Glucocorticoid-Induced Skeletal Muscle Atrophy

mTOR Signaling in Growth Control and Disease

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Identification of ubiquitin ligases required for skeletal muscle atrophy.

Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521 · see citing works

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00400-3 · Cited by 3,012 · see citing works

Double muscling in cattle due to mutations in the myostatin gene

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Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways

Rommel, C., Bodine, S. C., Clarke, B. A., Rossman, R., Nunez, L., Stitt, T. N., Yancopoulos, G. D., & Glass, D. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1009 · Cited by 1,583 · see citing works

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

Lecker, S. H., Jagoe, R. T., Gilbert, A., Gomes, M., Baracos, V., Bailey, J., Price, S. R., Mitch, W. E., & Goldberg, A. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-0610com · Cited by 1,539 · see citing works

Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway

Mitch, W. E., & Goldberg, A. L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612193352507 · Cited by 1,163 · see citing works

Growth Hormone and the Insulin-Like Growth Factor System in Myogenesis*

Florini, J. R., Ewton, D. Z., & Coolican, S. A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-5-481 · Cited by 1,092 · see citing works

Myostatin, a Negative Regulator of Muscle Growth, Functions by Inhibiting Myoblast Proliferation

Thomas, M., Langley, B., Berry, C., Sharma, M., Kirk, S., Bass, J., & Kambadur, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004356200 · Cited by 1,014 · see citing works

Myostatin negatively regulates satellite cell activation and self-renewal

McCroskery, S., Thomas, M., Maxwell, L., Sharma, M., & Kambadur, R. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207056 · Cited by 784 · see citing works

Muscle Protein Breakdown and the Critical Role of the Ubiquitin-Proteasome Pathway in Normal and Disease States

Lecker, S. H., Solomon, V., Mitch, W. E., & Goldberg, A. L. (1999) · Journal of Nutrition · doi:10.1093/jn/129.1.227s · Cited by 732 · see citing works

Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions

Du, J., Wang, X., Miereles, C., Bailey, J. L., Debigaré, R., Zheng, B., Price, S. R., & Mitch, W. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18330 · Cited by 730 · see citing works

The E3 Ligase MuRF1 Degrades Myosin Heavy Chain Protein in Dexamethasone-Treated Skeletal Muscle

Clarke, B. A., Drujan, D., Willis, M. S., Murphy, L. O., Corpina, R. A., Burova, E., Rakhilin, S. V., Stitt, T. N., Patterson, C., Latres, E., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.009 · Cited by 683 · see citing works

Signaling Pathways and Molecular Mechanisms through which Branched-Chain Amino Acids Mediate Translational Control of Protein Synthesis

Kimball, S. R., & Jefferson, L. S. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.227s · Cited by 637 · see citing works

IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1

Sacheck, J. M., Ohtsuka, A., McLary, S. C., & Goldberg, A. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00073.2004 · Cited by 606 · see citing works

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

Cohen, S., Brault, J. J., Gygi, S. P., Glass, D. J., Valenzuela, D. M., Gartner, C. A., Latres, E., & Goldberg, A. L. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200901052 · Cited by 584 · see citing works

Skeletal Muscle FOXO1 (FKHR) Transgenic Mice Have Less Skeletal Muscle Mass, Down-regulated Type I (Slow Twitch/Red Muscle) Fiber Genes, and Impaired Glycemic Control

Kamei, Y., Miura, S., SUZUKI, M. T., Kai, Y., Mizukami, J., Taniguchi, T., Mochida, K., Tomoko, H. A. T. A., Matsuda, J., Aburatani, H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400674200 · Cited by 574 · see citing works

Growth hormone and the insulin-like growth factor system in myogenesis

Florini, J. R. (1996) · Endocrine Reviews · doi:10.1210/er.17.5.481 · Cited by 536 · see citing works

Testosterone administration to older men improves muscle function: molecular and physiological mechanisms

