Chemo-physical properties of asbestos bodies in human lung tissues studied at the nano-scale by non-invasive, label free X-ray imaging and spectroscopic techniques
Open accessAbstract
In the lungs, asbestos develops an Fe-rich coating (Asbestos Body, AB) that becomes the actual interface between the foreign fibers and the host organism. Conventional approaches to study ABs require an invasive sample preparation that can alter them. In this work, a novel combination of x-ray tomography and spectroscopy allowed studying unaltered lung tissue samples with chrysotile and crocidolite asbestos. The thickness and mass density maps of the ABs obtained by x-ray tomography were used to derive a truly quantitative elemental analysis from scanning x-ray fluorescence spectroscopy data. The average mass density of the ABs is compatible with that of highly loaded ferritin, or hemosiderin. The composition of all ABs analyzed was similar, with only minor differences in the relative elemental fractions. Silicon concentration decreased in the core-to-rim direction, indicating a possible partial dissolution of the inner fiber. The Fe content in the ABs was higher than that possibly contained in chrysotile and crocidolite. This finding opens two opposite scenarios, the first with Fe coming from the fiber bulk and concentrating on the surface as long as the fiber dissolves, the second where the Fe that takes part to the formation of the AB originates from the host organism Fe-pool.
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Iron in the coat of asbestos bodies does not appear to directly participate in the generation of reactive oxygen species.
“Iron in the coat of asbestos bodies does not appear to directly participate in the generation of reactive oxygen species [100].”
From Asbestos and Iron (2023) · cites this paper as [100]
The Introduction (page not provided) says that experiments found asbestos bodies induce free-radical generation and that iron in their coating is catalytically active. That is contrary to the claim that coating iron does not appear to participate directly in reactive-oxygen-species generation. (LLM, conf=0.85)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredChrysotile asbestos bodies occur but account for a very small number of asbestos bodies (usually less than 1 to 3% with a mean of 0.14%).
“Chrysotile asbestos bodies do occur but account for a very small number of asbestos bodies (usually less than 1 to 3% with a mean of 0.14%) [100,101].”
From Asbestos and Iron (2023) · cites this paper as [100]
The discussion (journal pre-proof; page unavailable) reports that 2% of 600 asbestos bodies had chrysotile cores, supporting the claim that chrysotile bodies occur but are uncommon. It also reports a 0.14% average for the proportion of chrysotile fibers that form asbestos bodies—not the proportion of all asbestos bodies that are chrysotile—and does not establish the stated usual range of less than 1–3%. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIt is proposed that the coats on these other particles/fibers reflect a disruption in cell iron homeostasis comparable to that following exposure to asbestos and result from the same process.
“It is proposed that the coats on these other particles/fibers reflect a disruption in cell iron homeostasis comparable to that following exposure to asbestos and result from the same process [100].”
From Asbestos and Iron (2023) · cites this paper as [100]
The Introduction (page unavailable) describes an iron-rich coat forming around asbestos fibers after frustrated phagocytosis, and the discussion (page unavailable) suggests a common formation mechanism across the asbestos fiber types studied. It does not establish that coats on other, non-asbestos particles or fibers reflect comparable disruption of cellular iron homeostasis or arise by the same process; the discussion says the iron's source remains unresolved. (LLM, conf=0.82)
Experimental — accuracy not yet measuredWith the exception of silicon, all elements appear to co-localize to the coat on the asbestos body.
“With the exception of silicon, all elements appear to co-localize to the coat on the asbestos body [100].”
From Asbestos and Iron (2023) · cites this paper as [100]
An analysis of their coat revealed the same elements in all asbestos bodies, with only minor differences in the relative amounts of the elements.
“An analysis of their coat revealed the same elements in all asbestos bodies, with only minor differences in the relative amounts of the elements [100].”
