Are dental diseases examples of ecological catastrophes?
Abstract
Dental diseases are among the most prevalent and costly diseases affecting industrialized societies, and yet are highly preventable. The microflora of dental plaque biofilms from diseased sites is distinct from that found in health, although the putative pathogens can often be detected in low numbers at normal sites. In dental caries, there is a shift towards community dominance by acidogenic and acid-tolerant Gram-positive bacteria (e.g. mutans streptococci and lactobacilli) at the expense of the acid-sensitive species associated with sound enamel. In contrast, the numbers and proportions of obligately anaerobic bacteria, including Gram-negative proteolytic species, increase in periodontal diseases. Modelling studies using defined consortia of oral bacteria grown in planktonic and biofilm systems have been undertaken to identify environmental factors responsible for driving these deleterious shifts in the plaque microflora. Repeated conditions of low pH (rather than sugar availability per se) selected for mutans streptococci and lactobacilli, while the introduction of novel host proteins and glycoproteins (as occurs during the inflammatory response to plaque), and the concomitant rise in local pH, enriched for Gram-negative anaerobic and asaccharolytic species. These studies emphasized (a). significant properties of dental plaque as both a biofilm and a microbial community, and (b). the dynamic relationship existing between the environment and the composition of the oral microflora. This research resulted in a novel hypothesis (the 'ecological plaque hypothesis') to better describe the relationship between plaque bacteria and the host in health and disease. Implicit in this hypothesis is the concept that disease can be prevented not only by directly inhibiting the putative pathogens, but also by interfering with the environmental factors driving the selection and enrichment of these bacteria. Thus, a more holistic approach can be taken in disease control and management strategies.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Caries and periodontal disease are polymicrobial, plaque-mediated infections thought to result from perturbation of a healthy, ecologically balanced oral biofilm that can occur from dietary changes such as increased consumption of fermentable carbohydrates.
“Caries and periodontal disease are both polymicrobial, plaque-mediated infections, thought to result from perturbation of a healthy, ecologically balanced oral biofilm23,24 that can occur from dietary changes, such as the increased consumption of fermentable carbohydrates25,26.”
From Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions (2013) · cites this paper as [24]
Cites
Microbial complexes in subgingival plaque
Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L. (1998) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1998.tb02419.x · Cited by 5,050 · see citing works
Costerton, J. W., Lewandowski, Z., Caldwell, D. E., Korber, D. R., & Lappin-Scott, H. M. (1995) · Annual Review of Microbiology · doi:10.1146/annurev.mi.49.100195.003431 · Cited by 4,718 · see citing works
Role of Streptococcus mutans in human dental decay
Loesche, W. J. (1986) · Microbiological Reviews · doi:10.1128/mr.50.4.353-380.1986 · Cited by 3,363 · see citing works
Bacterial Biofilms in Nature and Disease
Costerton, J. W., Cheng, K. J., Geesey, G. G., Ladd, T. I., Nickel, J. C., Dasgupta, M., & Marrie, T. J. (1987) · Annual Review of Microbiology · doi:10.1146/annurev.mi.41.100187.002251 · Cited by 3,145 · see citing works
Bacterial Diversity in Human Subgingival Plaque
Paster, B. J., Boches, S. K., Galvin, J. L., Ericson, R. E., Lau, C. N., Levanos, V. A., Sahasrabudhe, A., & Dewhirst, F. E. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.12.3770-3783.2001 · Cited by 2,008 · see citing works
Role of Streptococcus mutans in human dental decay.
Loeshe, W. J. (1986) · Medical Entomology and Zoology · Cited by 1,346 · see citing works
Microbial ecology of dental plaque and its significance in health and disease
Marsh, P. D. (1994) · Advances in Dental Research · doi:10.1177/08959374940080022001 · Cited by 1,278 · see citing works
Self-citationThe bacteria of periodontal diseases
Moore, W. E., & Moore, L. V. H. (1994) · Periodontology 2000 · doi:10.1111/j.1600-0757.1994.tb00019.x · Cited by 1,077 · see citing works
Biofilms, the customized microniche
Costerton, J. W., Lewandowski, Z., de Beer, D., Caldwell, D. E., Korber, D. R., & James, G. A. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.8.2137-2142.1994 · Cited by 999 · see citing works
Adhere today, here tomorrow: oral bacterial adherence
Kolenbrander, P. E., & London, J. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.11.3247-3252.1993 · Cited by 717 · see citing works
The microbial challenge in periodontitis
Darveau, R. P., Tanner, A. C. R., & Page, R. C. (1997) · Periodontology 2000 · doi:10.1111/j.1600-0757.1997.tb00190.x · Cited by 633 · see citing works
Bacterial diversity within the human subgingival crevice
Kroes, I., Lepp, P. W., & Relman, D. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14547 · Cited by 606 · see citing works
MECHANISMS OF ADHESION BY ORAL BACTERIA
Whittaker, C. J., Klier, C. M., & Kolenbrander, P. E. (1996) · Annual Review of Microbiology · doi:10.1146/annurev.micro.50.1.513 · Cited by 424 · see citing works
Cyanobacterial toxins: Occurrence, properties and biological significance
Codd, G. A. (1995) · Water Science & Technology · doi:10.1016/0273-1223(95)00692-3 · Cited by 376 · see citing works
Microorganisms Indigenous to Man
(1963) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1963.tb26581.x · Cited by 374 · see citing works
Bradshaw, D. J., Marsh, P. D., Watson, G. K., & Allison, C. (1998) · Infection and Immunity · doi:10.1128/iai.66.10.4729-4732.1998 · Cited by 351 · see citing works
Self-citationChemotherapy of Dental Plaque Infections
Bowers, G. M., Hardin, J. F., & Moffitt, W. C. (1970) · Dental Clinics of North America · doi:10.1016/s0011-8532(22)01548-8 · Cited by 337 · see citing works
Saliva-Bacterium Interactions in Oral Microbial Ecology
Scannapieco, F. A. (1994) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411940050030201 · Cited by 328 · see citing works
Depth Penetration and Detection of pH Gradients in Biofilms by Two-Photon Excitation Microscopy
Vroom, J. M., De Grauw, K. J., Gerritsen, H. C., Bradshaw, D. J., Marsh, P. D., Watson, G. K., Birmingham, J. J., & Allison, C. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.8.3502-3511.1999 · Cited by 303 · see citing works
Self-citationAntimicrobial actions of fluoride for oral bacteria
Marquis, R. E. (1995) · Canadian Journal of Microbiology · doi:10.1139/m95-133 · Cited by 293 · see citing works
The non‐specific theory in microbial etiology of inflammatory periodontal diseases
Theilade, E. (1986) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1986.tb01425.x · Cited by 283 · see citing works
Streptococcal Adhesion and Colonization
Jenkinson, H. F., & Lamont, R. J. (1997) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411970080020601 · Cited by 272 · see citing works
Chemotherapy of dental plaque infections.
