Perspectives on the replacement of harmful organic solvents in analytical methodologies: a framework toward the implementation of a generation of eco-friendly alternatives
Abstract
This perspective addresses the replacement of harmful organic solvents by a novel generation of promising alternatives using sustainable analytical methodologies.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
NADES components are abundantly present in nature, readily available, and biorenewable.
“Components of NADES are abundantly present in nature, readily available, and biorenewable (Dai et al. 2013a;Pena-Pereira, Kloskowski, and Namieśnik, 2015)”
From The perspectives of natural deep eutectic solvents in agri-food sector (2020) · cites this paper as Pena-Pereira, Kloskowski, and Namieśnik, 2015
Simple and easy preparation of NADES with high purity and without waste generation meets the 12 principles of green chemistry.
“Simple and ease preparation of NADES with high purity and without waste generation (Pena-Pereira et al. 2015), meets the 12 principles of green chemistry (Anastas and Eghbali 2010).”
From The perspectives of natural deep eutectic solvents in agri-food sector (2020) · cites this paper as Pena-Pereira et al. 2015
Cites
Low-transition-temperature mixtures (LTTMs): A new generation of designer solvents
Francisco, M., van den Bruinhorst, A., & Kroon, M. C. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201207548 · Cited by 1,378 · see citing works
A survey of solvent selection guides
Prat, D., Hayler, J., & Wells, A. (2014) · Green Chem. · doi:10.1039/c4gc01149j · Cited by 984 · see citing works
Florindo, C., Oliveira, F. S., Rebelo, L. P. N., Fernandes, A. M., & Marrucho, I. M. (2014) · ACS Sustainable Chemistry & Engineering · doi:10.1021/sc500439w · Cited by 977 · see citing works
Francisco, M., van den Bruinhorst, A., & Kroon, M. C. (2012) · Green Chemistry · doi:10.1039/c2gc35660k · Cited by 814 · see citing works
Ethyl lactate as a solvent: Properties, applications and production processes – a review
Pereira, C. S. M., Silva, V. M. T. M., & Rodrigues, A. E. (2011) · Green Chemistry · doi:10.1039/c1gc15523g · Cited by 544 · see citing works
Dai, Y., Verpoorte, R., & Choi, Y. H. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.02.155 · Cited by 416 · see citing works
Compressed fluids for the extraction of bioactive compounds
Herrero, M., Castro-Puyana, M., Mendiola, J. A., & Ibañez, E. (2013) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2012.12.008 · Cited by 351 · see citing works
Dispersive liquid-liquid microextraction for determination of organic analytes
Herrera-Herrera, A. V., Asensio-Ramos, M., Hernández-Borges, J., & Rodríguez-Delgado, M. Á. (2010) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2010.03.016 · Cited by 267 · see citing works
Liquid-phase microextraction techniques within the framework of green chemistry
Pena-Pereira, F., Lavilla, I., & Bendicho, C. (2010) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2010.02.016 · Cited by 221 · see citing works
Self-citationCardellini, F., Tiecco, M., Germani, R., Cardinali, G., Corte, L., Roscini, L., & Spreti, N. (2014) · RSC Adv. · doi:10.1039/c4ra10628h · Cited by 140 · see citing works
Ghanemi, K., Navidi, M.-A., Fallah-Mehrjardi, M., & Dadolahi-Sohrab, A. (2014) · Anal. Methods · doi:10.1039/c3ay41843j · Cited by 79 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Zhao, B.-Y., Xu, P., Yang, F.-X., Wu, H., Zong, M.-H., & Lou, W.-Y. (2015) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.5b00619 · Cited by 617 · see citing works
Natural designer solvents for greening analytical chemistry
Espino, M., de los Ángeles Fernández, M., Gomez, F. J. V., & Silva, M. F. (2016) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.11.006 · Cited by 418 · see citing works
The perspectives of natural deep eutectic solvents in agri-food sector
