Cited by 106Genetic Syndromes and ImprintingPregnancy and preeclampsia studiesBirth, Development, and Health

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Maternally-inherited Grb10 reduces placental size and efficiency

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Charalambous, Marika, Cowley, Michael, Geoghegan, Fleur, Smith, Florentia M., Radford, Elizabeth J., Marlow, Benjamin P., Graham, Christopher F., Hurst, Laurence D., Ward, Andrew·2010·Developmental Biology

DOI 10.1016/j.ydbio.2009.10.011

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Abstract

The control of foetal growth is poorly understood and yet it is critically important that at birth the body has attained appropriate size and proportions. Growth and survival of the mammalian foetus is dependent upon a functional placenta throughout most of gestation. A few genes are known that influence both foetal and placental growth and might therefore coordinate growth of the conceptus, including the imprinted Igf2 and Grb10 genes. Grb10 encodes a signalling adapter protein, is expressed predominantly from the maternally-inherited allele and acts to restrict foetal and placental growth. Here, we show that following disruption of the maternal allele in mice, the labyrinthine volume was increased in a manner consistent with a cell-autonomous function of Grb10 and the enlarged placenta was more efficient in supporting foetal growth. Thus, Grb10 is the first example of a gene that acts to limit placental size and efficiency. In addition, we found that females inheriting a mutant Grb10 allele from their mother had larger litters and smaller offspring than those inheriting a mutant allele from their father. This grandparental effect suggests Grb10 can influence reproductive strategy through the allocation of maternal resources such that offspring number is offset against size.

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Authors: Charalambous, M., Cowley, M., Geoghegan, F., Smith, F. M., Radford, E. J., Marlow, B. P., Graham, C. F., Hurst, L. D., & Ward, A.
Affiliations: University of Bath (GB)
University of Cambridge (GB)
University of Oxford (GB)
Corresponding author: Ward, Andrew
ORCID: Charalambous, Marika
Cowley, Michael
Radford, Elizabeth J.
Marlow, Benjamin P.
Hurst, Laurence D.
Ward, Andrew
Venue: Developmental Biology
Publisher: Elsevier BV
Published: 2010-01
Volume: 337
Issue: 1
Pages: 1-8
ISSN: 0012-1606 (ISSN-L)
DOI: 10.1016/j.ydbio.2009.10.011
OpenAlex: W1983878712
Cited by: 101
References: 48
Citations by year: 2025: 4 · 2024: 12 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 7 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 11 · 2013: 6 · 2012: 13
FWCI: 5.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1329 d)
Locations: Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (publishedVersion, other-oa)
Funders: University of Bath
Directorate for Biological Sciences
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords: Grb10, placental development, placental efficiency, maternal allele, insulin-like growth factor II, genomic imprinting, fetal growth, litter size, offspring size, maternal resource allocation, reproductive strategies
MeSH terms: Alleles, Animals, Endothelium, Female, Immunohistochemistry, Mice, Inbred CBA, Mice, Inbred C57BL, Placenta, Pregnancy, Genomic Imprinting, Mice, GRB10 Adaptor Protein

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Maternally-inherited Grb10 reduces placental size and efficiency

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