CoChat
Sign Up
Cited by 239Ultrasound and Hyperthermia ApplicationsNanoparticle-Based Drug DeliveryLipid Membrane Structure and Behavior

Controlling liposomal drug release with low frequency ultrasound: mechanism and feasibility.

Schroeder, Avi, Avnir, Yuval, Weisman, Sarah, Najajreh, Yousef, Gabizon, Alberto, Talmon, Yeshayahu, Kost, Joseph, Barenholz, Yechezkel·2007·Langmuir
DOI 10.1021/la0631668
Open this paper in CoChat — free account

Abstract

The ability of low-frequency ultrasound (LFUS) to release encapsulated drugs from sterically stabilized liposomes in a controlled manner was demonstrated. Three liposomal formulations having identical lipid bilayer compositions and a similar size ( approximately 100 nm) but differing in their encapsulated drugs and methods of drug loading have been tested. Two of the drugs, doxorubicin and methylpredinisolone hemisuccinate, were remote loaded by transmembrane gradients (ammonium sulfate and calcium acetate, respectively). The third drug, cisplatin, was loaded passively into the liposomes. For all three formulations, a short exposure to LFUS (<3 min) released nearly 80% of the drug. The magnitude of drug release was a function of LFUS amplitude and actual exposure time, irrespective of whether irradiation was pulsed or continuous. Furthermore, no change in liposome size distribution or in the chemical properties of the lipids or of the released drugs occurred due to exposure to LFUS. Based on our results, we propose that the mechanism of release is a transient introduction of porelike defects in the liposome membrane, which occurs only during exposure to LFUS, after which the membrane reseals. This explains the observed uptake of the membrane-impermeable fluorophore pyranine from the extraliposomal medium during exposure to LFUS. The implications of these findings for clinical applications of controlled drug release from liposomes are discussed.

Integrity signals

Registry

Crossref · 10.1021/la0631668

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Schroeder, A., Avnir, Y., Weisman, S., Najajreh, Y., Gabizon, A., Talmon, Y., Kost, J., & Barenholz, Y.
Affiliations
  • Ben-Gurion University of the Negev (IL)
  • Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel, Laboratory of Liposome and Membrane Research, Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel, Department of Chemical Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel, Faculty of Pharmacy, Al-Quds University, P.O.B. 20002 Abu-Dies, The Palestinian Authority, and Department of Oncology, Shaare Zedek Medical Center, Jerusalem 91031, Israel
Corresponding author
Barenholz, Yechezkel
ORCID
Venue
Langmuir
Publisher
American Chemical Society (ACS)
Published
2007-02-24
Volume
23
Issue
7
Pages
4019-4025
ISSN
  • 0743-7463 (ISSN-L)
  • 1520-5827
DOI
10.1021/la0631668
OpenAlex
W2095156612
Cited by
239
References
32
Citations by year
2026: 3 · 2025: 5 · 2024: 10 · 2023: 10 · 2022: 14 · 2021: 15 · 2020: 15 · 2019: 12 · 2018: 8 · 2017: 13 · 2016: 8 · 2015: 13 · 2014: 13 · 2013: 15 · 2012: 23
FWCI
8.84
Type
journal article
Language
en
Open access
closed
Locations
  • Langmuir (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords
low-frequency ultrasound, controlled drug release, PEGylated liposomes, doxorubicin, cisplatin, ultrasonic amplitude, pore formation, membrane resealing
MeSH terms
Acetates, Ammonium Sulfate, Arylsulfonates, Cisplatin, Delayed-Action Preparations, Doxorubicin, Liposomes, Methylprednisolone Hemisuccinate, Ultrasonics, Calcium Compounds

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review