The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Autophagic machinery activated by dengue virus enhances virus replication
Open accessAbstract
Autophagy is a cellular response against stresses which include the infection of viruses and bacteria. We unravel that Dengue virus-2 (DV2) can trigger autophagic process in various infected cell lines demonstrated by GFP-LC3 dot formation and increased LC3-II formation. Autophagosome formation was also observed under the transmission electron microscope. DV2-induced autophagy further enhances the titers of extracellular and intracellular viruses indicating that autophagy can promote viral replication in the infected cells. Moreover, our data show that ATG5 protein is required to execute DV2-induced autophagy. All together, we are the first to demonstrate that DV can activate autophagic machinery that is favorable for viral replication.
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Cites
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Cited by
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Self-citationBiology of Zika Virus Infection in Human Skin Cells
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Biochemistry and Molecular Biology of Flaviviruses
Barrows, N. J., Campos, R. K., Liao, K.-C., Prasanth, K. R., Soto-Acosta, R., Yeh, S.-C., Schott-Lerner, G., Pompon, J., Sessions, O. M., Bradrick, S. S., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00719 · Cited by 341
Metadata
- Authors
- Lee, Y.-R., Lei, H.-Y., Liu, M.-T., Wang, J.-R., Chen, S.-H., Jiang-Shieh, Y.-F., Lin, Y.-S., Yeh, T.-M., Liu, C.-C., & Liu, H.-S.
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 374
- Issue
- 2
- Pages
- 240-248
- ISSN
- 0042-6822 (ISSN-L)
- OpenAlex
- W1969339170
- Cited by
- 360
- References
- 27
- FWCI
- 12.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, Y.-R., Lei, H.-Y., Liu, M.-T., Wang, J.-R., Chen, S.-H., Jiang-Shieh, Y.-F., Lin, Y.-S., Yeh, T.-M., Liu, C.-C., & Liu, H.-S. (2008). Autophagic machinery activated by dengue virus enhances virus replication. Virology. https://doi.org/10.1016/j.virol.2008.02.016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
