Cited by 168Marine Invertebrate Physiology and EcologyDevelopmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanisms

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Origins of neurogenesis, a cnidarian view

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Galliot, Brigitte, Quiquand, Manon, Ghila, Luiza, de Rosa, Renaud, Miljkovic-Licina, Marijana, Chera, Simona·2009·Developmental Biology

DOI 10.1016/j.ydbio.2009.05.563

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Abstract

New perspectives on the origin of neurogenesis emerged with the identification of genes encoding post-synaptic proteins as well as many "neurogenic" regulators as the NK, Six, Pax, bHLH proteins in the Demosponge genome, a species that might differentiate sensory cells but no neurons. However, poriferans seem to miss some key regulators of the neurogenic circuitry as the Hox/paraHox and Otx-like gene families. Moreover as a general feature, many gene families encoding evolutionarily-conserved signaling proteins and transcription factors were submitted to a wave of gene duplication in the last common eumetazoan ancestor, after Porifera divergence. In contrast gene duplications in the last common bilaterian ancestor, Urbilateria, are limited, except for the bHLH Atonal-class. Hence Cnidaria share with Bilateria a large number of genetic tools. The expression and functional analyses currently available suggest a neurogenic function for numerous orthologs in developing or adult cnidarians where neurogenesis takes place continuously. As an example, in the Hydra polyp, the Clytia medusa and the Acropora coral, the Gsx/cnox2/Anthox-2 ParaHox gene likely supports neurogenesis. Also neurons and nematocytes (mechanosensory cells) share in hydrozoans a common stem cell and several regulatory genes indicating that they can be considered as sister cells. Performed in anthozoan and medusozoan species, these studies should tell us more about the way(s) evolution hazards achieved the transition from epithelial to neuronal cell fate, and about the robustness of the genetic circuitry that allowed neuromuscular transmission to arise and be maintained across evolution.

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Authors: Galliot, B., Quiquand, M., Ghila, L., de Rosa, R., Miljkovic-Licina, M., & Chera, S.
Affiliations: University of Geneva (CH)
Corresponding author: Galliot, Brigitte
ORCID: Galliot, Brigitte
Ghila, Luiza
Chera, Simona
Venue: Developmental Biology
Publisher: Elsevier BV
Published: 2009-08
Volume: 332
Issue: 1
Pages: 2-24
ISSN: 0012-1606 (ISSN-L)
DOI: 10.1016/j.ydbio.2009.05.563
OpenAlex: W2037815161
Cited by: 168
References: 274
Citations by year: 2026: 2 · 2025: 8 · 2024: 9 · 2023: 8 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 12 · 2018: 6 · 2017: 13 · 2016: 5 · 2015: 19 · 2014: 14 · 2013: 12 · 2012: 14
FWCI: 1.40
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1446 d)
Locations: Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (acceptedVersion, other-oa)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders: Canton de Genève
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: Cnidaria, sponges, gene duplication, ParaHox genes, Hox genes, Acropora corals, nematocytes, stem cells, neuromuscular transmission
MeSH terms: Animals, Cnidaria, Biological Evolution, Nervous System, Neurogenesis

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Origins of neurogenesis, a cnidarian view

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