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Cited by 391SARS-CoV-2 and COVID-19 Researchinterferon and immune responsesCOVID-19 Clinical Research Studies

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Human immunopathogenesis of severe acute respiratory syndrome (SARS)

Open access
Cameron, Mark J., Bermejo-Martin, Jesus F., Danesh, Ali, Muller, Matthew P., Kelvin, David J.·2008·Virus Research
DOI 10.1016/j.virusres.2007.02.014PMC PMC7114310
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Abstract

Progressive immune-associated injury is a hallmark of severe acute respiratory syndrome (SARS). Viral evasion of innate immunity, hypercytokinemia and systemic immunopathology in the SARS coronavirus (SARS CoV) infected host have been suggested as possible mechanisms for the cause of severe pathology and morbidity in SARS patients. The molecular and cellular basis for how SARS CoV impacts the host immune system resulting in severe SARS, however, has not been elucidated. The variable clinical course of SARS may be the result of complex programs of host responses against the infectious agent. Therefore, the systematic analysis of innate and adaptive immune responses to SARS CoV is imperative in building as complete an immunological model as possible of host immunity and inflammatory responses during illness. Here we review recent advances in SARS immunopathogenesis research and present a summary of our findings regarding host responses in SARS patients. We contend that dysregulated type I and II interferon (IFN) responses during SARS may culminate in a failure of the switch from hyper-innate immunity to protective adaptive immune responses in the human host.

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Metadata

Authors
Cameron, M. J., Bermejo-Martin, J. F., Danesh, A., Muller, M. P., & Kelvin, D. J.
Affiliations
  • University Health Network (CA)
  • Mount Sinai Hospital (CA)
Corresponding author
Kelvin, David J.
ORCID
Venue
Virus Research
Publisher
Elsevier BV
Published
2008-04
Volume
133
Issue
1
Pages
13-19
ISSN
0168-1702 (ISSN-L)
DOI
10.1016/j.virusres.2007.02.014
PMC
PMC7114310
OpenAlex
W2076401107
Cited by
391
References
39
Citations by year
2026: 1 · 2025: 6 · 2024: 17 · 2023: 21 · 2022: 65 · 2021: 95 · 2020: 126 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 1 · 2014: 6 · 2013: 2 · 2012: 9
FWCI
4.44
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Virus Research (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Genome Canada
  • Ontario Genomics
  • Ontario Genomics Institute
  • Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
SARS, SARS coronavirus, immunopathogenesis, cytokine storm, innate immunity, adaptive immunity, type I interferon, interferon-gamma, viral evasion, host immune response, inflammation
MeSH terms
Humans, Immunity, Innate, Models, Biological, Cytokines, Oligonucleotide Array Sequence Analysis, Severe Acute Respiratory Syndrome, Severe acute respiratory syndrome-related coronavirus, Host-Pathogen Interactions

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