Cited by 391SARS-CoV-2 and COVID-19 Researchinterferon and immune responsesCOVID-19 Clinical Research Studies

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Human immunopathogenesis of severe acute respiratory syndrome (SARS)

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Cameron, Mark J., Bermejo-Martin, Jesus F., Danesh, Ali, Muller, Matthew P., Kelvin, David J.·2008·Virus Research

DOI 10.1016/j.virusres.2007.02.014PMC PMC7114310

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Abstract

Progressive immune-associated injury is a hallmark of severe acute respiratory syndrome (SARS). Viral evasion of innate immunity, hypercytokinemia and systemic immunopathology in the SARS coronavirus (SARS CoV) infected host have been suggested as possible mechanisms for the cause of severe pathology and morbidity in SARS patients. The molecular and cellular basis for how SARS CoV impacts the host immune system resulting in severe SARS, however, has not been elucidated. The variable clinical course of SARS may be the result of complex programs of host responses against the infectious agent. Therefore, the systematic analysis of innate and adaptive immune responses to SARS CoV is imperative in building as complete an immunological model as possible of host immunity and inflammatory responses during illness. Here we review recent advances in SARS immunopathogenesis research and present a summary of our findings regarding host responses in SARS patients. We contend that dysregulated type I and II interferon (IFN) responses during SARS may culminate in a failure of the switch from hyper-innate immunity to protective adaptive immune responses in the human host.

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Authors: Cameron, M. J., Bermejo-Martin, J. F., Danesh, A., Muller, M. P., & Kelvin, D. J.
Affiliations: University Health Network (CA)
Mount Sinai Hospital (CA)
Corresponding author: Kelvin, David J.
ORCID: Cameron, Mark J.
Danesh, Ali
Muller, Matthew P.
Kelvin, David J.
Venue: Virus Research
Publisher: Elsevier BV
Published: 2008-04
Volume: 133
Issue: 1
Pages: 13-19
ISSN: 0168-1702 (ISSN-L)
DOI: 10.1016/j.virusres.2007.02.014
PMC: PMC7114310
OpenAlex: W2076401107
Cited by: 391
References: 39
Citations by year: 2026: 1 · 2025: 6 · 2024: 17 · 2023: 21 · 2022: 65 · 2021: 95 · 2020: 126 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 1 · 2014: 6 · 2013: 2 · 2012: 9
FWCI: 4.44
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Virus Research (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Genome Canada
Ontario Genomics
Ontario Genomics Institute
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords: SARS, SARS coronavirus, immunopathogenesis, cytokine storm, innate immunity, adaptive immunity, type I interferon, interferon-gamma, viral evasion, host immune response, inflammation
MeSH terms: Humans, Immunity, Innate, Models, Biological, Cytokines, Oligonucleotide Array Sequence Analysis, Severe Acute Respiratory Syndrome, Severe acute respiratory syndrome-related coronavirus, Host-Pathogen Interactions

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