Wj, L. (1976) · PubMed · Cited by 259 · see citing works
Bowden, G. H., & Hamilton, I. R. (1998) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411980090010401 · Cited by 241 · see citing works
Effect of hemin on the physiology and virulence of Bacteroides gingivalis W50
McKee, A. S., McDermid, A. S., Baskerville, A., Dowsett, A. B., Ellwood, D. C., & Marsh, P. (1986) · Infection and Immunity · doi:10.1128/iai.52.2.349-355.1986 · Cited by 235 · see citing works
Self-citationAnalysis of pH–Driven Disruption of Oral Microbial Communities in vitro
Bradshaw, D. J., & Marsh, P. D. (1998) · Caries Research · doi:10.1159/000016487 · Cited by 223 · see citing works
Self-citationLow pH Adaptation and the Acid Tolerance Response ofSalmonella typhimurium
Foster, J. W. (1995) · Critical Reviews in Microbiology · doi:10.3109/10408419509113541 · Cited by 212 · see citing works
Metabolic cooperation in oral microbial communities during growth on mucin
Bradshaw, D. J., Homer, K. A., Marsh, P. D., & Beighton, D. (1994) · Microbiology · doi:10.1099/13500872-140-12-3407 · Cited by 199 · see citing works
Self-citationBradshaw, D. J., McKee, A. S., & Marsh, P. D. (1989) · Journal of Dental Research · doi:10.1177/00220345890680090101 · Cited by 199 · see citing works
Self-citationThe Microbiota of Young Children from Tooth and Tongue Samples
Tanner, A. C. R., Milgrom, P., Kent, R., Mokeem, S. A., Page, R. C., Riedy, C. A., Weinstein, P., & BRUSS, J. B. (2002) · Journal of Dental Research · doi:10.1177/002203450208100112 · Cited by 185 · see citing works
MICROBIOLOGIC ASPECTS OF DENTAL PLAQUE AND DENTAL CARIES
Marsh, P. D. (1999) · Dental Clinics of North America · doi:10.1016/s0011-8532(22)00816-3 · Cited by 184 · see citing works
Self-citationThe diversity of periodontal spirochetes by 16S rRNA analysis
Dewhirst, F. E., Tamer, M. A., Ericson, R. E., Lau, C. N., Levanos, V. A., Boches, S. K., Galvin, J. L., & Paster, B. J. (2000) · Oral Microbiology and Immunology · doi:10.1034/j.1399-302x.2000.150308.x · Cited by 182 · see citing works
Sansone, C., van Houte, J., JOSHIPURA, K. J., Kent, R., & Margolis, H. C. (1993) · Journal of Dental Research · doi:10.1177/00220345930720020701 · Cited by 179 · see citing works
Physico-Chemical Interactions in Initial Microbial Adhesion and Relevance for Biofilm Formation
Busscher, H. J., & van der Mei, H. C. (1997) · Advances in Dental Research · doi:10.1177/08959374970110011301 · Cited by 177 · see citing works
Normal microflora: an introduction to microbes inhabiting the human body
(1996) · Choice Reviews Online · doi:10.5860/choice.33-2722 · Cited by 176 · see citing works
Oxygen metabolism, oxidative stress and acid-base physiology of dental plaque biofilms
Marquis, R. (1995) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/bf01569826 · Cited by 176 · see citing works
Microbiology of Root Surface Caries in Humans
Bowden, G. H. (1990) · Journal of Dental Research · doi:10.1177/00220345900690051701 · Cited by 168 · see citing works
Cyanobacterial toxins: occurrence, properties and biological significance
Codd, G. A. (1995) · Water Science & Technology · doi:10.2166/wst.1995.0177 · Cited by 160 · see citing works
Cysteine Proteases of Porphyromonas Gingivalis
Curtis, M. A., Aduse‐Opoku, J., & Rangarajan, M. (2001) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411010120030101 · Cited by 152 · see citing works
Protein expression by planktonic and biofilm cells of Streptococcus mutans
Svensäter, G., Welin, J., Wilkins, J. C., Beighton, D., & Hamilton, I. R. (2001) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2001.tb10937.x · Cited by 152 · see citing works
Asikainen, S. E., & Chen, C. (1999) · Periodontology 2000 · doi:10.1111/j.1600-0757.1999.tb00158.x · Cited by 150 · see citing works
Role of the Oral Microflora in Health
Marsh, P. D. (2000) · Microbial Ecology in Health and Disease · doi:10.1080/089106000750051800 · Cited by 149 · see citing works
Self-citationContinuous culture 6: Applications and new fields
Rowley, B. I. (1977) · Biochemical Education · doi:10.1016/0307-4412(77)90047-4 · Cited by 148 · see citing works
Normal flora: diversity and functions
McFarland, L. V. (2000) · Microbial Ecology in Health and Disease · doi:10.1080/08910600050216183 · Cited by 136 · see citing works
Effect of oxygen, inoculum composition and flow rate on development of mixed-culture oral biof ilms
Bradshaw, D. J., Marsh, P. D., Allison, C., & Schilling, K. (1996) · Microbiology · doi:10.1099/13500872-142-3-623 · Cited by 135 · see citing works
Self-citationPhysiological Approaches to the Control of Oral Biofilms
Marsh, P. D., & Bradshaw, D. J. (1997) · Advances in Dental Research · doi:10.1177/08959374970110010901 · Cited by 132 · see citing works
Self-citationBradshaw, D. J., Marsh, P. D., Hodgson, R., & Visser, J. M. (2002) · Caries Research · doi:10.1159/000057864 · Cited by 129 · see citing works
