Natural designer solvents for greening analytical chemistry

Novel solvent properties of choline chloride/urea mixturesElectronic supplementary information (ESI) available: spectroscopic data. See http://www.rsc.org/suppdata/cc/b2/b210714g/

Abbott, A. P., Capper, G., Davies, D. L., Rasheed, R. K., & Tambyrajah, V. (2003) · Chemical Communications · doi:10.1039/b210714g · Cited by 5,738

Deep eutectic solvents formed between choline chloride and carboxylic acids: Versatile alternatives to ionic liquids

Abbott, A. P., Boothby, D., Capper, G., Davies, D. L., & Rasheed, R. K. (2004) · Journal of the American Chemical Society · doi:10.1021/ja048266j · Cited by 4,340

Natural deep eutectic solvents as new potential media for green technology

Dai, Y., van Spronsen, J., Witkamp, G.-J., Verpoorte, R., & Choi, Y. H. (2013) · Analytica Chimica Acta · doi:10.1016/j.aca.2012.12.019 · Cited by 2,694

Natural Deep Eutectic Solvents – Solvents for the 21st Century

Paiva, A., Craveiro, R., Aroso, I., Martins, M., Reis, R. L., & Duarte, A. R. C. (2014) · ACS Sustainable Chemistry & Engineering · doi:10.1021/sc500096j · Cited by 2,458

Low-transition-temperature mixtures (LTTMs): A new generation of designer solvents

Francisco, M., van den Bruinhorst, A., & Kroon, M. C. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201207548 · Cited by 1,378

Are Natural Deep Eutectic Solvents the Missing Link in Understanding Cellular Metabolism and Physiology?

Choi, Y. H., van Spronsen, J., Dai, Y., Verberne, M., Hollmann, F., Arends, I. W. C. E., Witkamp, G.-J., & Verpoorte, R. (2011) · Plant Physiology · doi:10.1104/pp.111.178426 · Cited by 1,368

Tailoring properties of natural deep eutectic solvents with water to facilitate their applications

Dai, Y., Witkamp, G.-J., Verpoorte, R., & Choi, Y. H. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.03.123 · Cited by 1,367

Deep Eutectic Solvents: Physicochemical Properties and Gas Separation Applications

García, G., Aparicio, S., Ullah, R., & Atilhan, M. (2015) · Energy & Fuels · doi:10.1021/ef5028873 · Cited by 1,112

Solubility of Metal Oxides in Deep Eutectic Solvents Based on Choline Chloride

Abbott, A. P., Capper, G., Davies, D. L., McKenzie, K. J., & Obi, S. U. (2006) · Journal of Chemical & Engineering Data · doi:10.1021/je060038c · Cited by 794

Natural Deep Eutectic Solvents as a New Extraction Media for Phenolic Metabolites in Carthamus tinctorius L.

Dai, Y., Witkamp, G., Verpoorte, R., & Choi, Y. H. (2013) · Analytical Chemistry · doi:10.1021/ac400432p · Cited by 706

Are deep eutectic solvents benign or toxic?

Hayyan, M., Hashim, M. A., Hayyan, A., Al-Saadi, M. A., AlNashef, I. M., Mirghani, M. E. S., & Saheed, O. K. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2012.11.004 · Cited by 675

Natural deep eutectic solvent mediated pretreatment of rice straw: bioanalytical characterization of lignin extract and enzymatic hydrolysis of pretreated biomass residue

Kumar, A. K., Parikh, B. S., & Pravakar, M. (2016) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-4780-4 · Cited by 571

Freeze-Drying of Aqueous Solutions of Deep Eutectic Solvents: A Suitable Approach to Deep Eutectic Suspensions of Self-Assembled Structures

Gutiérrez, M. C., Ferrer, M. L., Mateo, C. R., & del Monte, F. (2009) · Langmuir · doi:10.1021/la900552b · Cited by 540

Electrodeposition of zinc–tin alloys from deep eutectic solvents based on choline chloride

