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Enhanced on-Chip modification and intracellular hydrogen peroxide detection via gigahertz acoustic streaming microfluidic platform
Open accessAbstract
Developing effective strategies for the flexible control of fluid is vital for microfluidic electrochemical biosensing. In this study, a gigahertz (GHz) acoustic streaming (AS) based sonoelectrochemical system was developed to realize an on-chip surface modification and sensitive hydrogen peroxide (H2O2) detection from living cells. The flexible and controlled fluid surrounding the electrochemical chip was optimized theoretically and applied in the sonoelectrochemical deposition of Au nanoparticles (AuNPs) first. Under the steady and fast flow stimulus of AS, AuNPs could be synthesized with a smaller and evener size distribution than the normal condition, allowing AuNPs to show an excellent peroxidase-like activity. Moreover, the AS also accelerated the mass transport of target molecules and improved the catalytic rate, leading to the enhancement of H2O2 detection, with an extremely low detection limit of 32 nM and a high sensitivity of 4.34 μA/ (mM·mm2). Finally, this system was successfully applied in tracking H2O2 release from different cell lines to distinguish the cancer cells from normal cells. This study innovatively integrated the surface modification and molecules detection process on a chip, and also proposed a simple but sensitive platform for microfluidic biosensing application.
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PMA is a known initiator of reactive oxygen species.
“PMA, a known initiator of reactive oxygen species, [5] was used to stimulate cellular oxidative stress, and the intrinsic SERS spectrum of PMA is negligible compared to the Raman reporter molecule (Figure S6, Supporting Information).”
From Multiplex Cellular Microenvironment Detection Based on Surface-Enhanced Raman Scattering Patch (2025) · cites this paper as [5]
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Metadata
- Authors
- Zhu, F., Liu, Z., Wu, X., Xu, D., Li, Q., Chen, X., Pang, W., Duan, X., & Wang, Y.
- Affiliations
- Tianjin University (CN)
- Corresponding author
- Wang, Yanyan
- Venue
- Ultrasonics Sonochemistry
- Publisher
- Elsevier BV
- Published
- 2023-11
- Volume
- 100
- Pages
- 106618
- ISSN
- 1350-4177 (ISSN-L)
- PMC
- PMC10543187
- OpenAlex
- W4386986807
- Cited by
- 7
- References
- 43
- Citations by year
- 2025: 4 · 2024: 3
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Ultrasonics Sonochemistry (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (61971302)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Keywords
- sonoelectrochemistry, hydrogen peroxide detection, peroxidase-like activity, electrochemical biosensor, microfluidic biosensing, mass transfer enhancement, cancer cell detection
- MeSH terms
- Acoustics, Gold, Hydrogen Peroxide, Biosensing Techniques, Microfluidics, Metal Nanoparticles, Electrochemical Techniques
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