Ferrando, A. A., Sheffield-Moore, M., Yeckel, C. W., Gilkison, C., Jiang, J., Achacosa, A., Lieberman, S. A., Tipton, K., Wolfe, R. R., & Urban, R. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00362.2001 · Cited by 522 · see citing works

Insulin-like Growth Factor-1 (IGF-1) Inversely Regulates Atrophy-induced Genes via the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Pathway*

Latres, E., Amini, A. R., Amini, A. A., Griffiths, J. S., Martin, F. J., Wei, Y., Lin, H. C., Yancopouloš, G., & Glass, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m407517200 · Cited by 514 · see citing works

Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle

Shimizu, N., Yoshikawa, N., Ito, N., Maruyama, T., Suzuki, Y., Takeda, S.-I., Nakae, J., Tagata, Y., Nishitani, S., Takehana, K., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.001 · Cited by 498 · see citing works

Corticosteroids Contribute to Muscle Weakness in Chronic Airflow Obstruction

Decramer, M., Lacquet, L. M., Fagard, R., & Rogiers, P. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.1.8025735 · Cited by 481 · see citing works

Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF‐κB‐independent, FoxO1‐dependent mechanism

McFarlane, C., Plummer, E., Thomas, M., Hennebry, A., Ashby, M. G., Ling, N., Smith, H., Sharma, M., & Kambadur, R. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20757 · Cited by 480 · see citing works

Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression

Ma, K., Mallidis, C., Bhasin, S., Mahabadi, V., Artaza, J., González-Cadavid, N. F., Arias, J., & Salehian, B. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00487.2002 · Cited by 416 · see citing works

Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells

Taylor, W. E., Bhasin, S., Artaza, J., Byhower, F., Azam, M., Willard, D. H., Kull, F. C., & González-Cadavid, N. F. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e221 · Cited by 410 · see citing works

The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene

Waddell, D. S., Baehr, L. M., van den Brandt, J., Johnsen, S. A., Reichardt, H. M., Furlow, J. D., & Bodine, S. C. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00646.2007 · Cited by 360 · see citing works

Glucocorticoids activate the ATP-ubiquitin-dependent proteolytic system in skeletal muscle during fasting

Wing, S. S., & Goldberg, A. L. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.4.e668 · Cited by 345 · see citing works

Interaction and functional collaboration of p300 and C/EBPβ

Mink, S., Haenig, B., & Klempnauer, K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6609 · Cited by 344 · see citing works

Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin

Reisz‐Porszasz, S., Bhasin, S., Artaza, J. N., Shen, R., Sinha‐Hikim, I., Hogue, A., Fielder, T. J., & González-Cadavid, N. F. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00107.2003 · Cited by 333 · see citing works

Regulation of Muscle Protein Degradation

Lee, S. W., Dai, G., Hu, Z., Wang, X., Du, J., & Mitch, W. E. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000127211.86206.e1 · Cited by 324 · see citing works

Glucocorticoids and muscle catabolism

Hasselgren, P.-O. (1999) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-199905000-00002 · Cited by 297 · see citing works

Effect of glucocorticoid administration on the rate of muscle protein breakdown in vivo in rats, as measured by urinary excretion of Nτ-methylhistidine

Tomas, F. M., Munro, H. N., & Young, V. R. (1979) · Biochemical Journal · doi:10.1042/bj1780139 · Cited by 293 · see citing works

Down-Regulation of Akt/Mammalian Target of Rapamycin Signaling Pathway in Response to Myostatin Overexpression in Skeletal Muscle

Amirouche, A., Durieux, A., Banzet, S., Koulmann, N., Bonnefoy, R., Mouret, C., Bigard, X. A., Peinnequin, A., & Freyssenet, D. G. (2008) · Endocrinology · doi:10.1210/en.2008-0959 · Cited by 282 · see citing works

Muscle Cachexia: Current Concepts of Intracellular Mechanisms and Molecular Regulation