Abbott, A. P., Capper, G., McKenzie, K. J., & Ryder, K. S. (2006) · Journal of Electroanalytical Chemistry · doi:10.1016/j.jelechem.2006.04.024 · Cited by 482

Enhanced extraction of bioactive natural products using tailor-made deep eutectic solvents: Application to flavonoid extraction from Flos sophorae

Nam, M. W., Zhao, J., Lee, M. S., Jeong, J. H., & Lee, J. (2015) · Green Chemistry · doi:10.1039/c4gc01556h · Cited by 467

Green solvents for green technologies

Cvjetko Bubalo, M., Vidović, S., Radojčić Redovniković, I., & Jokić, S. (2015) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.4668 · Cited by 453

Ionic Liquid Analogues Formed from Hydrated Metal Salts

Abbott, A. P., Capper, G., Davies, D. L., & Rasheed, R. K. (2004) · Chemistry - A European Journal · doi:10.1002/chem.200400127 · Cited by 453

Natural deep eutectic solvents providing enhanced stability of natural colorants from safflower (Carthamus tinctorius)

Dai, Y., Verpoorte, R., & Choi, Y. H. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.02.155 · Cited by 416

Selective Extraction of Metals from Mixed Oxide Matrixes Using Choline-Based Ionic Liquids

Abbott, A. P., Capper, G., Davies, D. L., Rasheed, R. K., & Shikotra, P. (2005) · Inorganic Chemistry · doi:10.1021/ic0505450 · Cited by 360

The role of green extraction techniques in Green Analytical Chemistry

Armenta, S., Garrigues, S., & de la Guardia, M. (2015) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2014.12.011 · Cited by 329

Electrochemistry in Deep Eutectic Solvents

Nkuku, C. A., & LeSuer, R. J. (2007) · The Journal of Physical Chemistry B · doi:10.1021/jp075794j · Cited by 318

Application of natural deep eutectic solvents for extraction and determination of phenolics in Cajanus cajan leaves by ultra performance liquid chromatography

Wei, Z., Qi, X., Li, T., Luo, M., Wang, W., Zu, Y., & Fu, Y. (2015) · Separation and Purification Technology · doi:10.1016/j.seppur.2015.05.015 · Cited by 274

Perspectives on the replacement of harmful organic solvents in analytical methodologies: a framework toward the implementation of a generation of eco-friendly alternatives

Pena-Pereira, F., Kloskowski, A., & Namieśnik, J. (2015) · Green Chemistry · doi:10.1039/c5gc00611b · Cited by 257

Fast and green extraction and separation of main bioactive flavonoids from Radix Scutellariae

Wei, Z.-F., Wang, X.-Q., Peng, X., Wang, W., Zhao, C.-J., Zu, Y.-G., & Fu, Y.-J. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2014.10.013 · Cited by 205

Halogenation reactions in biodegradable solvent: Efficient bromination of substituted 1-aminoanthra-9,10-quinone in deep eutectic solvent (choline chloride : urea)

Phadtare, S. B., & Shankarling, G. S. (2010) · Green Chemistry · doi:10.1039/b923589b · Cited by 200

Deep eutectic liquid organic salt as a new solvent for liquid-phase microextraction and its application in ligandless extraction and preconcentraion of lead and cadmium in edible oils

Karimi, M., Dadfarnia, S., Shabani, A. M. H., Tamaddon, F., & Azadi, D. (2015) · Talanta · doi:10.1016/j.talanta.2015.07.021 · Cited by 182

Organic reactions in low melting mixtures based on carbohydrates and l-carnitine—a comparison

Ilgen, F., & König, B. (2009) · Green Chemistry · doi:10.1039/b816551c · Cited by 174

Environmentally benign and energy efficient methodology for condensation: an interesting facet to the classical Perkin reaction

Pawar, P. M., Jarag, K. J., & Shankarling, G. S. (2011) · Green Chemistry · doi:10.1039/c0gc00712a · Cited by 145

