Comparison of placental blood microscopy and the ICT HRP2 rapid diagnostic test to detect placental malaria
Abstract
Monitoring interventions to prevent malaria in pregnancy requires sensitive detection of placental infection. Rapid diagnostic tests (RDTs) are good candidates, but little information is available on their sensitivity on placental blood. We have evaluated the agreement (kappa coefficient) between microscopy and a Plasmodium falciparum histidine-rich protein 2 (HRP2)-based immuno-chromatographic test (ICT) on placental blood from 1151 women at delivery. Prevalences of placental infection by microscopy and RDT were 5.1% and 5.0%, respectively, showing 82.9% agreement (p<0.0001). Discordances were found at low parasitemias (<500 parasites/μL) or negative microscopy. The results suggest that the HRP2-RDTs from ICT diagnostics is a good alternative to microscopy for diagnosing placental malaria at delivery.
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The prevalence of placental infection determined by microscopy and RDT was 5.1% and 5.0%, respectively, with highly significant agreement (82.9%); discordances were observed between the two methods at low level parasitaemias.
“Recently, the prevalence of placental infection, as determined by microscopy and RDT, was 5.1% and 5.0%, respectively, with highly significant agreement (82.9%); however discordances were observed between the two methods at low level parasitaemias [12].”
From Reliability of rapid diagnostic test for diagnosing peripheral and placental malaria in an area of unstable malaria transmission in Eastern Sudan (2013) · cites this paper as [12]
There are few published data on the performance of RDT for diagnosing malaria during pregnancy, especially in areas of unstable malaria transmission.
“While RDT have been extensively evaluated in malaria among the non-pregnant population, there are few published data on the performance of RDT for diagnosing malaria during pregnancy, especially in areas of unstable malaria transmission [12-17].”
From Reliability of rapid diagnostic test for diagnosing peripheral and placental malaria in an area of unstable malaria transmission in Eastern Sudan (2013) · cites this paper as [12]
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Kashif, A. H., Adam, G. K., Mohmmed, A. A., Elzaki, S. E., AbdelHalim, A. M., & Adam, I. (2013) · Diagnostic Pathology · doi:10.1186/1746-1596-8-59 · Cited by 18 · see citing works
- Authors
- Aguilar, R., Machevo, S., Menéndez, C., Bardají, A., Nhabomba, A., Alonso, P. L., & Mayor, A.
- Affiliations
- Hospital Clínic de Barcelona (ES)
- Manhiça Health Research Centre (MZ)
- Corresponding author
- Aguilar, Ruth
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-09
- Volume
- 106
- Issue
- 9
- Pages
- 573-575
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W1977795648
- Cited by
- 12
- References
- 10
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 3
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transactions of the Royal Society of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
- Keywords
- placental malaria, Plasmodium falciparum, diagnostic sensitivity, test agreement, malaria in pregnancy, low parasitemia
- MeSH terms
- Adult, Antigens, Protozoan, Blood, Female, Humans, Mozambique, Placenta Diseases, Pregnancy, Reagent Kits, Diagnostic, Sensitivity and Specificity, Protozoan Proteins, Malaria, Falciparum
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