Hasselgren, P.-O., & Fischer, J. E. (2001) · Annals of Surgery · doi:10.1097/00000658-200101000-00003 · Cited by 278 · see citing works

Myostatin Gene Deletion Prevents Glucocorticoid-Induced Muscle Atrophy

Gilson, H., Schakman, O., Combaret, L., Lause, P., Grobet, L., Attaix, D., Ketelslegers, J., & Thissen, J. (2006) · Endocrinology · doi:10.1210/en.2006-0539 · Cited by 278 · see citing works

Dexamethasone Represses Signaling through the Mammalian Target of Rapamycin in Muscle Cells by Enhancing Expression of REDD1

Wang, H., Kubica, N., Ellisen, L. W., Jefferson, L. S., & Kimball, S. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610023200 · Cited by 262 · see citing works

Hormonal regulation of protein degradation and synthesis in skeletal muscle.

Goldberg, A. L., Tischler, M., Demartino, G., & Griffin, G. E. (1980) · PubMed · Cited by 253 · see citing works

Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.

Tiao, G. M., Fagan, J. M., Roegner, V., Lieberman, M. A., Wang, J. J., Fischer, J. E., & Hasselgren, P. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118421 · Cited by 248 · see citing works

Randomized Placebo-Controlled Trial of Androgen Effects on Muscle and Bone in Men Requiring Long-Term Systemic Glucocorticoid Treatment

Crawford, B. A. L., Liu, P. Y., Kean, M. T., Bleasel, J. F., & Handelsman, D. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021827 · Cited by 235 · see citing works

Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids

Baehr, L. M., Furlow, J. D., & Bodine, S. C. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.212845 · Cited by 234 · see citing works

Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice

Mavalli, M. D., DiGirolamo, D. J., Fan, Y., Riddle, R. C., Campbell, K. S., van Groen, T., Frank, S. J., Sperling, M. A., Esser, K. A., Bamman, M. M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42447 · Cited by 213 · see citing works

Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic–pituitary–adrenal axis

Braun, T. P., Zhu, X., Szumowski, M., Scott, G. D., Grossberg, A. J., Levasseur, P. R., Graham, K., Khan, S., Damaraju, S., Colmers, W. F., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20111020 · Cited by 213 · see citing works

Characterization of 5′-regulatory region of human myostatin gene: regulation by dexamethasone in vitro

Ma, K., Mallidis, C., Artaza, J., Taylor, W. E., González-Cadavid, N. F., & Bhasin, S. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.6.e1128 · Cited by 208 · see citing works

Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice

Hu, Z., Wang, H., Lee, I. H., Du, J., & Mitch, W. E. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38770 · Cited by 205 · see citing works

CORTICOSTEROID MYOPATHY: A CLINICAL AND PATHOLOGICAL STUDY

Khaleeli, A. A., Edwards, R. H. T., Gohil, K., McPhail, G., Rennie, M. J., Round, J. M., & Ross, E. J. (1983) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1983.tb03198.x · Cited by 190 · see citing works

Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice

Porporato, P. E., Filigheddu, N., Reano, S., Ferrara, M., Angelino, E., Gnocchi, V. F., Prodam, F., Ronchi, G., Fagoonee, S., Fornaro, M., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci39920 · Cited by 190 · see citing works

Ubiquitin Ligase Cbl-b Is a Negative Regulator for Insulin-Like Growth Factor 1 Signaling during Muscle Atrophy Caused by Unloading

Nakao, R., Hirasaka, K., Goto, J., Ishidoh, K., Yamada, C., Ohno, A., Okumura, Y., Nonaka, I., Yasutomo, K., Baldwin, K. M., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01347-08 · Cited by 188 · see citing works

Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting

Deval, C., Mordier, S. B., Obled, C., Béchet, D., Combaret, L., Attaix, D., & Ferrara, M. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3600143 · Cited by 184 · see citing works

