Notch signaling regulates regeneration in the avian retina

Notch signalling: a simple pathway becomes complex

Bray, S. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2009 · Cited by 2,620

Notch signalling regulates stem cell numbers in vitro and in vivo

Androutsellis‐Theotokis, A., Leker, R. R., Soldner, F., Hoeppner, D. J., Ravin, R., Poser, S., Rueger, M. A., Bae, S., Kittappa, R., & McKay, R. D. G. (2006) · Nature · doi:10.1038/nature04940 · Cited by 963

SOX2, a Persistent Marker for Multipotential Neural Stem Cells Derived from Embryonic Stem Cells, the Embryo or the Adult

Ellis, P., Fagan, B. M., Magness, S. T., Hutton, S. R., Taranova, O., Hayashi, S., McMahon, A. P., Rao, M. S., & Pevny, L. (2004) · Developmental Neuroscience · doi:10.1159/000082134 · Cited by 756

Müller glia are a potential source of neural regeneration in the postnatal chicken retina

Fischer, A. J., & Reh, T. A. (2001) · Nature Neuroscience · doi:10.1038/85090 · Cited by 579

SOX2 is a dose-dependent regulator of retinal neural progenitor competencePreprint

Taranova, O., Magness, S. T., Fagan, B. M., Wu, Y., Surzenko, N., Hutton, S. R., & Pevny, L. H. (2006) · Genes & Development · doi:10.1101/gad.1407906 · Cited by 554

rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells.

Furukawa, T., Mukherjee, S., Bao, Z., Morrow, E. M., & Cepko, C. (2000) · Neuron · doi:10.1016/s0896-6273(00)81171-x · Cited by 545

Molecular characterization of retinal stem cells and their niches in adult zebrafish

Raymond, P. A., Barthel, L. K., Bernardos, R. L., & Perkowski, J. J. (2006) · BMC Developmental Biology · doi:10.1186/1471-213x-6-36 · Cited by 504

A γ‐secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

Geling, A., Steiner, H., Willem, M., Bally‐Cuif, L., & Haass, C. (2002) · The EMBO Reports · doi:10.1093/embo-reports/kvf124 · Cited by 497 · cited 1×

Potential for neural regeneration after neurotoxic injury in the adult mammalian retina

Ooto, S., Akagi, T., Kageyama, R., Akita, J., Mandai, M., Honda, Y., & Takahashi, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402129101 · Cited by 454

Maintenance of neuroepithelial progenitor cells by Delta–Notch signalling in the embryonic chick retina

Henrique, D., Hirsinger, E., Adam, J., Roux, I., Pourquié, O., Ish‐Horowicz, D., & Lewis, J. H. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00293-4 · Cited by 431

Prostaglandin E2 Enhances Proliferation, Dedifferentiation and Stem-Like Properties of Rat Retinal Müller Glial Cells in vitro

Wang, L., Lang, L.-L., Wang, Y., Shi, S., & Liu, L. (2012) · Ophthalmic Research · doi:10.1159/000345256 · Cited by 6

Regenerating axolotl retinas regrow diverse cell types with modulation by Notch signaling and reconnect to the brainPreprint

Yandulskaya, A. S., Miller, M. N., Ansaripour, R., Carrier, R. L., & Monaghan, J. R. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.28.489898 · Cited by 6

Notch Is Required for Neural Progenitor Proliferation During Embryonic Eye Regrowth

Guerin, D. J., Gutierrez, B., Zhang, B., & Tseng, K. A.-S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062637 · Cited by 4

BAC-Dkk3-EGFPTransgenic Mouse: AnIn VivoAnalytical Tool forDkk3Expression

Muranishi, Y., & Furukawa, T. (2012) · BioMed Research International · doi:10.1155/2012/973140 · Cited by 5

A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia

Tresenrider, A. M., Hooper, M. J., Todd, L. J., Kierney, F., Blasdel, N., Trapnell, C., & Reh, T. A. (2023) · eLife · doi:10.7554/elife.92091.3 · Cited by 11

Protein phosphatases regulate the formation of Müller glia-derived progenitor cells in the chick retina

Kelly, L. E., El‐Hodiri, H. M., Crider, A., & Fischer, A. J. (2024) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2024.103932 · Cited by 4

