The endoderm gene regulatory network in sea urchin embryos up to mid-blastula stage
Open accessAbstract
As the result of early specification processes, sea urchin embryos eventually form various mesodermal cell lineages and a gut consisting of fore-, mid- and hindgut. The progression of specification as well as the overall spatial organization of the organism is encoded in its gene regulatory networks (GRNs). We have analyzed the GRN driving endoderm specification up to the onset of gastrulation and present in this paper the mechanisms which determine this process up to mid-blastula stage. At this stage, the embryo consists of two separate lineages of endoderm precursor cells with distinct regulatory states. One of these lineages, the veg2 cell lineage, gives rise to endoderm and mesoderm cell types. The separation of these cell fates is initiated by the spatially confined activation of the mesoderm GRN superimposed on a generally activated endoderm GRN within veg2 descendants. Here we integrate the architecture of regulatory interactions with the spatial restriction of regulatory gene expression to model the logic control of endoderm development.
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The sea urchin mesoderm, endoderm, and oral/aboral ectoderm specification GRNs are deep, layered, and hierarchical.
“The GRNs underlying specification of the mesoderm, endoderm1,2,8 and of the oral and aboral ectoderm9 of the sea urchin embryo are similarly deep, layered and hierarchical.”
From Emerging properties of animal gene regulatory networks (2010) · cites this paper as [8]
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Self-citation
- Authors
- Peter, I. S., & Davidson, E. H.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Peter, Isabelle S.
- Davidson, Eric H.
- ORCID
- Peter, Isabelle S.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 340
- Issue
- 2
- Pages
- 188-199
- ISSN
- 0012-1606 (ISSN-L)
- PMC
- PMC3981691
- OpenAlex
- W2019433333
- Cited by
- 150
- References
- 47
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 7 · 2016: 10 · 2015: 12 · 2014: 11 · 2013: 8 · 2012: 19
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Institutes of Health (HD-37105)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- endoderm specification, gene regulatory networks, sea urchin embryo, gastrulation, mesoderm specification, intestinal development, cell fate specification, regulatory interactions
- MeSH terms
- Animals, Embryo, Nonmammalian, Endoderm, Genes, Regulator, Models, Biological, Sea Urchins, Gene Expression Regulation, Developmental, Cell Lineage, Blastula, Gene Regulatory Networks
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