Evolutionary crossroads in developmental biology: Cnidaria

A theory of biological pattern formation

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The dynamic genome of Hydra

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Pax 6: mastering eye morphogenesis and eye evolution

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WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra

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Unexpected complexity of the Wnt gene family in a sea anemone

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Untitled work

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Regeneration of Hydra from Reaggregated Cells

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More than just orphans: are taxonomically-restricted genes important in evolution?

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Apoptotic Cells Provide an Unexpected Source of Wnt3 Signaling to Drive Hydra Head Regeneration

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Investigating the origins of triploblasty: `mesodermal' gene expression in a diploblastic animal, the sea anemone <i>Nematostella vectensis</i> (phylum, Cnidaria; class, Anthozoa)

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Phylogeny of Medusozoa and the evolution of cnidarian life cycles

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EST Analysis of the Cnidarian Acropora millepora Reveals Extensive Gene Loss and Rapid Sequence Divergence in the Model Invertebrates

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Maintenance of ancestral complexity and non-metazoan genes in two basal cnidarians

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An ancient role for nuclear β-catenin in the evolution of axial polarity and germ layer segregation

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Multiple Wnts are involved in Hydra organizer formation and regeneration

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Transgenic Hydra allow in vivo tracking of individual stem cells during morphogenesis

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The Culture, Sexual and Asexual Reproduction, and Growth of the Sea Anemone Nematostella vectensis

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Formation of the head organizer in hydra involves the canonical Wnt pathway.

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The production of new hydranths in Hydra by the insertion of small grafts

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Advanced optics in a jellyfish eye

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The Invertebrates. Protozoa Through Ctenophora

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The evolution of eyes and visually guided behaviour

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Cell cycle kinetics and development of Hydra attenuata: I. epithelial cells

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Cell cycle kinetics and development of Hydra attenuata: III. nerve and nematocyte differentiation

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Molecular evidence for deep evolutionary roots of bilaterality in animal development

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Cnidarians: An evolutionarily conserved model system for regeneration?

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The interstitial cell lineage of hydra: a stem cell system that arose early in evolution

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Induction of gametogenesis in the basal cnidarian Nematostella vectensis (Anthozoa)

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On the origin and evolution of the lower Metazoa

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Rising starlet: the starlet sea anemone,Nematostella vectensis

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Exceptionally Preserved Jellyfishes from the Middle Cambrian

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Origin and evolution of endoderm and mesoderm

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Silencing of Developmental Genes in Hydra

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HyBra1, a Brachyury homologue, acts during head formation in Hydra

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Effect of Voids on Angular Correlation of Positron Annihilation Photons in Molybdenum

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Hydra transplantation phenomena and the mechanism of Hydra head regeneration

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Minimal ProtoHox cluster inferred from bilaterian and cnidarian Hox complements

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Generation and analysis of transcriptomic resources for a model system on the rise: the sea anemone Aiptasia pallida and its dinoflagellate endosymbiont

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A WNT of things to come: Evolution of Wnt signaling and polarity in cnidarians

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Elimination of Hydra interstitial and nerve cells by means of colchicine

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Role of Pax Genes in Eye Evolution

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The Wnt code: cnidarians signal the way

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Asymmetric expression of the BMP antagonists chordin and gremlin in the sea anemone Nematostella vectensis: Implications for the evolution of axial patterning

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Characterization of interstitial stem cells in hydra by cloning

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A maternally localised Wnt ligand required for axial patterning in the cnidarian Clytia hemisphaerica

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Origins of neurogenesis, a cnidarian view

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FGF signalling controls formation of the apical sensory organ in the cnidarianNematostella vectensis

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Analysis of forkhead and snail expression reveals epithelial–mesenchymal transitions during embryonic and larval development of Nematostella vectensis

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A muscle-specific transgenic reporter line of the sea anemone, <i>Nematostella vectensis</i>

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Two Oppositely Localised Frizzled RNAs as Axis Determinants in a Cnidarian Embryo

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Evolution and Functional Diversity of Jellyfish Opsins

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RNA Interference in Caenorhabditis elegans

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Cell cycle kinetics and development of Hydra attenuata: II. interstitial cells

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Move it or lose it: axis specification in Xenopus

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Parameters of self-organization in Hydra aggregates

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Wnt/β-Catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra

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Conservation of Brachyury, Mef2, and Snail in the Myogenic Lineage of Jellyfish: A Connection to the Mesoderm of Bilateria

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Assembly of the cnidarian camera-type eye from vertebrate-like components

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Pattern of epithelial cell cycling in hydra

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Hydra transplantation phenomena and the mechanism of Hydra head regeneration

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Embryogenesis in Hydra

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The ancestral role of Brachyury: expression of NemBra1 in the basal cnidarian Nematostella vectensis (Anthozoa)

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Early development and axis specification in the sea anemone Nematostella vectensis

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Hydra and the evolution of stem cells

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BMPs and Chordin regulate patterning of the directive axis in a sea anemone

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Gastrulation in the cnidarian Nematostella vectensis occurs via invagination not ingression

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Ordered progression of nematogenesis from stem cells through differentiation stages in the tentacle bulb of Clytia hemisphaerica (Hydrozoa, Cnidaria)

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Dorso/Ventral Genes Are Asymmetrically Expressed and Involved in Germ-Layer Demarcation during Cnidarian Gastrulation

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Characterization of the head organizer in hydra

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Genetic analysis of developmental mechanisms in hydra

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Transgenic stem cells in Hydra reveal an early evolutionary origin for key elements controlling self-renewal and differentiation

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Cnidarians and ancestral genetic complexity in the animal kingdom

