A xenodiagnostic method using Musca domestica for the diagnosis of gastric habronemosis and examining the anthelmintic efficacy of moxidectin
Abstract
Equine habronematidosis has a global distribution and is caused by three spirurid species, Habronema muscae, Habronema microstoma and Draschia megastoma. A case of cutaneous habronematidosis in a stallion in a stable in Dubai, UAE gave occasion to investigate the parasite situation on the farm. Patent H. muscae infections were diagnosed in 18 out of 49 horses in a stable in Dubai, UAE with a xenodiagnostic test using houseflies as indicator host. All horses in the stable were treated with a single dose of moxidectin administered orally as 2% gel in a dosage of 0.4 mg/kg body weight and the efficacy of this targeted treatment was studied. Habronema infection was terminated in all horses. A fly survey conducted at the farm prior and after treatment revealed two muscid species: Musca domestica and Stomoxys calcitrans. Only M. domestica caught at the farm showed a natural infection with Habronema larvae prior and shortly after anthelmintic treatment. Later, examination of flies caught at the farm in monthly intervals up to the end of observation (8 months after treatment) gave negative results. The absence of infection in the intermediate host was an indication of the eradication of stomach worms. The described xenodiagnostic test is a useful tool to diagnose H. muscae infections and can be used to evaluate the efficacy of nematocides in equines.
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A focused study proved the efficacy of moxidectin against H. muscae.
“as also confirmed by a focused study that ultimately proved the efficacy of moxidectin against H. muscae (77).”
From Habronematidosis in Equids: Current Status, Advances, Future Challenges (2020) · cites this paper as [77]
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Habronematidosis in Equids: Current Status, Advances, Future Challenges
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Gastric habronematidosis in mules: Gastroscopy and histopathology-based diagnosis
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- Authors
- Schuster, R. K., & Sivakumar, S.
- Affiliations
- Central Veterinary Research Laboratory (AE)
- Corresponding author
- Schuster, Rolf K.
- Venue
- Veterinary Parasitology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 197
- Issue
- 1-2
- Pages
- 176-181
- ISSN
- 0304-4017 (ISSN-L)
- OpenAlex
- W1971110160
- Cited by
- 14
- References
- 39
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2013: 1
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Veterinary Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Gulfrider Veterinary Medicines and Equipment Trading Est, Dubai
- Topics
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Health Sciences › Veterinary › Equine › Veterinary Equine Medical Research
- Keywords
- Habronema muscae, xenodiagnosis, Musca domestica, moxidectin, anthelmintic efficacy, equine parasitic nematodes, stallions, Stomoxys calcitrans, parasite eradication
- MeSH terms
- Animals, Anthelmintics, Horse Diseases, Horses, Houseflies, Stomach Diseases, United Arab Emirates, Spirurida Infections, Macrolides
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