Self-citationEffect of environmental pH on enzyme activity and growth of Bacteroides gingivalis W50
McDermid, A. S., McKee, A. S., & Marsh, P. D. (1988) · Infection and Immunity · doi:10.1128/iai.56.5.1096-1100.1988 · Cited by 123 · see citing works
Self-citationKinniment, S. L., WIMPENNY, J. W. T., Adams, D., & Marsh, P. D. (1996) · Microbiology · doi:10.1099/13500872-142-3-631 · Cited by 117 · see citing works
Self-citationAnalysis of Streptococcus mutans Proteins Modulated by Culture under Acidic Conditions
Wilkins, J. C., Homer, K. A., & Beighton, D. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.5.2382-2390.2002 · Cited by 117 · see citing works
Gmür, R., & Guggenheim, B. (1994) · Journal of Dental Research · doi:10.1177/00220345940730080501 · Cited by 116 · see citing works
Socransky, S. S., Haffajee, A. D., Ximenez‐Fyvie, L., Feres, M., & Mager, D. L. (1999) · Periodontology 2000 · doi:10.1111/j.1600-0757.1999.tb00165.x · Cited by 113 · see citing works
Predominant obligate anaerobes in human periodontal pockets
Uematsu, H., & Hoshino, E. (1992) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1992.tb02080.x · Cited by 110 · see citing works
The pH of gingival crevices and periodontal pockets in children, teenagers and adults
Eggert, F. M., Drewell, L., Bigelow, J. A., Speck, J. E., & Goldner, M. (1991) · Archives of Oral Biology · doi:10.1016/0003-9969(91)90091-8 · Cited by 108 · see citing works
Molecular Responses of Microbes to Environmental pH stress
Hall, H. K., Karem, K. L., & Foster, J. W. (1995) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/s0065-2911(08)60147-2 · Cited by 106 · see citing works
The Predominant Aciduric Microflora of Root-caries Lesions
Brailsford, S. R., Shah, B., Simons, D., Gilbert, S. C., Clark, D. T., Inés, I. M., Adams, S., Allison, C., & Beighton, D. (2001) · Journal of Dental Research · doi:10.1177/00220345010800091101 · Cited by 105 · see citing works
Sugar, fluoride, pH and microbial homeostasis in dental plaque.
Marsh, P. (1991) · PubMed · Cited by 103 · see citing works
Self-citationA modified chemostat system to study the ecology of oral biofilms
Bradshaw, D. J., Marsh, P., Schilling, K., & Cummins, D. (1996) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1996.tb03199.x · Cited by 97 · see citing works
Self-citationEnhanced Growth of Complex Communities of Dental Plaque Bacteria in Mucin-Limited Continuous Culture
Glenister, D. A., Salamon, K., Smith, K., Beighton, D., & Keevil, C. W. (1988) · Microbial Ecology in Health and Disease · doi:10.3109/08910608809140176 · Cited by 96 · see citing works
Marsh, P. D., McDermid, A. S., McKee, A. S., & Baskerville, A. (1994) · Microbiology · doi:10.1099/00221287-140-4-861 · Cited by 95 · see citing works
Self-citationter Steeg, P. F., van der Hoeven, J. S., Jong, M. H. D., Munster, P. J. J. V., & Jansen, M. J. H. (1987) · Antonie van Leeuwenhoek · doi:10.1007/bf00393933 · Cited by 94 · see citing works
Biology of the species Porphyromonas gingivalis
Grenier, D. (1993) · Medical Entomology and Zoology · Cited by 90 · see citing works
Ellwood, D. C., Phipps, P. J., & Hamilton, I. R. (1979) · Infection and Immunity · doi:10.1128/iai.23.2.224-231.1979 · Cited by 85 · see citing works
Cummins, D. (1991) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1991.tb02316.x · Cited by 83 · see citing works
Bacterial Transmission in Periodontal Diseases: A Critical Review
Greenstein, G., & Lamster, I. B. (1997) · Journal of Periodontology · doi:10.1902/jop.1997.68.5.421 · Cited by 80 · see citing works
A Microbiological Study of Early Caries of Approximal Surfaces in Schoolchildren
Marsh, P., Featherstone, A. S. R., McKee, A. S., Hallsworth, A. S., Robinson, C., Weatherell, J. A., Newman, H. N., & Pitter, A. F. V. (1989) · Journal of Dental Research · doi:10.1177/00220345890680070301 · Cited by 80 · see citing works
Self-citationMcKee, A. S., McDermid, A. S., Ellwood, D. C., & Marsh, P. D. (1985) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1985.tb01788.x · Cited by 79 · see citing works
Self-citationOral Bacterial Ecology. The Molecular Basis
Skovgaard, N. (2000) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(00)00392-5 · Cited by 76 · see citing works
McDermid, A. S., McKee, A. S., Ellwood, D. C., & Marsh, P. (1986) · Microbiology · doi:10.1099/00221287-132-5-1205 · Cited by 73 · see citing works
Self-citationBradshaw, D. J., & Marsh, P. D. (2009) · Caries Research · doi:10.1159/000261977 · Cited by 71 · see citing works
Self-citationPlaque and chronic inflammatory Periodontal disease A question of ecology
Newman, H. N. (1990) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1990.tb01102.x · Cited by 69 · see citing works
Marsh, P. D., Hunter, J. R., Bowden, G. H., Hamilton, I. R., McKee, A. S., Hardie, J. M., & Ellwood, D. C. (1983) · Microbiology · doi:10.1099/00221287-129-3-755 · Cited by 68 · see citing works
