Antioxidants Supplementation In Acute Amitriptyline Abuse for PainPreprint

Hameed Kadar Ali, S., Wasim Ali Raja, K., Navabshan, I., Habeeb, M., & Ismail, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-724699/v1

Oral treatment with amitriptyline induces coenzyme Q deficiency and oxidative stress in psychiatric patients

Moreno-Fernández, A. M., Cordero, M. D., Garrido-Maraver, J., Alcocer-Gómez, E., Casas-Barquero, N., Carmona-López, M. I., Sánchez-Alcázar, J. A., & de Miguel, M. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.11.002 · Cited by 54 · see citing works

Coenzyme Q10 and alpha-tocopherol protect against amitriptyline toxicity

Cordero, M. D., Moreno‐Fernández, A. M., Gómez-Skármeta, J. L., de Miguel, M., Garrido‐Maraver, J., Oropesa-Ávila, M., Hernández, M., Navas, P., & Sánchez-Alcázar, J. A. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.12.026 · Cited by 39 · see citing works

Amitriptyline down-regulates coenzyme Q10 biosynthesis in lung cancer cells

Ortíz, T., Paz, M. V., Díaz-Parrado, E., Illanes, M., Fernández-Rodríguez, A., Sánchez-Alcázar, J. A., & de Miguel, M. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.01.017 · Cited by 10 · see citing works

Evaluation of amitriptyline-induced toxicity in freshly isolated rat hepatocytes and the protective role of taurine"

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Protective effect of endogenous coenzyme Q on both lipid peroxidation and respiratory chain inactivation induced by an adriamycin-iron complex

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