Mišan, A., Nađpal, J., Stupar, A., Pojić, M., Mandić, A., Verpoorte, R., & Choi, Y. H. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1650717 · Cited by 316 · see citing works
Fernández, M. D. L. Á., Boiteux, J., Espino, M., Gomez, F. J. V., & Silva, M. F. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.07.059 · Cited by 307 · see citing works
Fernández, M. D. L. Á., Espino, M., Gomez, F. J. V., & Silva, M. F. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2017.06.150 · Cited by 257 · see citing works
A solvent selection guide based on chemometrics and multicriteria decision analysis
Tobiszewski, M., Tsakovski, S., Simeonov, V., Namieśnik, J., & Pena-Pereira, F. (2015) · Green Chemistry · doi:10.1039/c5gc01615k · Cited by 159 · see citing works
Self-citationGreener organic solvents in analytical chemistry
Tobiszewski, M., & Namieśnik, J. (2017) · Current Opinion in Green and Sustainable Chemistry · doi:10.1016/j.cogsc.2017.03.002 · Cited by 114 · see citing works
Self-citationMostafa, A., Shaaban, H., Alqarni, A. M., Alghamdi, M., Alsultan, S., Saleh Al-Saeed, J., Alsaba, S., AlMoslem, A., Alshehry, Y., & Ahmad, R. (2022) · Microchemical Journal · doi:10.1016/j.microc.2022.107976 · Cited by 75 · see citing works
The sustainability of emerging technologies for use in pharmaceutical manufacturing
Weaver, E., O’Hagan, C., & Lamprou, D. A. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2093857 · Cited by 70 · see citing works
“Solvent waste is a prime causative factor toward the risks posed by volatile organic compounds (VOC) [77], and is the 5 target to alter according to the American chemical society (ACS) 12 principles of green chemistry [78].”
BackgroundInfluentialSantana, A. P. R., Andrade, D. F., Guimarães, T. G. S., Amaral, C. D. B., Oliveira, A., & Gonzalez, M. H. (2020) · Talanta · doi:10.1016/j.talanta.2020.120956 · Cited by 69 · see citing works
Santana-Mayor, Á., Herrera-Herrera, A. V., Rodríguez-Ramos, R., Socas-Rodríguez, B., & Rodríguez-Delgado, M. Á. (2021) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.0c07686 · Cited by 59 · see citing works
Gómez-Nieto, B., Konomi, A., Gkotsis, G., Nika, M.-C., & Thomaidis, N. S. (2025) · Molecules · doi:10.3390/molecules30142988 · Cited by 5 · see citing works
“To address this limitation, recent research has focused on the use of more environmentally friendly solvents such as natural deep eutectic solvents (NADESs) in sample preparation procedures to reduce the use of organic solvents [23,24].”
Schincaglia, A., Cavazzini, A., Pasti, L., Purcaro, G., & Beccaria, M. (2025) · Green Analytical Chemistry · doi:10.1016/j.greeac.2025.100220 · Cited by 2 · see citing works
Alahmadi, S. M., & Abu-Dief, A. M. (2026) · Sustainable Chemistry · doi:10.3390/suschem7030033 · Cited by 1 · see citing works
- Authors
- Pena-Pereira, F., Kloskowski, A., & Namieśnik, J.
- Affiliations
- Analytical and Food Chemistry Department; Faculty of Chemistry; University of Vigo
- Gdańsk University of Technology (PL)
- Venue
- Green Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2015
- Volume
- 17
- Issue
- 7
- Pages
- 3687-3705
- ISSN
- 1463-9262 (ISSN-L)
- 1463-9270
- OpenAlex
- W2047484340
- Cited by
- 257
- References
- 11
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 30 · 2023: 17 · 2022: 35 · 2021: 30 · 2020: 22 · 2019: 31 · 2018: 16 · 2017: 14 · 2016: 19 · 2015: 8
- FWCI
- 14.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Green Chemistry (publishedVersion)
- Funders
- Xunta de Galicia
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Physical Sciences › Environmental Science › Environmental Chemistry › Chemistry and Chemical Engineering
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Various Chemistry Research Topics
- Keywords
- organic solvent replacement, green solvents, eco-friendly alternatives, green analytical chemistry, solvent toxicity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