Novel zwitterionic deep eutectic solvents from trimethylglycine and carboxylic acids: characterization of their properties and their toxicity

Cardellini, F., Tiecco, M., Germani, R., Cardinali, G., Corte, L., Roscini, L., & Spreti, N. (2014) · RSC Adv. · doi:10.1039/c4ra10628h · Cited by 140

Electrodeposition onto magnesium in air and water stable ionic liquids: From corrosion to successful plating

Bakkar, A., & Neubert, V. (2007) · Electrochemistry Communications · doi:10.1016/j.elecom.2007.07.010 · Cited by 138

The use of ionic liquids based on choline chloride for metal deposition: A green alternative?

Haerens, K., Matthijs, E., Chmielarz, A., & der Bruggen, B. V. (2009) · Journal of Environmental Management · doi:10.1016/j.jenvman.2009.04.013 · Cited by 134

Coupling Cloud Point Extraction to Instrumental Detection Systems for Metal Analysis

Silva, M. F., Cerutti, E. S., & Martinez, L. D. (2006) · Microchimica Acta · doi:10.1007/s00604-006-0511-3 · Cited by 129

Differential capacity of a deep eutectic solvent based on choline chloride and glycerol on solid electrodes

Figueiredo, M. C., Gomes, C., Costa, R., Martins, A. C., Pereira, C. M. D. M., & Silva, F. (2008) · Electrochimica Acta · doi:10.1016/j.electacta.2008.10.074 · Cited by 124

Separation Performance of BioRenewable Deep Eutectic Solvents

Verevkin, S. P., Sazonova, A. Y., Frolkova, A. K., Zaitsau, D. H., Prikhodko, I. V., & Held, C. (2015) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.5b00357 · Cited by 123

Low-melting mixtures based on choline ionic liquids

Rengstl, D., Fischer, V., & Kunz, W. (2014) · Physical Chemistry Chemical Physics · doi:10.1039/c4cp02860k · Cited by 95

Greener derivatization in analytical chemistry

Lavilla, I., Romero, V., Costas-Mora, I., & Bendicho, C. (2014) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2014.05.007 · Cited by 85

Synthesis of aurones under neutral conditions using a deep eutectic solvent

Hawkins, I., & Handy, S. T. (2013) · Tetrahedron · doi:10.1016/j.tet.2013.08.060 · Cited by 67

A green deep eutectic solvent-based ultrasound-assisted method to extract astaxanthin from shrimp byproducts

Zhang, H., Tang, B., & Row, K. H. (2014) · Analytical Letters · doi:10.1080/00032719.2013.855783 · Cited by 64

Synthesis of cadmium and zinc semiconductor compounds from an ionic liquid containing choline chloride and urea

Dale, P. J., Samantilleke, A. P., Shivagan, D. D., & Peter, L. M. (2007) · Thin Solid Films · doi:10.1016/j.tsf.2006.12.072 · Cited by 61

Extraction of saponins from sisal (Agave sisalana) and juá (Ziziphus joazeiro) with cholinium-based ionic liquids and deep eutectic solvents

Ribeiro, B. D., Coelho, M. A. Z., & Marrucho, I. M. (2013) · European Food Research and Technology · doi:10.1007/s00217-013-2068-9 · Cited by 59

The Electrochemical Behavior and Determination of Quercetin in Choline Chloride/Urea Deep Eutectic Solvent Electrolyte Based on Abrasively Immobilized Multi-Wall Carbon Nanotubes Modified Electrode

Zheng, Y. Q., Ye, L., Yan, L., & Gao, Y. (2014) · International Journal of Electrochemical Science · doi:10.1016/s1452-3981(23)07712-x · Cited by 44

Enhanced performance of supercritical fluid foaming of natural‐based polymers by deep eutectic solvents

Martins, M. D. J. O., Aroso, I. M., Reis, R. L., Duarte, A. R. C., Craveiro, R., & Paiva, A. (2014) · AIChE Journal · doi:10.1002/aic.14607 · Cited by 39

