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Cited by 18Fluoride Effects and RemovalOral microbiology and periodontitis researchDental Health and Care Utilization

The DOI matches its Crossref record; 75 of the 77 references it cites were found in a registry or an index.

Does fluoride exposure impact on the human microbiome?

Open access
Moran, Gary P., Zgaga, Lina, Daly, Blánaid, Harding, Mairead, Montgomery, Therese·2023·Toxicology Letters
DOI 10.1016/j.toxlet.2023.03.001
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Abstract

Fluoride is added to drinking water in some countries to prevent tooth decay (caries). There is no conclusive evidence that community water fluoridation (CWF) at WHO recommended concentrations for caries prevention has any harmful effects. However, research is ongoing regarding potential effects of ingested fluoride on human neurodevelopment and endocrine dysfunction. Simultaneously, research has emerged highlighting the significance of the human microbiome in gastrointestinal and immune health. In this review we evaluate the literature examining the effect of fluoride exposure on the human microbiome. Unfortunately, none of the studies retrieved examined the effects of ingested fluoridated water on the human microbiome. Animal studies generally examined acute fluoride toxicity following ingestion of fluoridated food and water and conclude that fluoride exposure can detrimentally perturb the normal microbiome. These data are difficult to extrapolate to physiologically relevant human exposure dose ranges and the significance to humans living in areas with CWF requires further investigation. Conversely, evidence suggests that the use of fluoride containing oral hygiene products may have beneficial effects on the oral microbiome regarding caries prevention. Overall, while fluoride exposure does appear to impact the human and animal microbiome, the long-term consequences of this requires further study.

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Crossref · 10.1016/j.toxlet.2023.03.001

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2 of the 77 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. Lambe, K., Farragher, A., Moloney, T., Sunday, S., Long, J., 2022. Impact of community water fluoridation on systemic health excluding oral health: An evidence review. Health Research Board, Dublin.
  2. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific Opinion on Dietary Reference Values for fluoride, EFSA Journal.

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Metadata

Authors
Moran, G. P., Zgaga, L., Daly, B., Harding, M., & Montgomery, T.
Affiliations
  • Trinity College Dublin (IE)
  • Atlantic Technological University (IE)
Corresponding author
Moran, Gary P.
ORCID
Venue
Toxicology Letters
Publisher
Elsevier BV
Published
2023-04
Volume
379
Pages
11-19
ISSN
0378-4274 (ISSN-L)
DOI
10.1016/j.toxlet.2023.03.001
OpenAlex
W4323031097
Cited by
18
References
77
Citations by year
2026: 7 · 2025: 4 · 2024: 4 · 2023: 3
FWCI
0.25
Type
journal article
Language
en
Open access
Licence
Locations
  • Toxicology Letters (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Funders
Health Research Board
Topics
  • Physical Sciences › Environmental Science › Water Science and Technology › Fluoride Effects and Removal
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
Keywords
fluoride exposure, human microbiome, water fluoridation, oral microbiota, gastrointestinal microbiome, dental caries prevention, fluoride toxicity, oral care products, brain development, endocrine dysfunction
MeSH terms
Animals, Fluoridation, Fluorides, Food, Humans, Fluorosis, Dental, Microbiota

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