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Cited by 972Microtubule and mitosis dynamicsAlzheimer's disease research and treatmentsCancer Treatment and Pharmacology

The MAP1 family of microtubule-associated proteins.

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Dehmelt·2004·Genome biology
DOI 10.1186/gb-2004-6-1-204PMC PMC549057
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Abstract

Microtubule-associated proteins (MAPs) of the MAP2/Tau family include the vertebrate proteins MAP2, MAP4, and Tau and homologs in other animals. All three vertebrate members of the family have alternative splice forms; all isoforms share a conserved carboxy-terminal domain containing microtubule-binding repeats, and an amino-terminal projection domain of varying size. MAP2 and Tau are found in neurons, whereas MAP4 is present in many other tissues but is generally absent from neurons. Members of the family are best known for their microtubule-stabilizing activity and for proposed roles regulating microtubule networks in the axons and dendrites of neurons. Contrary to this simple, traditional view, accumulating evidence suggests a much broader range of functions, such as binding to filamentous (F) actin, recruitment of signaling proteins, and regulation of microtubule-mediated transport. Tau is also implicated in Alzheimer's disease and other dementias. The ability of MAP2 to interact with both microtubules and F-actin might be critical for neuromorphogenic processes, such as neurite initiation, during which networks of microtubules and F-actin are reorganized in a coordinated manner. Various upstream kinases and interacting proteins have been identified that regulate the microtubule-stabilizing activity of MAP2/Tau family proteins.

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Authors
Dehmelt
Venue
Genome biology
Publisher
Springer Science and Business Media LLC
Published
2004
Volume
6
Issue
1
Pages
204
ISSN
1465-6906 (ISSN-L)
DOI
10.1186/gb-2004-6-1-204
PMC
PMC549057
OpenAlex
W2166555967
Cited by
972
References
5
Citations by year
2026: 36 · 2025: 39 · 2024: 59 · 2023: 67 · 2022: 59 · 2021: 66 · 2020: 62 · 2019: 60 · 2018: 69 · 2017: 39 · 2016: 58 · 2015: 45 · 2014: 49 · 2013: 45 · 2012: 36
FWCI
4.34
Type
journal article
Language
en
Open access
Locations
  • Genome biology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (R01MH050861)
  • National Institute of Neurological Disorders and Stroke (R01NS037311)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
Keywords
microtubule-associated proteins, MAP2, MAP4, tau protein, alternative splicing, microtubule-binding repeats, microtubule stabilization, actin binding, neurite initiation, Alzheimer's disease, mitogen-activated protein kinase, neurons
MeSH terms
Animals, Gene Expression Regulation, Microtubule-Associated Proteins, Neurons, tau Proteins, Evolution, Molecular

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