Modulating skeletal muscle mass by postnatal, muscle‐specific inactivation of the myostatin gene

Grobet, L., Pirottin, D., Farnir, F., Poncelet, D. A., Royo, L. J., Brouwers, B., Christians, E., Desmecht, D. J.-M., Coignoul, F. L., Kahn, R., et al. (2003) · genesis · doi:10.1002/gene.10188 · Cited by 182 · see citing works

Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol

Kline, W. O., Panaro, F. J., Yang, H., & Bodine, S. C. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00873.2006 · Cited by 177 · see citing works

11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle

Morgan, S., Sherlock, M., Gathercole, L., Lavery, G. G., Lenaghan, C., Bujalska, I. J., Laber, D., Yu, A., Convey, G., Mayers, R. M., et al. (2009) · Diabetes · doi:10.2337/db09-0525 · Cited by 165 · see citing works

Role of leucine in the regulation of mTOR by amino acids: revelations from structure-activity studies.

Lynch, C. J. (2001) · Journal of NutriLife · doi:10.1093/jn/131.3.861s · Cited by 163 · see citing works

Ectopic Expression of Myostatin Induces Atrophy of Adult Skeletal Muscle by Decreasing Muscle Gene Expression

Durieux, A., Amirouche, A., Banzet, S., Koulmann, N., Bonnefoy, R., Pasdeloup, M., Mouret, C., Bigard, X. A., Peinnequin, A., & Freyssenet, D. G. (2007) · Endocrinology · doi:10.1210/en.2006-1500 · Cited by 162 · see citing works

Randomized, blinded trial of weekend vs daily prednisone in Duchenne muscular dystrophy

Escolar, D. M., Hache, L. P., Clemens, P. R., Cnaan, A., McDonald, C. M., Viswanathan, V., Kornberg, A. J., Bertoríni, T. E., Nevo, Y., Lotze, T. E., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e318227b164 · Cited by 161 · see citing works

GSK-3β negatively regulates skeletal myotube hypertrophy

Vyas, D. R., Spangenburg, E. E., Abraha, T. W., Childs, T. E., & Booth, F. W. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00049.2002 · Cited by 149 · see citing works

Role of the Insulin-Like Growth Factor I Decline in the Induction of Atrogin-1/MAFbx during Fasting and Diabetes

Dehoux, M., Beneden, R. V., Pasko, N., Lause, P., Verniers, J., Underwood, L. E., Ketelslegers, J., & Thissen, J. (2004) · Endocrinology · doi:10.1210/en.2004-0406 · Cited by 147 · see citing works

Muscle actin is polyubiquitinylated in vitro and in vivo and targeted for breakdown by the E3 ligase MuRF1

Polge, C., Heng, A.-É., Jarzaguet, M., Ventadour, S., Claustre, A., Combaret, L., Béchet, D., Matondo, M., Uttenweiler‐Joseph, S., Monsarrat, B., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-180968 · Cited by 146 · see citing works

Genome-wide analysis of glucocorticoid receptor-binding sites in myotubes identifies gene networks modulating insulin signaling

Kuo, T., Lew, M. J., Mayba, O., Harris, C. A., Speed, T. P., & Wang, J.-C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111334109 · Cited by 146 · see citing works

FOXO3a mediates signaling crosstalk that coordinates ubiquitin and atrogin-1/MAFbx expression during glucocorticoid-induced skeletal muscle atrophy

Zheng, B., Ohkawa, S., Li, H., Roberts‐Wilson, T. K., & Price, S. R. (2010) · The FASEB Journal · doi:10.1096/fj.09-151480 · Cited by 145 · see citing works

Effects of high doses of glucocorticoids on free amino acids, ribosomes and protein turnover in human muscle

Löfberg, E., Gutiérrez, A., Wernerman, J., Anderstam, B., Mitch, W. E., Price, S. R., Bergström, J. P., & Alvestrand, A. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.00993.x · Cited by 142 · see citing works

