The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
RIG-I is cleaved during picornavirus infection
Open accessAbstract
The innate immune system senses RNA virus infections through membrane-bound Toll-like receptors or the cytoplasmic proteins RIG-I and MDA-5. RIG-I is believed to recognize the 5′-triphosphate present on many viral RNAs, and hence is important for sensing infections by paramyxoviruses, influenza viruses, rhabdoviruses, and flaviviruses. MDA-5 recognizes dsRNA, and senses infection with picornaviruses, whose RNA 5′-ends are linked to a viral protein, VPg, not a 5′-triphosphate. We previously showed that MDA-5 is degraded in cells infected with different picornaviruses, and suggested that such cleavage might be a mechanism to antagonize production of type I IFN in response to viral infection. Here we examined the state of RIG-I during picornavirus infection. RIG-I is degraded in cells infected with poliovirus, rhinoviruses, echovirus, and encephalomyocarditis virus. In contrast to MDA-5, cleavage of RIG-I is not accomplished by cellular caspases or the proteasome. Rather, the viral proteinase 3Cpro cleaves RIG-I, both in vitro and in cells. Cleavage of RIG-I during picornavirus infection may constitute another mechanism for attenuating the innate response to viral infection.
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Cites
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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
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RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates
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Cloning and synthesis of infectious cardiovirus RNAs containing short, discrete poly(C) tracts
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Cited by
Lee (2019) · doi:10.1038/s12276-019-0299-y · Cited by 635
Fung, G., Luo, H., Qiu, Y., Yang, D., & McManus, B. (2016) · Circulation Research · doi:10.1161/circresaha.115.306573 · Cited by 444
Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5
Brisse, M., & Ly, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01586 · Cited by 365
Atkinson, N. J., Witteveldt, J., Evans, D. J., & Simmonds, P. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku075 · Cited by 192
Enteroviruses: A Gut-Wrenching Game of Entry, Detection, and Evasion
Wells, A. I., & Coyne, C. B. (2019) · Viruses · doi:10.3390/v11050460 · Cited by 109
Metadata
- Authors
- Barral, P. M., Sarkar, D., Fisher, P. B., & Racaniello, V. R.
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 391
- Issue
- 2
- Pages
- 171-176
- ISSN
- 0042-6822 (ISSN-L)
- OpenAlex
- W2040589516
- Cited by
- 215
- References
- 7
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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