The antioxidant role of coenzyme Q
Abstract
A number of functions for coenzyme Q (CoQ) have been established during the years but its role as an effective antioxidant of the cellular membranes remains of dominating interest. This compound is our only endogenously synthesized lipid soluble antioxidant, present in all membranes and exceeding both in amount and efficiency that of other antioxidants. The protective effect is extended to lipids, proteins and DNA mainly because of its close localization to the oxidative events and the effective regeneration by continuous reduction at all locations. Its biosynthesis is influenced by nuclear receptors which may give the possibility, in the future, by using agonists or antagonists, of reestablishing the normal level in deficiencies caused by genetic mutations, aging or cardiomyopathy. An increase in CoQ concentration in specific cellular compartments in the presence of various types of oxidative stress appears to be of considerable interest.
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CoQ10 is able to reduce superoxide production in mitochondria.
“It is a fat-soluble micronutrient synthesized by all human cells and tissues that can also be taken exogenously to mitigate ROS damage, as CoQ10 is able to reduce superoxide production in mitochondria176,177.”
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- Authors
- Bentinger, M., Brismar, K., & Dallner, G.
- Affiliations
- Stockholm University (SE)
- Karolinska Institutet (SE)
- Corresponding author
- Dallner, Gustav
- ORCID
- Brismar, Kerstin
- Venue
- Mitochondrion
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 7
- Pages
- S41-S50
- ISSN
- 1567-7249 (ISSN-L)
- OpenAlex
- W2007761806
- Cited by
- 543
- References
- 2
- Citations by year
- 2026: 12 · 2025: 24 · 2024: 36 · 2023: 31 · 2022: 35 · 2021: 55 · 2020: 41 · 2019: 35 · 2018: 16 · 2017: 18 · 2016: 33 · 2015: 36 · 2014: 31 · 2013: 20 · 2012: 31
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mitochondrion (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Keywords
- coenzyme Q10, antioxidant activity, plasma membrane, lipid peroxidation, oxidative stress, nuclear receptors, DNA protection, protein protection, cardiomyopathy, aging, genetic mutations
- MeSH terms
- Animals, Antioxidants, DNA, Humans, Lipids, Mevalonic Acid, Models, Biological, Models, Chemical, Oxygen, Ubiquinone, Oxidants, Reactive Oxygen Species, Oxidative Stress
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