Increased IGF mRNA in Human Skeletal Muscle after Creatine Supplementation

DELDICQUE, L., LOUIS, M., THEISEN, D., NIELENS, H., DEHOUX, M., THISSEN, J.-P., RENNIE, M. J., & FRANCAUX, M. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000162690.39830.27 · Cited by 141 · see citing works

The Coactivator p300 Directly Acetylates the Forkhead Transcription Factor Foxo1 and Stimulates Foxo1-Induced Transcription

Perrot, V., & Rechler, M. M. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0292 · Cited by 127 · see citing works

Acute attenuation of translation initiation and protein synthesis by glucocorticoids in skeletal muscle

Shah, O. J., Kimball, S. R., & Jefferson, L. S. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.1.e76 · Cited by 127 · see citing works

Recruitment of p300 by C/EBPβ triggers phosphorylation of p300 and modulates coactivator activity

Schwartz, C., Schachtrup, K., Mink, S., Schmolke, M., Budde, B., Wenning, D., & Klempnauer, K.-H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg076 · Cited by 122 · see citing works

Muscle-specific MicroRNA1 (miR1) Targets Heat Shock Protein 70 (HSP70) during Dexamethasone-mediated Atrophy*

Kukreti, H., Amuthavalli, K., Harikumar, A., Sathiyamoorthy, S., Feng, P. Z., Anantharaj, R., Tan, S. L. K., Lokireddy, S., Bonala, S., Sriram, S., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.390369 · Cited by 121 · see citing works

The Orphan Nuclear Receptor, NOR-1, Is a Target of β-Adrenergic Signaling in Skeletal Muscle

Pearen, M. A., Ryall, J. G., Maxwell, M., Ohkura, N., Lynch, G. S., & Muscat, G. E. O. (2006) · Endocrinology · doi:10.1210/en.2006-0447 · Cited by 120 · see citing works

A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure

Watson, M. L., Baehr, L. M., Reichardt, H. M., Tuckermann, J. P., Bodine, S. C., & Furlow, J. D. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00512.2011 · Cited by 120 · see citing works

Identification of Androgen Response Elements in the Insulin-Like Growth Factor I Upstream Promoter

Wu, Y., Zhao, W., Zhao, J., Pan, J., Wu, Q., Zhang, Y., Bauman, W. A., & Cardozo, C. P. (2007) · Endocrinology · doi:10.1210/en.2006-1653 · Cited by 117 · see citing works

Glycogen synthase kinase-3 is the predominant insulin-regulated eukaryotic initiation factor 2B kinase in skeletal muscle

Jefferson, L. S., Fabian, J. R., & Kimball, S. R. (1999) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(98)00141-1 · Cited by 116 · see citing works

Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cells

Artaza, J. N., Bhasin, S., Mallidis, C., Taylor, W. E., Ma, K., & González-Cadavid, N. F. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10044 · Cited by 115 · see citing works

The deleterious effects of bed rest on human skeletal muscle fibers are exacerbated by hypercortisolemia and ameliorated by dietary supplementation

Fitts, R. H., Romatowski, J. G., Peters, J., Paddon‐Jones, D., Wolfe, R. R., & Ferrando, A. A. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00573.2006 · Cited by 113 · see citing works

Posttranscriptional mechanisms involving microRNA-27a and b contribute to fast-specific and glucocorticoid-mediated myostatin expression in skeletal muscle

Allen, D. L., & Loh, A. S. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00142.2010 · Cited by 111 · see citing works

Differential regulation of cyclooxygenase-2 (COX-2) mRNA stability by interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in human in vitro differentiated macrophages

Huang, Z.-F., Massey, J. B., & Via, D. P. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00312-3 · Cited by 110 · see citing works

Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16

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p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle

Judge, S. M., Sandesara, P. B., Reed, S. A., & Judge, A. R. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00255.2010 · Cited by 108 · see citing works

Inhibition of glycogen synthase kinase-3β activity is sufficient to stimulate myogenic differentiation

van der Velden, J. L. J., LANGEN, R. C. J., KELDERS, M. C. J. M., Wouters, E. F. �., Janssen-Heininger, Y. M. W., & Schols, A. M. W. J. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00068.2005 · Cited by 105 · see citing works

Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats

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Myofibrillar protein synthesis in myostatin-deficient mice.