Self-citationBradshaw, D. J., Marsh, P. D., Watson, G. K., & Cummins, D. (1993) · Journal of Dental Research · doi:10.1177/00220345930720010301 · Cited by 66 · see citing works
Self-citationBradshaw, D. J., McKee, A. S., & Marsh, P. (1990) · Journal of Dental Research · doi:10.1177/00220345900690020301 · Cited by 66 · see citing works
Self-citationMarsh, P., Keevil, C. W., McDermid, A. S., Williamson, M. I., & Ellwood, D. C. (1983) · Archives of Oral Biology · doi:10.1016/0003-9969(83)90152-8 · Cited by 62 · see citing works
Self-citationRl, S. (1984) · PubMed · Cited by 62 · see citing works
The effect of chlorhexidine on defined, mixed culture oral biofilms grown in a novel model system
Kinniment, S. L., WIMPENNY, J. W. T., Adams, D., & Marsh, P. (1996) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1996.tb04488.x · Cited by 59 · see citing works
Self-citationSugar transport and metabolism in gram-positive bacteria
West, I. (1988) · Endeavour · doi:10.1016/0160-9327(88)90102-0 · Cited by 58 · see citing works
Hamilton, I. R., Phipps, P. J., & Ellwood, D. C. (1979) · Infection and Immunity · doi:10.1128/iai.26.3.861-869.1979 · Cited by 57 · see citing works
Bradshaw, D. J., Marsh, P., Watson, G. K., & Allison, C. (1997) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.1997.tb00001.x · Cited by 52 · see citing works
Self-citationMicrobial community interactions in biofilms
Marsh, P. D., & Bowden, G. H. W. (2000) · Cambridge University Press eBooks · doi:10.1017/cbo9780511754814.010 · Cited by 51 · see citing works
Self-citationWoodman, A., Vidic, J., Newman, H. N., & Marsh, P. D. (1985) · Journal of Medical Microbiology · doi:10.1099/00222615-19-1-15 · Cited by 51 · see citing works
Self-citationMcDermid, A. S., McKee, A. S., & Marsh, P. (1987) · Journal of Dental Research · doi:10.1177/00220345870660080501 · Cited by 46 · see citing works
Self-citationEffect of Temperature on Growth, Hemagglutination, and Protease Activity of Porphyromonas gingivalis
Percival, R. S., Marsh, P. D., DeVine, D., Rangarajan, M., Aduse‐Opoku, J., Shepherd, P., & Curtis, M. A. (1999) · Infection and Immunity · doi:10.1128/iai.67.4.1917-1921.1999 · Cited by 45 · see citing works
Self-citationLACEY, R. W., Howson, G. L., Lord, V. L., Luxton, D. E. A., & Trotter, I. S. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90566-4 · Cited by 42 · see citing works
Initial microbial adhesion events: mechanisms and implications
Busscher, H. J., & van der Mei, H. C. (2000) · Cambridge University Press eBooks · doi:10.1017/cbo9780511754814.003 · Cited by 37 · see citing works
Spadaro, A. C. C. (1993) · Biochemical Education · doi:10.1016/0307-4412(93)90150-x · Cited by 36 · see citing works
Coaggregation and coadhesion in oral biofilms
Kolenbrander, P. E., Andersen, R. N., Kazmerzak, K. M., & Palmer, R. J., Jr. (2000) · Cambridge University Press eBooks · doi:10.1017/cbo9780511754814.006 · Cited by 36 · see citing works
Jensen, M. E., & Schachtele, C. F. (1983) · Journal of Dental Research · doi:10.1177/00220345830620101001 · Cited by 34 · see citing works
Bonass, W. A., Marsh, P. D., Percival, R. S., Aduse‐Opoku, J., Hanley, S. A., DeVine, D., & Curtis, M. A. (2000) · Infection and Immunity · doi:10.1128/iai.68.7.4012-4017.2000 · Cited by 33 · see citing works
Self-citationThe effect of sweeteners on acid production in plaque.
Edgar, W. M., & Dodds, M. W. J. (1985) · PubMed · Cited by 28 · see citing works
The use of defined inocula stored in liquid nitrogen for mixed culture chemostat studies
Bradshaw, D. J., McKee, A. S., & Marsh, P. (1989) · Journal of Microbiological Methods · doi:10.1016/0167-7012(89)90062-6 · Cited by 27 · see citing works
Self-citation[22] Use of continuous flow techniques in modeling dental plaque biofilms
Bradshaw, D. J., & Marsh, P. D. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)10024-7 · Cited by 26 · see citing works
Self-citationThe role of continuous culture in modelling the human microflora
Marsh, P. D. (1995) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.280640102 · Cited by 22 · see citing works
Self-citationFactors Controlling Skin Bacterial Flora
Aly, R., & Maïbach, H. I. (1981) · Springer eBooks · doi:10.1007/978-1-4612-5868-1_4 · Cited by 20 · see citing works
Grenby, T. H., & Saldanha, M. G. (2009) · Caries Research · doi:10.1159/000260914 · Cited by 18 · see citing works
Marsh, P. D., McDermid, A. S., Keevil, C. W., & Ellwood, D. C. (1985) · Microbiology · doi:10.1099/00221287-131-10-2505 · Cited by 17 · see citing works
Self-citationMurro, C. D., Paolantonio, M., Pedrazzoli, V., Lopatin, D. E., & Cattabriga, M. (1997) · Journal of Periodontology · doi:10.1902/jop.1997.68.1.18 · Cited by 17 · see citing works
DNA probe detection of key periodontal pathogens in juveniles.
