Serine phosphorylation of STATs
Abstract
Tyrosine phosphorylation regulates the dimerization of STATs as an essential prerequisite for the establishment of a classical JAK-STAT signaling path. However, most vertebrate STATs contain a second phosphorylation site within their C-termini. The phosphorylated residue in this case is a serine contained within a P(M)SP motif, and in the majority of situations its mutation to alanine alters transcription factor activity. This review addresses recent advances in understanding the regulation of STAT serine phosphorylation, as well as the kinases and other signal transducers implied in this process. The biochemical and biological consequences of STAT serine phosphorylation are discussed. Oncogene (2000).
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STAT3 Ser phosphorylation plays a negative role in STAT3 nuclear dynamics and transcriptional activities.
“our study and others (Chung et al., 1997; Decker and Kovarik, 2000; Kim and Baumann, 1997) highlight a negative role of STAT3 Ser phosphorylation in STAT3 nuclear dynamics and transcriptional activities.”
From CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene loci (2020) · cites this paper as Decker and Kovarik, 2000
Cites
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- Authors
- Decker, T., & Kovarik, P.
- Affiliations
- Vienna Biocenter (AT)
- Venue
- Oncogene
- Published
- 2000-05-25
- Volume
- 19
- Issue
- 21
- Pages
- 2628-2637
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W1993034428
- Cited by
- 887
- References
- 2
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 12 · 2023: 24 · 2022: 22 · 2021: 40 · 2020: 29 · 2019: 32 · 2018: 33 · 2017: 35 · 2016: 32 · 2015: 45 · 2014: 48 · 2013: 47 · 2012: 40
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- STAT proteins, JAK/STAT signaling, tyrosine phosphorylation, transcription factor activity, serine/threonine kinase, signal transduction, transcriptional regulation
- MeSH terms
- Amino Acid Sequence, Animals, Cell Nucleus, DNA-Binding Proteins, Humans, Molecular Sequence Data, Phosphorylation, Phosphoserine, Transcriptional Activation, Trans-Activators, Conserved Sequence, Phosphotyrosine, MAP Kinase Signaling System, STAT1 Transcription Factor
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