The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
The autophagy machinery is required to initiate hepatitis C virus replication
Open accessAbstract
In addition to its cellular homeostasis function, autophagy is emerging as a central component of antimicrobial host defense against diverse infections. To counteract this mechanism, many pathogens have evolved to evade, subvert, or exploit autophagy. Here, we report that autophagy proteins (i.e., Beclin-1, Atg4B, Atg5, and Atg12) are proviral factors required for translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but they are not required once infection is established. These results illustrate a previously unappreciated role for autophagy in the establishment of a viral infection and they suggest that different host factors regulate the translation of incoming viral genome and translation of progeny HCV RNA once replication is established.
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Cites
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Cited by
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
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Autophagy and Viruses: Adversaries or Allies?
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Self-citationAutophagy in immunity and inflammation
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Metadata
- Authors
- Dreux, M., Gastaminza, P., Wieland, S. F., & Chisari, F. V.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-08-18
- Volume
- 106
- Issue
- 33
- Pages
- 14046-14051
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2127481048
- Cited by
- 477
- References
- 42
- FWCI
- 23.04
- Type
- journal article
- Language
- en
- Open access
- green
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