Specification of retinal cell types

Bösze, B., Hufnagel, R. B., & Brown, N. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00021-7 · Cited by 4

Developing zebrafish models of Notch-related CNS pathologies

Erofeeva, N., Galstyan, D. S., Yang, L., Strekalova, T., Lim, L. W., de Abreu, M. S., Golushko, N. I., Stewart, A., & Kalueff, A. V. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106059 · Cited by 3

Formation of Müller glia-derived progenitor cells in retinas depleted of microgliaPreprint

El‐Hodiri, H. M., Bentley, J. R., Reske, A., Palazzo, I., Campbell, W. A., Halloy, N. R., & Fischer, A. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.08.544205 · Cited by 3

MMP-9 inhibition facilitates amacrine cell loss after ouabain-induced retinal damage

Li, Y., & Zhou, G. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.03.003 · Cited by 2

Regenerative Medicine for Diseases of the Retina

Lamba, D. A., & Reh, T. A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-381422-7.10024-0 · Cited by 2

Retinal regeneration after injury induced by gamma-ray irradiation during early embryogenesis in medaka, Oryzias latipes

Yasuda, T., Nakazawa, T., Hirakawa, K., Matsumoto, I., Nagata, K., Mori, S., Igarashi, K., Sagara, H., Oda, S., & Mitani, H. (2023) · International Journal of Radiation Biology · doi:10.1080/09553002.2023.2242932 · Cited by 1

Ibudilast Protects Retinal Bipolar Cells From Excitotoxic Retinal Damage and Activates the mTOR Pathway

Hamadmad, S., Heisler‐Taylor, T., Goswami, S., Hawthorn, E. C., Chaurasia, S., Martini, D., Summitt, D., Zatari, A., Shalash, R., Sohail, M., et al. (2025) · Glia · doi:10.1002/glia.24657 · Cited by 1

Plagl1 regulates the retinal progenitor cell to Müller glial cell transition

Touahri, Y., Pak, A., David, L. A., Hanna, J., Liu, H., Xiao, Y., Belfiore, L., Ilnytskyy, Y., van Oosten, E., 橘, 信., et al. (2026) · PLoS Genetics · doi:10.1371/journal.pgen.1012020 · Cited by 1

Mobilizing Endogenous Stem Cells for Retinal Repair

Yu, H., Talib, M., Vu, T. H. K., Cho, K., Guo, C., & Chen, D. F. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800548-4.00020-6 · Cited by 1

Neurogenesis in the damaged mammalian brain

Nakafuku, M., & Grande, A. W. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00023-0 · Cited by 1

A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller gliaPreprint

Tresenrider, A. M., Hooper, M. J., Todd, L. J., Kierney, F., Blasdel, N., Trapnell, C., & Reh, T. A. (2024) · eLife · doi:10.7554/elife.92091.2 · Cited by 2

Activation of developmental signaling pathways in hematopoietic stem cell regeneration

Lento, W. E. (2010) · DukeSpace (Duke University)

Notch signaling and bone fracture healing

Dishowitz, M. I. (2013) · ScholarlyCommons (University of Pennsylvania)

Estudio de la expresión y función de los receptores tipo Toll (TLRs) en células madre de la retina de mamífero adulto

Flores, A. I. (2015) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)

A GtPase Rac1 participa da proliferação de células gliais de Müller após lesão excitotóxica.

da Silva, L. C. (2011) · doi:10.11606/d.42.2011.tde-22072011-155029

Molecular mechanisms of neural plasticity after spinal cord injury in the lamprey central nervous system

Lau, B. Y. B. (2012) · Texas ScholarWorks (Texas Digital Library)

Development of Methods for Retinal Ganglion Cell Replacement in Glaucoma

Jones, M. F. (2013) · UCL Discovery (University College London)

Caracterización in vivo e in vitro de progenitores neuronales en la retina de peces teleósteos

González, M. R. S. (2009) · doi:10.14201/gredos.76311

Chemical Biology of Stem Cell Modulation

Davies, S. G., & Russell, A. J. (2010) · Royal Society of Chemistry eBooks · doi:10.1039/9781849732178-00097

