The epidemiology of invasive meningococcal disease in EU/EEA countries, 2004–2014
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BACKGROUND: Invasive meningococcal disease (IMD) is a major cause of bacterial meningitis and septicaemia although infection by some serogroups may be prevented through vaccination. We aimed to describe the epidemiology of IMD in EU/EEA countries during 2004-2014 to monitor serogroup- and age-specific trends, and compare country trends by the period of meningococcal C conjugate (MCC) vaccine introduction. METHODS: We analysed IMD surveillance data by age, gender, serogroup, country and outcome. We estimated the percentage change in annual notification rate (NR), using linear regression analysis of the log of the annual NR. We grouped countries by the year they introduced MCC vaccination into their routine immunisation programmes. RESULTS: The overall NR was 0.9/100 000 population, and decreased 6.6% (95%CI: -8.0%;-5.1%) annually. Infants had the highest NR (16.0/100 000), and there were decreasing trends in all age groups <50years. Serogroup B (SgB) caused 74% of all cases, and the majority of cases in all age groups. There were decreasing trends in SgB and serogroup C (SgC) and an increasing trend in serogroup Y. Countries that introduced MCC vaccination before, and between 2004 and 2014, had decreasing trends in NR of SgC, but not countries without routine MCC vaccination. CONCLUSIONS: Our findings support evidence that routine MCC vaccination was the driving force behind the decreasing SgC trend. Vaccinating against SgB in the first year of life could help reduce the burden of IMD due to this serogroup. Changing serogroup-specific NR trends highlight the need for high-quality surveillance data to accurately assess the changing epidemiology of IMD, the effectiveness and impact of implemented vaccines, and the need for future vaccines.
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In recent years, serogroup B N. meningitidis is responsible for the majority of meningococcal disease in Europe.
“Previous studies have identified that in recent years serogroup B N. meningitidis is responsible for the majority of meningococcal disease in Europe, [79, 80]”
From Global etiology of bacterial meningitis: A systematic review and meta-analysis. (2018) · cites this paper as [79]
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- Authors
- Whittaker, R., Dias, J. G., Ramliden, M., Ködmön, C., Economopoulou, A., Beer, N., Pastore Celentano, L., Kanitz, E., Richter, L., Mattheus, W., Bleyenheuft, C., Georgieva, T., Simeonovski, I., Vučina, V. V., Filipović, S. K., Koliou, M., Bagatzouni, D. P., Krizova, P., Sebestova, H., Hoffmann, S., Valentiner-Branth, P., Kerbo, N., Peetso, R., Kuusi, M., Toropainen, M., Parent, I., Taha, M.-K., Vogel, U., Hellenbrand, W., Georgakopoulou, T., Tzanakaki, G., Krisztalovics, K., Tirczka, T., Gudnason, T., Hardardottir, H., O'Lorcain, P., Bennett, D., D'Ancona, F., Stefanelli, P., Savrasova, L., Vasilevska, D., Kuprevičienė, N., Liausedienė, R., Demuth, I., Scheiden, G., Melillo, J. M., Caruana, P., van der Ende, A., Mollema, L., Caugant, D., Blystad, H., Skoczyńska, A., Zota, L., Pana, M., Grgič Vitek, M., Paragi, M., Cano, R., Abad, R., Lepp, T., & Campbell, H.
- Affiliations
- European Centre for Disease Prevention and Control (SE)
- Tufts University (US)
- Corresponding author
- Whittaker, Robert
- ORCID
- Whittaker, Robert
- Dias, Joana Gomes
- Ramliden, Miriam
- Ködmön, Csaba
- Richter, Lukas
- Mattheus, Wesley
- Simeonovski, Ivan
- Vučina, Vesna Višekruna
- Koliou, Maria
- Hoffmann, Steen
- Toropainen, Maija
- Taha, Muhamed-Kheir
- Vogel, Ulrich
- Hellenbrand, Wiebke
- Georgakopoulou, Theano
- Tzanakaki, Georgina
- Stefanelli, Paola
- Mollema, Liesbeth
- Caugant, Dominique
- Skoczyńska, Anna
- Cano, Rosa
- Abad, Raquel
- Lepp, Tiia
- Campbell, Helen
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 35
- Issue
- 16
- Pages
- 2034-2041
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W2602921194
- Cited by
- 179
- References
- 32
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 4 · 2023: 19 · 2022: 27 · 2021: 22 · 2020: 29 · 2019: 32 · 2018: 30 · 2017: 4
- FWCI
- 21.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Vaccine (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- European Centre for Disease Prevention and Control
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Keywords
- invasive meningococcal disease, Neisseria meningitidis serogroups, serogroup B, serogroup C, serogroup Y, meningococcal C vaccine, vaccine impact, notification rates, age trends, bacterial meningitis, septicemia, disease surveillance
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Europe, Female, Humans, Infant, Male, Meningitis, Meningococcal, Middle Aged, Neisseria meningitidis, Incidence, Age Distribution, Sex Distribution, Sepsis, Meningococcal Vaccines, Young Adult, Serogroup
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