Meningococcal vaccines and herd immunity: lessons learned from serogroup C conjugate vaccination programs
Open accessAbstract
Effective vaccines provide direct protection to immunized individuals, but may also provide benefits to unvaccinated individuals by reducing transmission and thereby lowering the risk of infection. Such herd immunity effects have been demonstrated following the introduction of meningococcal serogroup C conjugate (MCC) vaccines, with reductions in disease attack rates in unimmunized individuals and significantly lower serogroup C carriage attributable to the vaccine introduction. In the UK, targeting teenagers for immunization was crucial in maximizing indirect effects, as most meningococcal transmission occurs in this age group. Questions remain regarding the duration of herd protection and the most appropriate long-term immunization strategies. The magnitude of the herd effects following MCC vaccination was largely unanticipated, and has important consequences for the design and evaluation of new meningococcal vaccines.
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Vaccine-mediated protection of adolescents leads to community protection through herd immunity.
“vaccine-mediated protection of this age group leads to community protection through herd immunity58.”
From A guide to vaccinology: from basic principles to new developments (2021) · cites this paper as [58]
Currently, the strategy for control of capsular groups A, C, W and Y meningococci in the UK is vaccination of adolescents.
“Currently, the strategy for control of capsular groups A, C, W and Y meningococci in the UK is vaccination of adolescents”
From A guide to vaccinology: from basic principles to new developments (2021) · cites this paper as [58]
Adolescents are mainly responsible for transmission of capsular groups A, C, W and Y meningococci.
“as they are mainly responsible for transmission”
From A guide to vaccinology: from basic principles to new developments (2021) · cites this paper as [58]
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- Authors
- Trotter, C. L., & Maiden, M. C.
- Affiliations
- University of Bristol (GB)
- University of Oxford (GB)
- Venue
- Expert Review of Vaccines
- Publisher
- Informa UK Limited
- Published
- 2009-07
- Volume
- 8
- Issue
- 7
- Pages
- 851-861
- ISSN
- 1476-0584 (ISSN-L)
- 1744-8395
- PMC
- PMC3988355
- OpenAlex
- W1992790837
- Cited by
- 203
- References
- 82
- Citations by year
- 2026: 5 · 2024: 3 · 2023: 7 · 2022: 12 · 2021: 15 · 2020: 11 · 2019: 14 · 2018: 12 · 2017: 13 · 2016: 19 · 2015: 20 · 2014: 14 · 2013: 18 · 2012: 20
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Expert Review of Vaccines (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (087622)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- meningococcal serogroup C, conjugate vaccines, herd immunity, indirect protection, adolescent vaccination, vaccine introduction, vaccination strategies
- MeSH terms
- Carrier State, United Kingdom, Humans, Meningococcal Infections, Meningococcal Vaccines, Immunity, Herd
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