Cited by 89Bacterial Infections and VaccinesMicrobial infections and disease researchBacterial Identification and Susceptibility Testing

Effectiveness of meningococcal serogroup C vaccine programmes

Borrow, Ray, Abad, Raquel, Trotter, Caroline, van der Klis, Fiona R.M., Vazquez, Julio A.·2013·Vaccine

Abstract

Since the introduction of monovalent meningococcal serogroup C (MenC) glycoconjugate (MCC) vaccines and the implementation of national vaccination programmes, the incidence of MenC disease has declined markedly as a result of effective short-term vaccination and reduction in acquisition of MenC carriage leading to herd protection. Monovalent and quadrivalent conjugate vaccines are commonly used vaccines to provide protection against MenC disease worldwide. Studies have demonstrated that MCC vaccination confers protection in infancy (0-12 months) from the first dose but this is only short-term. NeisVac-C(®) has the greatest longevity of the currently licensed MCC vaccines in terms of antibody persistence, however antibody levels have been found to fall rapidly after early infant vaccination with two doses of all MCC vaccines - necessitating a booster at ∼12 months. In toddlers, only one dose of the MCC vaccine is required for routine immunization. If herd protection wanes following catch-up campaigns, many children may become vulnerable to infection. This has led many to question whether an adolescent booster is also required.

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Crossref · 10.1016/j.vaccine.2013.07.083

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  • Protein-polysaccharide conjugate vaccines contain the same polysaccharides from the bacterial surface chemically conjugated to a protein carrier.

    “Protein–polysaccharide conjugate vaccines contain the same polysaccharides from the bacterial surface, but in this case they are chemically conjugated to a protein carrier (mostly tetanus toxoid, or diphtheria toxoid or a mutant protein derived from it, known as CRM197)32–34.”

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Authors
Borrow, R., Abad, R., Trotter, C., van der Klis, F. R. M., & Vazquez, J. A.
Affiliations
  • Manchester Royal Infirmary (GB)
  • Instituto de Salud Carlos III (ES)
  • University of Cambridge (GB)
Corresponding author
Borrow, Ray
Venue
Vaccine
Publisher
Elsevier BV
Published
2013-09
Volume
31
Issue
41
Pages
4477-4486
ISSN
0264-410X (ISSN-L)
OpenAlex
W2091951392
Cited by
88
References
70
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 10 · 2017: 14 · 2016: 12 · 2015: 11 · 2014: 11 · 2013: 1
FWCI
1.53
Type
journal article
Language
en
Open access
closed
Locations
  • Vaccine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Baxter Healthcare Corporation
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
Keywords
meningococcal serogroup C, glycoconjugate vaccines, immunization programs, herd protection, antibody persistence, booster vaccination, catch-up vaccination, disease incidence decline
MeSH terms
Antibodies, Bacterial, Humans, Meningitis, Meningococcal, Vaccination, Treatment Outcome, Meningococcal Vaccines, Neisseria meningitidis, Serogroup C

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