Le, K., Savitt, E. D., French, C. K., & Peros, W. J. (1989) · PubMed · Cited by 17 · see citing works
The effects on chronic periodontitis of a subgingivally‐placed redox agent in a slow release device
Ower, P., Ciantar, M., Newman, H. N., Wilson, M., & Bulman, J. S. (1995) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1995.tb00184.x · Cited by 16 · see citing works
Homer, K. A., & Beighton, D. (1992) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1992.tb05163.x · Cited by 16 · see citing works
Homer, K. A. (1992) · FEMS Microbiology Letters · doi:10.1016/0378-1097(92)90657-a · Cited by 12 · see citing works
Microbial interactions on skin
Allaker, R. P., & Noble, W. C. (1993) · Cambridge University Press eBooks · doi:10.1017/cbo9780511527012.015 · Cited by 11 · see citing works
Consensus Statements on Fluoride Usage and Associated Research Questions
ten Cate, J. M. (2001) · Caries Research · doi:10.1159/000049115 · Cited by 11 · see citing works
The control of oral biofilms New approaches for the future
Marsh, P. (1998) · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Microbial interactions: from networks to models
Faust, K., & Raes, J. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2832 · Cited by 4,138 · see citing works
Microbiota in health and diseases
Hou, K., Wu, Z.-X., Chen, X.-Y., Wang, J.-Q., Zhang, D., Xiao, C., Zhu, D., Koya, J. B., Wei, L., Li, J., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00974-4 · Cited by 3,171 · see citing works
The Oral Microbiota: Dynamic Communities and Host Interactions
Lamont, R. J., Koo, H., & Hajishengallis, G. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0089-x · Cited by 2,217 · see citing works
Pitts, N. B., Zero, D. T., Marsh, P. D., Ekstrand, K., Weintraub, J. A., Ramos-Gomez, F., Tagami, J., Twetman, S., Tsakos, G., & Ismail, A. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.30 · Cited by 1,823 · see citing works
Self-citationOral multispecies biofilm development and the key role of cell–cell distance
Kolenbrander, P. E., Palmer, R. J., Periasamy, S., & Jakubovics, N. S. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2381 · Cited by 1,309 · see citing works
Hajishengallis, G., & Lamont, R. J. (2012) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2012.00663.x · Cited by 1,267 · see citing works
The role of bacterial biofilms in chronic infections
Bjarnsholt, T. (2013) · Apmis · doi:10.1111/apm.12099 · Cited by 1,213 · see citing works
Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response
Hajishengallis, G. (2014) · Trends in Immunology · doi:10.1016/j.it.2013.09.001 · Cited by 1,150 · see citing works
The oral microbiome – an update for oral healthcare professionals
Kilian, M., Chapple, I. L. C., Hannig, M., Marsh, P. D., Meuric, V., Pedersen, A. M. L., Tonetti, M. S., Wade, W. G., & Zaura, E. (2016) · British Dental Journal · doi:10.1038/sj.bdj.2016.865 · Cited by 1,269 · see citing works
Self-citationDental plaque as a biofilm and a microbial community—Implications for health and disease
Marsh, P. D. (2006) · BMC Oral Health · doi:10.1186/1472-6831-6-s1-s14 · Cited by 1,094 · see citing works
Self-citationGriffen, A. L., Beall, C. J., Campbell, J. H., Firestone, N. D., Kumar, P., Yang, Z. K., Podar, M., & Leys, E. J. (2011) · The ISME Journal · doi:10.1038/ismej.2011.191 · Cited by 1,006 · see citing works
Dental Plaque as a Microbial Biofilm
Marsh, P. D. (2004) · Caries Research · doi:10.1159/000077756 · Cited by 763 · see citing works
Self-citationMineral weathering by bacteria: ecology, actors and mechanisms
Uroz, S., Calvaruso, C., Turpault, M., & Frey‐Klett, P. (2009) · Trends in Microbiology · doi:10.1016/j.tim.2009.05.004 · Cited by 710 · see citing works
Molecular aspects of the pathogenesis of periodontitis
Meyle, J., & Chapple, I. (2015) · Periodontology 2000 · doi:10.1111/prd.12104 · Cited by 705 · see citing works
Pathogens and host immunity in the ancient human oral cavity
Warinner, C., Rodrigues, J. F. M., Vyas, R., Trachsel, C., Shved, N., Grossmann, J., Radini, A., Hancock, Y., Tito, R. Y., Fiddyment, S., et al. (2014) · Nature Genetics · doi:10.1038/ng.2906 · Cited by 618 · see citing works
The Role of Sucrose in Cariogenic Dental Biofilm Formation—New Insight
Leme, A. F. P., Koo, H., Bellato, C. M., Bedi, G. S., & Cury, J. A. (2006) · Journal of Dental Research · doi:10.1177/154405910608501002 · Cited by 635 · see citing works
Adler, C. J., Dobney, K., Weyrich, L. S., Kaidonis, J., Walker, A. W., Haak, W., Bradshaw, C. J. A., Townsend, G., Sołtysiak, A., Alt, K. W., et al. (2013) · Nature Genetics · doi:10.1038/ng.2536 · Cited by 621 · see citing works
The role of inflammation and genetics in periodontal disease
Loos, B. G., & Dyke, T. E. V. (2020) · Periodontology 2000 · doi:10.1111/prd.12297 · Cited by 637 · see citing works
Cullin, N., Azevedo Antunes, C., Straussman, R., Stein-Thoeringer, C. K., & Elinav, E. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.08.006 · Cited by 578 · see citing works
Biomedical applications of nisin
Shin, J. M., Gwak, J. W., Kamarajan, P., Fenno, J. C., Rickard, A. H., & Kapila, Y. L. (2016) · Journal of Applied Microbiology · doi:10.1111/jam.13033 · Cited by 607 · see citing works
Dental plaque: biological significance of a biofilm and community life‐style
Marsh, P. (2005) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2005.00790.x · Cited by 599 · see citing works
Self-citationCaries Ecology Revisited: Microbial Dynamics and the Caries Process
Takahashi, N., & Nyvad, B. (2008) · Caries Research · doi:10.1159/000159604 · Cited by 598 · see citing works
Falsetta, M. L., Klein, M. I., Colonne, P. M., Scott-Anne, K., Gregoire, S., Pai, C.-H., González–Begne, M., Watson, G. E., Krysan, D. J., Bowen, W. H., et al. (2014) · Infection and Immunity · doi:10.1128/iai.00087-14 · Cited by 564 · see citing works
Dental biofilm: ecological interactions in health and disease
Marsh, P., & Zaura, E. (2017) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12679 · Cited by 569 · see citing works