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A simple plan-Cnidarians and the origins of developmental mechanisms

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Phylogeny and biogeography of Hydra (Cnidaria: Hydridae) using mitochondrial and nuclear DNA sequences

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Clytia hemisphaerica: a jellyfish cousin joins the laboratory

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Axial Patterning and Diversification in the Cnidaria Predate the Hox System

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The Mesoderm Specification Factor Twist in the Life Cycle of Jellyfish

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A genomic view of 500 million years of cnidarian evolution

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β-catenin plays a central role in setting up the head organizer in hydra

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A Novel Gene Family Controls Species-Specific Morphological Traits in Hydra

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Cell sorting during the regeneration of Hydra from reaggregated cells

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Wnt signaling promotes oral but suppresses aboral structures in Hydractinia metamorphosis and regeneration

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The Notch signaling pathway in the cnidarian Hydra

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A Hypervariable Invertebrate Allodeterminant

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The morphogenesis of nematocytes in Hydra and Forsklia: an ultrastructural study

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Are Hox Genes Ancestrally Involved in Axial Patterning? Evidence from the Hydrozoan Clytia hemisphaerica (Cnidaria)

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Head regeneration in wild-type hydra requires de novo neurogenesis

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The p53 Tumor Suppressor-Like Protein nvp63 Mediates Selective Germ Cell Death in the Sea Anemone Nematostella vectensis

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The GPCR repertoire in the demosponge Amphimedon queenslandica: insights into the GPCR system at the early divergence of animals

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The colonial cnidarian Hydractinia

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Peptide-gated ion channels and the simple nervous system of <i>Hydra</i>

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The Skeleton of the Staghorn Coral Acropora millepora: Molecular and Structural Characterization

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The role of cnidarian developmental biology in unraveling axis formation and Wnt signaling

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Bcs T x3 is a founder of a novel sea anemone toxin family of potassium channel blocker

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Meganuclease-assisted generation of stable transgenics in the sea anemone Nematostella vectensis

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Feeding-dependent tentacle development in the sea anemone Nematostella vectensis

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Activation of the cnidarian oxidative stress response by ultraviolet light, polycyclic aromatic hydrocarbons and crude oil

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Gastrulation and germ layer formation in the sea anemone Nematostella vectensis and other cnidarians

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Signaling Pathways and Axis Formation in the Lower Metazoa

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Regeneration Potential of Jellyfish: Cellular Mechanisms and Molecular Insights

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In vivo imaging of epithelial wound healing in the cnidarian Clytia hemisphaerica demonstrates early evolution of purse string and cell crawling closure mechanisms

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Disentangling compartment functions in sessile marine invertebrates

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TRF2 and the evolution of the bilateriaPreprint

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Microfluidics for electrophysiology, imaging, and behavioral analysis of Hydra

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Insights into how development and life-history dynamics shape the evolution of venom

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Nematostella vectensis, an Emerging Model for Deciphering the Molecular and Cellular Mechanisms Underlying Whole-Body Regeneration

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Modern genomic tools reveal the structural and cellular diversity of cnidarian nervous systems

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Microinjection to deliver protein, mRNA, and DNA into zygotes of the cnidarian endosymbiosis model Aiptasia sp.

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Antagonistic BMP–cWNT signaling in the cnidarian Nematostella vectensis reveals insight into the evolution of mesoderm

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Genomics and development of Nematostella vectensis and other anthozoans

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Cadherin switch marks germ layer formation in the diploblastic sea anemone Nematostella vectensis

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The methyltransferase HEN1 is required in Nematostella vectensis for microRNA and piRNA stability as well as larval metamorphosis

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A comparison of the structure and function of nematocysts in free-living and parasitic cnidarians (Myxozoa)

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A complete biomechanical model of Hydra contractile behaviors, from neural drive to muscle to movement

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Unraveling the non-senescence phenomenon in Hydra

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A population of Vasa2 and Piwi1 expressing cells generates germ cells and neurons in a sea anemone

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The Hydra stem cell system – Revisited

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The Hydra model - a model for what?

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Stem cells in Nanomia bijuga (Siphonophora), a colonial animal with localized growth zones

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Hypoxia as a physiological cue and pathological stress for coral larvae

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Camello, a novel family of Histone Acetyltransferases that acetylate histone H4 and is essential for zebrafish development

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Functional studies on the role of Notch signaling in Hydractinia development

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Nervous system immunohistochemistry of the parasitic cnidarian Polypodium hydriforme at its free-living stage

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Cell proliferation controls body size growth, tentacle morphogenesis, and regeneration in hydrozoan jellyfish Cladonema pacificum

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Functional Characterization of the Cnidarian Antiviral Immune Response Reveals Ancestral Complexity

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Insm1 -expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone Nematostella vectensis

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Endogenous tagging of multiple cellular components in the sea anemone Nematostella vectensis

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A bipolar role of the transcription factor ERG for cnidarian germ layer formation and apical domain patterning

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Hedgehog signaling is required for endomesodermal patterning and germ cell development in the sea anemone Nematostella vectensis

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Two Distinct Bacterial Biofilm Components Trigger Metamorphosis in the Colonial Hydrozoan Hydractinia echinata

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In preprints: the ins and outs of Cnidaria germ layers

Leclère, L., & Sinigaglia, C. (2025) · Development · doi:10.1242/dev.204730

Genomics and development of Nematostella vectensis and other anthozoans

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Gastrulation and germ layer formation in the sea anemone Nematostella vectensis and other cnidarians

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Molecular and developmental biology of the Cnidaria--basic aspects and phylogenetic implications.

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Coral development: from classical embryology to molecular control

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