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Principles of fluoride toxicity and the cellular response: a review
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“and F− concentrations are higher still in areas affected by industrial pollution or by use of fluoride-contaminated fertilizers; and in niches such as the oral microbiome, where exposure to fluoride for dental hygiene – the concentration of fluoride ion is ~70 mM in toothpaste – is routine(4, 8).”
From Membrane exporters of fluoride ion (2021) · cites this paper as [8]
In the citing paper
“some reports indicate that HF hydrolyzes to H+ + F− upon the acid form is transported to the cytoplasm, thereby decreasing the intracellular pH and mediating acid stress due to the resulting HF ↔ H+ + F− equilibrium (Johnston & Strobel, 2020).”
From Role of the CrcB transporter of Pseudomonas putida in the multi‐level stress response elicited by mineral fluoride (2022) · cites this paper as Johnston & Strobel, 2020
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“Several of these enzymes require Mg2+ and Mn2+ for their activity, and it has been shown that F− sequesters the cofactors and impairs enzyme activity in a rather unspecific fashion (Adamek et al., 2005; Johnston & Strobel, 2020).”
From Role of the CrcB transporter of Pseudomonas putida in the multi‐level stress response elicited by mineral fluoride (2022) · cites this paper as Johnston & Strobel, 2020
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“In some areas, human activity further increases ambient F− concentrations over environmental levels.”
From Membrane exporters of fluoride ion (2021) · cites this paper as [8]
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Tan, D., Xu, B., Zhou, X., & Reiter, R. (2018) · Molecules · doi:10.3390/molecules23020301 · Cited by 220
Acidification of blood is superior to sodium fluoride alone as an inhibitor of glycolysis
Gambino, R., Piscitelli, J., Ackattupathil, T. A., Theriault, J. L., Andrin, R. D., Sanfilippo, M. L., & Etienne, M. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.121707 · Cited by 160
Bacterial fluoride resistance, Fluc channels, and the weak acid accumulation effect
Ji, C., Stockbridge, R. B., & Miller, C. (2014) · Journal of General Physiology · doi:10.1085/jgp.201411243 · Cited by 97
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Metadata
- Authors
- Johnston, N. R., & Strobel, S. A.
- ORCID
- Johnston, Nichole R.
- Venue
- Archives of Toxicology
- Published
- 2020-03-09
- Volume
- 94
- Issue
- 4
- Pages
- 1051-1069
- ISSN
- 0340-5761
- 1432-0738
- PMC
- PMC7230026
- Cited by
- 356
- References
- 3
- Language
- en
- Funders
- National Institutes of Health (Chemical Biology Interface training grant)
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