Self-citationOptimization of the ligature-induced periodontitis model in mice
Abe, T., & Hajishengallis, G. (2013) · Journal of Immunological Methods · doi:10.1016/j.jim.2013.05.002 · Cited by 550 · see citing works
Insights into the human oral microbiome
Verma, D., Garg, P. K., & Dubey, A. K. (2018) · Archives of Microbiology · doi:10.1007/s00203-018-1505-3 · Cited by 552 · see citing works
Disparities in Access to Oral Health Care
Northridge, M. E., Kumar, A., & Kaur, R. (2020) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-040119-094318 · Cited by 544 · see citing works
Periodontitis: a host‐mediated disruption of microbial homeostasis. Unlearning learned concepts
Bartold, P. M., & Dyke, T. E. V. (2013) · Periodontology 2000 · doi:10.1111/j.1600-0757.2012.00450.x · Cited by 540 · see citing works
Human Microbiome in Health and Disease
Pflughoeft, K. J., & Versalovic, J. A. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132421 · Cited by 528 · see citing works
Diet and Dental Caries: The Pivotal Role of Free Sugars Reemphasized
Sheiham, A., & James, W. P. T. (2015) · Journal of Dental Research · doi:10.1177/0022034515590377 · Cited by 520 · see citing works
Xiao, J., Klein, M. I., Falsetta, M. L., Lu, B., Delahunty, C. M., Yates, J. R., Heydorn, A., & Koo, H. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002623 · Cited by 514 · see citing works
Solving the etiology of dental caries
Simón‐Soro, Á., & Mira, Á. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.10.010 · Cited by 509 · see citing works
Gross, E. L., Beall, C. J., Kutsch, S. R., Firestone, N. D., Leys, E. J., & Griffen, A. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047722 · Cited by 508 · see citing works
Koo, H., Xiao, J., Klein, M. I., & Jeon, J. G. (2010) · Journal of Bacteriology · doi:10.1128/jb.01649-09 · Cited by 508 · see citing works
Bacterial interactions in dental biofilm
Huang, R., Li, M., & Gregory, R. L. (2011) · Virulence · doi:10.4161/viru.2.5.16140 · Cited by 493 · see citing works
Management of deep caries and the exposed pulp.
Bjørndal, L., Simon, S., Tomson, P., & Duncan, H. F. (2019) · International Endodontic Journal · doi:10.1111/iej.13128 · Cited by 444 · see citing works
The role of natural salivary defences in maintaining a healthy oral microbiota
Pedersen, A. M. L., & Belstrøm, D. (2019) · Journal of Dentistry · doi:10.1016/j.jdent.2018.08.010 · Cited by 496 · see citing works
The oralome and its dysbiosis: New insights into oral microbiome-host interactions
Radaic, A., & Kapila, Y. L. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.02.010 · Cited by 492 · see citing works
Streptococcus mutans, Caries and Simulation Models
Forssten, S. D., Björklund, M., & Ouwehand, A. C. (2010) · Nutrients · doi:10.3390/nu2030290 · Cited by 459 · see citing works
Kreth, J., Merritt, J. L., Shi, W., & Qi, F. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.21.7193-7203.2005 · Cited by 454 · see citing works
Dental plaque biofilms: communities, conflict and control
Marsh, P. D., Moter, A., & DeVine, D. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00339.x · Cited by 432 · see citing works
Self-citationResilience of the Oral Microbiota in Health: Mechanisms That Prevent Dysbiosis
Rosier, B. T., Marsh, P. D., & Mira, A. (2018) · Journal of Dental Research · doi:10.1177/0022034517742139 · Cited by 448 · see citing works
Self-citationThe inflammophilic character of the periodontitis-associated microbiota
Hajishengallis, G. (2014) · Molecular Oral Microbiology · doi:10.1111/omi.12065 · Cited by 407 · see citing works
Microbial signatures of health, gingivitis and periodontitis
Abusleme, L., Hoare, A., Hong, B., & Diaz, P. I. (2021) · Periodontology 2000 · doi:10.1111/prd.12362 · Cited by 400 · see citing works
Valm, A. M. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.05.016 · Cited by 425 · see citing works
Microbiology of Dental Plaque Biofilms and Their Role in Oral Health and Caries
Marsh, P. D. (2010) · Dental Clinics of North America · doi:10.1016/j.cden.2010.03.002 · Cited by 372 · see citing works
Self-citationOral Biofilms: Emerging Concepts in Microbial Ecology
Filoche, S. K., Wong, L., & Sissons, C. H. (2009) · Journal of Dental Research · doi:10.1177/0022034509351812 · Cited by 370 · see citing works
Saliva microbiomes distinguish caries-active from healthy human populations
Yang, F., Zeng, X., Ning, K., Liu, K.-L., Lo, C., Wang, W., Chen, J., Wang, D., Huang, R., Chang, X., et al. (2011) · The ISME Journal · doi:10.1038/ismej.2011.71 · Cited by 363 · see citing works
Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis
Abdulkareem, A. A., Al-Taweel, F. B. H., Al-Sharqi, A. J. B., Gul, S. S., Sha, A. M., & Chapple, I. (2023) · Journal of Oral Microbiology · doi:10.1080/20002297.2023.2197779 · Cited by 402 · see citing works
Newly Identified Pathogens Associated with Periodontitis
Pérez‐Chaparro, P. J., Gonçalves, C., Figueiredo, L. C., Faveri, M., Lobão, E., Tamashiro, N. S., Duarte, P., & Feres, M. (2014) · Journal of Dental Research · doi:10.1177/0022034514542468 · Cited by 357 · see citing works
Lessons learned and unlearned in periodontal microbiology
Teles, R. P., Teles, F., Frias‐Lopez, J., Paster, B. J., & Haffajee, A. D. (2013) · Periodontology 2000 · doi:10.1111/prd.12010 · Cited by 377 · see citing works
Streptococcus mutans-derived extracellular matrix in cariogenic oral biofilms
Klein, M. I., Hwang, G., Santos, P. H. S., Campanella, O. H., & Koo, H. (2015) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2015.00010 · Cited by 351 · see citing works
Understanding dental caries as a non-communicable disease
Pitts, N. B., Twetman, S., Fisher, J., & Marsh, P. D. (2021) · British Dental Journal · doi:10.1038/s41415-021-3775-4 · Cited by 346 · see citing works
Self-citationRedefining the Persistent Infection in Root Canals: Possible Role of Biofilm Communities
de Paz, L. C. (2007) · Journal of Endodontics · doi:10.1016/j.joen.2006.11.004 · Cited by 325 · see citing works