Welle, S., Bhatt, K., & Pinkert, C. (2006) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00433.2005 · Cited by 104 · see citing works

USP19 is a ubiquitin-specific protease regulated in rat skeletal muscle during catabolic states

Combaret, L., Adegoke, O. A. J., Bedard, N., Baracos, V. E., Attaix, D., & Wing, S. S. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00281.2004 · Cited by 104 · see citing works

Acute Treatment with Corticosteroids Decreases IGF-1 and IGF-2 Expression in the Rat Diaphragm and Gastrocnemius

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Monotropein Improves Dexamethasone-Induced Muscle Atrophy via the AKT/mTOR/FOXO3a Signaling Pathways

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Glucocorticoid Excess in Bone and Muscle

Sato, A. Y., Peacock, M., & Bellido, T. (2018) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-018-9242-3 · Cited by 48 · see citing works

Sex Difference in Corticosterone-Induced Insulin Resistance in Mice

Kaikaew, K., Steenbergen, J., van Dijk, T. H., Grefhorst, A., & Visser, J. A. (2019) · Endocrinology · doi:10.1210/en.2019-00194 · Cited by 50 · see citing works

Natural and synthetic compounds as dissociated agonists of glucocorticoid receptor

Zhang, T., Liang, Y., & Zhang, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104802 · Cited by 49 · see citing works

FGF-2 targets sclerostin in bone and myostatin in skeletal muscle to mitigate the deleterious effects of glucocorticoid on musculoskeletal degradation

Adhikary, S., Choudhary, D., Tripathi, A. K., Karvande, A., Ahmad, N., Kothari, P., & Trivedi, R. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.05.022 · Cited by 47 · see citing works

Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs

Rodgers, B. D., & Ward, C. W. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab030 · Cited by 111 · see citing works

Acute Sarcopenia: Mechanisms and Management

Damanti, S., Senini, E., LORENZO, R. D., Merolla, A., Santoro, S., Festorazzi, C., Messina, M., Vitali, G., Sciorati, C., & Rovere, P. Q. (2024) · Nutrients · doi:10.3390/nu16203428 · Cited by 50 · see citing works

Mechanisms of Muscle Atrophy Induced by Glucocorticoids

Schakman, O., Gilson, H., Kalista, S., & Thissen, J. (2009) · Hormone Research in Paediatrics · doi:10.1159/000229762 · Cited by 134 · see citing works

Mechanisms of glucocorticoid-induced myopathy

Schakman, O., Gilson, H., & Thissen, J. P. (2008) · Journal of Endocrinology · doi:10.1677/joe-07-0606 · Cited by 521 · see citing works

Glucocorticoid-Induced Muscle Atrophy: Insights And Therapies

Uchechukwu, O., Obinna, N. T., Anayo, O. V., & Onyekachi, O. L. (2026) · Japan Journal of Research · doi:10.33425/2690-8077.1237

Glucocorticoid-Mediated Skeletal Muscle Atrophy: Molecular Mechanisms and Potential Therapeutic Targets

Permpoon, U., Moon, J., Kim, C. Y., & Nam, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157616 · Cited by 52 · see citing works

Role of glucocorticoids in the molecular regulation of muscle wasting

Menconi, M. J., Fareed, M. U., O’Neal, P., Poylin, V. Y., Wei, W., & Hasselgren, P. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000279194.11328.77 · Cited by 115 · see citing works