The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
Serine in plants: biosynthesis, metabolism, and functions
Abstract
Serine (Ser) has a fundamental role in metabolism and signaling in living organisms. In plants, the existence of different pathways of Ser biosynthesis has complicated our understanding of this amino acid homeostasis. The photorespiratory glycolate pathway has been considered to be of major importance, whereas the nonphotorespiratory phosphorylated pathway has been relatively neglected. Recent advances indicate that the phosphorylated pathway has an important function in plant metabolism and development. Plants deficient in this pathway display developmental defects in embryos, male gametophytes, and roots. We propose that the phosphorylated pathway is more important than was initially thought because it is the only Ser source for specific cell types involved in developmental events. Here, we discuss its importance as a link between metabolism and development in plants.
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“Banana peel is a cheap source of starch, crude lipids, proteins, dietary fibers and polyunsaturated fatty acids, especially linoleic and alpha-linolenic acid, pectin, minerals and essential amino acids (Table 1).”
From Functional, nutritional and medicinal potential of banana peel (2023) · cites this paper as [31]
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Cites
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
Possemato, R., Marks, K. M., Shaul, Y. D., Pacold, M. E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.-K., Jang, H. G., Jha, A. K., et al. (2011) · Nature · doi:10.1038/nature10350 · Cited by 1,683
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.
Mothet, J., Parent, A., Wolosker, H., Brady, R., Linden, D. J., Ferris, C., Rogawski, M., & Snyder, S. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.97.9.4926 · Cited by 1,164
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
Locasale, J. W., Grassian, A. R., Melman, T., Lyssiotis, C. A., Mattaini, K. R., Bass, A. J., Heffron, G., Metallo, C. M., Muranen, T., Sharfi, H., et al. (2011) · Nature Genetics · doi:10.1038/ng.890 · Cited by 1,120
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
Maddocks, O. D. K., Berkers, C. R., Mason, S. M., Zheng, L., Blyth, K., Gottlieb, E., & Vousden, K. H. (2013) · Nature · doi:10.1038/nature11743 · Cited by 1,007
New Insights into the Shikimate and Aromatic Amino Acids Biosynthesis Pathways in Plants
Tzin, V., & Galili, G. (2010) · Molecular Plant · doi:10.1093/mp/ssq048 · Cited by 737
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
Chaneton, B., Hillmann, P., Zheng, L., Martin, A. C. L., Maddocks, O. D. K., Chokkathukalam, A., Coyle, J. E., Jankevics, A., Holding, F. P., Vousden, K. H., et al. (2012) · Nature · doi:10.1038/nature11540 · Cited by 661
Photorespiration: players, partners and origin
Bauwe, H., Hagemann, M., & Fernie, A. R. (2010) · Trends in Plant Science · doi:10.1016/j.tplants.2010.03.006 · Cited by 652
Pagnussat, G. C., Yu, H., Ngo, Q. A., Sarojam, R., Sevugan, M., Johnson, C. S., Capron, A., Xie, L., Ye, D., & Sundaresan, V. (2005) · Development · doi:10.1242/dev.01595 · Cited by 607
The glycine decarboxylase system: a fascinating complex
Douce, R., Bourguignon, J., Neuburger, M., & Rébeillé, F. (2001) · Trends in Plant Science · doi:10.1016/s1360-1385(01)01892-1 · Cited by 460
O NE -C ARBON M ETABOLISM IN H IGHER P LANTS
Hanson, A. D., & Roje, S. (2001) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.52.1.119 · Cited by 454
Cited by
Sorted by citations
Amino Acid Catabolism in Plants
Hildebrandt, T. M., Nunes‐Nesi, A., Araújo, W. L., & Braun, H. (2015) · Molecular Plant · doi:10.1016/j.molp.2015.09.005 · Cited by 1,345
“, serine, proline, and leucine) have been shown to act as signaling molecules themselves and others are precursors for the synthesis of phytohormones or other secondary metabolites with signaling function (Hannah et al., 2010; Szabados and Savoure, 2010; Timm et al., 2012; Häusler et al., 2014; Ros et al., 2014).”
BackgroundCassava haplotype map highlights fixation of deleterious mutations during clonal propagation
Ramu, P., Esuma, W., Kawuki, R., Rabbi, I. Y., Egesi, C. N., Bredeson, J. V., Bart, R. S., Verma, J., Buckler, E. S., & Lü, F. (2017) · Nature Genetics · doi:10.1038/ng.3845 · Cited by 250
Plants increase CO2 uptake by assimilating nitrogen via the photorespiratory pathway
Busch, F. A., Sage, R. F., & Farquhar, G. D. (2017) · Nature Plants · doi:10.1038/s41477-017-0065-x · Cited by 260
Gagné-Bourque, F., Bertrand, A., Claessens, A., Aliferis, K. A., & Jabaji, S. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00584 · Cited by 243
Photorespiration in the context of Rubisco biochemistry, CO 2 diffusion and metabolism
Busch, F. A. (2020) · The Plant Journal · doi:10.1111/tpj.14674 · Cited by 248
Metadata
- Authors
- Ros, R., Muñoz-Bertomeu, J., & Krueger, S.
- Affiliations
- Universitat de València (ES)
- University of Cologne (DE)
- Corresponding author
- Ros, Roc
- Venue
- Trends in Plant Science
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 19
- Issue
- 9
- Pages
- 564-569
- ISSN
- 1360-1385 (ISSN-L)
- OpenAlex
- W2073447660
- Semantic Scholar
- 154570f017e6fc826ddb368e9b522b6e8b67ae54
- Cited by
- 279
- References
- 48
- Citations by year
- 2026: 19 · 2025: 31 · 2024: 29 · 2023: 30 · 2022: 33 · 2021: 25 · 2020: 33 · 2019: 20 · 2018: 17 · 2017: 16 · 2016: 15 · 2015: 9 · 2014: 2
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Plant Science (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Nitrogen and Sulfur Effects on Brassica
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
- Keywords
- serine biosynthesis, serine metabolism, amino acid homeostasis, plant development, embryonic development, male gametophyte development, root development
- MeSH terms
- Glycolysis, Phosphorylation, Photosynthesis, Plant Proteins, Plants, Seeds, Serine, Stress, Physiological, Gene Expression Regulation, Plant, Plant Roots
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