Natural Products in Caries Research: Current (Limited) Knowledge, Challenges and Future Perspective
Jeon, J., Rosalen, P. L., Falsetta, M. L., & Koo, H. (2011) · Caries Research · doi:10.1159/000327250 · Cited by 314 · see citing works
The Oral Microbiome in Health and Its Implication in Oral and Systemic Diseases
(2016) · Advances in Applied Microbiology · doi:10.1016/bs.aambs.2016.08.002 · Cited by 306 · see citing works
Oral Lactobacilli and Dental Caries
Caufield, P. W., Schön, C. N., Saraithong, P., Li, Y., & Argimón, S. (2015) · Journal of Dental Research · doi:10.1177/0022034515576052 · Cited by 286 · see citing works
Hajishengallis, G., & Lamont, R. J. (2021) · Periodontology 2000 · doi:10.1111/prd.12371 · Cited by 302 · see citing works
Acquiring and maintaining a normal oral microbiome: current perspective
Zaura, E., Nicu, E. A., Krom, B. P., & Keijser, B. J. F. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00085 · Cited by 284 · see citing works
Role of microbial communities in the pathogenesis of periodontal diseases and caries
Mira, Á., Simón‐Soro, Á., & Curtis, M. A. (2017) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12671 · Cited by 283 · see citing works
The subgingival microbiome of clinically healthy current and never smokers
Mason, M. R., Preshaw, P. M., Nagaraja, H. N., Dabdoub, S. M., Rahman, A., & Kumar, P. (2014) · The ISME Journal · doi:10.1038/ismej.2014.114 · Cited by 277 · see citing works
Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives
Salonen, A., de Vos, W. M., & Palva, A. (2010) · Microbiology · doi:10.1099/mic.0.043257-0 · Cited by 264 · see citing works
How is the development of dental biofilms influenced by the host?
Marsh, P. D., & DeVine, D. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01673.x · Cited by 268 · see citing works
Self-citationBiofilms, a new approach to the microbiology of dental plaque
ten Cate, J. M. (2006) · Odontology · doi:10.1007/s10266-006-0063-3 · Cited by 264 · see citing works
Biofilm in endodontics: A review
Jhajharia, K., Parolia, A., Shetty, K., & Mehta, L. K. (2015) · Journal of International Society of Preventive and Community Dentistry · doi:10.4103/2231-0762.151956 · Cited by 262 · see citing works
Controlling the oral biofilm with antimicrobials
Marsh, P. (2010) · Journal of Dentistry · doi:10.1016/s0300-5712(10)70005-1 · Cited by 253 · see citing works
Self-citationIntrinsic apoptotic pathways of gingival epithelial cells modulated by Porphyromonas gingivalis
Mao, S., Park, Y., Hasegawa, Y., Tribble, G. D., James, C. E., Handfield, M., Stavropoulos, M. F., Yilmaz, Ö., & Lamont, R. J. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00931.x · Cited by 246 · see citing works
Haukioja, A. (2010) · European Journal of Dentistry · doi:10.1055/s-0039-1697851 · Cited by 239 · see citing works
Bacterial invasion of epithelial cells and spreading in periodontal tissue
Tribble, G. D., & Lamont, R. J. (2009) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00323.x · Cited by 229 · see citing works
Biofilms in endodontic infections
Svensäter, G., & Bergenholtz, G. (2004) · Endodontic Topics · doi:10.1111/j.1601-1546.2004.00112.x · Cited by 228 · see citing works
Host modulation: controlling the inflammation to control the infection
Bartold, P. M., & Dyke, T. E. V. (2017) · Periodontology 2000 · doi:10.1111/prd.12169 · Cited by 231 · see citing works
Responses of Cariogenic Streptococci to Environmental Stresses
Lemos, J. A. C., Abranches, J., & Burne, R. A. (2005) · Current Issues in Molecular Biology · doi:10.21775/cimb.007.095 · Cited by 221 · see citing works
The Microbiome in Populations with a Low and High Prevalence of Caries
Johansson, I., Witkowska, E., Kaveh, B., Holgerson, P. L., & Tanner, A. C. R. (2015) · Journal of Dental Research · doi:10.1177/0022034515609554 · Cited by 227 · see citing works
Composition and development of oral bacterial communities
Palmer, R. J., Jr. (2013) · Periodontology 2000 · doi:10.1111/j.1600-0757.2012.00453.x · Cited by 222 · see citing works
In Sickness and in Health—What Does the Oral Microbiome Mean to Us? An Ecological Perspective
Marsh, P. (2018) · Advances in Dental Research · doi:10.1177/0022034517735295 · Cited by 219 · see citing works
Self-citationIntegrated hypothesis of dental caries and periodontal diseases
Nyvad, B., & Takahashi, N. (2020) · Journal of Oral Microbiology · doi:10.1080/20002297.2019.1710953 · Cited by 227 · see citing works
Biofilms 2003: Emerging Themes and Challenges in Studies of Surface-Associated Microbial Life
Parsek, M. R., & Fuqua, C. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.14.4427-4440.2004 · Cited by 216 · see citing works
Microbiological and immuno-pathological aspects of peri-implant diseases
Belibasakis, G. N. (2013) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2013.09.013 · Cited by 217 · see citing works
Host Genetic Control of the Oral Microbiome in Health and Disease
Gomez, A. M., Espinoza, J. L., Harkins, D. M., Leong, P., Saffery, R., Bockmann, M. R., Torralba, M., Kuelbs, C., Kodukula, R., Inman, J. M., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.08.013 · Cited by 213 · see citing works
Ecological Approaches to Oral Biofilms: Control without Killing
Marsh, P. D., Head, D. A., & DeVine, D. (2015) · Caries Research · doi:10.1159/000377732 · Cited by 209 · see citing works
Self-citationChronic Inflammation as a Link between Periodontitis and Carcinogenesis
Hoare, A., Soto, C., Rojas-Celis, V., & Bravo, D. (2019) · Mediators of Inflammation · doi:10.1155/2019/1029857 · Cited by 213 · see citing works
Malic, S., Hill, K. E., Hayes, A. J., Percival, S. L., Thomas, D. W., & Williams, D. W. (2009) · Microbiology · doi:10.1099/mic.0.028712-0 · Cited by 206 · see citing works
Endpoints of active periodontal therapy
Loos, B., & Needleman, I. (2020) · Journal of Clinical Periodontology · doi:10.1111/jcpe.13253 · Cited by 182 · see citing works
Historical and contemporary hypotheses on the development of oral diseases: are we there yet?
