Cited by 203Bacterial Infections and VaccinesMicrobial infections and disease researchVirology and Viral Diseases

Meningococcal vaccines and herd immunity: lessons learned from serogroup C conjugate vaccination programs

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Trotter, Caroline L, Maiden, Martin CJ·2009·Expert Review of Vaccines

Abstract

Effective vaccines provide direct protection to immunized individuals, but may also provide benefits to unvaccinated individuals by reducing transmission and thereby lowering the risk of infection. Such herd immunity effects have been demonstrated following the introduction of meningococcal serogroup C conjugate (MCC) vaccines, with reductions in disease attack rates in unimmunized individuals and significantly lower serogroup C carriage attributable to the vaccine introduction. In the UK, targeting teenagers for immunization was crucial in maximizing indirect effects, as most meningococcal transmission occurs in this age group. Questions remain regarding the duration of herd protection and the most appropriate long-term immunization strategies. The magnitude of the herd effects following MCC vaccination was largely unanticipated, and has important consequences for the design and evaluation of new meningococcal vaccines.

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  1. [6]Fine PE Plotkin SA Orenstein WO Community Immunity Vaccines 2004 1443 62 Saunders Philadelphia Fourth ed. Thorough and clear description of the concept of herd immunity and the mathematical theory underpinning this.

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Authors
Trotter, C. L., & Maiden, M. C.
Affiliations
  • University of Bristol (GB)
  • University of Oxford (GB)
Venue
Expert Review of Vaccines
Published
2009-07
Volume
8
Issue
7
Pages
851-861
ISSN
  • 1476-0584 (ISSN-L)
  • 1744-8395
OpenAlex
W1992790837
Cited by
203
References
82
Citations by year
2026: 5 · 2024: 3 · 2023: 7 · 2022: 12 · 2021: 15 · 2020: 11 · 2019: 14 · 2018: 12 · 2017: 13 · 2016: 19 · 2015: 20 · 2014: 14 · 2013: 18 · 2012: 20
FWCI
1.67
Type
journal article
Language
en
Open access
Locations
  • Expert Review of Vaccines (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
Wellcome Trust (087622)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
meningococcal serogroup C, conjugate vaccines, herd immunity, indirect protection, adolescent vaccination, vaccine introduction, vaccination strategies
MeSH terms
Carrier State, United Kingdom, Humans, Meningococcal Infections, Meningococcal Vaccines, Immunity, Herd

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