From Asbestos and Iron (2023) · cites this paper as [100]
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Giacobbe, C., Giuseppe, D. D., Zoboli, A., Gualtieri, M. L., Bonasoni, M. P., Moliterni, A., Corriero, N., Altomare, A., Wright, J. P., & Gualtieri, A. F. (2020) · IUCrJ · doi:10.1107/s2052252520015079 · Cited by 15 · see citing works
The mechanism of iron binding processes in erionite fibres
Pacella, A., Cremisini, C., Nardi, E., Montereali, M. R., Pettiti, I., & Ballirano, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-01477-x · Cited by 13 · see citing works
Capella, S., Bellis, D., Fioretti, E., Marinelli, R., & Belluso, E. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114384 · Cited by 11 · see citing works
Self-citationCluff, D. L., & Patitsas, A. J. (1992) · Aerosol Science and Technology · doi:10.1080/02786829208959570 · Cited by 9 · see citing works
Life science applications and research potential of the TwinMic spectromicroscopy station at ELETTRA
Gianoncelli, A., Kourousias, G., Pascolo, L., Rizzardi, C., Ceccone, G., Kaulich, B., & Kiskinova, M. P. (2013) · Journal of Physics Conference Series · doi:10.1088/1742-6596/463/1/012004 · Cited by 9 · see citing works
Biological in Vitro and in Vivo Responses of Chrysotile versus Amphiboles
Bignon, J., & Jaurand, M. (1983) · Environmental Health Perspectives · doi:10.2307/3429731 · Cited by 4 · see citing works
Pacella, A., Andreozzi, G. B., Nodari, L., et al. (2019) · IRIS Research product catalog (Sapienza University of Rome) · doi:10.2451/2019pm910
Flagged first, then by citations
3 of the 99 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Eckhardt, C. M., & Wu, H. (2021) · Current Environmental Health Reports · doi:10.1007/s40572-021-00328-2 · Cited by 82 · see citing works
Ghio, A. J., Stewart, M., Sangani, R. G., Pavlisko, E. N., & Roggli, V. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512390 · Cited by 15 · see citing works
“With the exception of silicon, all elements appear to co-localize to the coat on the asbestos body [100].”
BackgroundInfluentialClosing the knowledge gap on the composition of the asbestos bodies
Bardelli, F., Giacobbe, C., Ballirano, P., Borelli, V., Benedetto, F. D., Montegrossi, G., Bellis, D., & Pacella, A. (2023) · Environmental Geochemistry and Health · doi:10.1007/s10653-023-01557-0 · Cited by 7 · see citing works
Self-citationDose-efficient multimodal microscopy of human tissue at a hard X-ray nanoprobe beamline
Sala, S., Zhang, Y., Rosa, N. D. L., Dreier, T., Kahnt, M., Langer, M., Dahlin, L. B., Bech, M., Villanueva‐Perez, P., & Kalbfleisch, S. (2022) · Journal of Synchrotron Radiation · doi:10.1107/s1600577522001874 · Cited by 5 · see citing works
Broadband Ptychotomography with a Hyperspectral Detector
Stolp, W., Assche, F. V., Tang, R., Desplenter, K., Organista, C., Ziesche, R. F., Cipiccia, S., Batey, D., & Boone, M. (2025) · Physical Review Letters · doi:10.1103/kbrf-gb9c · Cited by 3 · see citing works
Caraballo-Arias, Y., Zunarelli, C., Caffaro, P., Roccuzzo, F., Nocilla, M. R., Imperiale, M. C., Romano, C., Boffetta, P., & Violante, F. S. (2022) · Life · doi:10.3390/life12121969 · Cited by 2 · see citing works
- Authors
- Bardelli, F., Brun, F., De Panfilis, S., Cloetens, P., Capella, S., Belluso, E., Bellis, D., Di Napoli, A., & Cedola, A.
- Affiliations
- Istituto di Nanotecnologia (IT)
- University of Trieste (IT)
- European Synchrotron Radiation Facility (FR)
- University of Turin (IT)
- Ospedale degli Infermi (IT)
- Corresponding author
- Bardelli, Fabrizio
- ORCID
- Venue
- Toxicology Letters
- Publisher
- Elsevier BV
- Published
- 2021-09
- Volume
- 348
- Pages
- 18-27
- ISSN
- 0378-4274 (ISSN-L)
- OpenAlex
- W3164946435
- Cited by
- 6
- References
- 99
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2021: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Toxicology Letters (publishedVersion)
- PubMed (publishedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion, cc-by-nc-nd)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Funders
- Horizon 2020 Marie Skłodowska-Curie Actions
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Physical Sciences › Physics and Astronomy › Radiation › X-ray Spectroscopy and Fluorescence Analysis
- Physical Sciences › Physics and Astronomy › Radiation › Advanced X-ray Imaging Techniques
- Keywords
- asbestos bodies, chrysotile, crocidolite, lung tissue, ferritin, hemosiderin, fiber dissolution, silicon concentration, mass density, elemental composition, X-ray tomography
- MeSH terms
- Aged, 80 and over, Asbestos, Asbestosis, Female, Humans, Lung, Male, Spectrometry, Fluorescence, Tomography, X-Ray
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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