Modulation of the Progenitor Cell and Homeostatic Capacities of Müller Glia Cells in Retina : Focus on α2-Adrenergic and Endothelin Receptor Signaling Systems

Harun‐Or‐Rashid, M. (2016) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Initiation of Retina Regeneration By a Conserved Mechanism of Adult NeurogenesisPreprint

Rao, M. B., Didiano, D., & Patton, J. G. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/057893

Retinal Repair Using Stem Cells

Gutierrez, M. A., & Lamba, D. A. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1232-8_15

The Role of Signaling Pathway Integration in Neurogenesis

Ringuette, R. (2016) · uO Research (University of Ottawa) · doi:10.20381/ruor-5369

The Role of the Notch Signaling Pathway during Postembryonic Retinal Neurogenesis in Danio rerio

Chiang, R. Y. (2015) · TSpace (University of Toronto)

Dedifferentiation and Vision System

Fu, X., Zhao, A., & Hu, T. H. (2018) · Springer eBooks · doi:10.1007/978-3-662-56179-9_7

Growth Hormone and Synaptogenesis in the Chick Retina

Fleming, T. (2018) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3cj8818f

Cellular and molecular mechanisms of retinal regeneration in the axolotl salamander

Yandulskaya, A. S. (2022) · Digital Repository Service (Northeastern University) · doi:10.17760/d20439213

A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller gliaPreprint

Tresenrider, A. M., Hooper, M. J., Todd, L. J., Kierney, F., Blasdel, N., Trapnell, C., & Reh, T. A. (2023) · eLife · doi:10.7554/elife.92091.1

Synergistic inhibition of Notch signaling and forced cell cycle re-entry drive Müller glia reprogramming in uninjured mouse retina

Liao, B., Lyu, C., Jiang, Y., Liu, S. H., Wong, W., Zhang, J., Tsang, H., Xie, J., Chen, L., Zhang, Q., et al. (2026) · eLife · doi:10.7554/elife.111251.3

Synergistic inhibition of Notch signaling and forced cell cycle re-entry drive Müller glia reprogramming in uninjured mouse retinaPreprint

Liao, B., Lyu, C., Jiang, Y., Liu, S. H., Wong, W., Zhang, J., Tsang, H., Xie, J., Chen, L. L., Zhang, Q., et al. (2026) · eLife · doi:10.7554/elife.111251

Synergistic Inhibition of Notch Signaling and Forced Cell Cycle Re-entry Drive Müller Glia Reprogramming in Uninjured Mouse RetinaPreprint

Liao, B., Lyu, C., Jiang, Y., Liu, S. H., Wong, W., Zhang, J., Tsang, H., Xie, J., Chen, L. L., Zhang, Q., et al. (2026) · eLife · doi:10.7554/elife.111251.1

Reprogramming Mammal Müller Glial Cells for Retinal Neuroregeneration

Huang, L. J., Yao, E., Yang, M., & Chen, D. F. (2026) · American Journal Of Pathology · doi:10.1016/j.ajpath.2026.06.006

Restoring Vision: Where are We with Stem Cells?

Zhu, J., & Lamba, D. A. (2015) · Current Ophthalmology Reports · doi:10.1007/s40135-015-0078-4

Retinal regeneration requires dynamic Notch signaling

Hyde, D. R., Campbell, L. J., Levendusky, J., & Steines, S. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.327326 · Cited by 49

The Role of Notch Signaling During Retinal Regeneration in Zebrafish

Conner, H. C. (2022) · Figshare · doi:10.7274/3b59183371f

The Regulation of Notch Signaling in Retinal Development and Regeneration

Mills, E. A., & Goldman, D. J. (2017) · Current Pathobiology Reports · doi:10.1007/s40139-017-0153-7 · Cited by 57

Notch signaling influences neuroprotective and proliferative properties of mature Müller glia

Ghai, K., Zelinka, C., & Fischer, A. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4919-09.2010 · Cited by 111

Notch3 and DeltaB maintain Müller glia quiescence and act as negative regulators of regeneration in the light‐damaged zebrafish retina

Campbell, L. J., Hobgood, J. S., Jia, M. X., Boyd, P., Hipp, R. I., & Hyde, D. R. (2020) · Glia · doi:10.1002/glia.23912 · Cited by 61