The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Atg5–Atg12 conjugate associates with innate antiviral immune responses
Open accessAbstract
Autophagy is an essential process for physiological homeostasis, but its role in viral infection is only beginning to be elucidated. We show here that the Atg5–Atg12 conjugate, a key regulator of the autophagic process, plays an important role in innate antiviral immune responses. Atg5-deficient mouse embryonic fibroblasts (MEFs) were resistant to vesicular stomatitis virus replication, which was largely due to hyperproduction of type I interferons in response to immunostimulatory RNA (isRNA), such as virus-derived, double-stranded, or 5′-phosphorylated RNA. Similar hyperresponse to isRNA was also observed in Atg7-deficient MEFs, in which Atg5–Atg12 conjugation is impaired. Overexpression of Atg5 or Atg12 resulted in Atg5–Atg12 conjugate formation and suppression of isRNA-mediated signaling. Molecular interaction studies indicated that the Atg5–Atg12 conjugate negatively regulates the type I IFN production pathway by direct association with the retinoic acid-inducible gene I (RIG-I) and IFN-β promoter stimulator 1 (IPS-1) through the caspase recruitment domains (CARDs). Thus, in contrast to its role in promoting the bactericidal process, a component of the autophagic machinery appears to block innate antiviral immune responses, thereby contributing to RNA virus replication in host cells.
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Cites
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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
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Self-citationCardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
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Cited by
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y.-J., Jiang, Q., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,304
Pattern Recognition Receptors and Inflammation
Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895
Self-citationAutophagy in immunity and inflammation
Levine, B., Mizushima, N., & Virgin, H. W. (2011) · Nature · doi:10.1038/nature09782 · Cited by 3,289
Biological Functions of Autophagy Genes: A Disease Perspective
Levine, B., & Kroemer, G. (2019) · Cell · doi:10.1016/j.cell.2018.09.048 · Cited by 2,832
Autophagy in infection, inflammation and immunity
Deretic, V., Saitoh, T., & Akira, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3532 · Cited by 1,919
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Metadata
- Authors
- Jounai, N., Takeshita, F., Kobiyama, K., Sawano, A., Miyawaki, A., Xin, K.-Q., Ishii, K. J., Kawai, T., Akira, S., Suzuki, K., & Okuda, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-08-28
- Volume
- 104
- Issue
- 35
- Pages
- 14050-14055
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2060098032
- Cited by
- 565
- References
- 9
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Jounai, N., Takeshita, F., Kobiyama, K., Sawano, A., Miyawaki, A., Xin, K.-Q., Ishii, K. J., Kawai, T., Akira, S., Suzuki, K., & Okuda, K. (2007). The Atg5–Atg12 conjugate associates with innate antiviral immune responses. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0704014104
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