Rosier, B. T., de Jager, M., Zaura, E., & Krom, B. P. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00092 · Cited by 199 · see citing works
Burton, J. P., Drummond, B. K., Chilcott, C. N., Tagg, J. R., Thomson, W. M., Hale, J. D. F., & Wescombe, P. A. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.056663-0 · Cited by 199 · see citing works
New developments in neutrophil biology and periodontitis
Hajishengallis, G. (2019) · Periodontology 2000 · doi:10.1111/prd.12313 · Cited by 198 · see citing works
Zhang, Q., Ma, Q., Wang, Y., Wu, H., & Zou, J. (2021) · International Journal of Oral Science · doi:10.1038/s41368-021-00137-1 · Cited by 198 · see citing works
Uroz, S., Kelly, L., Turpault, M., Lepleux, C., & Frey‐Klett, P. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.10.004 · Cited by 191 · see citing works
Gregoire, S., Xiao, J., Bueno‐Silva, B., Gonzalez, I., Agidi, P. S., Klein, M. I., Ambatipudi, K., Rosalen, P. L., Bauserman, R. G., Waugh, R. E., et al. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.05203-11 · Cited by 190 · see citing works
Khadka, S., Khan, S., King, A. I. I., Goldberg, L., Crocombe, L., & Bettiol, S. (2020) · Age and Ageing · doi:10.1093/ageing/afaa102 · Cited by 176 · see citing works
Xu, X., Zhou, X., & Wu, C. D. (2011) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2011.10.021 · Cited by 184 · see citing works
The Importance of Nitrate Reduction for Oral Health
Rosier, B. T., Takahashi, N., Zaura, E., Krom, B. P., MartÍnez-Espinosa, R. M., van Breda, S. G. J., Marsh, P. D., & Mira, A. (2022) · Journal of Dental Research · doi:10.1177/00220345221080982 · Cited by 175 · see citing works
Self-citationMicrobiology of aggressive periodontitis
Könönen, E., & Müller, H. (2014) · Periodontology 2000 · doi:10.1111/prd.12016 · Cited by 178 · see citing works
Koo, H., Duarte, S., Murata, R. M., Scott‐Anne, K., Gregoire, S., Watson, G. E., Singh, A. P., & Vorsa, N. (2010) · Caries Research · doi:10.1159/000296306 · Cited by 176 · see citing works
Siqueira, J. F., Jr., & Rôças, I. N. (2009) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2009.01.044 · Cited by 176 · see citing works
The Oral Microbiome of Children: Development, Disease, and Implications Beyond Oral Health
Gomez, A., & Nelson, K. E. (2017) · Microbial Ecology · doi:10.1007/s00248-016-0854-1 · Cited by 175 · see citing works
Life as an endodontic pathogen
Sundqvist, G., & Figdor, D. (2003) · Endodontic Topics · doi:10.1111/j.1601-1546.2003.00054.x · Cited by 175 · see citing works
Porphyromonas gingivalis disturbs host–commensal homeostasis by changing complement function
Olsen, I., Lambris, J. D., & Hajishengallis, G. (2017) · Journal of Oral Microbiology · doi:10.1080/20002297.2017.1340085 · Cited by 175 · see citing works
Resolvin E1 Reverses Experimental Periodontitis and Dysbiosis
Lee, C.-T., Teles, R. P., Kantarcı, A., Chen, T., McCafferty, J., Starr, J. R., Brito, L. C. N., Paster, B. J., & Dyke, T. E. V. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600859 · Cited by 173 · see citing works
Metatranscriptomics reveals overall active bacterial composition in caries lesions
Simón‐Soro, Á., Navarro, M. G., & Mira, Á. (2014) · Journal of Oral Microbiology · doi:10.3402/jom.v6.25443 · Cited by 170 · see citing works
- Authors
- Marsh, P. D.
- Affiliations
- Research Division, Centre for Applied Microbiology and Research, Salisbury SP4 0JG, and Division of Oral Biology, Leeds Dental Institute, Clarendon Way, Leeds LS2 9LU, UK
- Corresponding author
- Marsh, P. D.
- ORCID
- Marsh, P. D.
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 2003-02-01
- Volume
- 149
- Issue
- 2
- Pages
- 279-294
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2098976315
- Cited by
- 1,256
- References
- 105
- Citations by year
- 2026: 40 · 2025: 54 · 2024: 56 · 2023: 50 · 2022: 74 · 2021: 79 · 2020: 63 · 2019: 76 · 2018: 58 · 2017: 76 · 2016: 75 · 2015: 81 · 2014: 83 · 2013: 57 · 2012: 54
- FWCI
- 24.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Keywords
- dental plaque, oral microbiota, dental caries, periodontal disease, mutans streptococci, lactobacilli, Gram-negative anaerobic bacteria, acidogenic bacteria, microbial community dynamics, disease prevention, oral microbiology
- MeSH terms
- Bacteria, Anaerobic, Dental Plaque, Gram-Negative Anaerobic Bacteria, Gram-Positive Bacteria, Homeostasis, Humans, Mouth, Periodontal Diseases, Tooth Diseases, Ecosystem
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