Spectrofluorimetric and micelle-enhanced spectrofluorimetric methods for determination of Felodipine and Nimodipine in pharmaceutical preparations and human plasma

Mohamed, A. I., Omar, M. A., Hammad, M. A., & Mohamed, A. A. (2015) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2015.05.026 · Cited by 33

Natural eutectic salts catalyzed one-pot synthesis of 5-arylidene-2-imino-4-thiazolidinones

Mobinikhaledi, A., & Amiri, A. K. (2012) · Research on Chemical Intermediates · doi:10.1007/s11164-012-0707-6 · Cited by 27

Electrochemical oxidation behavior of hydroxypivalaldehyde in the ionic liquids

Zhong, J., He, D. L., Zhou, Z., & Xu, Y. B. (2008) · Chinese Chemical Letters · doi:10.1016/j.cclet.2007.12.017 · Cited by 19

Analytical Chemistry Today and Tomorrow

Valcárcel, M. (2012) · Analytical Chemistry · doi:10.5772/50497 · Cited by 4

Insights into the Nature of Eutectic and Deep Eutectic Mixtures

Martins, M. A. R., Pinho, S. P., & Coutinho, J. A. P. (2018) · Journal of Solution Chemistry · doi:10.1007/s10953-018-0793-1 · Cited by 1,235

Deep eutectic solvents for the production and application of new materials

Tomé, L. I. N., Baião, V., da Silva, W., & Brett, C. M. A. (2017) · Applied Materials Today · doi:10.1016/j.apmt.2017.11.005 · Cited by 718

Review of Alternative Solvents for Green Extraction of Food and Natural Products: Panorama, Principles, Applications and Prospects

Chemat, F., Vian, M. A., Ravi, H. K., Khadhraoui, B., Hilali, S., Périno, S., & Fabiano‐Tixier, A. (2019) · Molecules · doi:10.3390/molecules24163007 · Cited by 698

Application of deep eutectic solvents in analytical chemistry. A review

Shishov, A., Bulatov, A., Locatelli, M., Carradori, S., & Andruch, V. (2017) · Microchemical Journal · doi:10.1016/j.microc.2017.07.015 · Cited by 561

Natural deep eutectic solvents for lignocellulosic biomass pretreatment: Recent developments, challenges and novel opportunities

Satlewal, A., Agrawal, R., Bhagia, S., Sangoro, J. R., & Ragauskas, A. J. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.08.009 · Cited by 572

Natural Deep Eutectic Solvents – Solvents for the 21st Century

Paiva, A., Craveiro, R., Aroso, I., Martins, M., Reis, R. L., & Duarte, A. R. C. (2014) · ACS Sustainable Chemistry & Engineering · doi:10.1021/sc500096j · Cited by 2,458

Natural Deep Eutectic Solvents (NADES): Manufacture, Characteristics, and Their Significance as Designer Solvents

Satija, P., Chambyal, A., Singh, G., Ritvik, Singh, G., Devi, S., & Singh, J. (2024) · ChemistrySelect · doi:10.1002/slct.202401212 · Cited by 34

Research on the Design and Application of Natural Deep Eutectic Solvents

Zang, Y. (2025) · International journal of agriculture and food sciences research. · doi:10.62051/ijafsr.v3n1.01

Natural deep eutectic solvents as new potential media for green technology

Dai, Y., van Spronsen, J., Witkamp, G.-J., Verpoorte, R., & Choi, Y. H. (2013) · Analytica Chimica Acta · doi:10.1016/j.aca.2012.12.019 · Cited by 2,694

Green solvents from ionic liquids and deep eutectic solvents to natural deep eutectic solvents

Vanda, H., Dai, Y., Wilson, E. G., Verpoorte, R., & Choi, Y. H. (2018) · Comptes Rendus. Chimie · doi:10.1016/j.crci.2018.04.002 · Cited by 467